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Establishment of sex differences through sex-specific enhancer

Planned Research

Project AreaMolecular mechanisms for establishment of sex differences.
Project/Area Number 22132002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyushu University

Principal Investigator

MOROHASHI Ken-ichirou  九州大学, 医学(系)研究科(研究院), 主幹教授 (30183114)

Co-Investigator(Renkei-kenkyūsha) SHIMA Yuichi  九州大学, 大学院医学研究院, 講師 (80425420)
BABA Takashi  九州大学, 大学院医学研究院, 助教 (40435524)
YOKOYAMA Atsushi  東北大学, 大学院医学系研究科, 助教 (20572332)
MATSUMOTO Takahiro  徳島大学, 大学院医歯薬学研究部, 准教授 (70447374)
Project Period (FY) 2010-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥227,890,000 (Direct Cost: ¥175,300,000、Indirect Cost: ¥52,590,000)
Fiscal Year 2014: ¥49,920,000 (Direct Cost: ¥38,400,000、Indirect Cost: ¥11,520,000)
Fiscal Year 2013: ¥52,260,000 (Direct Cost: ¥40,200,000、Indirect Cost: ¥12,060,000)
Fiscal Year 2012: ¥43,810,000 (Direct Cost: ¥33,700,000、Indirect Cost: ¥10,110,000)
Fiscal Year 2011: ¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2010: ¥38,610,000 (Direct Cost: ¥29,700,000、Indirect Cost: ¥8,910,000)
Keywordsゲノム / 発生 / 遺伝子発現 / クロマチン構造 / 精巣 / ライディッヒ細胞 / セルトリ細胞 / 発現制御 / 発生・分化 / 性差構築 / 性特異的エンハンサー / 卵巣 / 性差 / トランスジェニック
Outline of Final Research Achievements

The gonads, testis and ovary, acquire the sexes under genetic regulation, and then establish endocrine regulation by starting sex steroid production. Thereafter, genetic and endocrine regulation, through their synergistic interaction, result in exhibition of sex differences in the gonads and other many organs. In the present study, based on the hypothesis that the sex-dependent gene expression in the establishment of the sex differences would be regulated by sex-specific chromatin structure via variety of histone modification, we aimed to uncover the molecular bases for establishment of the sex differences. In particular, we focused on the function of Ad4BP essential for gonadal development and the chromatin structure. As the consequence, we succeeded to elucidate the molecular mechanisms for sex-dependent differentiation of Sertoli (nursing cells) and Leydig cells (steroid hormone producing cells), both of which are crucial for testicular functions.

Report

(6 results)
  • 2015 Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (64 results)

All 2016 2015 2014 2013 2012 2011 2010 Other

All Int'l Joint Research (2 results) Journal Article (21 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 21 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (36 results) (of which Int'l Joint Research: 3 results,  Invited: 15 results) Remarks (5 results)

  • [Int'l Joint Research] Academia Cinica/National Taiwan University(台湾)

    • Related Report
      2014 Annual Research Report
  • [Int'l Joint Research] 韓国科学技術院(韓国)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] solation and characterization of mouse fetal Leydig progenitor cells2016

    • Author(s)
      Miki Inoue, Yuichi Shima, Kanako Miyabayashi, Tetsuya Sato, Takashi Baba, Yasuyuki Ohkawa, Haruhiko Akiyama, Mikita Suyama, Ken-ichirou Morohashi
    • Journal Title

      Endocrinology

      Volume: 157 Issue: 3 Pages: 1222-1233

    • DOI

      10.1210/en.2015-1773

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Heterogeneity of ovarian theca and interstitial gland cells in mice2015

    • Author(s)
      Kanako Miyabayashi, Kaori Tokunaga, Hiroyuki Otake, Takashi Baba, Yuichi Shima, Ken-ichirou Morohashi
    • Journal Title

      PLoS One

      Volume: 10

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lack of Skeletal Dysplasia in Patients with Missense Mutations and Upstream Deletion of SOX9.2015

