Elucidation of the regulatory network involving non-coding RNAs in human cancers

• Project Area: Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
• Project/Area Number: 22134005
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Nagoya University
• Principal Investigator: TAKAHASHI Takashi 名古屋大学, 医学(系)研究科(研究院), 教授 (50231395)
• Co-Investigator(Kenkyū-buntansha): OSADA Hirotaka 愛知県がんセンター研究所, 分子腫瘍学部, 室長 (30204176)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥237,250,000 (Direct Cost: ¥182,500,000、Indirect Cost: ¥54,750,000); Fiscal Year 2014: ¥41,990,000 (Direct Cost: ¥32,300,000、Indirect Cost: ¥9,690,000); Fiscal Year 2013: ¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000); Fiscal Year 2012: ¥46,930,000 (Direct Cost: ¥36,100,000、Indirect Cost: ¥10,830,000); Fiscal Year 2011: ¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000); Fiscal Year 2010: ¥57,460,000 (Direct Cost: ¥44,200,000、Indirect Cost: ¥13,260,000)
• Keywords: 肺がん / ノンコーディングRNA / マイクロRNA / ネットワーク / パスウェイ / がん

Outline of Final Research Achievements

We have taken an integrative approach between cancer biology and systems biology using supercomputer in order to dissect the molecular pathogenesis of human lung cancers, with the emphasis on the involvement of non-coding RNAs (ncRNAs) such as microRNAs and long non-coding RNAs. We have consequently succeeded in identifying multiple ncRNAs involved in this devastating cancer, which included miR-375, miR-30c, miR-342-3p, and a novel lncRNA, MYMLR.

Research Products

• [Journal Article] Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features (2014)
  • Author(s): Arima C, Kajino T, Tamada Y, Imoto S, ShimadaY, Nakatochi, M, Suzuki M, Isomura H, Yatabe Y, Yamaguchi T, Yanagisawa K, Miyano S, Takahashi T
  • Journal Title: Carcinogenesis Volume: 35 Issue: 10 Pages: 2224-2231
  • DOI: 10.1093/carcin/bgu127
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascad (2014)
  • Author(s): Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y
  • Journal Title: Oncogene Volume: 34 Issue: 1 Pages: 73-83
  • DOI: 10.1038/onc.2013.528
  • Peer Reviewed / Open Access
• [Journal Article] CD74-NRG1 fusions in lung adenocarcinoma (2014)
  • Author(s): Fernandez-Cuesta L1, Plenker D, Osada H, Sun R, Menon R, Leenders F, Ortiz-Cuaran S, Peifer M, Bos M, Dassler J, Malchers F, Schuttle J, Vogel W, Dahmen I, Koker M, Ullrich RT, Wright GM, Russell PA, Wainer Z, Solomon B, 他31名
  • Journal Title: Cancer Discov Volume: 4 Issue: 4 Pages: 415-422
  • DOI: 10.1158/2159-8290.cd-13-0633
  • Peer Reviewed
• [Journal Article] Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib (2014)
  • Author(s): Younes M, Wu Z, Dupouy S, Lupo AM, Mourra N, Takahashi T, Flejou JF, Tredaniel J, Regnard JF, Damotte D, Alifano M, Forgez P
  • Journal Title: Oncotarget Volume: 5 Pages: 8252-8269
  • Peer Reviewed / Open Access
• [Journal Article] Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation (2014)
  • Author(s): Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S
  • Journal Title: Int J Cancer Volume: 135 Issue: 2 Pages: 308-318
  • DOI: 10.1002/ijc.28692
  • Peer Reviewed
• [Journal Article] Tumor-derived Interleukin-1 promotes lymphangiogenesis and lymph node metastasis through M2-type macrophages (2014)
  • Author(s): Watari K, Shibata T, Kawahara A, Sata K, Nabeshima H, Shinoda A, Abe H, Azuma K, Murakami Y, Izumi, H, Takahashi T, Kage M, Kuwano M, Ono M.
