|Budget Amount *help
¥170,430,000 (Direct Cost: ¥131,100,000、Indirect Cost: ¥39,330,000)
Fiscal Year 2014: ¥31,590,000 (Direct Cost: ¥24,300,000、Indirect Cost: ¥7,290,000)
Fiscal Year 2013: ¥33,280,000 (Direct Cost: ¥25,600,000、Indirect Cost: ¥7,680,000)
Fiscal Year 2012: ¥35,100,000 (Direct Cost: ¥27,000,000、Indirect Cost: ¥8,100,000)
Fiscal Year 2011: ¥34,710,000 (Direct Cost: ¥26,700,000、Indirect Cost: ¥8,010,000)
Fiscal Year 2010: ¥35,750,000 (Direct Cost: ¥27,500,000、Indirect Cost: ¥8,250,000)
|Outline of Final Research Achievements
Significant achievements about mechanisms for sexual differences in reproductive organ formation were obtained (GT). We identified Wnt signal regulating sexual differences of external genitalia and identified a regulatory gene, Mafb (PNAS, 2014). Mafb KO male GTs exhibit defective urethral formation like the cases for hypospadias.
We also identified gene functions related with early WD formation (Endocrinology. 2014,D B. 2015). We further identified P63 as downstream in such epithelia (Endocrinology, 2014). We also found that Bmp (Bone morphogenic protein) as playing important roles for prostate (Endocrinology, 2014). We identified mechanisms regulating male type of muscle formation (Endocriponology, 2014). We gave symposium talk at Endocrinology meeting in U.S., Gordon Conference, European DSD. In sum, future perspectives for sexual regulation, sexual plasticity is obtained.