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Molecular Basis and Disorders of Control of Appetite and Fat Accumulation

Planned Research

Project AreaMolecular Basis and Disorders of Control of Apetite and Fat Accumulation
Project/Area Number 22126012
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

HOSODA KIMINORI  京都大学, 医学(系)研究科(研究院), 教授 (40271598)

Co-Investigator(Renkei-kenkyūsha) MORI Kiyoshi  京都大学, 医学研究科, 准教授 (60343232)
TOMITA Tsutomu  京都大学, 医学研究科, 助教 (50402897)
Project Period (FY) 2010-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥150,670,000 (Direct Cost: ¥115,900,000、Indirect Cost: ¥34,770,000)
Fiscal Year 2014: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2013: ¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2012: ¥28,080,000 (Direct Cost: ¥21,600,000、Indirect Cost: ¥6,480,000)
Fiscal Year 2011: ¥27,690,000 (Direct Cost: ¥21,300,000、Indirect Cost: ¥6,390,000)
Fiscal Year 2010: ¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
KeywordsGPR40 / 脂質異常症 / インスリン抵抗性 / GPCR / インスリン分泌 / レプチン / 膵臓 / 肥満 / 脂肪蓄積 / 脂肪毒性 / レプチン抵抗性 / 脳内報酬系 / 脂肪細胞 / 脂肪萎縮症 / iPS細胞 / 細胞治療 / ミトコンドリア遺伝子変異 / インスリン
Outline of Final Research Achievements

We demonstrated that the increase of triglyceride accumulation and the decrease of GPR40 gene expression in the pancreas of genetically obese rats deficient in leption receptor gene.We created GPR40 KO rat and now investigate the abnormalities in glucose and lipid metabolism.We established leptin gene deficient rats as a new genetically obese animal model.We succeeded in differentiation of human iPS cells into adipocyte for the first time in the world. We also established iPS cell lines from congenital lipodystrophy patients, and established a tool for the elucidation of pathogenesis and pathophysiology.

Report

(6 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (47 results)

All 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article (28 results) (of which Peer Reviewed: 28 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (18 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] The G-Protein-Coupled Long-Chain Fatty Acid Receptor GPR40 and Glucose Metabolism2014

    • Author(s)
      T. Tomita, K. Hosoda, J. Fujikura, N. Inagaki, K. Nakao
    • Journal Title

      Front Endocrinol (Lausanne).

      Volume: 5:152 Pages: 1-3

    • DOI

      10.3389/fendo.2014.00152

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Leptin restores the insulinotropic effect of exenatide in a mouse model of type 2 diabetes with increased adiposity induced by streptozotocin and high-fat diet2014

    • Author(s)
      T. Sakai, T. Kusakabe, K. Ebihara, D. Aotani, S. Yamamoto-Kataoka, Z. Mingming, VM. Gumbilai, C. Ebihara, M. Aizawa-Abe, Y. Yamamoto, M. Noguchi, J. Fujikura, K. Hosoda, N. Inagaki, K. Nakao
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 307 Issue: 8 Pages: 712-719

    • DOI

      10.1152/ajpendo.00272.2014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver.2013

    • Author(s)
      M. Aizawa-Abe, K. Ebihara, C. Ebihara, T. Mashimo, A. Takizawa, T. Tomita, T. Kusakabe, Y. Yamamoto, D. Aotani, S. Yamamoto-Kataoka, T. Sakai, K. Hosoda, T. Serikawa, K. Nakao
    • Journal Title

      Physiol Genomics.

      Volume: 45(17) Issue: 17 Pages: 786-793

    • DOI

      10.1152/physiolgenomics.00040.2013

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell transplantation therapy for diabetes mellitus: endocrine pancreas and adipocyte [Review]2013

    • Author(s)
      J. Fujikura, K. Hosoda, K. Nakao
    • Journal Title

      Endocrine Journal

      Volume: 60 Issue: 6 Pages: 697-708

    • DOI

      10.1507/endocrj.EJ13-0162

    • NAID

      10031184538

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production2013

    • Author(s)
      S. H. Chew, Y. Okazaki, H. Nagai, N. Misawa, S. Akatsuka, K. Yamashita, L. Jiang, Y. Yamashita, M. Noguchi, K. Hosoda, Y. Sekido, T. Takahashi, S. Toyokuni
    • Journal Title

      Carcinogenesis

      Volume: 35(1) Issue: 1 Pages: 164-172

    • DOI

      10.1093/carcin/bgt267

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro characterization and engraftment of adipocytes derived from human induced pluripotent stem cells and embryonic stem cells.2013

