Development of Systems Cancer Research by Computation and Simulation

• Project Area: Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
• Project/Area Number: 22134004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: The University of Tokyo
• Principal Investigator: MIYANO SATORU 東京大学, 医科学研究所, 教授 (50128104)
• Co-Investigator(Kenkyū-buntansha): IMOTO Seiya 東京大学, 医科学研究所, 准教授 (10345027) ; YAMAGUCHI Rui 東京大学, 医科学研究所, 講師 (90380675) ; SHIRAISHI Yuichi 東京大学, 医科学研究所, 助教 (70516880) ; TAMADA Yoshinori 東京大学, 大学院情報理工学研究科, 助教 (80435495) ; SHIMAMURA Teppei 名古屋大学, 医学系研究科, 特任准教授 (00623943) ; NAGASAKI Masao 東京大学, 医科学研究所, 准教授 (90396862)
• Co-Investigator(Renkei-kenkyūsha): HIGUCHI Tomoyuki 大学共同利用機関法人情報, システム研究機構統計数理研究所, 所長 (70202273) ; KAYANO Mitsunori 帯広畜産大学, 畜産学部, 講師 (20590095) ; GOTOH Noriko 東京大学, 医科学研究所, 特任准教授 (10251448)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥207,740,000 (Direct Cost: ¥159,800,000、Indirect Cost: ¥47,940,000); Fiscal Year 2014: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000); Fiscal Year 2013: ¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000); Fiscal Year 2012: ¥42,640,000 (Direct Cost: ¥32,800,000、Indirect Cost: ¥9,840,000); Fiscal Year 2011: ¥42,250,000 (Direct Cost: ¥32,500,000、Indirect Cost: ¥9,750,000); Fiscal Year 2010: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
• Keywords: がん / システム生物学 / ゲノム科学 / バイオインフォマティクス / 統計的モデリング / 遺伝統計学 / スーパーコンピュータ / 遺伝子ネットワーク / シークエンス解析

Outline of Final Research Achievements

We developed a new research area “systems cancer research” by fusing large-scale data analysis and mathematical modelling that made full use of mathematics and supercomputers. Methodologies for system cancer research were installed in each cancer study of the members. Methodologies and utilization of supercomputers innovated integrative studies among “wet” and “dry” laboratories. As a result, our comprehensive understanding of cancer systems advanced drastically. Our collaboration with Seishi Ogawa about myelodysplasia (MDS) showed for the first time in the world that the abnormality of the RNA splicing is the cause of MDS. This discovery that abnormal RNA splicing is a cause of cancer held a special place in the pages of cancer research history. Our collaboration with Takashi Takahashi discovered the prognostic hubs and subnetworks which switch survival/death of lung cancer patients.

Research Products

• [Journal Article] Genomon ITDetector: A tool for somatic internal tandem duplication detection from cancer genome sequencing data. Bioinformatics (2015)
  • Author(s): Chiba K, Shiraishi Y, Nagata Y, Yoshida K, Imoto S, Ogawa S, Miyano S.
  • Journal Title: Bioinformatics Volume: 31(1) Pages: 116-118
  • Peer Reviewed / Open Access
• [Journal Article] Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity (2015)
  • Author(s): Fujimoto A, Furuta M, Shiraishi Y, Gotoh K, Kawakami Y, Arihiro K, Nakamura T, Ueno M, Ariizumi SI, Hai Nguyen H, Shigemizu D, Abe T, Boroevich KA, Nakano K, Sasaki A, Kitada R, Maejima K, Yamamoto Y, Tanaka H, Shibuya T, Shibata T, Ojima H, Shimada K, Hayami S, Shigekawa Y, Aikata H, Ohdan H, Marubashi S, et al.
  • Journal Title: Nat Commun. Volume: 6 Pages: 6120
  • Peer Reviewed / Open Access
• [Journal Article] PRPF8 defects cause missplicing in myeloid malignancies (2015)
  • Author(s): Kurtovic-Kozaric A, Przychodzen B, Singh J, Konarska MM, Clemente MJ, Otrock ZK, Nakashima M, Hsi ED, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Boultwood J, Makishima H, Maciejewski JP, Padgett RA
  • Journal Title: Leukemia Volume: 29(1) Pages: 126-136
  • Peer Reviewed / Open Access
• [Journal Article] Genomic data assimilation using a higher moment filtering technique for restoration of gene regulatory networks (2015)
  • Author(s): Hasegawa T, Mori T, Yamaguchi R, Shimamura T, Miyano S, Imoto S, Akutsu T
  • Journal Title: MC Syst Biol Volume: 9(1) Pages: 14
  • Peer Reviewed / Open Access
• [Journal Article] Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features (2014)
  • Author(s): Arima C, Kajino T, Tamada Y, Imoto S, Shimada Y, Nakatochi M, Suzuki M, Isomura H, Yatabe Y, Yamaguchi T, Yanagisawa K, Miyano S, Takahashi T
  • Journal Title: Carcinogenesis Volume: 35(10) Pages: 2224-2231
  • Peer Reviewed / Open Access
• [Journal Article] Tracing the development of acute myeloid leukemia in CBL syndrome (2014)
  • Author(s): Becker H, Yoshida K, Blagitko-Dorfs N, Claus R, Pantic M, Abdelkarim M, Niemoller C, Greil C, Hackanson B, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Dohner K, Schnittger S, Henneke P, Niemeyer CM, Flotho C, Pfeifer D, Ogawa S, Lubbert M
  • Journal Title: Blood Volume: 123(12) Pages: 1883-1886
  • Peer Reviewed / Open Access
• [Journal Article] Acquired initiating mutations in early hematopoietic cells of CLL patients (2014)
  • Author(s): Damm F, Mylonas E, Cosson A, Yoshida K, Della Valle V, Mouly E, Diop M, Scourzic L, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Kikushige Y, Davi F, Lambert J, Gautheret D, Merle-Beral H, Sutton L, Dessen P, Solary E, Akashi K, Vainchenker W, Mercher T, Droin N, Ogawa S, Nguyen-Khac F, Bernard OA
  • Journal Title: Cancer Discov Volume: 4(9) Pages: 1088-1101
  • Peer Reviewed / Open Access
• [Journal Article] A tutorial to identify nonlinear associations in gene expression time series data (2014)
  • Author(s): Fujita A, Miyano S
  • Journal Title: Methods Mol Biol. Volume: 1164 Pages: 87-95
  • Peer Reviewed / Open Access
• [Journal Article] Landscape of genetic lesions in 944 patients with myelodysplastic syndromes (2014)