  • Journal Title: PLoS ONE Volume: 9 Issue: 6 Pages: e99568-e99568
  • DOI: 10.1371/journal.pone.0099568
  • Peer Reviewed / Open Access
• [Journal Article] Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma (2014)
  • Author(s): Jiang L, Yamashita Y, Chew SH, Akatsuka S, Ukai S, Wang S, Nagai H, Okazaki Y, Takahashi T, Toyokuni S
  • Journal Title: J Pathol Volume: 233 Issue: 4 Pages: 402-414
  • DOI: 10.1002/path.4377
  • Peer Reviewed / Open Access
• [Journal Article] Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production (2013)
  • Author(s): S. H. Chew, Y. Okazaki, H. Nagai, N. Misawa, S. Akatsuka, K. Yamashita, L. Jiang, Y. Yamashita, M. Noguchi, K. Hosoda, Y. Sekido, T. Takahashi, S. Toyokuni
  • Journal Title: Carcinogenesis Volume: 35(1) Issue: 1 Pages: 164-172
  • DOI: 10.1093/carcin/bgt267
  • Peer Reviewed / Open Access
• [Journal Article] NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression (2013)
  • Author(s): Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T
  • Journal Title: Cancer Cell Volume: 23 Issue: 6 Pages: 718-723
  • DOI: 10.1016/j.ccr.2013.04.002
  • Peer Reviewed
• [Journal Article] Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex (2013)
  • Author(s): Kawahara T, Hotta N, Ozawa Y, Kato S, Kano K, Yokoyama Y, Nagino M, Takahashi T, Yanagisawa K
  • Journal Title: PLoS ONE Volume: 8 Issue: 12 Pages: e79654-e79654
  • DOI: 10.1371/journal.pone.0079654
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The DNA methylation landscape of small cell lung cancer suggests a differentiation defect of neuroendocrine cells. (2013)
  • Author(s): Kalari S, Jung M, Kernstine KH, Takahashi T, Pfeifer GP
  • Journal Title: Oncogene Volume: 32 Issue: 30 Pages: 3559-3568
  • DOI: 10.1038/onc.2012.362
  • Peer Reviewed
• [Journal Article] Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis (2013)
  • Author(s): Yamashita Y, Akatsuka S, Shinjo K, Yatabe Y, Kobayashi H, Seko H, Kajiyama H, Kikkawa F, Takahashi T, Toyokuni S
  • Journal Title: PLoS ONE Volume: 8 Issue: 3 Pages: e57724-e57724
  • DOI: 10.1371/journal.pone.0057724
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory effects of salinomycin on cell survival, colony growth, migration, and invasion of human non-small cell lung cancer A549 and LNM35: Involvement of NAG-1 (2013)
  • Author(s): Arafat K, Iratni R, Takahashi T, Parekh K, Al Dhaheri Y, Adrian TE, Attoub S.
  • Journal Title: PLoS ONE Volume: 8 Issue: 6 Pages: e66931-e66931
  • DOI: 10.1371/journal.pone.0066931
  • Peer Reviewed / Open Access
• [Journal Article] Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells (2013)
  • Author(s): Roth FC, Mulder JE, Brien JF, Takahashi T, Massey TE
  • Journal Title: Chem Biol Interact Volume: 204 Issue: 3 Pages: 135-139
  • DOI: 10.1016/j.cbi.2013.05.006
  • Peer Reviewed
• [Journal Article] SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers (2013)
  • Author(s): Matsuura S, Kahyo T, Shinmura K, Iwaizumi M, Yamada H, Funai K, Kobayashi J, Tanahashi M, Niwa H, Ogawa H, Takahashi T, Inui N, Suda T, Chida K, Watanabe Y, *Sugimura H.