    • Author(s)
      Katoh-Fukui Y, Igarashi M, Nagasaki K, Horikawa R, Nagai T, Tsuchiya T, Suzuki E, Miyado M, Hata K, Nakabayashi K, Hayashi K, Matsubara Y, Baba T, Morohashi K, Igarashi A, Ogata T, Takada S, and Fukami M
    • Journal Title

      Molecular Genetics & Genomic Medicine

      Volume: 3 Issue: 6 Pages: 550-557

    • DOI

      10.1002/mgg3.165

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation2015

    • Author(s)
      Megumi Tsuchiya, Shin Isogai, Hiroaki Taniguchi, Hidehito Tochio, Masahiro Shirakawa, Ken-ichirou Morohashi, Yasushi Hiraoka, Tokuko Haraguchi & Hidesato Ogawa
    • Journal Title

      Scientific Report

      Volume: 5 Issue: 1 Pages: 14498-14498

    • DOI

      10.1038/srep14498

    • NAID

      120005820894

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fetal Leydig Cells are Androgen Independent and Persist as an Androgen-independent Subpopulation in the Postnatal Testis2015

    • Author(s)
      Yuichi Shima, Sawako Matsuzaki, Kanako Miyabayashi, Hiroyuki Otake, Takashi Baba, Shigeaki Kato, Ilpo Huhtaniemi, Ken-ichirou Morohashi
    • Journal Title

      Mol Endocrinol

      Volume: 29 Issue: 11 Pages: 1581-1593

    • DOI

      10.1210/me.2015-1200

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Glycolytic gene as the targets of nuclear receptor Ad4BP/SF-12014

    • Author(s)
      Takashi Baba, Hiroyuki Otake, Tetsuya Sato, Kanako Miyabayashi, Yurina Shishido, Chia-Yih Wang, Yuichi Shima, Hiroshi Kimura, Mikako Yagi, Yasuhiro Ishihara, Shinjiro Hino, Hidesato Ogawa, Mitsuyoshi Nakao, Takeshi Yamazaki, Dongchon, Kang, Yasuyuki Ohkawa, Mikita Suyama, Bon-Chu Chung, Ken-ichirou Morohashi
    • Journal Title

      Nature Commun

      Volume: 5 Issue: 1 Pages: 3634-3634

    • DOI

      10.1038/ncomms4634

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.2014

    • Author(s)
      Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I M, Shishido Y, Baba T, Ito R, Kanno J, Ohkawa Y, Morohashi K, Sugawara A.
    • Journal Title

      J Biol Chem.

      Volume: 289 Issue: 26 Pages: 18152-18162

    • DOI

      10.1074/jbc.m114.566448

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes2013

    • Author(s)
      Yuichi Shima
    • Journal Title

      Molecular Endocrinology

      Volume: 27 Issue: 1 Pages: 63-73

    • DOI

      10.1210/me.2012-1256

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Steroid hormones and the development of reproductive organs2013

    • Author(s)
      Ken-ichirou Morohashi, Takashi Baba, Minoru Tanaka
    • Journal Title

      Sexual Development

      Volume: 7 Pages: 61-79

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aristaless related homeobox gene, Arx, is implicated in mouse fetal Leydig cell differentiation possibly through expressing in the progenitor cells2013

    • Author(s)
      Kanako Miyabayashi, Yuko Katoh-Fukui, Hidesato Ogawa, Takashi Baba, Yuichi Shima, Noriyuki Sugiyama, Kunio Kitamura, Ken-ichirou Morohashi
    • Journal Title

      PLOS One

      Volume: 8

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity in sexual bipotentiality and plasticity of granulosa cells in developing mouse ovaries2013

    • Author(s)
      Kyoko Harikae, Kento Miura, Mai Shinomura, Shogo Matoba, Ryuji Hiramatsu, Naoki Tsunekawa, Masami Kanai-Azuma, Masamichi Kurohmaru, Ken-ichirou Morohashi, and Yoshiakira Kanai
    • Journal Title

      J Cell Sci

      Volume: 126 Pages: 2834-2844

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development2013

    • Author(s)
      Yuka Fujimoto, Satomi S. Tanaka, Yasuka L. Yamaguchi, Hiroki Kobayashi, Shunsuke Kuroki, Makoto Tachibana, Mai Shinomura, Yoshiakira Kanai, Ken-ichirou Morohashi, Kiyoshi Kawakami, and Ryuichi Nishinakamura
    • Journal Title