  • Author(s): Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G, Schnittger S, Sanada M, Kon A, Alpermann T, Yoshida K, Roller A, Nadarajah N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Kohlmann A, Miyano S, Haferlach C, Kern W, Ogawa S
  • Journal Title: Leukemia Volume: 28(2) Pages: 241-247
  • Peer Reviewed / Open Access
• [Journal Article] An efficient data assimilation schema for restoration and extension of gene regulatory networks using time-course observation data (2014)
  • Author(s): Hasegawa T, Mori T, Yamaguchi R, Imoto S, Miyano S, Akutsu T
  • Journal Title: J Comput Biol Volume: 21(11) Pages: 785-798
  • Peer Reviewed / Open Access
• [Journal Article] An efficient method of exploring simulation models by assimilating literature and biological observational data (2014)
  • Author(s): Hasegawa T, Nagasaki M, Yamaguchi R, Imoto S, Miyano S
  • Journal Title: Biosystems Volume: 121 Pages: 54-66
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent genetic defects on chromosome 7q in myeloid neoplasms (2014)
  • Author(s): Hosono N, Makishima H, Jerez A, Yoshida K, Przychodzen B, McMahon S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Sanada M, Gomez-Segui I, Verma AK, McDevitt MA, Sekeres MA, Ogawa S, Maciejewski JP
  • Journal Title: Leukemia Volume: 28(6) Pages: 1348-1351
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients (2014)
  • Author(s): Kihara R, Nagata Y, Kiyoi H, Kato T, Yamamoto E, Suzuki K, Chen F, Asou N, Ohtake S, Miyawaki S, Miyazaki Y, Sakura T, Ozawa Y, Usui N, Kanamori H, Kiguchi T, Imai K, Uike N, et. al.
  • Journal Title: Leukemia Volume: 28(8) Pages: 1586-1595
  • Peer Reviewed / Open Access
• [Journal Article] CSML2SBML: a novel tool for converting quantitative biological pathway models from CSML into SBML (2014)
  • Author(s): Li C, Nagasaki M, Ikeda E, Sekiya Y, Miyano S
  • Journal Title: Biosystems Volume: 121 Pages: 22-28
  • Peer Reviewed / Open Access
• [Journal Article] Clonal leukemic evolution in myelodysplastic syndromes with TET2 and IDH1/2 mutations (2014)
  • Author(s): Lin TL, Nagata Y, Kao HW, Sanada M, Okuno Y, Huang CF, Liang DC, Kuo MC, Lai CL, Lee EH, Shih YS, Tanaka H, Shiraishi Y, Chiba K, Lin TH, Wu JH, Miyano S, Ogawa S, Shih LY
  • Journal Title: Haematologica Volume: 99(1) Pages: 28-36
  • Peer Reviewed / Open Access
• [Journal Article] Haploinsufficiency of Sf3b1 leads to compromised stem cell function but not to myelodysplasia (2014)
  • Author(s): Matsunawa M, Yamamoto R, Sanada M, Sato-Otsubo A, Shiozawa Y, Yoshida K, Otsu M, Shiraishi Y, Miyano S, Isono K, Koseki H, Nakauchi H, Ogawa S
  • Journal Title: Leukemia Volume: 28(9) Pages: 1844-1850
  • Peer Reviewed / Open Access
• [Journal Article] Robust prediction of anti-cancer drug sensitivity and sensitivity-specific biomarker (2014)
  • Author(s): Park H, Shimamura T, Miyano S, Imoto S
  • Journal Title: PLoS One Volume: 9(1) Pages: e108990
  • Peer Reviewed / Open Access
• [Journal Article] Somatic RHOA mutation in angioimmunoblastic T cell lymphoma (2014)
  • Author(s): Sakata-Yanagimoto M, Enami T, Yoshida K, Shiraishi Y, Ishii R, Miyake Y, Muto H, Tsuyama N, Sato-Otsubo A, Okuno Y, Sakata S, Kamada Y, Nakamoto-Matsubara R, et. al.
  • Journal Title: Nat Genet. Volume: 46(2) Pages: 171-175
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome (2014)
  • Author(s): Sato Y, Maekawa S, Ishii R, Sanada M, Morikawa T, Shiraishi Y, Yoshida K, Nagata Y, Sato-Otsubo A, Yoshizato T, Suzuki H, Shiozawa Y, Kataoka K, Kon A, Aoki K, Chiba K, Tanaka H, Kume H, Miyano S, Fukayama M, Nureki O, Homma Y, Ogawa S
  • Journal Title: Science Volume: 344(6186) Pages: 917-920
  • Peer Reviewed / Open Access
• [Journal Article] Loss of CDCP1 expression promotes invasiveness and poor prognosis in esophageal squamous cell carcinoma (2014)
  • Author(s): Sawada G, Takahashi Y, Niida A, Shimamura T, Kurashige J, Matsumura T, Ueo H, Uchi R, Takano Y, Ueda M, Hirata H, Sakimura S, Shinden Y, Eguchi H, Sudo T, Sugimachi K, Miyano S, Doki Y, Mori M, Mimori K
  • Journal Title: Ann Surg Oncol Volume: 21 Suppl 4 Pages: 640-647
  • Peer Reviewed / Open Access
• [Journal Article] Biallelic DICER1 mutations in sporadic pleuropulmonary blastoma (2014)
  • Author(s): Seki M, Yoshida K, Shiraishi Y, Shimamura T, Sato Y, Nishimura R, Okuno Y, Chiba K, Tanaka H, Kato K, Kato M, Hanada R, Nomura Y, Park MJ, Ishida T, Oka A, Igarashi T, Miyano S, Hayashi Y, Ogawa S, Takita J
  • Journal Title: Cancer Res. Volume: 74（１０） Pages: 2742-2749
  • Peer Reviewed / Open Access
• [Journal Article] A feature selection method using fixed-point algorithm for DNA microarray gene expression data (2014)
  • Author(s): Sharma A, Paliwal KK, Imoto S, Miyano S, Sharma V, Ananthanarayanan R
  • Journal Title: International Journal of Knowledge Based and Intelligent Engineering Systems Volume: 18(1) Pages: 55-59
  • Peer Reviewed / Open Access
• [Journal Article] A feature selection method using improved regularized linear discriminant analysis (2014)
  • Author(s): Sharma A, Paliwal KK, Imoto S, Miyano S
  • Journal Title: Mach Vis Appl. Volume: 25(3) Pages: 775-786
  • Peer Reviewed / Open Access
• [Journal Article] Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria (2014)
  • Author(s): Shen W, Clemente MJ, Hosono N, Yoshida K, Przychodzen B, Yoshizato T, Shiraishi Y, Miyano S, Ogawa S, Maciejewski JP, Makishima H
  • Journal Title: J Clin Invest Volume: 124(10) Pages: 4529-4538
  • Peer Reviewed / Open Access
• [Journal Article] Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers (2014)
  • Author(s): Shiraishi Y, Fujimoto A, Furuta M, Tanaka H, Chiba K, Boroevich KA, Abe T, Kawakami Y, Ueno M, Gotoh K, Ariizumi S, Shibuya T, Nakano K, Sasaki A, Maejima K, Kitada R, Hayami S, Shigekawa Y, Marubashi S, Yamada T, Kubo M, et. al.