    • Author(s)
      M. Noguchi, K. Hosoda, E. Mori, M. Nakane, K. Nakao, D. Taura, Y. Yamamoto, T. Kusakabe, M. Sone, H. Sakurai, J. Fujikura, K. Ebihara, K. Nakao
    • Journal Title

      Stem Cells and Development

      Volume: 22(21) Issue: 21 Pages: 2895-2905

    • DOI

      10.1089/scd.2013.0113

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early Changes of Abdominal Adiposity Detected with Weekly Dual Bioelectrical Impedance Analysis During Calorie Restriction.2013

    • Author(s)
      M. Ida, M. Hirata, S. Odori, E. Mori, E. Kondo, J. Fujikura, T. Kusakabe, K. Ebihara, K. Hosoda, K. Nakao.
    • Journal Title

      Obesity

      Volume: 21(9) Issue: 9

    • DOI

      10.1002/oby.20300

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracerebroventricular administration of C-type natriuretic peptide suppresses food intake via activation of the melanocortin system in mice.2013

    • Author(s)
      N. Yamada-Goto, G. Katsuura, K. Ebihara, M. Inuzuka, Y. Ochi, Y. Yamashita, T. Kusakabe, A. Yasoda, N. Asahara-Satoh, H. Ariyasu, K. Hosoda, K. Nakao.
    • Journal Title

      Diabetes

      Volume: 62(5) Issue: 5 Pages: 1500-1504

    • DOI

      10.2337/db12-0718

    • NAID

      120005244943

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation2012

    • Author(s)
      J.Fujikura, M.Sone, K.Hosoda, K.Nakao, et al
    • Journal Title

      Diabetologia

      Volume: (in press) Issue: 6 Pages: 1689-1698

    • DOI

      10.1007/s00125-012-2508-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Leptin activates hepatic 5’ AMP-Activated Protein Kinase through sympathetic nervous system and α1 adrenergic receptor: A potential mechanism for improvement of fatt Li Yver in lipodystrophy by leptin2012

    • Author(s)
      Miyamoto L, Nakao K, et al
    • Journal Title

      J. Biol. Chem.

      Volume: 287 Issue: 48 Pages: 40441-40447

    • DOI

      10.1074/jbc.m112.384545

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Magnetic Resonance Imaging Analysis of Food-Related Brain Activity in Patients with Lipodystrophy Undergoing Leptin Replacement Therapy2012

    • Author(s)
      Aotani D, Nakao K, et al
    • Journal Title

      J Clin Endocrinol Metab.

      Volume: 97 Issue: 10 Pages: 3663-3671

    • DOI

      10.1210/jc.2012-1872

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impairment of fear-conditioning responses and changes of brain neurotrophic factors in diet-induced obese mice2012

    • Author(s)
      N.Yamada-Goto, K.Ebihara, K.Hosoda, K.Nakao, et al
    • Journal Title

      J Neuroendocrinol

      Volume: (in press) Issue: 8 Pages: 1120-1125

    • DOI

      10.1111/j.1365-2826.2012.02327.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice2012

    • Author(s)
      T.Kusakabe, K.Ebihara, K.Nakao, et al
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 302 Issue: 8 Pages: E924-E931

    • DOI

      10.1152/ajpendo.00198.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo2012

    • Author(s)
      Bando M, Nakao K, et al
    • Journal Title

      Am. J. Physiol. Endocrinol. Metab.

      Volume: 302 Issue: 4 Pages: 403-408

    • DOI

      10.1152/ajpendo.00341.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function2012

    • Author(s)
      Odori S, Nakao K, et al
    • Journal Title

      Metabolism

      Volume: 62 Issue: 1 Pages: 70-78

    • DOI

      10.1016/j.metabol.2012.06.010

    • NAID

      120005242664

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intra-abdominal fat area is a predictor for new onset of individual components of metabolic syndrome: MEtabolic syndRome and abdominaL ObesiTy (MERLOT study)2012

    • Author(s)
      YM. Nakao, K. Hosoda, et al
    • Journal Title

      Proc Jpn Acad Ser B Phys Biol Sci.

