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Coevolution between HLA and bacteria or viruses

Planned Research

Project AreaHLA polymorphism, disease and evolution
Project/Area Number 22133007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe Graduate University for Advanced Studies

Principal Investigator

SATTA Yoko  総合研究大学院大学, 先導科学研究科, 教授 (20222010)

Research Collaborator YASUKOCHI Yoshiki  
LAU Quintin  
FUJITO Naoko  
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥51,740,000 (Direct Cost: ¥39,800,000、Indirect Cost: ¥11,940,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Keywords自然選択 / 免疫機構 / 進化速度 / ペプチド / 病原菌 / ペプチド結合領域 / HLA ペプチド結合能 / 平衡選択 / アミノ酸置換速度 / 細菌・ウィルス / 現生人類 / 脱アフリカ / 超優性選択 / DAAモデル / 進化 / HLAハプロタイプ / 環境 / ゲノム / 細菌・ウイルス / ハプロタイプ / 組み換え / 霊長類 / 多重遺伝子族 / 遺伝子重複 / エピトープ / 対立遺伝子のターンオーバー
Outline of Final Research Achievements

Human major histocompatibility complex (human MHC, HLA) genes play an important role in the acquired immune system so as to recognize infection by bacteria and viruses and to activate the immune system in order to protect a body against the infection. Because HLA needs to recognize unpredictable pathogens, HLA genes are the most polymorphic loci among the human genome. We have examined mechanisms for the generation and the maintenance of HLA polymorphisms, and results were as follows: 1) Estimates of the strength of natural selection operating on the six HLA loci is at the most 3% 2) Amino acid substitution rate at the peptide binding region (PBR) among HLA-DRB1 allelic lineages is not uniform, 3) Human-specific DRB1 allelic lineages, which diverged 28 myr ago, resulted from the loss of the allelic lineages in other primates. Furthermore, the relationship between genetic distances between HLA-DRB1 alleles and the extent of repertories of its binding peptides were elucidated .

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (18 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Nonsynonymous Substitution Rate Heterogeneity in the Peptide-Binding Region Among Different HLA-DRB1 Lineages in Humans.2014

    • Author(s)
      YASUKOCHI Y. and Y. SATTA
    • Journal Title

      G3-Genes Genomes Genetics

      Volume: 7 Issue: 7 Pages: 1217-1226

    • DOI

      10.1534/g3.114.011726

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A human-specific allelic group of the MHC DRB1 gene in primates.2014

    • Author(s)
      YASUKOCHI Y. and Y. SATTA,
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 33 Issue: 1 Pages: 14-22

    • DOI

      10.1186/1880-6805-33-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structural Basis for the Specific Recognition of the Major Antigenic Peptide from the Japanese Cedar Pollen Allergen Cry j 1 by HLA-DP5.2014

    • Author(s)
      Kusano S, Kukimoto-Niino M, Satta Y, Ohsawa N, Uchikubo-Kamo T, Wakiyama M, Ikeda M, Terada T, Yamamoto K, Nishimura Y, Shirouzu M, Sasazuki T, Yokoyama S.
    • Journal Title

      J Mol Biol.

      Volume: 426 Issue: 17 Pages: 3016-3027

    • DOI

      10.1016/j.jmb.2014.06.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Current perspectives on the intensity of natural selection of MHC loci.2013

    • Author(s)
      Yasukochi Y, Satta Y.
    • Journal Title

      Immunogenetics

      Volume: 65 Issue: 6 Pages: 479-483

    • DOI

      10.1007/s00251-013-0693-x

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HLAの分子進化が語るもの2013

    • Author(s)
      颯田葉子
    • Journal Title

      血液フロンティア

      Volume: 23 Pages: 91-96

    • Related Report
      2013 Annual Research Report
  • [Presentation] MHC haplotype evolution2015

    • Author(s)
      Yoko Satta
    • Organizer
      Evolutionary Genomics and Bioinformatics
    • Place of Presentation
      Academia Scinica, Taiwan
    • Year and Date
      2015-11-06 – 2015-11-07
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Further investigations of co-evolution of HLA and pathogens2014

