| Budget Amount *help |
¥62,140,000 (Direct Cost: ¥47,800,000、Indirect Cost: ¥14,340,000)
Fiscal Year 2014: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2013: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
Fiscal Year 2011: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Fiscal Year 2010: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
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| Outline of Final Research Achievements |
We investigated a role of epigenetic variation in HLA genomic region for better understanding of the pathogenesis of HLA-associated diseases. Through the association analysis between HLA alleles in HLA-A, -B, -C, -DRB1, -DQB1 and -DPB1 loci and DNA methylation levels of CpG sites located in 3.8 Mb of HLA region, we identified correlation of DPB1*05:01 or Cw*07:02 to the methylation levels of the sites around DPA1 and DPB1 promoter region or around Cw locus, respectively. In addition, the expression level of DPB1*05:01 was associated with the methylation levels. These results suggest that particular HLA alleles posses their own epigenetic status in HLA region.
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