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Variation and disease associations of HLA genes

Planned Research

Project AreaHLA polymorphism, disease and evolution
Project/Area Number 22133008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

TOKUNAGA KATSUSHI  東京大学, 医学(系)研究科(研究院), 教授 (40163977)

Co-Investigator(Kenkyū-buntansha) MIYAGAWA Taku  東京大学, 大学院医学系研究科, 助教 (20512263)
HONDA Makoto  公益財団法人東京都医学総合研究所, 精神行動医学研究分野, プロジェクトリーダー (50370979)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥207,740,000 (Direct Cost: ¥159,800,000、Indirect Cost: ¥47,940,000)
Fiscal Year 2014: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2013: ¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000)
Fiscal Year 2012: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000)
Fiscal Year 2011: ¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000)
Fiscal Year 2010: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
KeywordsHLA / 病因遺伝子 / ナルコレプシー / 自己免疫疾患 / 感染症 / 肝炎 / 原発性胆汁性肝硬変 / 過眠症 / 糖尿病 / 薬剤過敏症 / 疾病遺伝子 / 1型糖尿病
Outline of Final Research Achievements

By means of genome-wide association studies (GWAS) and comprehensive analyses of HLA gene polymorphisms, linkage disequilibrium and haplotypes, a number of HLA and non-HLA susceptibility gene variants have been identified for various immune-mediated diseases including narcolepsy, hepatitis B and C virus-related diseases, type I diabetes, primary biliary cirrhosis, rheumatoid arthritis, and Stevens-Johnson syndrome. Possible interactions between the susceptibility variants were also analyzed. The findings contribute to the elucidation of pathogenic mechanisms of these diseases.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (59 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (30 results) (of which Peer Reviewed: 30 results,  Open Access: 9 results,  Acknowledgement Compliant: 2 results) Presentation (20 results) (of which Invited: 17 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 1 results)

  • [Journal Article] New susceptibility variants to narcolepsy identified in HLA class II region.2015

    • Author(s)
      Miyagawa T, Toyoda H, Hirataka A, Kanbayashi T, Imanishi A, Honda M, Tokunaga K, et al.
    • Journal Title

      Hum. Mol. Genet.

      Volume: 24 Issue: 3 Pages: 891-898

    • DOI

      10.1093/hmg/ddu480

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Autoimmune susceptible HLA alleles encode unstable proteins.2015

    • Author(s)
      Miyadera, H., Ohashi, J., Lernmark, A., Kitamura, T., and Tokunaga, K.
    • Journal Title

      J. Clin. Invest.

      Volume: 125 Issue: 1 Pages: 275-291

    • DOI

      10.1172/jci74961

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IKZF1, a new susceptibility gene for cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis with severe mucosal involvement2015

    • Author(s)
      Ueta M, Sawai H, Sotozono C, Hitomi Y, Kaniwa N, Kim MK, Seo KY, Yoon KC, Joo CK, Kannabiran C, Wakamatsu TH, Sangwan V, Rathi V, Basu S, Ozeki T, Mushiroda T, Sugiyama E, Maekawa K, Nakamura R, Aihara M, Matsunaga K, Sekine A, Gomes JÁP, Hamuro J, Saito Y, Kubo M, Kinoshita S, Tokunaga K.
    • Journal Title

      J. Allergy Clin. Immunol.

      Volume: 135 Issue: 6 Pages: 1538

    • DOI

      10.1016/j.jaci.2014.12.1916

    • URL

      https://pure.teikyo.jp/en/publications/02935e01-50d6-48ae-8a93-b775b83b9c11

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immune-related pathways including HLA-DRB1(*)13:02 are associated with panic disorder.2015

    • Author(s)
      Shimada-Sugimoto M ほか
    • Journal Title

      Brain Behav Immun

      Volume: Epub Pages: 96-103

    • DOI

      10.1016/j.bbi.2015.01.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-accuracy imputation for HLA class I and II genes based on high-resolution SNP data of population-specific references.2015

    • Author(s)
      Khor SS, Yang W, Kawashima M, Kamitsuji S, Zheng X, Nishida N, Sawai H, Toyoda H, Miyagawa T, Honda M, Kamatani N, Tokunaga K.
    • Journal Title

      Pharmacogenomics J.