      Dev Cell

      Volume: 26 Pages: 416-430

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cbx2, a polycomb group gene, is required for Sry gene expression in mice.2012

    • Author(s)
      Katoh-Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T., Shima, Y, Kidokoro T, Kanai Y, Schedl A, Wilhelm D, Koopman P, Okuno Y, Morohashi K.
    • Journal Title

      Endocrinology

      Volume: 153(2) Issue: 2 Pages: 913-924

    • DOI

      10.1210/en.2011-1055

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Wnt family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice.2012

    • Author(s)
      Nakamura T, Miyagawa S, Katsu Y, Watanabe H, Mizutani T, Sato T, Morohashi KI, Takeuchi T, Iguchi T, Ohta Y
    • Journal Title

      Toxicology

      Volume: 296 Issue: 1-3 Pages: 13-19

    • DOI

      10.1016/j.tox.2012.02.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal Leydig cells but permits normal genital and reproductive development2012

    • Author(s)
      Miyado M, Nakamura M, Miyado K, Morohashi K, Sano S, Nagata E, Fukami M, Ogata T
    • Journal Title

      Endocrinology

      Volume: 153(12) Issue: 12 Pages: 6033-6040

    • DOI

      10.1210/en.2012-1324

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of enhancer specific for fetal Leydig cells in Ad4BP/SF-1 gene2011

    • Author(s)
      Yuichi Shima, et al
    • Journal Title

      Endocrinology

      Volume: 153 Issue: 1 Pages: 417-425

    • DOI

      10.1210/en.2011-1407

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA methylation of intronic enhancers directs tissue-specific expression of Steroidogenic Factor 1/Adrenal 4 Binding Protein (SF-1/Ad4BP)2011

    • Author(s)
      Erling A.Hoivik, et al
    • Journal Title

      Endocrinology

      Volume: 152 Issue: 5 Pages: 2100-2112

    • DOI

      10.1210/en.2010-1305

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA Methylation of Intronic Enhancers Directs Tissue-Specific Expression of Steroidogenic Factor 1/Adrenal 4 Binding Protein(SF-1/Ad4BP).2011

    • Author(s)
      Erling A, et al.
    • Journal Title

      Endocrinology

      Volume: 151(In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The fetal and adult adrenal cortex2011

    • Author(s)
      Morohashi K, Zubair M
    • Journal Title

      Mol.Cell.Endocrinol.

      Volume: 336 Pages: 193-197

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal epithelial cell polarity and migration of Emx2 KO embryonic gonads induced by ectopic EGFR expression2010

    • Author(s)
      Kusaka M, et al.
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 5893-5904

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Production and characterization of monoclonal antibodies to germ cells2010

    • Author(s)
      Yokoyama C, et al.
    • Journal Title

      Hybridoma

      Volume: 29 Pages: 53-57

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胎仔精巣におけるライディッヒ前駆細胞の単離とその分化誘導系の確立2015

    • Author(s)
      井上実紀、嶋雄一、宮林香奈子、佐藤哲也、馬場崇、大川恭行、須山幹太、諸橋憲一郎
    • Organizer
      第38回日本分子生物学会年会
    • Place of Presentation
      神戸市
    • Year and Date
      2015-12-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 教育講演;Ad4BPによる代謝制御とステロイド合成2015

    • Author(s)
      諸橋憲一郎、井上実紀、宮林香奈子、宍戸祐里菜、Bing Li、嶋雄一、馬場崇
    • Organizer
      第49回日本小児内分泌学会学術集会
    • Place of Presentation
      東京都
    • Year and Date
      2015-10-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 特別講演 Ad4BPレギュロンによる細胞内代謝連関2015

    • Author(s)
      諸橋憲一郎、井上実紀、宮林香奈子、宍戸祐里菜、Bing Ki、嶋雄一、馬場崇
    • Organizer
      日本アンドロロジー学会第34回学術大会
    • Place of Presentation
      福岡市
    • Year and Date
      2015-06-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Nuclear Receptor and metabolism2015