  • Journal Title: PLoS One Volume: 9(12) Pages: e114263
  • Peer Reviewed / Open Access
• [Journal Article] Allelic Imbalance at an 8q24 Oncogenic SNP is involved in activating MYC in human colorectal cancer (2014)
  • Author(s): Sugimachi K, Niida A, Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K
  • Journal Title: Ann Surg Oncol Volume: 21 Suppl 4 Pages: 515-521
  • Peer Reviewed / Open Access
• [Journal Article] The AURKA/TPX2 axis drives colon tumorigenesis cooperatively with MYC (2014)
  • Author(s): Takahashi Y, Sheridan P, Niida A, Sawada G, Uchi R, Mizuno H, Kurashige J, Sugimachi K, Sasaki S, Shimada Y, Hase K, Kusunoki M, Kudo S, Watanabe M, Yamada K, Sugihara K, Yamamoto H, Suzuki A, Doki Y, Miyano S, Mori M, Mimori K
  • Journal Title: Ann Oncol. Volume: 26(5) Pages: 935-942
  • Peer Reviewed / Open Access
• [Journal Article] Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma (2014)
  • Author(s): Totoki Y, Yoshida A, Hosoda F, Nakamura H, Hama N, Ogura K, Yoshida A, Fujiwara T, Arai Y, Toguchida J, Tsuda H, Miyano S, Kawai A, Shibata T
  • Journal Title: Genome Res Volume: 24(9) Pages: 1411-1420
  • Peer Reviewed / Open Access
• [Journal Article] HapMuC: somatic mutation calling using heterozygous germline variants near candidate mutations (2014)
  • Author(s): Usuyama N, Shiraishi Y, Sato Y, Kume H, Homma Y, Ogawa S, Miyano S, Imoto S
  • Journal Title: Bioinformatics Volume: 30(23) Pages: 3302-3309
  • Peer Reviewed / Open Access
• [Journal Article] BCOR and BCORL1 mutations in myelodysplastic syndromes and related disorders (2013)
  • Author(s): Damm F, Chesnais V, Nagata Y, Yoshida K, Okuno Y, Itzykson R, Sanada M, Shiraishi Y, Gelsi-Boyer V, Miyano S, Mori H, Shih LY, Park S, Dreyfus F, Rose C, Cheze S, Vey N, Legentil M, Duffourd Y, de Botton S, Preudhomme C, Birnbaum D, Bernard OA, Ogawa S, Fontenay M, Kosmider O.
  • Journal Title: Blood Volume: 122(18) Pages: 3169-3177
  • Peer Reviewed
• [Journal Article] Novel recurrent mutations in the RAS-like GTP-binding gene RIT1 in myeloid malignancies (2013)
  • Author(s): Gomez-Segui I, Makishima H, Jerez A, Yoshida K, Przychodzen B, Miyano S, Shiraishi Y, Husseinzadeh HD, Guinta K, Clemente M, Hosono N, McDevitt MA, Moliterno AR, Sekeres MA, Ogawa S, Maciejewski JP.
  • Journal Title: Leukemia Volume: 27(9) Pages: 1943-1946
  • Peer Reviewed
• [Journal Article] Twist2 functions as a tumor suppressor in murine osteosarcoma cells (2013)
  • Author(s): Ishikawa T, Shimizu T, Ueki A, Yamaguchi SI, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S, Saya H.
  • Journal Title: Cancer Sci. Volume: 104(7) Pages: 880-888
  • Peer Reviewed
• [Journal Article] Multi-omics approach for estimating metabolic networks using low-order partial correlations (2013)
  • Author(s): Kayano M, Imoto S, Yamaguchi R, Miyano S.
  • Journal Title: J Comput Biol. Volume: 20(8) Pages: 571-582
  • Peer Reviewed
• [Journal Article] Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms (2013)
  • Author(s): Kon A, Shih LY, Sanada M, Shiraishi Y, Okuno Y, Nagae G, Nishimoto A, Nowak D, Sato Y, Shimamura T, Tanaka H, Chiba K, Yamaguchi T, Otsu M, Obara N, Nakamaki T, Ishiyama K, Nolte F, Hofmann WK, Miyawaki S, Chiba S, Mori H, Nakauchi H, Koeffler HP, Aburatani H, Haferlach T, Shirahige K, Miyano S, Ogawa S.
  • Journal Title: Nature Genet. Volume: 45(10) Pages: 1232-1237
  • Peer Reviewed
• [Journal Article] Somatic SETBP1 mutations in myeloid malignancies (2013)
  • Author(s): Makishima H, Yoshida K, Nguyen N, Okuno Y, Ng KP, Gudmundsson KO, Vishwakarma BA, Jerez A, Gomez-Segui I, Takahashi M, Shiraishi Y, Nagata Y, Guinta K, Mori H, Sekeres MA, Chiba K, Tanaka H, Muramatsu H, Sakaguchi H, Paquette RL, McDevitt MA, Kojima S, Saunthararajah Y, Miyano S, Shih LY, Du Y, Ogawa S, Maciejewski JP.
  • Journal Title: Nature Genet. Volume: 45(8) Pages: 942-946
  • Peer Reviewed
• [Journal Article] Multilayer cluster heat map visualizing biological tensor data (2013)
  • Author(s): Niida A, Tremmel G, Imoto S, Miyano S.