      Volume: 未定 Issue: 6 Pages: 1-8

    • DOI

      10.1038/tpj.2015.4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement2014

    • Author(s)
      Ueta M, Kaniwa N, Sotozono C, Tokunaga K, Saito Y, Sawai H, Miyadera H, Sugiyama E, Maekawa K, Nakamura R, Nagato M, Aihara M, Matsunaga K, Takahashi Y, Furuya H, Muramatsu M, Ikezawa Z, Kinoshita S.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 4862-4862

    • DOI

      10.1038/srep04862

    • URL

      https://pure.teikyo.jp/en/publications/6f008634-2fec-4098-9778-3bf0f47687a5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide analysis of CNV (copy number variation) and their associations with narcolepsy in a Japanese population2014

    • Author(s)
      Yamasaki M, Miyagawa T, Toyoda H, Khor SS, Koike A, Nitta A, Akiyama K, Sasaki T, Honda M, and Tokunaga K
    • Journal Title

      J. Hum. Genet.

      Volume: 印刷中 Issue: 5 Pages: 235-240

    • DOI

      10.1038/jhg.2014.13

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incrased plasma IL-6, IL-8, TNF-alpha and G-CSF in Japanese narcolepsy.2014

    • Author(s)
      Tanaka S, Honda M, Toyoda H, Kodama T.
    • Journal Title

      Hum. Immunol.

      Volume: 75 Issue: 8 Pages: 940-944

    • DOI

      10.1016/j.humimm.2014.06.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications.2014

    • Author(s)
      Ueta M, Kannabiran C, Wakamatsu TH, Kim MK, Yoon K-C, Seo KY, Joo C-K, Sangwan V, Rathi V, Basu S, Shamaila A, Lee HS, Yoon S, Sotozono C, Gomes JAP, Tokunaga K, Kinoshita S.
    • Journal Title

      Sci. Rep.

      Volume: 4 Issue: 1 Pages: 5981-5981

    • DOI

      10.1038/srep05981

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Challenges in diagnosing narcolepsy without cataplexy.2014

    • Author(s)
      Baumann CR, Mignot E, Lammers GJ, Overeem S, Arnulf I, Rye D, Dauvilliers Y, Honda M, Owens JA, Plazzi G, Scammell TE.
    • Journal Title

      Sleep

      Volume: 37 Issue: 6 Pages: 1035-42

    • DOI

      10.5665/sleep.3756

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New susceptibility and resistance HLA-DP alleles to HBV-related diseases identified by a trans-ethnic association study in Asia.2014

    • Author(s)
      Nishida N, Sawai H, Kashiwase K, Minami M, Sugiyama M, Seto WK, Yuen MF, Posuwan N, Poovorawan Y, Ahn SH, Han KH, Matsuura K, Tanaka Y, Kurosaki M, Asahina Y, Izumi N, Kang JK, (省略), Tokunaga K, and Mizokami M
    • Journal Title

      PLoS One

      Volume: 9 Issue: 2 Pages: e86449-e86449

    • DOI

      10.1371/journal.pone.0086449

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetics of rheumatoid arthritis contributes to biology and drug discovery.2014

    • Author(s)
      Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, (省略), GARNET consortium, (以下省略).
    • Journal Title

      Nature

      Volume: 506 Issue: 7488 Pages: 376-381

    • DOI

      10.1038/nature12873

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lessons from genome-wide search for disease-related genes with special reference to HLA-disease associations.2014

    • Author(s)
      Tokunaga K
    • Journal Title

      Genes

      Volume: 5 Issue: 1 Pages: 84-96

    • DOI

      10.3390/genes5010084

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement.2014

    • Author(s)
      Ueta M, Kaniwa N, Sotozono C, Tokunaga K, Saito Y, Sawai H, Miyadera H, Sugiyama E, Maekawa K, Nakamura R, Nagato M, Aihara M, Matsunaga K, Takahashi Y, Furuya H, Muramatsu M, Ikezawa Z, and Kinoshita S.
    • Journal Title

      Scientific Reports

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of HLA-DQB1*06:02 negative essential hypersomnia.2013

    • Author(s)
      Khor SS, Miyagawa T, Toyoda H, Yamasaki M, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Lin L, Faraco J, Rico T, Honda Y, Honda M, Mignot E, Tokunaga K.
    • Journal Title

      PeerJ

      Volume: 1 Pages: 66-80

    • DOI

      10.7717/peerj.66

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Passive transfer of narcolepsy: Anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice.2013

