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Integrative omics analysis to explore molecular targets and biomarkers for personalized medicine in cancer

Planned Research

Project AreaIntegrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
Project/Area Number 22134002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionTokyo Medical and Dental University

Principal Investigator

INAZAWA Johji  東京医科歯科大学, 難治疾患研究所, 教授 (30193551)

Co-Investigator(Kenkyū-buntansha) INOUE Jun  東京医科歯科大学, 難治疾患研究所, 講師 (50568326)
TANIMOTO Kosuke  東京医科歯科大学, 難治疾患研究所, 助教 (60611613)
KOZAKI Ken-ichi  岡山大学, 大学院医歯薬学総合研究科, 教授 (50270715)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥271,050,000 (Direct Cost: ¥208,500,000、Indirect Cost: ¥62,550,000)
Fiscal Year 2014: ¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
Fiscal Year 2013: ¥50,960,000 (Direct Cost: ¥39,200,000、Indirect Cost: ¥11,760,000)
Fiscal Year 2012: ¥53,430,000 (Direct Cost: ¥41,100,000、Indirect Cost: ¥12,330,000)
Fiscal Year 2011: ¥52,910,000 (Direct Cost: ¥40,700,000、Indirect Cost: ¥12,210,000)
Fiscal Year 2010: ¥65,260,000 (Direct Cost: ¥50,200,000、Indirect Cost: ¥15,060,000)
Keywordsがん / ゲノム / エピゲノム / システム生物学 / 分子標的治療 / マイクロRNA / ゲノム・エピゲノム解析 / がん治療標的分子 / バイオリソース / オミクス / オートファジー / NRF2 / miRNA / 薬剤耐性 / 分子標的 / がん遺伝子 / がん抑制遺伝子 / 遺伝子ネットワーク
Outline of Final Research Achievements

Integrative omics analysis was performed to explore molecular targets and biomarkers for personalized medicine in cancer. Several experimental models in vitro/ in vivo were established to uncover malignant properties including epithelial-mesenchymal transition (EMT), and invasion and/or metastasis. Bioresource infrastructure was prepared, and human bioresources have been collected and preserved to facilitate multi-omics data analysis in cancer. Consequently, novel and promising targets and biomarkers including tumor suppressor microRNAs were identified, facilitating the understanding of molecular pathogenesis of intractable cancer.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (176 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (48 results) (of which Peer Reviewed: 48 results,  Acknowledgement Compliant: 5 results,  Open Access: 4 results) Presentation (109 results) (of which Invited: 5 results) Book (8 results) Remarks (6 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 4 results)

  • [Journal Article] High expression of p62 protein is associated with poor prognosis and aggressive phenotypes in endometrial cancer2015

    • Author(s)
      Iwadate R, Inoue J, Tsuda H, Takano H, Furuya K, Hirasawa A, Aoki D, Inazawa J
    • Journal Title

      Am J Pathol

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Diverse involvement of isoforms and gene aberrations of Akt in human lung carcinomas2015

    • Author(s)
      Dobashi Y, Tsubochi H, Matsubara H, Inoue J, Inazawa J, Endo S, Ooi A
    • Journal Title

      Cancer Sci

      Volume: - Issue: 6 Pages: 772-781

    • DOI

      10.1111/cas.12669

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High Expression of SQSTM1/p62 Protein Is Associated with Poor Prognosis in Epithelial Ovarian Cancer2014

    • Author(s)
      Iwadate R, Inoue J, Tsuda H, Takano M, Furuya K, Hirasawa A, Aoki D, Inazawa J
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 47 Issue: 6 Pages: 295-301

    • DOI

      10.1267/ahc.14048

    • NAID

      130004902927

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Overexpression of SMYD2 contributes to malignant outcome in gastric cancer2014

    • Author(s)
      Komatsu S, Ichikawa D, Hirajima S, Nagata H, Nishimura Y, Kawaguchi T, Miyamae M, Okajima W, Ohashi T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Imoto I, Inazawa J, Otsuji E
    • Journal Title

      Br J Cancer

      Volume: 112 Issue: 2 Pages: 357-64

    • DOI

      10.1038/bjc.2014.543

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer.2014

    • Author(s)
      Hosoda F, Inazawa J, et al.
    • Journal Title

      Oncogene.

      Volume: in press Issue: 9 Pages: 1196-206

    • DOI

      10.1038/onc.2014.57

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NF-κB Inducing Kinase, a Central Signaling Component of the Non-Canonical Pathway of NF-κB, Contributes to Ovarian Cancer Progression.2014

    • Author(s)
      Uno M, Saitoh Y, Mochida K, Tsuruyama E, Kiyono T, Imoto I, Inazawa J, Yuasa Y, Kubota T, Yamaoka S.
    • Journal Title

      PLoS One

      Volume: 9(2) Issue: 2 Pages: e88347-e88347

    • DOI

      10.1371/journal.pone.0088347

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic variants in C5 and poor response to eculizumab.2014

    • Author(s)
      Nishimura J, Inazawa J, et al.
    • Journal Title

      N Engl J Med.

