| Budget Amount *help |
¥158,730,000 (Direct Cost: ¥122,100,000、Indirect Cost: ¥36,630,000)
Fiscal Year 2014: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2013: ¥30,550,000 (Direct Cost: ¥23,500,000、Indirect Cost: ¥7,050,000)
Fiscal Year 2012: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2011: ¥31,720,000 (Direct Cost: ¥24,400,000、Indirect Cost: ¥7,320,000)
Fiscal Year 2010: ¥37,960,000 (Direct Cost: ¥29,200,000、Indirect Cost: ¥8,760,000)
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| Outline of Final Research Achievements |
Heart does not develop normally without physical stimuli generated by heartbeat and circulation of blood. In fact, when heart contracts abnormally and/or blood circulates in a disturbed way, cardiac anomalies develop in both mouse and zebrafish. Onset of congenital heart diseases in human is believed to have the same mechanical background as other experimental model animals. Nonetheless, molecular mechanism by which cardic cells sense physical forces generated contraction and blood flow is largely unknown. To establish a solid logical link between force and heart development, we performed this project and found key factors that play important roles during the force-sensitive process of cardiogenesis. More importantly, we revealed a molecular mechanism underlying the force-induced gene expression. As an unexpected results, we have fond this force-sensitive process regulates other biological phenomena, such as metabolic homeostasis and regeneration/wound healing.
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