  • Journal Title: Sci Rep Volume: 3 Issue: 1 Pages: 3012-3012
  • DOI: 10.1038/srep03012
  • Peer Reviewed / Open Access
• [Journal Article] Thymoquinone as an anticancer agent: evidence from inhibition of cancer cells viability and invasion in vitro and tumor growth in vivo (2013)
  • Author(s): Attoub S, Sperandio O, Raza H, Arafat K, Al-Salam S, Al Sultan MA, Al Safi M, Takahashi T, Adem A
  • Journal Title: Fundam Clin Pharmacol Volume: 27 Issue: 5 Pages: 557-569
  • DOI: 10.1111/j.1472-8206.2012.01056.x
  • Peer Reviewed
• [Journal Article] Frondoside A suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis (2013)
  • Author(s): Attoub S, Arafat K, Gelaude A, Sultan MAA, Bracke M, Collin, P, Takahashi T, Adrian, T, De Wever O
  • Journal Title: PLoS ONE Volume: 8 Issue: 1 Pages: e53087-e53087
  • DOI: 10.1371/journal.pone.0053087
  • Peer Reviewed
• [Journal Article] NKX2-1/TITF1/TTF-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma (2012)
  • Author(s): Yamaguchi T, et al
  • Journal Title: Cancer Cell Volume: 21 Issue: 3 Pages: 348-361
  • DOI: 10.1016/j.ccr.2012.02.008
  • Peer Reviewed
• [Journal Article] MYBPH, a transcriptional target of TTF-1, inhibits ROCK1, and reduces cell motility and metastasis (2012)
  • Author(s): Hosono Y, et al
  • Journal Title: EMBO Journal Volume: 31 Issue: 2 Pages: 481-493
  • DOI: 10.1038/emboj.2011.416
  • Peer Reviewed
• [Journal Article] TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth (2012)
  • Author(s): Fujii M, Toyoda T, Nakanishi H, Yatabe Y, Sato A, Matsudaira Y, Ito H, Murakami H, Kondo Y, Kondo E, Hida T, Tsujimura T, Osada H, Sekido Y.
  • Journal Title: J Exp Med Volume: VOL.209(3) Issue: 3 Pages: 479-494
  • DOI: 10.1084/jem.20111653
  • Peer Reviewed
• [Journal Article] Seven-signal proteomic signature for detection of operable pancreatic cancer and their discrimination from autoimmune pancreatitis (2012)
  • Author(s): Yanagisawa K
  • Journal Title: Int J Proteomics Volume: 2012 Pages: 1-11
  • DOI: 10.1155/2012/510397
  • Peer Reviewed
• [Journal Article] Hybrid liposomes affect cellular lipid constituents and caveolae structures (2012)
  • Author(s): Cao K
  • Journal Title: Bioorg Med Chem Lett Volume: 22 Issue: 4 Pages: 1731-1733
  • DOI: 10.1016/j.bmcl.2011.12.093
  • Peer Reviewed
• [Journal Article] Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour (2012)
  • Author(s): Okamoto Y
  • Journal Title: Gut Volume: 61 Issue: 3 Pages: 392-401
  • DOI: 10.1136/gut.2011.241034
  • Peer Reviewed
• [Journal Article] miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dqjendent manner in lung cancer (2011)
  • Author(s): Nishikawa E, et al
  • Journal Title: Cancer Research Volume: 71 Issue: 19 Pages: 6165-6173
  • DOI: 10.1158/0008-5472.can-11-1020
  • Peer Reviewed
• [Journal Article] A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition (2011)
  • Author(s): Shimamura, T., Imoto, S., Shimada, Y., Hosono, Y., Niida, A., Nagasaki, M., Yamaguchi, R., Takahashi, T., Miyano, S
  • Journal Title: PLoS ONE Volume: 6 Issue: 6 Pages: e20804-e20804
  • DOI: 10.1371/journal.pone.0020804
  • Peer Reviewed
• [Journal Article] Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis (2011)
  • Author(s): Nagai H., Okazaki Y., Chew SH., Misawa N., Yamashita Y., Akatsuka S., Ishihara T., Yamashita K., Yoshikawa Y., Yasui H., Jiang L., Ohara H., Takahashi T., Ichihara G., Kostarelos K., Miyata Y., Shinohara H., Toyokuni S.