      Volume: 370 Issue: 7 Pages: 632-9

    • DOI

      10.1056/nejmoa1311084

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] γ-Glutamylcyclotransferase as a novel immunohistochemical biomarker for the malignancy of esophageal squamous tumors.2014

    • Author(s)
      Takemura K, Inazawa J, et al.
    • Journal Title

      Hum Pathol.

      Volume: 45 Issue: 2 Pages: 331-41

    • DOI

      10.1016/j.humpath.2013.09.009

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The impact of miRNA-based molecular diagnostics and treatment of NRF2-stabilized tumors.2014

    • Author(s)
      Yamamoto S, Inazawa J, et al.
    • Journal Title

      Mol Cancer Res.

      Volume: 12 Issue: 1 Pages: 58-68

    • DOI

      10.1158/1541-7786.mcr-13-0246-t

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of Akt activation and AKT gene increases in soft tissue tumors.2014

    • Author(s)
      Dobashi Y, Inazawa J, et al.
    • Journal Title

      Hum Pathol.

      Volume: 45 Issue: 1 Pages: 127-36

    • DOI

      10.1016/j.humpath.2013.06.024

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study of breast cancer in the Japanese population.2013

    • Author(s)
      Low SK, Inazawa J, et al.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 10 Pages: e76463-e76463

    • DOI

      10.1371/journal.pone.0076463

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of GSTP1 for predicting the prognosis and chemotherapeutic efficacy in esophageal squamous cell carcinoma.2013

    • Author(s)
      Yamamoto Y, Inazawa J, et al.
    • Journal Title

      Oncol Rep.

      Volume: 30 Issue: 4 Pages: 1687-94

    • DOI

      10.3892/or.2013.2606

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-655 is an EMT-suppressive microRNA targeting ZEB1 and TGFBR2.2013

    • Author(s)
      Harazono Y, Inazawa J, et al.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 5 Pages: e62757-e62757

    • DOI

      10.1371/journal.pone.0062757

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Tumor-suppressive mir-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma.2013

    • Author(s)
      Furuta M
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e60155-e60155

    • DOI

      10.1371/journal.pone.0060155

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential of tumor-suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer.2013

    • Author(s)
      Endo H, Inazawa J, et al.
    • Journal Title

      Carcinogenesis.

      Volume: 34 Issue: 3 Pages: 560-9

    • DOI

      10.1093/carcin/bgs376

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Esophageal Squamous Cell Carcinoma Developed 11 Years After Allogeneic Bone Marrow Transplantation for Acute Lymphatic Leukemia.2013

    • Author(s)
      Miyawaki Y, Inazawa J, et al.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 43 Issue: 1 Pages: 69-73

    • DOI

      10.1093/jjco/hys184

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification, basic characterization and evolutionary analysis of differentially spliced mRNA isoforms of human YAP1 gene.2012

    • Author(s)
      Gaffney CJ, Inazawa J, et al.
    • Journal Title

      Gene.

      Volume: 509 Issue: 2 Pages: 215-222

    • DOI

      10.1016/j.gene.2012.08.025

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic copy-number alterations of MYC and FHIT genes are associated with survival in esophageal squamous-cell carcinoma2012

    • Author(s)
      Miyawaki Y, Kawachi H, Ooi A, Eishi Y, Kawano T, Inazawa J, Imoto I
    • Journal Title

      Cancer Sci

      Volume: 103 Issue: 12 Pages: 1558-66

    • DOI

      10.1016/j.humpath.2012.03.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic copy-number alterations of MYC and FHIT genes are associated with survival in esophageal squamous-cell carcinoma.2012

    • Author(s)
      Miyawaki Y, Inazawa J, et al.
    • Journal Title

      Cancer Sci.

      Volume: 103 Issue: 8 Pages: 1558-1566

    • DOI

      10.1111/j.1349-7006.2012.02329.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma2012

    • Author(s)
      Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J
    • Journal Title

      Clin Cancer Res

      Volume: 18 Issue: 13 Pages: 3541-51

    • DOI

      10.1158/1078-0432.ccr-11-1007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese2012

    • Author(s)
      赤松秀輔, 他
    • Journal Title

      Nature Genetics

      Volume: 44 Issue: 4 Pages: 426-429

    • DOI

      10.1038/ng.1104

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ACTN4 gene amplification and actinin-4 protein overexpression drive tumour development and histological progression in a high-grade subset of ovarian clear-cell adenocarcinomas2012

    • Author(s)
      Yamamoto S, Inazawa J, et al
    • Journal Title

      Histopathology

      Volume: (Epub ahead of print) Issue: 7 Pages: 1073-1083

    • DOI

      10.1111/j.1365-2559.2011.04163.x

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation2012

    • Author(s)
      Ono H, Imoto I, Kozaki K, Tsuda H, Matsui T, Kurasawa Y, Muramatsu T, Sugihara K, Inazawa J
    • Journal Title

      Oncogene

      Volume: 31 Issue: 47 Pages: 4923-4934

    • DOI

      10.1038/onc.2011.646

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A transcriptional variant of the LC3A gene is involved in autophagy and frequently inactivated in human cancers2012