    • Author(s)
      Quitin Lau、Yoshiki Yasukochi, and Yoko Satta
    • Organizer
      遺伝学会
    • Place of Presentation
      長浜バイオ大学バイオサイエンス学部/研究科
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Symmetry or Asymmetry in maintaining extraordinary MHC polymorphism?2013

    • Author(s)
      Satta Yoko, Yasukouchi Yoshiki, Takahata Naoyuki
    • Organizer
      SMBE 2013
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] The human-specific HLA-DRB1 allelic lineages maintained by balancing selection.2013

    • Author(s)
      Yasukouchi Yoshiki, Satta Yoko
    • Organizer
      SMBE 2013
    • Place of Presentation
      シカゴ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Parasite-driven evolution of HLA pepide binding repertoires2012

    • Author(s)
      Yoko Satta, Yoshiki Yasukochi
    • Organizer
      Centennial of Hashimoto DiseaseInternational Symposium II
    • Place of Presentation
      ACROS Fukuoka( 福岡)
    • Year and Date
      2012-12-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] HLA-DRB1遺伝子座の二つの系統グループにおける分子進化2012

    • Author(s)
      安河内 彦輝、颯田 葉子
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      九州大学( 福岡)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトゲノムにかかる正の自然選択について2012

    • Author(s)
      颯田 葉子、Colm O'HUigin、高畑 尚之
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      九州大学( 福岡)
    • Year and Date
      2012-09-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] HLA-DRB1分子の進化過程における抗原ペプチド認識レパトリー多様化の制約2012

    • Author(s)
      安河内 彦輝、颯田 葉子
    • Organizer
      日本進化学会第14回大会
    • Place of Presentation
      首都大学東京( 東京)
    • Year and Date
      2012-08-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] Human Evolution Revealed from Molecular Evolution of Genes for Immunity2011

    • Author(s)
      Y.Satta
    • Organizer
      分子生物学会
    • Place of Presentation
      京都大学(京都)(招待講演)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] HLA-DRB1スーパータイプにおけるペプチド結合領域の進化経路2011

    • Author(s)
      安河内彦輝、颯田葉子
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] HLA-DRB1スーパータイプのペプチド結合領域における進化モード2011

    • Author(s)
      安河内彦輝、颯田葉子
    • Organizer
      日本遺伝学会
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] PBRの機能とHLAの進化2011

    • Author(s)
      安河内彦輝、颯田葉子
    • Organizer
      第20回日本組織適合性学会大会
    • Place of Presentation
      京都大学(京都)(招待講演)
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] PBR, peptides, and functional divergence in MHC2011

    • Author(s)
      Y.Satta, Y.Yasukochi
    • Organizer
      Society for Molecular Biology and Evolution 2011
    • Place of Presentation
      京都大学(京都)(招待講演)
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Selection intensity and evolutionary process on the peptide binding region in the HLA genes2011

    • Author(s)
      Y.Yasukochi, Y.Satta
    • Organizer
      Society for Molecular Biology and Evolution 2011
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] HLAの多型維持の機構についての再考

    • Author(s)
      颯田 葉子
    • Organizer
      第15回日本進化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] MHC多型維持とヘテロ接合体の適応度について

    • Author(s)
      颯田 葉子
    • Organizer
      第85回日本遺伝学会大会
    • Place of Presentation
      つくば
    • Related Report
      2013 Annual Research Report
  • [Presentation] MHC遺伝子の進化速度、進化様式、そして多型維持の機構

    • Author(s)
      颯田 葉子
    • Organizer
      第29回京都賞記念ワークショップ
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 最新の塩基配列データを用いたHLA遺伝子座における自然選択圧の強度の推定

    • Author(s)
      安河内 彦輝, 颯田 葉子
    • Organizer
      第85回日本遺伝学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Remarks] webページは現在構築中

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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