    • Author(s)
      Katzav A, Arango MT, Kivity S, Tanaka S, Givaty G, Agmon-LevinN, Honda M, Anaya JM, Chapman J, Shoenfeld Y
    • Journal Title

      J. Autoimmun.

      Volume: 45 Pages: 24-30

    • DOI

      10.1016/j.jaut.2013.06.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In silico risk assessment of HLA-A*02:06-associated Stevens-Johnson syndrome and toxic epidermal necrolysis caused by cold medicine ingredients.2013

    • Author(s)
      Isogai H, Miyadera H, Ueta M, Sotozono C, Kinoshita S, Tokunaga K, Hirayama N
    • Journal Title

      J Toxicol.

      Volume: Article ID 514068 Pages: 514068-514068

    • DOI

      10.1155/2013/514068

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of oral L-carnitine administration in narcolepsy patients: a randomized, double-blind, cross-over and placebo-controlled trial2013

    • Author(s)
      宮川 卓 他
    • Journal Title

      PLoS One

      Volume: 8(1) Issue: 1 Pages: e53707-e53707

    • DOI

      10.1371/journal.pone.0053707

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population2012

    • Author(s)
      Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, Yukioka M, Matsubara T, Wakitani S, Teshima R, Tohma S, Takasugi K, Shimada K, Murasawa A, Honjo S, Matsuo K, Tanaka H, Tajima K, Suzuki T, Iwamoto T, Kawamura Y, Tanii H, Okazaki Y, Sasaki T, Gregersen PK, Padyukov L, Worthington J, Siminovitch KA, Lathrop M, Taniguchi A, Takahashi A, Tokunaga K, Kubo M, Nakamura Y, Kamatani N, Mimori T, Plenge RM, Yamanaka H, Momohara S, Yamada R, Matsuda F, Yamamoto K.
    • Journal Title

      Nat Genet.

      Volume: (in press) Issue: 5 Pages: 511-6

    • DOI

      10.1038/ng.2231

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association studies of tuberculosis in Asians2012

    • Author(s)
      Mahasirimongkol S, Yanai H, Mushiroda T, Promphittayarat W, Wattanapokayakit S, Promjai J, Yuliwulandari R, Wichukchinda N, Yowang A, Yamada N, Kantipong P, Takahashi A, Kubo M, Sawanpanyalert P, Kamatani N, Nakamura Y, Tokunaga K
    • Journal Title

      Journal of Human Genetics

      Volume: 57巻(6) Issue: 6 Pages: 363-367

    • DOI

      10.1038/jhg.2012.35

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.2012

    • Author(s)
      Nishida N, Asahina Y, Mizokami M et al
    • Journal Title

      PLoS One

      Volume: 7 Issue: 6 Pages: 1-8

    • DOI

      10.1371/journal.pone.0039175

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HLA-A*0206 with TLR3 Polymorphisms Exerts More than Additive Effects in Stevens-Johnson Syndrome with Severe Ocular Surface Complications2012

    • Author(s)
      Ueta M, Tokunaga K, Sotozono C, Sawai H, Tamiya G, Inatomi T, Kinoshita S
    • Journal Title

      PLoS One, Peer-Reviewed papers

      Volume: 7(8) Issue: 8 Pages: e43650-e43650

    • DOI

      10.1371/journal.pone.0043650

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.2012

    • Author(s)
      Nakamura M
    • Journal Title

      Am J Hum Genet.

      Volume: 91 Issue: 4 Pages: 721-728

    • DOI

      10.1016/j.ajhg.2012.08.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evolutionary analysis of classical HLA class I and II genes suggests that recent positive selection acted on DPB1*04 : 01 in Japanese population2012

    • Author(s)
      Kawashima M, Nishida N, et al. (他2名)
    • Journal Title

      PLoS One

      Volume: 7(10) Issue: 10 Pages: e46806-e46806

    • DOI

      10.1371/journal.pone.0046806

    • NAID

      120007137181

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HLA-class II and class I genotypes among Japanese children with Type 1A diabetes and their families2012

    • Author(s)
      Sugihara S
    • Journal Title

      Pediatric Diabetes

      Volume: 13 Issue: 1 Pages: 33-44

    • DOI

      10.1111/j.1399-5448.2011.00833.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significant association of KIR2DL3-HLA-C1, combination with cerebral malaria and implications for co-evolution of KIR and HLA2012