  • Journal Title: Lecture Notes in Bioinformatics Volume: 8213 Pages: 116-125
  • Peer Reviewed
• [Journal Article] Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor associated macrophages (2013)
  • Author(s): Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro JI, Kanki Y, Wada Y, Yuasa Y, Aburatani H, Miyano S, Minami T, Kodama T, Shibuya M.
  • Journal Title: Cancer Res. Volume: 73(10) Pages: 3019-3028
  • Peer Reviewed
• [Journal Article] Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome (2013)
  • Author(s): Saida S, Watanabe K, Sato-Otsubo A, Terui K, Yoshida K, Okuno Y, Toki T, Wang RN, Shiraishi Y, Miyano S, Kato I, Morishima T, Fujino H, Umeda K, Hiramatsu H, Adachi S, Ito E, Ogawa S, Ito M, Nakahata T, Heike T.
  • Journal Title: Blood Volume: 121(21) Pages: 4377-4387
  • Peer Reviewed
• [Journal Article] Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia (2013)
  • Author(s): Sakaguchi H, Okuno Y, Muramatsu H, Yoshida K, Shiraishi Y, Takahashi M, Kon A, Sanada M, Chiba K, Tanaka H, Makishima H, Wang X, Xu Y, Doisaki S, Hama A, Nakanishi K, Takahashi Y, Yoshida N, Maciejewski JP, Miyano S, Ogawa S, Kojima S.
  • Journal Title: Nature Genet. Volume: 45(8) Pages: 937-941
  • Peer Reviewed
• [Journal Article] Integrated molecular analysis of clear-cell renal cell carcinoma (2013)
  • Author(s): Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, Shimamura T, Sato-Otsubo A, Nagae G, Suzuki H, Nagata Y, Yoshida K, Kon A, Suzuki Y, Chiba K, Tanaka H, Niida A, Fujimoto A, Tsunoda T, Morikawa T, Maeda D, Kume H, Sugano S, Fukayama M, Aburatani H, Sanada M, Miyano S, Homma Y, Ogawa S.
  • Journal Title: Nature Genet. Volume: 45(8) Pages: 860-867
  • Peer Reviewed
• [Journal Article] A strategy to select suitable physicochemical attributes of amino acids for protein fold recognition (2013)
  • Author(s): Sharma A, Paliwal KK, Dehzangi A, Lyons J, Imoto S, Miyano S.
  • Journal Title: BMC Bioinformatics Volume: 14(1) Pages: 233
  • Peer Reviewed
• [Journal Article] Principal component analysis using QR decomposition (2013)
  • Author(s): Sharma A, Paliwal KK, Imoto S, Miyano S
  • Journal Title: International J Machine Learning and Cybernetics Volume: 4(6) Pages: 679-683
  • Peer Reviewed
• [Journal Article] An empirical Bayesian framework for somatic mutation detection from cancer (2013)
  • Author(s): Shiraishi Y, Sato Y, Chiba K, Okuno Y, Nagata Y, Yoshida K, Shiba N, Hayashi Y, Kume H, Homma Y, Sanada M, Ogawa S, Miyano S
  • Journal Title: Nucleic Acids Res. Volume: 41(7) Pages: e89
  • Peer Reviewed
• [Journal Article] The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer (2013)
  • Author(s): Takatsuno Y, Mimori K, Yamamoto K, Sato T, Niida A, Inoue H, Imoto S, Kawano S, Yamaguchi R, Toh H, Iinuma H, Ishimaru S, Ishii H, Suzuki S, Tokudome S, Watanabe M, Tanaka JI, Kudo SE, Mochizuki H, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Miyano S, Sugihara K, Mori M
  • Journal Title: Ann Surg Oncol. Volume: 20(4) Pages: 1395-1402
  • Peer Reviewed
• [Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis (2013)
  • Author(s): Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M
  • Journal Title: Cancer Res. Volume: 73(7) Pages: 2059-2069
  • Peer Reviewed
• [Journal Article] The landscape of somatic mutations in Down syndrome-related myeloid disorders (2013)
  • Author(s): Yoshida K, Toki T, Okuno Y, Kanezaki R, Shiraishi Y, Sato-Otsubo A, Kon A, Nagata Y, Sato Y, Wang R, Shiba N, Chiba K, Tanaka H, Hama A, Hasegawa D, Nakamura K, Kanegane H, Tsukamoto K, Adachi S, Kawakami K, Kato K, Nishimura R, Izraeli S, Hayashi Y, Miyano S, Kojima S, Ito E, Ogawa S
  • Journal Title: Nature Genet. Volume: 45 Pages: 1293-1299
  • Peer Reviewed
• [Journal Article] Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells (2013)
  • Author(s): Yoshimaru T, Komatsu M, Matsuo T, Chen YA, Murakami Y, Mizuguchi K, Mizohata E, Inoue T, Akiyama M, Yamaguchi R, Imoto S, Miyano S, Miyoshi Y, Sasa M, Nakamura Y, Katagiri T
  • Journal Title: Nature Commun. Volume: 4 Pages: 2443-2013
  • Peer Reviewed
• [Journal Article] Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis (2013)
  • Author(s): Affara M, Sanders D, Araki H, Tamada Y, Dunmore B, Humphreys S, Imoto S, Savoie C, Miyano S, Kuhara S, Print C, Charnock-Jones DS
  • Journal Title: BMC Genomics Volume: 14(1) Pages: 23
  • DOI: doi: 10.1186/1471-2164-14-23
  • Peer Reviewed
• [Journal Article] The tumor-suppressive miR-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma (2013)
  • Author(s): Furuta M, Kozaki K, Tanimoto K, Tanaka S, Arii S, Shimamura S, Niida A, Miyano S, Inazawa J
  • Journal Title: PLOS One Volume: 8(3) Pages: e60155
  • DOI: doi: 10.1371/journal.pone.0060155
  • Peer Reviewed
• [Journal Article] Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis (2013)
  • Author(s): Komatsu M, Yoshimaru T, Matsuo T, Kiyotani K, Miyoshi Y, Tanahashi T, Rokutan K, Yamaguchi R, Saito A, Imoto S, Miyano S, Nakamura Y, Sasa M, Shimada M, Katagiri T
  • Journal Title: Int J Oncol Volume: 42(2) Pages: 478-506
  • DOI: doi: 10.3892/ijo.2012.1744
  • Peer Reviewed