  • Journal Title: Proceedings of the National Academy of Sciences USA Volume: 108 Issue: 49
  • DOI: 10.1073/pnas.1110013108
  • Peer Reviewed
• [Journal Article] The Epstein-Barr virus LMP 1 and TGF-β1 synergistically induce EMT in lung epithelial cells (2011)
  • Author(s): Sides M, et al
  • Journal Title: American Journal of Respiratory Cell and Molecular Biology Volume: 44 Issue: 6 Pages: 852-862
  • DOI: 10.1165/rcmb.2009-0232oc
  • Peer Reviewed
• [Journal Article] Mechanisms of amiodarone and desethylamiodarone cytotoxicity in non-transformed human peripheral lung epithelial cells (2011)
  • Author(s): Mulder JE, et al
  • Journal Title: Journal of Pharmacology and Experimental Therapeutics Volume: 336 Issue: 2 Pages: 551-559
  • DOI: 10.1124/jpet.110.173120
  • Peer Reviewed
• [Journal Article] LATS2 is a tumor suppressor gene of malignant mesothelioma (2011)
  • Author(s): Murakami H
  • Journal Title: Cancer Res Volume: 71 Issue: 3 Pages: 873-883
  • DOI: 10.1158/0008-5472.can-10-2164
  • Peer Reviewed
• [Journal Article] Distinct Profiles of Epigenetic Evolution between Colorectal Cancers with and without Metastasis (2011)
  • Author(s): Ju HX
  • Journal Title: Am J Pathol Volume: 178 Issue: 4 Pages: 1835-1846
  • DOI: 10.1016/j.ajpath.2010.12.045
  • Peer Reviewed
• [Journal Article] Epithelial to mesenchymal transition in an epidermal growth factor receptor-mutant lung cancer cell line with acquired resistance to erlotinib (2011)
  • Author(s): Suda K
  • Journal Title: Journal of Thoracic Oncoloy Volume: 6 Issue: 7 Pages: 1152-1161
  • DOI: 10.1097/jto.0b013e318216ee52
  • Peer Reviewed
• [Journal Article] Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas (2011)
  • Author(s): Matsuyama Y, et al
  • Journal Title: Mol.Carcinog. Volume: 50 Pages: 301-309
  • Peer Reviewed
• [Journal Article] let-7 and miR-17-92 : Small-sized major players in lung cancer development (2011)
  • Author(s): Osada H, et al
  • Journal Title: Cancer Sci Volume: 102(Review) Pages: 9-17
  • NAID: 10029287990
  • Peer Reviewed
• [Journal Article] International Association for the Study of Lung Cancer/Amerian Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma (2011)
  • Author(s): Travis WD, et al
  • Journal Title: J Thorac Oncol Volume: 6 Pages: 244-285
  • Peer Reviewed
• [Journal Article] Novel metastasis-related gene CIM functions in the regulation of multiple cellular stress response pathways (2010)
  • Author(s): Yanagisawa K, et al
  • Journal Title: Cancer Res Volume: 70 Pages: 9949-9958
  • Peer Reviewed
• [Journal Article] Functions of base selection step in human DNA polymerase alpha (2010)
  • Author(s): Tanaka S, et al
  • Journal Title: DNA Repair Volume: 9 Pages: 534-541
  • Peer Reviewed
• [Journal Article] Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer (2010)
  • Author(s): Huang QA, et al
  • Journal Title: Cancer Res Volume: 70 Pages: 8407-8416
  • Peer Reviewed
• [Journal Article] Roles of POLD4, smallest subunit of DNA polymerase δ in nuclear structures and genomic stability of human cells (2010)
  • Author(s): Huang QA, et al
  • Journal Title: Biochem.Biophys.Res.Comm. Volume: 66 Pages: 542-546
  • Peer Reviewed
• [Journal Article] Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations (2010)
  • Author(s): Miki D, et al
  • Journal Title: Nature Genet Volume: 42 Pages: 893-896
  • Peer Reviewed
• [Journal Article] Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma (2010)
  • Author(s): Hu Q, et al
  • Journal Title: Lab Invest Volume: 90 Pages: 5489-5498
  • Peer Reviewed
• [Journal Article] Clinically relevant characterization of lung adenocarcinoma subtypes based on cellular pathways (2010)
  • Author(s): Bryant CM, et al
  • Journal Title: Lab Invest Volume: 90 Pages: 5489-5498