    • Author(s)
      Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A, Takanashi M, Satake M, Nakajima K, Parham P, Arase H, Tokunaga K, Patarapotikul J, Yabe T
    • Journal Title

      PLoS Pathogens

      Volume: 8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common variants in P2RY11 are associated with narcolepsy.2011

    • Author(s)
      Kornum BR, et al.
    • Journal Title

      Nature Genetics

      Volume: 43(1) Pages: 66-71

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of HLA-A, -B, and -DRB1 with pulmonary tuberculosis in western Javanese Indonesia.2010

    • Author(s)
      Yuliwulandari R, et al.
    • Journal Title

      Human Immunology

      Volume: 71(7) Pages: 697-701

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-tribbles homolog 2 autoantibodies in Japanese patients with narcolepsy.2010

    • Author(s)
      Toyoda H, et al.
    • Journal Title

      Sleep

      Volume: 33(7) Pages: 875-878

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An approach based on a genome-wide association study reveals candidate loci for narcolepsy.2010

    • Author(s)
      Shimada M, et al
    • Journal Title

      Human Genetics

      Volume: 128(4) Pages: 433-441

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] CPT1 activity is a risk factor for narcolepsy: possible contribution of dietary habit2015

    • Author(s)
      Honda M
    • Organizer
      Symposium “Narcolepsy in Asia”, World Association of Sleep Medicine
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2015-03-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 肝炎、結核に見る病原微生物と宿主ゲノムの相互作用2014

    • Author(s)
      徳永勝士
    • Organizer
      シンポジウム「病原微生物との闘いとその戦果:先端生命科学からグローバルヘルスまで」、第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都府京都市
    • Year and Date
      2014-10-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Complex diseaseの遺伝子探索:現状と課題2014

    • Author(s)
      徳永勝士
    • Organizer
      セッション:個別化医療に向けたゲノム解析、生命医薬情報学連合大会2014
    • Place of Presentation
      仙台国際センター、宮城県仙台市
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] HLA and non-HLA susceptibility genes to human immune-mediated diseases2014

    • Author(s)
      Katsushi Tokunaga
    • Organizer
      Siriraj International Conference in Medicine and Public Health 2014
    • Place of Presentation
      Siriraj Hospital, Bangkok, Thailand
    • Year and Date
      2014-07-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 過眠症2014

    • Author(s)
      本多 真
    • Organizer
      「ICSD-3の概要と我が国の睡眠医療医学の課題」、第39回日本睡眠学会
    • Place of Presentation
      あわぎんホール、ホテルクレメント徳島、徳島県徳島市
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ナルコレプシーの長期予後2014

    • Author(s)
      本多 真、羽澄 恵、土井由利子、高橋康郎、本多 裕
    • Organizer
      シンポジウム「ナルコレプシー:基礎から臨床までの最新の知見」、第39回日本睡眠学会
    • Place of Presentation
      あわぎんホール、ホテルクレメント徳島、徳島県徳島市
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ナルコレプシーの感受性遺伝子の探索2014

    • Author(s)
      宮川 卓
    • Organizer
      シンポジウム「ナルコレプシー:基礎から臨床までの最新の知見」、日本睡眠学会第39回定期学術集会
    • Place of Presentation
      あわぎんホール、ホテルクレメント徳島、徳島県徳島市
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ゲノム解析から医療へ貢献する:薬剤応答遺伝子を中心に2014

    • Author(s)
      徳永勝士
    • Organizer
      医療薬学フォーラム2014・第22回クリニカルファーマシーシンポジウム
    • Place of Presentation
      ビッグサイトTFTホール、東京都江東区
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Search for drug response genes: towards clinical application2014

    • Author(s)
      Katsushi Tokunaga
    • Organizer
      International Seminar and Workshop on Molecular Medicine: From Basic Science to Clinical Care
    • Place of Presentation
      Yarsi University, Jakarta, Indonesia
    • Year and Date
      2014-04-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Genomic approaches to the etiology of autoimmune diseases2012

    • Author(s)
      Tokunaga K
    • Organizer
      Centennial of Hashimoto Disease International Symposium Ⅱ - Autoimmune Diseases - Etiology and Therapeutics
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-02
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Genome-wide search for disease genes and drug response genes: Implications and perspectives2012