    • Author(s)
      Bai H, Inazawa J, et al
    • Journal Title

      Oncogene

      Volume: (Epub ahead of print) Issue: 40 Pages: 4397-408

    • DOI

      10.1038/onc.2011.613

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene amplification of ESR1 in breast cancers-Fact or fiction? A fluorescence in situ hybridization and multiplex ligation-dep endent probe amplification study2011

    • Author(s)
      Ooi A, Inazawa J, et al
    • Journal Title

      J Pathol

      Volume: 227 Issue: 1 Pages: 8-16

    • DOI

      10.1002/path.3974

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stabilization of phenotypic plasticity through mesenchymal-specific DNA hypermethylation in cancer cells2011

    • Author(s)
      Kurasawa Y
    • Journal Title

      Oncogene

      Volume: 12.31(15) Issue: 15 Pages: 1963-74

    • DOI

      10.1038/onc.2011.373

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The HECT-type ubiquitin ligase ITCH targets lysosomal-associated prote in multispanning transmembrane 5 (LAPTM5)and prevents LAPTM5-mediated cell death2011

    • Author(s)
      Ishihara T, Inazawa J, et al
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 44086-4494

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer2011

    • Author(s)
      Tsuruta T, Inazawa J, et al
    • Journal Title

      Cancer Res

      Volume: 71 Issue: 20 Pages: 6450-6462

    • DOI

      10.1158/0008-5472.can-11-0364

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The tumor suppressive microRNA miE-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer2011

    • Author(s)
      Uesugi A, Inazawa J, et al
    • Journal Title

      Cancer Res

      Volume: 71 Issue: 17 Pages: 5765-5778

    • DOI

      10.1158/0008-5472.can-11-0368

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues2011

    • Author(s)
      Arai E, Inazawa J, et al
    • Journal Title

      Pathobiology

      Volume: 78 Issue: 1 Pages: 1-9

    • DOI

      10.1159/000322072

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification2011

    • Author(s)
      Gotoh M, Inazawa J, et al
    • Journal Title

      J Biomed Biotechnol

      Volume: 2011 Issue: 1 Pages: 780836-780836

    • DOI

      10.1155/2011/780836

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copy number alterations in urothelial carcinomas : Their clinicopathological significance and correlation with DNA methylation alterations2011

    • Author(s)
      Nishiyama N, Inazawa J, et al
    • Journal Title

      Carcinogenesis

      Volume: 32 Issue: 4 Pages: 462-469

    • DOI

      10.1093/carcin/bgq274

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YAP is a candidate oncogene for esophageal squamous cell carcinoma2011

    • Author(s)
      Muramatsu T, Imoto I, Matsui T, Kozaki K, Haruki S, Sudol M, Shimada Y, Tsuda H, Kawano T, Inazawa J
    • Journal Title

      Carcinogenesis

      Volume: 32 Issue: 3 Pages: 389-398

    • DOI

      10.1093/carcin/bgq254

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification.2011

    • Author(s)
      Gotoh M, Inazawa J, et al
    • Journal Title

      Biomed Biotechnol.

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copy number alterations in urothelial carcinomas : Their clinicopathological significance and correlation with DNA methylation alterations.2010

    • Author(s)
      Nishiyama N, Inazawa J, et al
    • Journal Title

      Carcinogenesis.

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YAP is a candidate oncogene for esophageal squamous-cell carcinoma.2010

    • Author(s)
      Muramatsu T, Inazawa J, et al
    • Journal Title

      Carcinogenesis.

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical application of array-based comparative genomic hybridization by two-stage screening for 536 patients with mental retardation and multiple congenital anomalies.2010

    • Author(s)
      Hayashi S, Inazawa J, et al
    • Journal Title

      J Hum Genet.

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of neuronal cells induced from human mesenchymal stem cells improves neurological functions after stroke without cell fusion.2010

    • Author(s)
      Xu H, Inazawa J, et al
    • Journal Title

      J Neurosci Res.

      Volume: 88 Pages: 3598-3609

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.2010

    • Author(s)
      Miki D, Inazawa J, et al
    • Journal Title

      Nat Genet.

      Volume: 42 Pages: 893-896

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.2010

    • Author(s)
      Takata R, Inazawa J, et al
    • Journal Title

      Nat Genet.

      Volume: 42 Pages: 751-754

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dermokine as a novel biomarker for early-stage colorectal cancer.2010

    • Author(s)
      Tagi T, Inazawa J, et al
    • Journal Title

      J Gastroenterol.

      Volume: 45 Pages: 1201-1211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis.2010

    • Author(s)
      Honda S, Inazawa J, et al
    • Journal Title

      J Hum Genet.

      Volume: 55 Pages: 590-599

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroradiologic Features of CASK Mutations.2010

    • Author(s)
      Takanashi J, Inazawa J, et al
    • Journal Title

      AJNR Am J Neuroradiol.

      Volume: 31 Pages: 1619-1622

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung.2010

    • Author(s)
      Shibata T, Inazawa J, et al
    • Journal Title

      Oncogene.

      Volume: 29 Pages: 4671-4681

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.2010

    • Author(s)
      Honda S, Inazawa J, et al
    • Journal Title

      J Hum Genet.