    • Author(s)
      Takashi Baba and Ken-ichirou Morohashi
    • Organizer
      19th International conference on Cytochrome P450
    • Place of Presentation
      東京都
    • Year and Date
      2015-06-13
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional importance of fetal Leydig cells in postnatal testis development2015

    • Author(s)
      Shima Y, Miyabayashi K, Suzuki K, Inoue M, Baba T, and Morohashi K
    • Organizer
      7th International Symposium on the Biology of Vertebrate Sex Differentiation
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2015-04-13
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] セルトリ細胞における性染色体構成に依存した遺伝子発現制御機構の解明2014

    • Author(s)
      宍戸祐里菜, 馬場崇, 大竹博之, 佐藤哲也, 宮林香奈子, 嶋雄一, 大川恭行, 須山幹太, 諸橋憲一郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜市
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dual Roles of Ad4BP/SF-1 in Steroidogenesis and Glycolysis2014

    • Author(s)
      Takashi Baba and Ken-ichirou Morohashi
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都市
    • Year and Date
      2014-10-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dual Roles of Ad4BP/SF-1 in Steroidogenesis and Glycolysis2014

    • Author(s)
      Takashi Baba and Ken-ichirou Morohashi
    • Organizer
      20th International Symposium on Microsomal and Drug Oxidations
    • Place of Presentation
      Stuttgart, Germany
    • Year and Date
      2014-05-18
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Regulation of energy metabolism by nuclear receptors2014

    • Author(s)
      Takashi Baba, Ken-ichirou Morohashi
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 胎仔型ライディッヒ細胞の細胞運命と生理機能の解明2014

    • Author(s)
      嶋 雄一、宮林 香奈子、松﨑 佐和子、井上 実紀、馬場 崇、大竹 博之、諸橋 憲一郎
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Regulation of energy metabolism by nuclear receptor regulon2014

    • Author(s)
      Ken Morohashi
    • Organizer
      IRG meeting
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A Novel Landscape of Target Genes for Ad4BP/SF-12013

    • Author(s)
      Ken Morohashi
    • Organizer
      Endocrine Society’s 95th Annual Meeting
    • Place of Presentation
      San Francisco
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 胎仔型ライディッヒ細胞の存在意義2013

    • Author(s)
      嶋雄一、宮林香奈子、大竹博之、馬場崇、諸橋 憲一郎
    • Organizer
      第32回日本アンドロロジー学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 性差の内分泌制御と遺伝的制御2013

    • Author(s)
      嶋雄一、宮林香奈子、大竹博之、馬場崇、諸橋 憲一郎
    • Organizer
      フォーラム2013 衛生環境・環境トキシコロジー学会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functional characterization of fetal Leydig cells in prenatal and postnatal stages2013

    • Author(s)
      Yuichi Shima, Kanako Miyabayashi, Kentaro Suzuki, Takashi Baba, Hiroyuki Otake, and Ken-ichirou Morohashi
    • Organizer
      SSR (Society for Study of Reproduction)’s 46th annual meeting
    • Place of Presentation
      Montreal, Quebec
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胎仔型ライディッヒ細胞における遺伝子発現プロファイルの経時的変化2013

    • Author(s)
      宮林香奈子、嶋 雄一、佐藤 哲也、馬場 崇、大竹 博之、大川 恭行、須山 幹太、諸橋 憲一郎
    • Organizer
      第18回日本生殖内分泌学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胎仔精巣におけるテストステロン合成経路の解明2012

    • Author(s)
      嶋 雄一
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 性差形成と維持の機構2012

    • Author(s)
      諸橋 憲一郎
    • Organizer
      第44回日本動脈硬化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Glycolytic genes as the targets of Ad4BP/SF-12012

    • Author(s)
      Ken-ichirou Morohashi
    • Organizer
      15th Conference on the adrenal cortex, Adrenal 2012
    • Place of Presentation
      Texas
    • Year and Date
      2012-06-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Functional characterization of fetal Leydig cells by cell-specific disruption of Ad4BP/SF-1 gene2012

