| Budget Amount *help |
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2014: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2010: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Outline of Final Research Achievements |
Variations in human leukocyte antigens (HLA) are strongly associated with immune-related disorders including autoimmune diseases and infections, among others. However, underlying mechanism has remained elusive for most of HLA-associated diseases. In this study, we aimed to uncover the mechanism of HLA association with autoimmune and other HLA-associated disorders. We have established a protocol to estimate allelic differences in the protein stability of HLA. Using this method, we analyzed the stability of diverse HLA-DQ allele products and found that HLA-DQ alleles that are associated with susceptibility to type 1 diabetes encoded extremely unstable proteins. Our finding suggests that a novel mechanistic basis might operate in the development of autoimmune diseases.
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