      Volume: 55 Pages: 244-247

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of NF-kappaB inducing kinase underlies constitutive NF-kappaB activation in lung cancer cells.2010

    • Author(s)
      Saitoh Y, Inazawa J, et al
    • Journal Title

      Lung Cancer.

      Volume: 70 Pages: 263-270

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] requent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous-cell carcinoma.2010

    • Author(s)
      Haruki S, Inazawa J, et al
    • Journal Title

      Carcinogenesis.

      Volume: 31 Pages: 1027-1036

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA amplification and expression of FADD in oral squamous cell carcinoma.2010

    • Author(s)
      Prapinjumrune C, Inazawa J, et al
    • Journal Title

      J Oral Pathol Med.

      Volume: 39 Pages: 525-532

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Exploration of mechanisms for chromothripsis by irradiation2015

    • Author(s)
      Morishita M. Muramatsu T. Hayashi S. Hirai M. Suto Y. Konishi T. Moriyama K. Inazawa J
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma2015

    • Author(s)
      Muramatsu T.Kozaki K. Imoto S.Yamaguchi R. Tsuda H.Kawano T. Morishita M.Miyano S. Inazawa J
    • Organizer
      AACR Annual Meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18 – 2015-04-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Function-based screening of cancer-related miRNAs2015

    • Author(s)
      Inazawa J
    • Organizer
      Seoul National University Cancer Research Center Symposium
    • Place of Presentation
      Hwasun, Korea
    • Year and Date
      2015-03-31 – 2015-04-03
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Exploring cancer-related miRNAs by function-based screening2014

    • Author(s)
      Inazawa J
    • Organizer
      International conference on the 19th Annual Meeting of Korean Society of cancer Prevention
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-12-12 – 2014-12-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Exploring Tumor Suppressor microRNAs Silenced by Tumor-specific DNA Hyper-Methylation in Cancer2014

    • Author(s)
      Inazawa J
    • Organizer
      the 17th Annual Conference A-IMBN
    • Place of Presentation
      Manila, Philippines
    • Year and Date
      2014-12-01 – 2014-12-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 新世代ゲノム解析技術によって浮上するがんのバックシートドライバー.2012

    • Author(s)
      稲澤讓治
    • Organizer
      第5回岐阜大学先端創薬医療シンポジウム
    • Place of Presentation
      TKP品川カンファレンスセンター(東京)
    • Year and Date
      2012-12-07
    • Related Report
      2012 Annual Research Report
  • [Presentation] よくわかるゲノム解析入門.2012

    • Author(s)
      稲澤讓治
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2012-10-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食道扁平上皮癌において高頻度に発現抑制される新規癌関連プロトカドヘリン遺伝子の同定.2012

    • Author(s)
      宮脇豊、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館(北海道
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト口腔癌細胞株を用いた癌転移分子メカニズムの解析.2012

    • Author(s)
      村松智輝、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 尿路上皮がんにおけるゲノム構造異常:臨床病理学的意義ならびにDNAメチル化異常との関係.2012

    • Author(s)
      西山直隆、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳がん原発巣とリンパ節転移巣における遺伝的変異の解析.2012

    • Author(s)
      細田文恵、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] Argonute2免疫沈降と統合的情報解析による肝細胞癌抑制性miRNAクラスターの標的遺伝子群の同定.2012

    • Author(s)
      古田繭子、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      さっぽろ芸文館(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 胃がんにおける新規がん遺伝子グリオキサラーゼIの機能解析NRF2 pathwayを負に制御するmicroRNAの同定.2012

    • Author(s)
      山本信祐、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      さっぽろ芸文館(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食道癌におけるオートファジーATG7の不活性化食道扁平上皮癌の術後予後因子として遺伝子MYCおよびFHITにおけるゲノムコピー数異常の意義.2012

    • Author(s)
      宮脇豊、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるDNAメチル化関連遺伝子の統合的スクリーニング.2012

    • Author(s)
      永田啓明、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト癌におけるオートファジー関連遺伝子の異常.2012

    • Author(s)
      井上純、稲澤讓治
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      さっぽろ芸文館(北海道)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] E-cadherinの発現変化を指標とした機能的スクリーニングによるMET誘導生microRNAの探索.2012

    • Author(s)
      原園陽介、稲澤讓治 他
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      さっぽろ芸文館(北海道)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] がんDNAメチル異常を指標とした癌抑制遺伝子型microRNAの探索.2012

    • Author(s)
      小崎健一、遠藤寛則、稲澤讓治
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市教育文化会館(北海道)
    • Year and Date
      2012-09-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exploring of tumor suppressive micro-RNAs silenced by tumor-specific DNA hypermethylation in cancer.2012

    • Author(s)
      稲澤讓治
    • Organizer
      The 22nd HCS/the 4th JARI Joint International Symposium.
    • Place of Presentation
      グランドプリンスホテル広島(広島県)
    • Year and Date
      2012-08-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] がんのおけるリソソーム分解系の障害.2012

    • Author(s)
      稲澤讓治
    • Organizer
      第21回日本Cell Death学会学術集会
    • Place of Presentation
      名古屋大学(愛知)
    • Year and Date
      2012-07-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新世代ゲノム解析技術によって浮上するがんのバックシートドライバー.2012