  • Peer Reviewed
• [Journal Article] Relationship of mRNA expressions of RanBP2 and topoisomerase II isoforms to cytotoxicity of amrubicin in human lung cancer cell lines (2010)
  • Author(s): Horio Y, et al
  • Journal Title: Cancer Chemother Pharmacol Volume: 66 Pages: 237-243
  • Peer Reviewed
• [Journal Article] Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer (2010)
  • Author(s): Suda K, et al
  • Journal Title: Clin Cancer Res Volume: 16 Pages: 5489-5498
  • Peer Reviewed
• [Journal Article] Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers (2010)
  • Author(s): An B, et al
  • Journal Title: Int J Cancer Volume: 127 Pages: 2095-2105
  • Peer Reviewed
• [Journal Article] Endogenous angiogenesis inhibitor vasohibin1 exhibits a broad-spectrum anti-lymphangiogenic activity and suppresses lymph node metastasis (2010)
  • Author(s): Heishi T, et al
  • Journal Title: Am J Pathol Volume: 176 Pages: 1950-1958
  • Peer Reviewed
• [Journal Article] Tetraspanin CD151 regulates TGF-β signalling : implication in tumour metastasis (2010)
  • Author(s): Sadej R, et al
  • Journal Title: Cancer Res Volume: 70 Pages: 6059-6070
  • Peer Reviewed
• [Journal Article] Neurotensin receptor 1 determines the outcome of non-small cell lung cancer (2010)
  • Author(s): Alifano M, et al
  • Journal Title: Am J Pathol Volume: 16 Pages: 4401-4410
  • Peer Reviewed
• [Presentation] Genome editingを用いた転移関連遺伝子CLCP1の機能解析 (2014)
  • Author(s): 6.長田啓隆、柳澤聖、立松義朗、谷田部恭、小野健一郎、関戸好孝、高橋隆
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] ROR1, a transcriptional target of TTF-1/NKX2-1 oncogene, sustains lineage-survival signaling in lung adenocarcinoma (2014)
  • Author(s): Takahashi T
  • Organizer: 14th Japanese-German Workshop
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-11-14 – 2014-11-16
  • Invited
• [Presentation] Proteomic analyses for biomarker discovery in human pancreatic cancer (2014)
  • Author(s): Yanagisawa K, Kawahara T, Ozawa Y, Hotta N, Nagino M, Takahashi T
  • Organizer: 13th Annual World Congress of the Human Proteome Organization
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2014-10-05 – 2014-10-08
• [Presentation] Elucidation of transcriptional regulatory circuitry involved in the molecular pathogenesis of lung cancer (2014)
  • Author(s): Takahashi T
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
  • Invited
• [Presentation] CKAP4 confers resistance to amino acid insufficiency through sequestration of GCN2 in malignant pulmonary mesothelioma (2014)
  • Author(s): Yanagisawa K, Kato S, Hotta N, Nakamura S, and Takahashi T
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] CRISPR-Cas9-derived Knockout of CLCP1 gene revealed its functional role in lung cancer progression (2014)
  • Author(s): Osada H, Yanagisawa K, Tatematsu Y, Sekido Y, Takahashi T
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] Multifaceted dissection of regulatory circuitry involved in pathogenesis of lung cancer (2013)
  • Author(s): Takahashi T
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2013-12-03 – 2013-12-06
  • Invited
• [Presentation] Analysis of CLCP1, a potential target for lung cancer diagnostics and therapeutics (2013)
  • Author(s): Osada H, Yagi K, Yanagisawa K, Akatsuka J, Tatematsu Y, Kato S, Yatabe Y, Ono K, Sekido Y, Takahashi T
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場（神戸市）
  • Year and Date: 2013-12-03 – 2013-12-06
• [Presentation] Multifaceted dissection of genetic regulatory circuitry involved in the pathogenesis of lung cancers (2013)
  • Author(s): Takahashi T
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2013-10-03 – 2013-10-05
  • Invited
• [Presentation] Proteomic identirfication of potential biomarkers of human lung malignancies (2013)