    • Author(s)
      Yuichi Shima
    • Organizer
      Sixth International Symposium on the Biology of Vertebrate Sex Determination
    • Place of Presentation
      Hawaii
    • Year and Date
      2012-04-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] 胎仔ライディッヒ細胞と成獣ライディッヒ細胞の異質性について2012

    • Author(s)
      諸橋 憲一郎
    • Organizer
      第85回日本内分泌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-04-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 核内受容体 Ad4BP/SF-1 の副腎皮質における新たな機能2012

    • Author(s)
      馬場 崇
    • Organizer
      第85回日本内分泌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-04-19
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 胎仔型ライディッヒ細胞特異的Ad4BP/SF-1遺伝子ノックアウトマウスの解析2011

    • Author(s)
      嶋雄一, その他
    • Organizer
      第19回日本ステロイドホルモン学会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] RNA-SeqおよびChIP-Seq法によるAd4BP/SF-1標的遺伝子の同定2011

    • Author(s)
      馬場崇, その他
    • Organizer
      第4回性差生物医学研究会
    • Place of Presentation
      山口大学
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生殖腺におけるステロイドホルモン産生2011

    • Author(s)
      諸橋憲一郎
    • Organizer
      第6回日本生殖内分泌学会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胎仔型ライディッヒ細胞の生理学的機能の解明2011

    • Author(s)
      嶋雄一、諸橋憲一郎
    • Organizer
      第84回日本内分泌学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional characterization of fetal Leydig cells by cell-specific disruption of Ad4BP/SF-1 gene2011

    • Author(s)
      嶋雄一, その他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of Ad4BP/SF-1 target genes by ChIP-Seq in Y-1 adrenocortical cells2011

    • Author(s)
      馬場崇, その他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] RNA-Seq解析による胎仔型および成獣型ライディッヒ細胞特異的発現マーカー遺伝子の探索2011

    • Author(s)
      宮林香奈子, その他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生殖腺の性差構築2011

    • Author(s)
      諸橋憲一郎
    • Organizer
      第4回 日本性差医学・医療学会
    • Place of Presentation
      下関
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular and Cellular Mechanisms of Testis Differentiation2010

    • Author(s)
      Morohashi K
    • Organizer
      Gordon Research Conference, 2010 Reproductive Tract Biology
    • Place of Presentation
      New Hampshire, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Common Steroidogenic Primordia in Gonadal and Adrenal Morphogenesis Lineage of Testicular Leydig cells and Adrenal Cortex2010

    • Author(s)
      Morohashi K, et al.
    • Organizer
      43 rd Annual Meeting of the Society for the Study of Reproduction
    • Place of Presentation
      Milwaukee, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ad4BP/SF-1 as the key factor for steroidogenic cell development2010

    • Author(s)
      Morohashi K
    • Organizer
      14th Adrenal Cortex Conference
    • Place of Presentation
      San Diego, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] ステロイド産生細胞の発生2010

    • Author(s)
      諸橋憲一郎
    • Organizer
      第28回内分泌代謝サマーセミナー
    • Place of Presentation
      長崎
    • Related Report
      2010 Annual Research Report
  • [Presentation] Transcriptomic analysis of fetal Leydig cells2010

    • Author(s)
      嶋雄一、諸橋憲一郎, 他
    • Organizer
      第33回 日本分子生物学会、第83回 日本生化学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression profile of steroidogenic genes in the fetal LEydig cells2010

    • Author(s)
      宮林香奈子、諸橋憲一郎, 他
    • Organizer
      第33回 日本分子生物学会、第83回 日本生化学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Remarks] 平成22年度~平成26年度 文部科学省科学研究費補助金 新学術領域研究「性差構築の分子基盤」

    • URL

      http://www.seisa.med.kyushu-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 領域ホームページ

    • URL

      http://www.seisa.med.kyushu-u.ac.jp

    • Related Report
      2012 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.med.kyushu-u.ac.jp/seisaseibutu/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.seisa.med.kyushu-u.ac.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.seisa.med.kyushu-u.ac.jp/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2022-03-01  

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