    • Author(s)
      稲澤讓治
    • Organizer
      第16回日本がん分子標的治療学会
    • Place of Presentation
      西日本総合展示場(福岡)
    • Year and Date
      2012-06-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of tumor-suppressor micro-RNAs silenced by DNA hypermethylation in cancer.2012

    • Author(s)
      稲澤讓治
    • Organizer
      2012 Seoul National University Cancer Research Institute Symposium.
    • Place of Presentation
      Seoul National University ,South Korea.
    • Year and Date
      2012-05-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] Exploration of EMT-related microRNAs using function-based screening with expression analysis of E-cadherin in Panc1 line.2012

    • Author(s)
      原園陽介、稲澤讓治 他
    • Organizer
      American Association for Cancer Research, 103th Annual Meeting 2012.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2012-04-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] HECT-type ubiquitin ligase ITCH targets lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) and prevents LAPTM5-mediated cell death.2012

    • Author(s)
      井上純、稲澤讓治 他
    • Organizer
      American Association for Cancer Research, 103th Annual Meeting 2012.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2012-04-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Phenotypic stabilization of mesenchymal-like cancer cells through mesenchymal-specific DNA hypermethylation.2012

    • Author(s)
      小崎健一、稲澤讓治 他
    • Organizer
      American Association for Cancer Research, 103th Annual Meeting 2012.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2012-04-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] A transcriptional variant of the LC3A gene is involved in autophagy and frequently inactivated in human cancers.2012

    • Author(s)
      山本信祐、稲澤讓治 他
    • Organizer
      American Association for Cancer Research, 103th Annual Meeting 2012.
    • Place of Presentation
      Chicago, USA.
    • Year and Date
      2012-04-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functionalスクリーニングを用いた肝細胞癌抑制性microRNAの同定2011

    • Author(s)
      古田繭子、稲澤譲治, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] がんの統合的ゲノム・エピゲノム解析2011

    • Author(s)
      稲澤譲治
    • Organizer
      日本人類遺伝学会第56回大会/第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Genome-wide association study of lung cancer : Association of variation in TP63 with lung adenocarcinoma susceptibility2011

    • Author(s)
      醍醐弥太郎、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第56回大会/第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pitt-Hopkins症候群を考える4例2011

    • Author(s)
      岡本伸彦、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第56回大会/第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] SNPアレイを用いた先天異常疾患症例におけるゲノム異常評価とアレイポテンシャルの比較2011

    • Author(s)
      林深、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第56回大会/第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] DNA過剰メチル化により発現抑制される癌抑制遺伝子型microRNAの機能的スクリーニング2011

    • Author(s)
      小崎健一、稲澤譲治
    • Organizer
      日本人類遺伝学会第56回大会/第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] BACアレイ・SNPアレイを用いた日系ブラジル人100家系のトリオ解析による日本人健常者CNVデータベースの構築2011

    • Author(s)
      林深、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第56回大会/第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 遺伝子解析研究とバイオリソースバンクに関する医療者の意識調査2011

    • Author(s)
      藍真澄、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第56回大会/第11回東アジア人類遺伝学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Function-based screening of tumor-suppressor microRNAs silenced by DNA hypermethylation in cancer2011

    • Author(s)
      稲澤譲治
    • Organizer
      The 8th Nikko International Symposium 2011
    • Place of Presentation
      Jichi Medical University, Tochigi, Japan
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functionalスクリーニングを用いた肝細胞癌抑制性microRNAの同定2011

    • Author(s)
      古田繭子、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 日本人と韓国人の肺腺癌発症に関連するTP63の一塩基多型の同定2011

    • Author(s)
      三木大樹、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肝癌再発を予測するオミックス解析と分子標的治療への応用2011

    • Author(s)
      田中真二、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 統合的アレイ解析による肝細胞癌の新規がん抑制遺伝子候補PACAPの同定2011

    • Author(s)
      松村聡、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] がんの統合的ゲノム・エピゲノム解析の最近の進歩2011

    • Author(s)
      稲澤譲治
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] がんの統合的ゲノム・エピゲノム解析の最近の進歩日本人と韓国人の肺腺癌発症に関連するTP63の一塩基多型の同定2011

    • Author(s)
      三木大樹、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん細胞においてDNA過剰メチル化により発現抑制される癌抑制遺伝子型microRNAの機能的スクリーニング2011

    • Author(s)
      小崎健一、稲澤譲治
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃がんにおける新規がん遺伝子グリオキサラーゼIの機能解析2011

    • Author(s)
      細田文恵、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食道癌におけるオートファジーATG7の不活性化2011

    • Author(s)
      小西博貴、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 癌におけるオートファジー関連遺伝子LC3Avariant-1の不活性化2011

    • Author(s)
      井上純、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食道扁平上皮癌において高頻度に発現抑制される新規癌関連プロトカドヘリン遺伝子の同定2011

    • Author(s)
      宮脇豊、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 機能的スクリーニングとDNAメチル化解析による口腔癌関連新規癌抑制遺伝子型microRNAの探索2011