    • Author(s)
      Tokunaga K
    • Organizer
      The 39th International Symposium on Nucleic Acids Chemistry ISNAC2012
    • Place of Presentation
      名古屋
    • Year and Date
      2012-11-17
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ナルコレプシーの疾患感受性遺伝子の探索及び治療への応用2012

    • Author(s)
      宮川 卓
    • Organizer
      日本睡眠学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2012-06-30
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Genome-wide approaches to complex disease: advances and perspectives, Genomic Analysis of Diseases Workshop2012

    • Author(s)
      Tokunaga K
    • Organizer
      Nature Conference
    • Place of Presentation
      Hang zhou, China
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] HLA and population genetics2011

    • Author(s)
      Juji T, Tokunaga K
    • Organizer
      22^<nd> Regional Congress of the International Society of Blood Transfusion
    • Place of Presentation
      台北,台湾(招待講演)
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lessons from genome-wide search for disease-related genes2011

    • Author(s)
      Tokunaga K
    • Organizer
      20^<th> Annual Conference of Korean Genome Organization
    • Place of Presentation
      Gangoe-myeon,韓国(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゲノム・遺伝子解析研究がもたらす革新(教育講演)

    • Author(s)
      徳永勝士
    • Organizer
      第62回日本医学検査学会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Single nucleotide polymorphisms (SNPs) in humans: Associations with disease susceptibilities and drug responses

    • Author(s)
      Katsushi Tokunaga
    • Organizer
      nternational Conference in Medicine and Public Health 2013 (ICMPH2013) “Healthy Society beyond Frontiers”
    • Place of Presentation
      Mahidol University, Siriraj Hospital(タイ国、バンコク市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 肝炎の診断と治療、(シンポジウム「GWAS成果と応用」)

    • Author(s)
      徳永勝士
    • Organizer
      第58回日本人類遺伝学会大会
    • Place of Presentation
      江陽グランドホテル(仙台市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ナルコレプシーの感受性遺伝子の探索及び治療への応用

    • Author(s)
      宮川 卓
    • Organizer
      日本人類遺伝学会第58回大会(受賞講演)
    • Place of Presentation
      江陽グランドホテル(仙台市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 10-50 years long-term prognosis of narcolepsy

    • Author(s)
      Honda M, Doi Y, Honda Y
    • Organizer
      Asian Narcolepsy Forum 2013
    • Place of Presentation
      Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 細胞2013

    • Author(s)
      澤井裕美
    • Total Pages
      58
    • Publisher
      ニューサイエンス社
    • Related Report
      2012 Annual Research Report
  • [Book] 医学のあゆみ233(13)HLAと疾患-最新トピックス2010

    • Author(s)
      徳永勝士(監)
    • Total Pages
      70
    • Publisher
      医歯薬出版
    • Related Report
      2010 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科人類遺伝学分野 ホームページ

    • URL

      http://www.humgenet.m.u-tokyo.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学医学系研究科人類遺伝学分野ホームページ

    • URL

      http://www.humgenet.m.u-tokyo.ac.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京大学大学院医学系研究科人類遺伝学分野

    • URL

      http://www.humgenet.m.u-tokyo.ac.jp/

    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] B型肝炎の慢性化の素因の検出方法2014

    • Inventor(s)
      徳永勝士、澤井裕美、溝上雅史、西田奈央
    • Industrial Property Rights Holder
      東京大学、国立国際医療センター
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-08-28
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 眼合併症を伴う重症薬疹の発症リスクの評価方法2014

    • Inventor(s)
      上田真由美、外園千恵、木下茂、徳永勝士、澤井裕美
    • Industrial Property Rights Holder
      京都府立医科大学、東京大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-052761
    • Filing Date
      2014-03-14
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] B型肝炎の慢性化に関与するHLA遺伝子多型2013

    • Inventor(s)
      徳永勝士、澤井裕美、溝上雅史、西田奈央
    • Industrial Property Rights Holder
      東京大学、国立国際医療研究センター
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-179634
    • Filing Date
      2013-08-30
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 眼合併症を伴う重症薬疹の発症リスクの評価方法2013

    • Inventor(s)
      上田真由美、外園千恵、木下茂、徳永勝士、澤井裕美
    • Industrial Property Rights Holder
      東京大学、京都府立医科大学、凸版印刷株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-052232
    • Filing Date
      2013-03-14
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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