| Budget Amount *help |
¥148,850,000 (Direct Cost: ¥114,500,000、Indirect Cost: ¥34,350,000)
Fiscal Year 2014: ¥27,170,000 (Direct Cost: ¥20,900,000、Indirect Cost: ¥6,270,000)
Fiscal Year 2013: ¥28,600,000 (Direct Cost: ¥22,000,000、Indirect Cost: ¥6,600,000)
Fiscal Year 2012: ¥30,030,000 (Direct Cost: ¥23,100,000、Indirect Cost: ¥6,930,000)
Fiscal Year 2011: ¥27,300,000 (Direct Cost: ¥21,000,000、Indirect Cost: ¥6,300,000)
Fiscal Year 2010: ¥35,750,000 (Direct Cost: ¥27,500,000、Indirect Cost: ¥8,250,000)
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| Outline of Final Research Achievements |
Compartment-based modularity is one of the important features in the development of multi-cellular organisms. We examined the mechanisms underlying the establishment and maintenance of the dorsal compartment in the somite, characterized by the expression of zic1/zic4 genes in the trunk region of medaka fish. We demonstrated that the dorsoventral boundary of this compartment is established by a special group of cells, called “boundary cells”. They are born in the region near the notochord and migrate out to the presumptive boundary. We also found that boundary cells finally differentiate into the horizontal myoceptum which mechanically dives the dorsal and ventral compartment of the somite. At later stages, the horizontal myoceptum could play an essential role in the maintenance of the compartment bourdary.
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