    • Author(s)
      上杉篤史、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腫瘍特異的DNA過剰メチル化によって発現抑制される口腔扁平上皮癌抑制遺伝子型microRNAの探索2011

    • Author(s)
      遠藤寛則、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 大腸癌においてSIX1はZEB1を介し上皮間葉転換を誘導する2011

    • Author(s)
      小野宏晃、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 卵巣癌細胞における恒常的NF-κB活性化と足場非依存性増殖能に対するNIKの寄与2011

    • Author(s)
      宇野雅哉、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膵癌細胞株におけるE-cadherinの発現変化を指標とした機能的スクリーニングによるEMT関連microRNAの探索2011

    • Author(s)
      原園陽介、稲澤譲治, 他
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膵臓がん細胞株Panc1を用いた自発的転移モデルの構築と検証2011

    • Author(s)
      村松智輝、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第56回大会/第11回東アジア人類遺伝学会第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pathogenic CNVs and causative genes detected by two-stage screening in 647 patients with mental retardation and multiple congenital anomalies of unknown etiology2011

    • Author(s)
      林深、稲澤譲治, 他
    • Organizer
      The 12^<th> International Congress of Human Genetics/The American Society of Human Genetics 61th annual meeting
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] HRAS mutants identified in Costello syndrome patients have the ability to induce cellular senescence : Possible association with the pathogenesis of Costello syndrome2011

    • Author(s)
      新堀哲也、稲澤譲治, 他
    • Organizer
      The 12^<th> International Congress of Human Genetics/The American Society of Human Genetics 61th annual meeting
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] アレイCGHの臨床応用とCNVデータベースの構築2010

    • Author(s)
      林深、稲澤譲治
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道扁平上皮癌において高頻度に発現抑制を受ける新規癌抑制遺伝子候補Protocadherin 17(PCDH17)2010

    • Author(s)
      井本逸勢、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] BAC-based X-tiling arrayを用いたX連鎖性精神発達遅滞(XLMR)の原因遺伝子探索2010

    • Author(s)
      本田尚三、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Xp11.2微細重複症候群の1例2010

    • Author(s)
      岡本伸彦、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規症候群の可能性がある10p12.1-p11.23欠失の2症例2010

    • Author(s)
      岡本奈那、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] UBE2Aを含むXq24のゲノム欠失により特徴的な臨床症状を示した男児例2010

    • Author(s)
      小林淳也、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 複数のゲノムアレイによる先天異常疾患におけるゲノム評価2010

    • Author(s)
      林深、稲澤譲治, 他
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮ソニックシティ(埼玉)
    • Year and Date
      2010-10-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞癌の肉眼形態が示す特異的遺伝子発現パターンと分子標的EpCAMの意義2010

    • Author(s)
      田中真二、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌細胞においてDNAメチル化異常により発現抑制されるEMT関連分子の探索2010

    • Author(s)
      倉沢泰浩、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮体癌細胞株の機能的スクリーニングを用いたエピゲノム異常により発現抑制される癌抑制遺伝子型microRNAの同定2010

    • Author(s)
      鶴田智彦、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔癌細胞株の機能的スクリーニングを用いたDNAメチル化異常により発現抑制される癌抑制遺伝子型microRNAの探索2010

    • Author(s)
      上杉篤史、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functionalスクリーニングを用いた肝細胞癌抑制性microRNAの同定2010

    • Author(s)
      古田繭子、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腫瘍特異的DNA過剰メチル化によって発現抑制される口腔扁平上皮癌関連癌抑制遺伝子型microRNAの探索2010

    • Author(s)
      遠藤寛則、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 癌細胞におけるオートファジー経路の障害.第69回日本癌学会学術総会2010

    • Author(s)
      井上純、稲澤譲治
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発現アレイを用いた大腸癌におけるEMT関連遺伝子の探索2010

    • Author(s)
      小野宏晃、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肝細胞癌におけるCpGアイランドの過剰メチル化により発現制御される新規がん抑制遺伝子の同定2010

    • Author(s)
      松村聡、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道扁平上皮癌で高頻度に発現消失する新規癌抑制遺伝子候補protocadherin172010

    • Author(s)
      井本逸勢、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道扁平上皮がんにおけるYes-associated protein(YAP)のがん遺伝子としての可能性2010

    • Author(s)
      村松智輝、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道癌(ESCC)細胞株におけるhomo欠失領域から同定された癌抑制遺伝子候補の検討2010

    • Author(s)
      小西博貴、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道扁平上皮癌において高頻度に発現抑制される癌関連抑制遺伝子PCDH-X,Yの同定2010

    • Author(s)
      宮脇豊、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] LAPTM5はHECT型ユビキチンリガーゼITCHの基質である2010

    • Author(s)
      石原孝也、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 卵巣癌細胞におけるNF-kB inducing kinaseによる恒常的NF-kB活性化調節2010

    • Author(s)
      宇野雅哉、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] がん細胞においてDNA過剰メチル化により発現抑制される癌抑制遺伝子型microRNA2010

    • Author(s)
      小崎健一、稲澤譲治
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト癌におけるLC3A variant-1の発現低下の意義2010