      Volume: 88(8) Pages: 454-61

    • NAID

      130001924760

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic overexpression of intraislet ghrelin does not affect insulin secretion or glucose metabolism in vivo2012

    • Author(s)
      M.Bando, K.Hosoda, et al
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 302(4)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice2011

    • Author(s)
      M.Naito, K.Ebihara, M.Mukoyama, K.Hosoda, K.Nakao, et al
    • Journal Title

      Diabetes

      Volume: 60(9) Issue: 9 Pages: 2265-73

    • DOI

      10.2337/db10-1795

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats2011

    • Author(s)
      M. Zhao, K. Ebihara(8人中4番目)
    • Journal Title

      Diabetes Obes Metab

      Volume: 12 Issue: 12 Pages: 1123-1129

    • DOI

      10.1111/j.1463-1326.2011.01471.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin and Dopamine Stimulate Ghrelin Secretion by the Ghrelin-Producing Cell Line, MGN3-1 in Vitro2011

    • Author(s)
      H. Iwakura, K. Hosoda, et al
    • Journal Title

      Endocrinology

      Volume: 152 (7) Issue: 7 Pages: 2619-2625

    • DOI

      10.1210/en.2010-1455

    • NAID

      120004397870

    • URL

      http://repository.kulib.kyoto-u.ac.jp/dspace/handle/2433/158372

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired CNS leptin action is implicated in depression associated with obesity2011

    • Author(s)
      N.Yamada, K.Ebihara, K.Hosoda, K.Nakao, et al
    • Journal Title

      Endocrinology

      Volume: 152(7) Issue: 7 Pages: 2634-43

    • DOI

      10.1210/en.2011-0004

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic impact of leptin on diabetes, diabetic complications, and longevity in insulin-deficient diabetic mice2011

    • Author(s)
      M.Naito, K.Hosoda, et al
    • Journal Title

      Diabetes

      Volume: 60(9) Pages: 2265-73

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Azilsartan treatment improves insulin sensitivity in obese spontaneously hypertensive Koletsky rats2011

    • Author(s)
      M.Zhao, K.Hosoda, et al
    • Journal Title

      Diabetes Obes Metab

      Volume: 13(12) Pages: 1123-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxytocin and Dopamine Stimulate Ghrelin Secretion by the Ghrelin-Producing Cell Line, MGN3-1 in Vitro2011

    • Author(s)
      H.Iwakura, K.Hosoda, et al
    • Journal Title

      Endocrinology

      Volume: 152(7) Pages: 2619-2625

    • NAID

      120004397870

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a Novel Ghrelin-Producing Cell Line2010

    • Author(s)
      H.Iwakura, K.Hosoda, et al
    • Journal Title

      Endocrinology

      Volume: 151(6) Pages: 695-705

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relevant use of Klotho in FGF19 subfamily signaling system in vivo2010

    • Author(s)
      K.Tomiyama, K.Hosoda, et al
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 26;107(4) Pages: 1666-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipose Tissue-Specific Regulation of Angiotensinogen in Obese Humans and Mice : Impact of Nutritional Status and Adipocyte Hypertrophy2010

    • Author(s)
      S.Yasue, K.Hosoda, et al
    • Journal Title

      Am J Hypertens

      Volume: 23(4) Pages: 425-31

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity2010

    • Author(s)
      S.Okada, K.Hosoda, et al
    • Journal Title

      Metabolism

      Volume: 59(9) Pages: 1241-51

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝性肥満モデルmkyo/mkyoラット膵島での脂質受容体GPR40の遺伝子発現調節2016

    • Author(s)
      吉良由里、冨田努、細田公則、藤倉純二、海老原千尋、阿部恵、海老原健、中尾一和、稲垣暢也
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2016-04-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規の遺伝性肥満モデルmkyo/mkyoラット膵島における脂肪酸受容体GPR40の遺伝子発現調節2015

    • Author(s)
      吉良友里、冨田 努、細田公則、藤倉純二、海老原千尋、阿部 恵、海老原健、中尾一和、稲垣暢也
    • Organizer
      第36回日本肥満学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-10-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 新規の遺伝性肥満モデルmkyo/mkyoラット膵島における脂質受容体のGPR40の遺伝子発現調節2015

    • Author(s)
      吉良友里、冨田努、細田公則、藤倉純二、海老原千尋、阿部 恵、海老原健、中尾一和、稲垣暢也
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] GPR40の分子構造およびGPR40作動薬2015

    • Author(s)
      冨田 努、細田公則、中尾一和、稲垣暢也
    • Organizer
      第12回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京都江東区)
    • Year and Date
      2015-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] GPR40の遺伝子肥満・耐糖能異常モデルKoletskyラット膵島における発現調節の検討2015