• [Journal Article] XiP: a computational environment to create, extend and share workflows (2013)
  • Author(s): Nagasaki M, Fujita A, Sekiya Y, Saito A, Ikeda E, Li C, Miyano S
  • Journal Title: Bioinformatics Volume: 29(1) Pages: 137-139
  • DOI: doi: 10.1093/bioinformatics/bts630
  • Peer Reviewed
• [Journal Article] PRD: A protein-RNA interaction database (2012)
  • Author(s): Fujimori S, Hino K, Saito A, Miyano S, Miyamoto-Sato E
  • Journal Title: Bioinformation Volume: 8(15) Pages: 729-730
  • DOI: doi: 10.6026/97320630008729
  • Peer Reviewed
• [Journal Article] IRView: a database and viewer for protein interacting regions (2012)
  • Author(s): Fujimori S, Hirai N, Masuoka K, Oshikubo T, Yamashita T, Washio T, Saito A, Nagasaki M, Miyano S, Miyamoto-Sato E
  • Journal Title: Bioinformatics Volume: 28(14) Pages: 1949-1950
  • DOI: doi: 10.1093/bioinformatics/bts289
  • Peer Reviewed
• [Journal Article] Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators (2012)
  • Author(s): Fujimoto A, Totoki Y, （11名）, Nagasaki M, Shibuya T, （2名）, Tanaka H, （19名）, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, Nakagawa H
  • Journal Title: Nature Genetics Volume: 44(7) Pages: 760-764
  • DOI: doi: 10.1038/ng.2291
  • Peer Reviewed
• [Journal Article] Functional clustering of time series gene expression data by Granger causality (2012)
  • Author(s): Fujita A, Severino P, Kojima K, Sato JR, Patriota AG, Miyano S
  • Journal Title: BMC Systems Biology Volume: 6 Pages: 137
  • DOI: doi: 10.1186/1752-0509-6-137
  • Peer Reviewed
• [Journal Article] Gene network inference and visualization tools for biologists: application to new human transcriptome datasets (2012)
  • Author(s): Hurley D, Araki H, Tamada Y, （４名）, Imoto S, Yasuda K, Tomiyasu Y, Tashiro K, Savoie C, Cho V, Smith S, Kuhara S, Miyano S, Charnock-Jones DS, Crampin EJ, Print CG
  • Journal Title: Nucleic Acids Res Volume: 40(6) Pages: 2377-2398
  • DOI: doi: 10.1093/nar/gkr902
  • Peer Reviewed
• [Journal Article] Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24 (2012)
  • Author(s): Ishimaru S, Mimori K, Yamamoto K, Inoue H, Imoto S, Kawano S, Yamaguchi R, (18名), Miyano S, Mori M
  • Journal Title: Ann Surg Oncol Volume: 19(9) Pages: 2853-2858
  • DOI: doi: 10.1245/s10434-012-2278-6
  • Peer Reviewed
• [Journal Article] Identifying Gene pathways associated with cancer characteristics via sparse statistical methods (2012)
  • Author(s): Kawano S, Shimamura T, Niida A, Imoto S, Yamaguchi R, Nagasaki M, Yoshida R, Print C, Miyano S
  • Journal Title: IEEE/ACM Transactions on Computational Biology and Bioinformatics Volume: 9(4) Pages: 966-972
  • DOI: doi: 10.1109/TCBB.2012.48
  • Peer Reviewed
• [Journal Article] Statistical model-based testing to evaluate the recurrence of genomic aberrations (2012)
  • Author(s): Niida A, Imoto S, Shimamura T, Miyano S
  • Journal Title: Bioinformatics Volume: 28(12) Pages: i115-i120
  • DOI: doi: 10.1093/bioinformatics/bts203
  • Peer Reviewed
• [Journal Article] Computational gene network analysis reveals TNF-induced angiogenesis (2012)
  • Author(s): Ogami K, Yamaguchi R, Imoto S, Tamada Y, Araki H, Print C, Miyano S
  • Journal Title: BMC Systems Biology Volume: 6 (Suppl 2) Pages: S12
  • DOI: doi: 10.1186/1752-0509-6-S2-S12
  • Peer Reviewed
• [Journal Article] A between-class overlapping filter-based method for transcriptome data analysis (2012)
  • Author(s): Sharma A, Imoto S, Miyano S
  • Journal Title: J Bioinformatics and Computational Biology Volume: 10(5) Pages: 1250010
  • DOI: doi: 10.1142/S0219720012500102
  • Peer Reviewed
• [Journal Article] A top-r feature selection algorithm for microarray gene expression data (2012)
  • Author(s): Sharma A, Imoto S, Miyano S
  • Journal Title: IEEE/ACM Transactions on Computational Biology and Bioinformatics Volume: 9(3) Pages: 754-764
  • DOI: doi: 10.1109/TCBB.2011.151
  • Peer Reviewed
• [Journal Article] Cell cycle gene networks are associated with melanoma prognosis (2012)
  • Author(s): Wang L, Hurley D, Watkins W, Araki1 H, Tamada Y, Muthukaruppan A, Ranjard L, Derkac E, Imoto S, Miyano S, Crampin E, Print C
  • Journal Title: PLoS One Volume: 7(4) Pages: e34247
  • DOI: doi: 10.1371/journal.pone.0034247
  • Peer Reviewed
• [Journal Article] Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma (2012)
  • Author(s): Yamauchi M, Yamaguchi R, Nakata A, Kohno T, Nagasaki M, Shimamura T, Imoto S, Saito A, Ueno K, Hatanaka Y, Yoshida R, Higuchi T, Nomura M, Beer DG, Yokota J, Miyano S, Gotoh N
  • Journal Title: PLoS One Volume: 7(9) Pages: e43923
  • DOI: doi: 10.1371/journal.pone.0043923
  • Peer Reviewed
• [Journal Article] ChopSticks: High-resolution analysis of homozygous deletions by exploiting concordant read pairs (2012)
  • Author(s): Yasuda T, Suzuki S, Nagasaki M, Miyano S
  • Journal Title: BMC Bioinformatics Volume: 13(1) Pages: 279
  • DOI: doi: 10.1186/1471-2105-13-279
  • Peer Reviewed
• [Journal Article] Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing (2012)
  • Author(s): Kojima K, Imoto S, Yamaguchi R, Fujita A, Yamauchi M, Gotoh N, Miyano S
  • Journal Title: BMC Genomics Volume: 13(Suppl 1) Pages: S6
  • DOI: doi:10.1186/1471-2164-13-S1-S6