    • Author(s)
      白樺、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] DNAメチル化プロファイルに基づいた膵がんの存在診断・病態診断指標の確率2010

    • Author(s)
      後藤政広、稲澤譲治, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場・リーガロイヤルホテル(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経芽腫自然退縮におけるImpaired autophagyを伴うLAPTM5依存性細胞死2010

    • Author(s)
      稲澤譲治
    • Organizer
      第19回日本Cell Death学会学術集会
    • Place of Presentation
      愛知県産業労働センター(愛知)
    • Year and Date
      2010-07-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] miR-124 and miR-203 are epigenetically silenced tumor-suppressivemicro RNAs in hepatocellular carcinoma2010

    • Author(s)
      古田繭子、稲澤譲治, 他
    • Organizer
      101th annual meeting of American Association for Cancer Research 2010
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas2010

    • Author(s)
      井上純、稲澤譲治, 他
    • Organizer
      101th annual meeting of American Association for Cancer Research 2010
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization2010

    • Author(s)
      石原孝也、稲澤譲治, 他
    • Organizer
      101th annual meeting of American Association for Cancer Research 2010
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Gene expression signature of the non-cancerous liver tissue associated with the early recurrence of hepatocellular carcinoma2010

    • Author(s)
      田中真二、稲澤譲治, 他
    • Organizer
      101th annual meeting of American Association for Cancer Research 2010
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional significance of potential oncogene YAP and its isoforms in esophageal squamouse cell carcinoma (ESCC)2010

    • Author(s)
      村松智輝、稲澤譲治, 他
    • Organizer
      101th annual meeting of American Association for Cancer Research 2010
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional screening of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral squamous cell carcinoma2010

    • Author(s)
      小崎健一、稲澤譲治, 他
    • Organizer
      101th annual meeting of American Association for Cancer Research 2010
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous-cell carcinoma2010

    • Author(s)
      井本逸勢、稲澤譲治, 他
    • Organizer
      101th annual meeting of American Association for Cancer Research 2010
    • Place of Presentation
      Washington, DC, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genetic and epigenetic aberrations of autophagy-related genes in human cancers.

    • Author(s)
      稲澤譲治
    • Organizer
      2013 SNUCRI & SNUCH Cancer Symposium.
    • Place of Presentation
      Phooenixisland,Jeju, Korea.
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌治療におけるオートファジー活性の評価.

    • Author(s)
      井上純、稲澤譲治
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] Eカドヘリン・プロモーター活性を指標としたEMT抑制性microRNAの機能的探索.

    • Author(s)
      小崎健一、稲澤譲治
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん抑制型マイクロRNAの探索.

    • Author(s)
      稲澤譲治
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      江陽グランドホテル.宮城
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chromosome 19 amplicon in oral cancer cell line have the potential to promote metastasis via Rho signaling pathway.

    • Author(s)
      村松智輝、稲澤譲治 他
    • Organizer
      平成25年度文部科学省科学研究費補助金・新学術領域研究「がん研究分野の特性等を踏まえた支援活動」. がん若手研究者ワークショップ
    • Place of Presentation
      蓼科グランドホテル滝の湯.長野
    • Related Report
      2013 Annual Research Report
  • [Presentation] がん抑制型マイクロRNAの探索.

    • Author(s)
      稲澤譲治
    • Organizer
      第9回トランスレーショナルリサーチワークショップ
    • Place of Presentation
      都市センターホテル.東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌ゲノム研究と個別化医療.

    • Author(s)
      稲澤譲治
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] がんと遺伝疾患のゲノム・エピゲノム解析.

    • Author(s)
      稲澤譲治
    • Organizer
      第439回日本皮膚科学会大阪地方会/第20回小林浩記念講演
    • Place of Presentation
      朝日生命ホール.大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔・食道扁平上皮癌の統合的ゲノム・エピゲノム解析.

    • Author(s)
      稲澤譲治
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      京王プラザホテル.東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食道扁平上皮癌におけるリンパ節転移予測マーカー同定を目指した網羅的DNAメチル化探索.

    • Author(s)
      永田啓明、稲澤譲治 他
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] オートファジー障害を持つ癌細胞における化合物スクリーニング.

    • Author(s)
      岩舘怜子、稲澤譲治 他
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] NRF2活性化癌に対するMicroRNAを基盤とした診断・治療.

    • Author(s)
      山本信祐、稲澤譲治 他
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 食道癌におけるLAPTM5遺伝子の発現低下.

    • Author(s)
      Michelle Nuylan、稲澤譲治 他
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] Inherent resistance to eculizumab in PNH.

    • Author(s)
      山本正樹、稲澤譲治 他
    • Organizer
      第75回日本血液学会学術総会
    • Place of Presentation
      さっぽろ芸文館.北海道
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔扁平上皮癌患者のゲノム構造異常解析による治療抵抗性予測.

    • Author(s)
      森田圭一、稲澤譲治 他
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      国立京都国際会館.京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小脳脳幹部低形成(MICPCH)の原因となる多彩な病態の探索.

    • Author(s)
      林深、稲澤譲治 他
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      江陽グランドホテル.宮城
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔扁平上皮癌患者のゲノム構造異常解析による治療抵抗性予測.