    • Author(s)
      冨田努、細田公則、小鳥真司、藤倉純二、中尾一和、稲垣暢也
    • Organizer
      第88回日本内分泌学会学術総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2015-04-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 第35回日本肥満学会2014

    • Author(s)
      冨田努、細田公則、小鳥真司、藤倉純二、稲垣暢也、中尾一和
    • Organizer
      GPR40の遺伝性肥満・耐糖能異常モデルKoletskyラット膵島における発現調節の検討
    • Place of Presentation
      シーガイアコンベンションセンター(宮崎市)
    • Year and Date
      2014-10-24
    • Related Report
      2013 Annual Research Report
  • [Presentation] G蛋白共役型-脂肪酸受容体GPR40の肥満糖尿病における発現調節と意義2014

    • Author(s)
      冨田努、細田公則、小鳥真司、藤倉純二、日下部徹、海老原健、稲垣暢也、中尾一和
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2014-05-23
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規のインスリン分泌調節因子GPR40の遺伝子肥満モデルでの発現調節2011

    • Author(s)
      冨田努, 細田公則, その他
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-04-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膜型脂質受容体GPR40の遺伝性肥満Koletskyラット膵島での発現調節とその意義

    • Author(s)
      冨田努、細田公則、小鳥真司、藤倉純二、日下部徹、海老原健、中尾一和
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台国際センター(宮城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] G蛋白共役型-脂肪酸受容体GPR40の糖尿病における発現調節と意義

    • Author(s)
      冨田努、細田公則、小鳥真司、藤倉純二、日下部徹、海老原健、中尾一和
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      テトリア熊本ビル(熊本県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 部分性脂肪萎縮症に対するレプチン補充療法の有効性

    • Author(s)
      青谷大介、海老原健、日下部徹、阿部恵、片岡祥子、酒井建、海老原千尋、藤倉純二、細田公則、中尾一和
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      ホテル日航熊本(熊本県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ニューロメジンUのインスリン抵抗性における意義

    • Author(s)
      青谷大介、海老原健、日下部徹、阿部恵、片岡祥子、酒井建、海老原千尋、藤倉純二、細田公則、中尾一和
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高脂肪食負荷レプチントランスジェニック(LepTg)マウスにおけるレプチン感受性の検討

    • Author(s)
      野村英生、孫徹、後藤伸子、勝浦五郎、野口倫生、冨田努、藤倉純二、海老原健、細田公則、中尾一和
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 膜型脂質受容体GPR40の遺伝性肥満Koletskyラット膵島での発現調節とその意義

    • Author(s)
      冨田努、細田公則、小鳥真司、藤倉純二、海老原健、中尾一和
    • Organizer
      第34回日本肥満学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Role of Neuromedin U in Glucose Homeostasis

    • Author(s)
      D. Aotani, K. Ebihara, T. Kusakabe, M. Aizawa-Abe, S. Y. Kataoka, T. Sakai, C. Ebihara, K. Hosoda, K. Nakao
    • Organizer
      OBESITY 2013 31th Annual Scientific Meeting of The Obesity Society
    • Place of Presentation
      Atlanta,Georgia
    • Related Report
      2012 Annual Research Report
  • [Presentation] Leptin Transgenic Mice on Short-Term High Fat Diet Show Leptin Resistance without Obesity

    • Author(s)
      H. Nomura, C. Son, K. Ebihara, K. Hosoda, K. Nakao
    • Organizer
      OBESITY 2013 31th Annual Scientific Meeting of The Obesity Society
    • Place of Presentation
      Atlanta,Georgia
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトips細胞由来の脂肪細胞の脂肪細胞機能解析と細胞移植

    • Author(s)
      野口倫生、細田公則、田浦大輔、森栄作、松原正樹、曽根正勝、藤倉純二、海老原健、中尾一和
    • Organizer
      第109回日本内科学会
    • Place of Presentation
      みやこめっせ(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規のインスリン分泌促進因子GPR40の遺伝性肥満モデルの発現調節と機能的意義

    • Author(s)
      冨田努、細田公則、小鳥真司、孫徹、藤倉純二、岩倉浩、野口倫生、日下部徹、海老原健、中尾一和
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] Mitochondrial Disease-Specific Induced Pluripotent Stem Cells, Method of Producing Same and Use Thereof2011

    • Inventor(s)
      中尾一和, 藤倉純二, 細田公則, 曽根正勝, 中尾一泰
    • Industrial Property Rights Holder
      中尾一和, 藤倉純二, 細田公則, 曽根正勝, 中尾一泰
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-06-30
    • Related Report
      2011 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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