  • Peer Reviewed
• [Journal Article] Identification of genes up-regulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas (2011)
  • Author(s): Okayama H, Kohno T, Ishii Y, Shimada Y, Shiraishi K, Iwakawa R, Furuta K, Tsuta K, Shibata T, Yamamoto S, Watanabe S, Sakamoto H, Kumamoto K, Takenoshita S, Gotoh N, Mizuno H, Sarai A, Kawano S, Yamaguchi R, Miyano S, Yokota J
  • Journal Title: Cancer Res. Volume: 72(1) Pages: 100-111
  • DOI: doi:10.1158/0008-5472.CAN-11-1403
  • Peer Reviewed
• [Journal Article] Inferring contagion in regulatory networks (2011)
  • Author(s): Fujita A, Sato JR, Demas MAA, Yamaguchi R, Shimamura T, Ferreira CE, Sogayar, MC, Miyano S
  • Journal Title: IEEE/ACM Transactions on Computational Biology and Bioinformatics Volume: 8(2) Pages: 570-576
  • DOI: doi:10.1109/TCBB.2010.40
  • Peer Reviewed
• [Journal Article] Comprehensive pharmacogenomic pathway screening by data assimilation (2011)
  • Author(s): Hasegawa T, Yamaguchi R, Nagasaki M, Imoto S, Miyano S
  • Journal Title: Lecture Notes in Bioinformatics Volume: 6674 Pages: 160-171
  • DOI: DOI:10.1007/978-3-642-21260-4_18
  • Peer Reviewed
• [Journal Article] MIRACH : Efficient model checker for quantitative biological pathway models (2011)
  • Author(s): Koh CH, Nagasaki M, Saito A, Li C, Wong L, Miyano S
  • Journal Title: Bioinformatics Volume: 27(5) Pages: 734-735
  • DOI: doi:10.1093/bioinformatics/btq727
  • Peer Reviewed
• [Journal Article] A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition (2011)
  • Author(s): Shimamura T, Imoto S, Shimada Y, Hosono Y, Niida A, Nagasaki M, Yamaguchi R, Takahashi T, Miyano S
  • Journal Title: PLoS ONE Volume: 6(6) Pages: e20804
  • DOI: doi:10.1371/journal.pone.0020804
  • Peer Reviewed
• [Journal Article] A rank-based statistical test for measuring synergistic effects between two gene sets (2011)
  • Author(s): Shiraishi U, Okada-Hatakeyama M, Miyano S
  • Journal Title: Bioinformatics Volume: 27(17) Pages: 2399-2405
  • DOI: doi:10.1093/bioinformatics/btr382
  • Peer Reviewed
• [Journal Article] ClipCrop : a tool for detecting structural variations with single-base resolution using soft-clipping information (2011)
  • Author(s): Suzuki S, Yasuda T, Shiraishi Y, Miyano S, Nagasaki M
  • Journal Title: BMC Bioinformatics Volume: 12 Pages: S7
  • DOI: doi:10.1186/1471-2105-12-S14-S7
  • Peer Reviewed
• [Journal Article] Parallel algorithm for learning optimal Bayesian network structure (2011)
  • Author(s): Tamada Y, Imoto S, Miyano S
  • Journal Title: J Machine Learning Research Volume: 12 Pages: 2437-2459
  • Peer Reviewed
• [Journal Article] Estimating genome-wide gene networks using nonparametric Bayesian network models on massively parallel computers (2011)
  • Author(s): Tamada Y, Imoto S, Araki H, Nagasaki M, Print C, Charnock-Jones DS, Miyano S
  • Journal Title: IEEE/ACM Transactions on Computational Biology and Bioinformatics Volume: 8(3) Pages: 683-697
  • DOI: doi:10.1109/TCBB.2010.68
  • Peer Reviewed
• [Journal Article] SiGN : large-scale gene network estimation environment for high performance computing (2011)
  • Author(s): Tamada Y, Shimamura T, Yamaguchi R, Imoto S, Nagasaki M, Miyano S
  • Journal Title: Genome Informatics Volume: 25 Pages: 40-52
  • Peer Reviewed
• [Journal Article] SiGN-SSM : open source parallel software for estimating gene networks with state space models (2011)
  • Author(s): Tamada Y, Yamaguchi R, Imoto S, Hirose O, Yoshida R, Nagasaki M, Miyano S
  • Journal Title: Bioinformatics Volume: 27(8) Pages: 1172-1173
  • DOI: doi:10.1093/bioinformatics/btr078
  • Peer Reviewed
• [Journal Article] MRG-binding protein contributes to development of colorectal cancer (2011)
  • Author(s): Yamaguchi K, Sakai M, Kim J, Tsunesumi SI, Fujii T, Ikenoue T, Yamada Y, Akiyama Y, Muto Y, Yamaguchi R, Miyano S, Nakamura Y, Furukawa Y
  • Journal Title: Cancer Science Volume: 102(8) Pages: 1486-1492
  • DOI: DOI:10.1111/j.1349-7006.2011.01971.x
  • Peer Reviewed
• [Journal Article] N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells (2011)
  • Author(s): Yamauchi M, Yoshino I, Yamaguchi R, Shimamura T, Nagasaki M, Imoto S, Niida A, Koizumi F, Kohno T, Yokota J, Miyano S, Gotoh N
  • Journal Title: Am J Cancer Res Volume: 1(7) Pages: 828-833
  • Peer Reviewed
• [Journal Article] Frequent pathway mutations of splicing machinery in myelodysplasia (2011)
  • Author(s): Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyano S, Ogawa S
  • Journal Title: Nature Volume: 478(7364) Pages: 64-69
  • DOI: doi:10.1038/nature10496
  • Peer Reviewed
• [Journal Article] Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing (2010)
  • Author(s): Fujimoto, A., Nakagawa, H., Hosono, N., Nakano, K., Abe, G., Boroevich, K.A., Nagasaki, M., Yamaguchi, R., Shibuya, T., Kubo, M., Miyano, S., Nakamura, Y., Tsunoda, T.
  • Journal Title: Nature Genetics Volume: 42 Pages: 931-936
  • Peer Reviewed
• [Journal Article] A fast and robust statistical test based on likelihood ratio with Bartlett correction to identify Granger causality between gene sets (2010)
  • Author(s): Fujita, A., Kojima, K., Patriota, A.G., Sato, J.R., Severino, P., Miyano, S.