  • Author(s): Yanagisawa K, Takahashi T
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2013-10-03 – 2013-10-05
  • Invited
• [Presentation] Targeting ceramide homeostasis and metastasis-prone phenotypes in human lung cancer cells (2013)
  • Author(s): Suzuki M, Kato S, Komizu Y, Ueoka R, Arima C, Yanagisawa K, Tamiya-Koizumi K, Murate T, Kyogashima M, Takahashi T
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2013-10-03 – 2013-10-05
• [Presentation] Functional analysis of CLCP1 as potential target for lung cancer diagnostics and therapeutics (2013)
  • Author(s): Osada H, Yagi K, Yanagisawa K, Akatsuka J, Tatematsu Y, Kato S, Yatabe Y, Ono K, Sekido Y, Takahashi T
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Year and Date: 2013-10-03 – 2013-10-05
• [Presentation] TTF-1/NKX2-1: an enigmatic oncogene that functions as a double-edged sward in lung adenocarcinoma (2013)
  • Author(s): Takahashi T
  • Organizer: SNU CRI & SNU CH Cancer Symposium
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2013-05-02 – 2013-05-04
  • Invited
• [Presentation] TTF-1/NKX2-1: an enigmatic oncogene that functions as a double-edged sword in lung adenocarcinoma (2013)
  • Author(s): Takahashi T
  • Organizer: SNUCRI & SNUCH Cancer Symposium
  • Place of Presentation: Jeju, Korea
  • Invited
• [Presentation] Multifaceted dissection of genetic regulatory circuitry involved in the pathogenesis of lung cancers (2013)
  • Author(s): Takahashi T
  • Organizer: 第７２回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Invited
• [Presentation] Targeting ceramide homeostasis and metastasis-prone phenotypes in human lung cancer cells (2013)
  • Author(s): Motoshi Suzuki, Seiichi Kato, Yuji Komizu, Ryuichi Ueoka, Chinatsu Arima, Kiyoshi Yanagisawa, Keiko Tamiya-Koizumi, Takashi Murate, Mamoru Kyogashima and Takashi Takahashi
  • Organizer: 第７２回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
• [Presentation] Proteomic identification of potential biomarkers of human lung malignancies (2013)
  • Author(s): Yanagisawa K and Takahashi T
  • Organizer: 第７２回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（横浜市）
  • Invited
• [Presentation] TTF-1 lineage-survival oncogene in the pathogenesis of lung adenocarcinoma (2011)
  • Author(s): 高橋隆
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] Roles of ASH1-regulated miRNAs and lincRNAs in lung cancer development. (2011)
  • Author(s): 長田啓隆
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] Roles of ASH1-miR-375 pathway in development of lung cancers with neuroendocrine features (2011)
  • Author(s): Osada H
  • Organizer: 102nd Annual Meeting of the Amer Assoc of Cancer Res
  • Place of Presentation: Orland
• [Presentation] Metastasis-suppressing MYBPH as a novel transcriptional target of TTF-1 lineage-survival oncogene in lung adenocarcinoma (2011)
  • Author(s): Takahashi T
  • Organizer: US-Japan Cancer Genomics Workshop
  • Place of Presentation: Kyoto
  • Invited
• [Presentation] 肺癌におけるmiRNA異常 (2010)
  • Author(s): 長田啓隆、高橋隆
  • Organizer: 第51回日本肺癌学会総会
  • Place of Presentation: 広島
  • Year and Date: 2010-11-03
• [Presentation] miRNA alterations in cancer development (2010)
  • Author(s): 高橋隆
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] Roles of ASH1-regulated miRNAs in lung cancers with neuroendocrine features (2010)
  • Author(s): 長田啓隆、高橋隆
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Remarks] 分子腫瘍学分野 研究テーマ
  • URL: http://www.med.nagoya-u.ac.jp/molcar/jp/research.html
• [Remarks] 分子腫瘍学分野 研究テーマ
  • URL: http://www.med.nagoya-u.ac.jp/molcar/jp/research.html
• [Remarks] 名古屋大学大学院医学系研究科分子腫瘍学分野
  • URL: http://www.med.nagoya-u.ac.jp/molcar/jp/research.html
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/molcar/jp/index.html