| Budget Amount *help |
¥181,480,000 (Direct Cost: ¥139,600,000、Indirect Cost: ¥41,880,000)
Fiscal Year 2014: ¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
Fiscal Year 2013: ¥34,450,000 (Direct Cost: ¥26,500,000、Indirect Cost: ¥7,950,000)
Fiscal Year 2012: ¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
Fiscal Year 2011: ¥35,620,000 (Direct Cost: ¥27,400,000、Indirect Cost: ¥8,220,000)
Fiscal Year 2010: ¥42,510,000 (Direct Cost: ¥32,700,000、Indirect Cost: ¥9,810,000)
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| Outline of Final Research Achievements |
CSCs have been postulated as key drivers of cancer relapse and progression, and are supposed to be maintained under the specialized microenvironment called niche. To explore the niche mimicry for rat C6 glioma side population (SP) cells (recognized as CSCs), nearly 400 types of acrylate- and urethane-based synthetic polymers were examined. We found that urethane-based PU10 polymer exhibited the highest niche activity in supporting C6 CSCs. TOF/MS analysis of PU10-bound proteins identified an iron carrier transferrin (Tf). Iron is stored in tumor infiltrating CD204+ macrophages, whose protumoral activity is potently enhanced by CSC-secreted soluble factors. Supportively, the clinical data of 376 glioma patients obtained from NCI (USA) database revealed that expressions of Tf receptor and CD204 genes are found to be predictive of glioma patients' malignancies. Our findings will help elucidate the complex nature of the CSC niche and provide novel therapeutic targets to eradicate cancers.
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