  • Journal Title: Bioinformatics Volume: 26(18) Pages: 2349-2351
  • Peer Reviewed
• [Journal Article] Identifying hidden confounders in gene networks by Bayesian networks (2010)
  • Author(s): Higashigaki, T., Kojima, K., Yamaguchi, R., Inoue, M., Imoto, S., Miyano, S.
  • Journal Title: Proc.10th IEEE Bioinformatics and Bioengineering Pages: 168-173
  • Peer Reviewed
• [Journal Article] Granger causality in systems biology : modeling gene networks in time series microarray data using vector autoregressive models (2010)
  • Author(s): Fujita, A., Severino, P., Sato, J.R., Miyano, S.
  • Journal Title: Lecture Notes in Computer Science Volume: 6268 Pages: 13-24
  • Peer Reviewed
• [Journal Article] Discovering functional gene pathways associated with cancer heterogeneity via sparse supervised learning (2010)
  • Author(s): Kawano, S., Shimamura, T., Niida, A., Imoto, S., Yamaguchi, R., Nagasaki, M., Yoshida, R., Print, C., Miyano, S.
  • Journal Title: Proc.IEEE 10th International Symposium on Bioinformatics & Bioengineering Pages: 253-258
  • Peer Reviewed
• [Journal Article] Gene regulatory network clustering for graph layout based on microarray gene expression data (2010)
  • Author(s): Kojima, K., Imoto, S., Nagasaki, M., Miyano, S.
  • Journal Title: Genome Informatics Volume: 24 Pages: 84-95
  • Peer Reviewed
• [Journal Article] An efficient biological pathway layout algorithm combining grid-layout and spring embedder for complicated cellular location information (2010)
  • Author(s): Kojima, K., Nagasaki, M., Miyano, S.
  • Journal Title: BMC Bioinformatics Volume: 11:335(掲載確定)
  • Peer Reviewed
• [Journal Article] Cell Illustrator 4.0 : A computational platform for systems biology (2010)
  • Author(s): Nagasaki, M., Saito, A., Jeong, E., Li, C., Kojima, K., Ikeda, E., Miyano, S.
  • Journal Title: In Silico Biology Volume: 10:0002(掲載確定)
  • Peer Reviewed
• [Journal Article] Gene set-based module discovery decodes cis-regulatory codes governing diverse gene expression across human multiple tissues (2010)
  • Author(s): Niida, A., Imoto, S., Yamaguchi, R., Nagasaki, M., Miyano, S.
  • Journal Title: PLoS ONE Volume: 5(6):e10910(掲載確定)
  • Peer Reviewed
• [Journal Article] Model-free unsupervised gene set screening based on information enrichment in expression profiles (2010)
  • Author(s): Niida, A., Imoto, S., Yamaguchi, R., Nagasaki, M., Fujita, A., Shimamura, T., Miyano, S.
  • Journal Title: Bioinformatics Volume: 26(24) Pages: 3090-3097
  • Peer Reviewed
• [Journal Article] Inferring dynamic gene networks under varying conditions for transcriptomic network comparison (2010)
  • Author(s): Shimamura, T., Imoto, S., Yamaguchi, R., Nagasaki, M., Miyano, S.
  • Journal Title: Bioinformatics Volume: 26(8) Pages: 1064-1072
  • Peer Reviewed
• [Journal Article] Collocation-based sparse estimation for constructing dynamic gene networks (2010)
  • Author(s): Shimamura, T., Imoto, S., Nagasaki, M., Yamauchi, M., Yamaguchi, R., Fujita, A., Tamada, Y, Gotoh, N., Miyano, S.
  • Journal Title: Genome Informatics Volume: 24 Pages: 164-178
  • Peer Reviewed
• [Journal Article] Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling (2010)
  • Author(s): Tasaki, S., Nagasaki, M., Kozuka-Hata, H., Semba, K., Gotoh, N., Hattori, S., Inoue, J., Yamamoto, T., Miyano, S., Sugano, S., Oyama, M.
  • Journal Title: PLoS ONE Volume: 5(11):e13926
  • Peer Reviewed
• [Presentation] スーパーコンピュータによる薬物標的、疾病応答遺伝子の探索 (2015)
  • Author(s): 宮野 悟
  • Organizer: 医薬ライセンシング協会第 239回月例会
  • Place of Presentation: 学士会館(東京都千代田区)
  • Year and Date: 2015-03-18
  • Invited
• [Presentation] Understanding Cancer Heterogeneity with Supercomputers (2015)
  • Author(s): Satoru Miyano
  • Organizer: The Third BMIRC International Symposium
  • Place of Presentation: 池のおく園(福岡県田川市)
  • Year and Date: 2015-03-05
  • Invited
• [Presentation] Identification of Oncogenic Co-regulators using Infinite Relational Models (2014)
  • Author(s): Yoichi Chikahara, Atsushi Niida, Rui Yamaguchi, Seiya Imoto, Satoru Miyano
  • Organizer: The 15th International Conference on Systems Biology (ICSB) 2014
  • Place of Presentation: メルボルン(オーストラリア)
  • Year and Date: 2014-09-14 – 2014-09-18
• [Presentation] Supercomputers for Cancer Research and Cancer Big Data (2014)
  • Author(s): Satoru Miyano
  • Organizer: The 3rd SNU International Bioinformatics Workshop 2014
  • Place of Presentation: ソウル(韓国)
  • Year and Date: 2014-06-23
  • Invited
• [Presentation] バイオインフォマティクスとシステム生物学によるバイオマーカー探索 (2014)
  • Author(s): 宮野 悟
  • Organizer: 第21回HAB研究機構学術年会
  • Place of Presentation: 昭和大学(東京都品川区)
  • Year and Date: 2014-05-17
  • Invited
• [Presentation] Cancer Gene Network Analysis (2013)
  • Author(s): Satoru Miyano
  • Organizer: The 24th International Conference on Genome Informatics (GIW 2013)
  • Place of Presentation: Biopolis, Singapore
  • Year and Date: 20131217-20131217
  • Invited
• [Presentation] Accelerating Systems Cancer Research by Supercomputer (2013)
  • Author(s): Satoru Miyano
  • Organizer: CSHL Asia Symposium “Frontiers in Bioinformatics and Computational Biology”