    • Author(s)
      森田圭一、稲澤譲治 他
    • Organizer
      第37回日本頭頸部癌学会
    • Place of Presentation
      京王プラザホテル.東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨軟部腫瘍におけるAktの活性化と遺伝子増加の意義.

    • Author(s)
      土橋洋、稲澤譲治 他
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 口腔がん細胞株に認められた19番染色体の増幅領域に座位する遺伝子は、Rhoシグナル経路を介して転移に寄与している可能性がある.

    • Author(s)
      村松智輝、稲澤譲治 他
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 複数癌腫における、MicroRNA-634による細胞死誘導機構.

    • Author(s)
      藤原直人、稲澤譲治 他
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜.神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] 次世代シーケンサーを用いたGorlin症候群患者におけるhedgehog pathwayのゲノム解析.

    • Author(s)
      森田圭一、稲澤譲治 他
    • Organizer
      第58回日本口腔外科学会学術総会
    • Place of Presentation
      福岡国際会議場・マリンメッセ福岡.福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] 次世代シーケンサーを用いたGorlin症候群患者におけるhedgehog pathwayのゲノム解析.

    • Author(s)
      森田圭一、稲澤譲治 他
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      江陽グランドホテル.宮城
    • Related Report
      2013 Annual Research Report
  • [Book] 肝細胞癌の早期診断:画像と分子マーカー.2012

    • Author(s)
      小崎健一、稲澤讓治 他
    • Publisher
      株式会社アークメディア
    • Related Report
      2012 Annual Research Report
  • [Book] 胆と膵.2012

    • Author(s)
      藤原直人、稲澤讓治 他
    • Publisher
      医学図書出版株式会社
    • Related Report
      2012 Annual Research Report
  • [Book] がん生物学イラストレイテッド2011

    • Author(s)
      渋谷正史、稲澤譲治, 他
    • Publisher
      株式会社羊土社
    • Related Report
      2011 Annual Research Report
  • [Book] 肝細胞癌の早期診断:画像と分子マーカー2011

    • Author(s)
      小崎健一、稲澤譲治, 他
    • Publisher
      株式会社アークメディア
    • Related Report
      2011 Annual Research Report
  • [Book] 日本臨林増刊号.大腸癌2011

    • Author(s)
      小野宏晃、稲澤譲治, 他
    • Publisher
      株式会社日本臨林社
    • Related Report
      2011 Annual Research Report
  • [Book] 最新医学2011

    • Author(s)
      宮脇豊、稲澤譲治, 他
    • Publisher
      株式会社最新医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 日本医師会雑誌 第139第3号 染色体異常-検査の進歩、結果の解釈2010

    • Author(s)
      稲澤譲治
    • Total Pages
      5
    • Publisher
      日本医師会
    • Related Report
      2010 Annual Research Report
  • [Book] 大腸癌FRONTIER.遺伝子・ゲノム変異と大腸癌発癌~全ゲノムを研究対象としてみえてきたこと~2010

    • Author(s)
      小野宏晃、稲澤譲治, 他
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Related Report
      2010 Annual Research Report
  • [Remarks] CGH Data Base

    • URL

      http://www.cghtmd.jp/CGHDatabase/index_j.jsp

    • Related Report
      2014 Annual Research Report
  • [Remarks] MCG CNV database

    • URL

      http://www.cghtmd.jp/CNVDatabase/top.action

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京医科歯科大学難治疾患研究所分子細胞遺伝ホームページ

    • URL

      http://www.tmd.ac.jp/mri/cgen/framepage.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京医科歯科大学難治疾患研究所分子細胞遺伝ホームページ

    • URL

      http://www.tmd.ac.jp/mri/cgen/framepage.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/cgen/framepage.htm

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/cgen/framepage.htm

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 卵巣癌の検出方法、及び抑制方法(US分割)2012

    • Inventor(s)
      稲澤譲治・井本逸勢・菊池良子
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学・富士写真フィルム株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-10-24
    • Acquisition Date
      2014-06-03
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 卵巣癌の検出方法2012

    • Inventor(s)
      稲澤譲治・井本逸勢・菊池良子
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学・富士フィルム株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-09-24
    • Acquisition Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 卵巣癌の検出方法、及び抑制方法2012

    • Inventor(s)
      稲澤譲治、井本逸勢、菊池良子
    • Industrial Property Rights Holder
      東京医科歯科大学、富士フイルム株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-10-24
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 癌の検出方法および癌抑制剤2010

    • Inventor(s)
      稲澤譲治、小崎健一、井本逸勢
    • Industrial Property Rights Holder
      東京医科歯科大学、富士フイルム株式会社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2010-12-09
    • Acquisition Date
      2012-05-22
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 核酸マイクロアレイの異常スポットを検出する方法2010

    • Inventor(s)
      金原秀行・吉田淳哉・氏原大・稲澤譲治・井本逸勢
    • Industrial Property Rights Holder
      東京医科歯科大学・富士写真フィルム株式会社
    • Industrial Property Number
      2009-128162
    • Filing Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
    • Overseas

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Published: 2010-08-23   Modified: 2019-07-29  

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