  • Place of Presentation: Suzhou Dushu Lake Conference Center, Cold Spring Harbor Laboratory Asia Watson Auditorium, PR China
  • Year and Date: 20130925-20130925
  • Invited
• [Presentation] Uncovering Gene Networks in Cancer by Computational Systems Biology (2013)
  • Author(s): Satoru Miyano
  • Organizer: The 48th Meeting of The Polish Biochemistry Society
  • Place of Presentation: Torun, Poland
  • Year and Date: 20130904-20130904
  • Invited
• [Presentation] ancer Gene Network Analysis with Supercomputer (2013)
  • Author(s): Satoru Miyano
  • Organizer: The 9th ISCB Student Council Symposium
  • Place of Presentation: Roof Graden, ICC, Berlin, Germany
  • Year and Date: 20130719-20130719
  • Invited
• [Presentation] Cancer Gene Network Analysis with Supercomputer (2013)
  • Author(s): Satoru Miyano
  • Organizer: The 3rd IEEE International Conference on Computational Advances in Bio and Medical Sciences (ICCABS 2013)
  • Place of Presentation: Crowne Plaza New Orleans-Airport, New Orleans, USA
  • Year and Date: 20130613-20130613
  • Invited
• [Presentation] Supercomputer for Personalized Genomic Medicine and Cancer Systems Biology (2013)
  • Author(s): Satoru Miyano
  • Organizer: The University of Chicago Department of Medicine Section of Hematology/ Oncology Seminar
  • Place of Presentation: 米国 シカゴ
  • Year and Date: 2013-02-19 – 2013-02-19
  • Invited
• [Presentation] Uncovering Diversity of Cancer as System by supercomputer (2013)
  • Author(s): Satoru Miyano
  • Organizer: 第6回高度医療都市を創出する未来技術国際シンポジウム
  • Place of Presentation: 岡山大学
  • Year and Date: 2013-02-08 – 2013-02-08
  • Invited
• [Presentation] Supercomputing for Next-Generation Cancer Research (2012)
  • Author(s): Satoru Miyano
  • Organizer: The Fourth Biosupercomputing Symposium
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2012-12-05 – 2012-12-05
  • Invited
• [Presentation] スパコンで焙り出すがんのシステムとしての薬剤応答性と多様性 (2012)
  • Author(s): 宮野 悟
  • Organizer: 第７１回日本癌学会学術総会 モーニングレクチャー
  • Place of Presentation: 札幌市教育文化会館
  • Year and Date: 2012-09-20 – 2012-09-20
  • Invited
• [Presentation] Whole genome sequencing and supercomputer for personalized genomic medicine: The IMSUT plan (2012)
  • Author(s): Satoru Miyano
  • Organizer: The 11th Surugadai International Symposium
  • Place of Presentation: 東京医科歯科大学
  • Year and Date: 2012-07-31 – 2012-07-31
  • Invited
• [Presentation] Uncovering Molecular Networks in Cancer by Supercomputer Towards Personalized Medicine (2011)
  • Author(s): Miyano S
  • Organizer: The 11th IEEE International Conference on BIOINFORMATICS & BIOENGINEERING
  • Place of Presentation: Splendor Hotel Taichung, Taiwan(招待講演)
  • Year and Date: 2011-10-24
• [Presentation] Uncovering Systems in Cancer by Supercomputer (2011)
  • Author(s): Miyano S
  • Organizer: JCA-AACR Joint Symposium at the 70th Annual Meeting of JCA
  • Place of Presentation: Nagoya Congress Center(招待講演)
  • Year and Date: 2011-10-03
• [Presentation] スパコンで焙り出すがんのシステム (2011)
  • Author(s): 宮野悟
  • Organizer: 生物物理学会シンポジウム
  • Place of Presentation: 兵庫県立大学(招待講演)
  • Year and Date: 2011-09-16
• [Presentation] スパコンが焙り出すシステムとしてのがんの薬剤応答性、個性、多様性 (2011)
  • Author(s): 宮野悟
  • Organizer: 日本がん分子標的治療学会学術集会
  • Place of Presentation: ホテル日航東京(招待講演)
  • Year and Date: 2011-06-24
• [Presentation] Breaking the Keys to Cancer Systems by Supercomputer (2010)
  • Author(s): Satoru Miyano
  • Organizer: The 21st International Conference on Genome Informatics
  • Place of Presentation: The First World Hotel, Hangzhou, China
  • Year and Date: 2010-12-16
• [Presentation] Can Supercomputer Hack Cancer Systems? (2010)
  • Author(s): Satoru Miyano
  • Organizer: Asian Regional Conference on Systems Biology
  • Place of Presentation: The Royal Chulan Kuala Lumpur, Malaysia
  • Year and Date: 2010-11-30
• [Presentation] Breaking the Keys to Cancer Systems with Supercomputer (2010)
  • Author(s): Satoru Miyano
  • Organizer: Seoul National University Cancer Research Institute Symposium
  • Place of Presentation: Seoul National University Dental Hospital, Seoul, Korea
  • Year and Date: 2010-11-06
• [Presentation] Can Supercomputer Hack Cancer Systems? (2010)
  • Author(s): Satoru Miyano
  • Organizer: CSH Asia Conference on Computational Biology
  • Place of Presentation: Suzhou, China
  • Year and Date: 2010-09-27
• [Presentation] がんをシステムとして読み解くために (2010)
  • Author(s): 宮野悟
  • Organizer: 統計関連連合大会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2010-09-07
• [Presentation] Supercomputing for Systems Biology (2010)
  • Author(s): Satoru Miyano
  • Organizer: Brazilian Symposium on Bioinformatics 2010
  • Place of Presentation: Ferradura Resort, Buzios, Rio de Janeiro, Brazil
  • Year and Date: 2010-09-01
• [Remarks] システム的統合理解に基づくがんの先端的診断、治療、予防法の開発
  • URL: http://cancersystem.hgc.jp/
• [Remarks] PART and PART-up
  • URL: http://www.hgc.jp/~niiyan/PART/manual.html
• [Remarks] Genomon-fusion
  • URL: http://genomon.hgc.jp/rna/
• [Remarks] Cancer integrative Pipeline
  • URL: http://cancerip.hgc.jp/
• [Remarks] エキソームシークエンサーデータ解析パイプラインGENOMON
  • URL: http://genomon.hgc.jp/exome/