Understanding cancer cell metabolism and biomarker discovery using metabolome analysis

• Project Area: Integrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
• Project/Area Number: 22134007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Complex systems
• Research Institution: Keio University
• Principal Investigator: SOGA Tomoyoshi 慶應義塾大学, 環境情報学部, 教授 (60338217)
• Co-Investigator(Renkei-kenkyūsha): SUGIMOTO Masahiro 慶應義塾大学, 政策メディア研究科および先端生命科学研究所, 特任准教授 (30458963) ; HIRAYAMA Akiyoshi 慶應義塾大学, 政策メディア研究科および先端生命科学研究所, 特任助教 (00572405) ; SATO Kiyotoshi 慶應義塾大学, 政策メディア研究科および先端命科学研究所, 特任助教 (50401386) ; TABATA Sho 慶應義塾大学, 政策メディア研究科および先端命科学研究所, 特任助教 (30708342)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥152,620,000 (Direct Cost: ¥117,400,000、Indirect Cost: ¥35,220,000); Fiscal Year 2014: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000); Fiscal Year 2013: ¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000); Fiscal Year 2012: ¥30,030,000 (Direct Cost: ¥23,100,000、Indirect Cost: ¥6,930,000); Fiscal Year 2011: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000); Fiscal Year 2010: ¥40,820,000 (Direct Cost: ¥31,400,000、Indirect Cost: ¥9,420,000)
• Keywords: 癌 / 生体分子 / バイオテクノロジー

Outline of Final Research Achievements

Although cancer cells produce ATP and the precursors of macromolecules by switching metabolism, underlying mechanisms have been poorly understood. Here, we have developed a highly sensitive metabolome analysis method based on sheathless CE-MS device.
This approach and together with systems biological technologies such as transcriptomics and proteomics were applied to fumarate hydratase (FH)　knock out mouse and FH deficient cell lines, which mimic Hereditary leiomyomatosis and renal cell carcinoma that develops benign cutaneous and uterine leiomyomas, renal cysts and kidney cancer.
Consequently, we found that accumulated fumarate caused by FH deletion regulated metabolism by activation transcription factor, inactivation of metabolic enzymes and conjugation to metabolites.

Research Products

• [Journal Article] Cystathionine is a novel substrate of cystine/glutamate transporter: implications for immune function (2015)
  • Author(s): Kobayashi, S., Sato, M., Kasakoshi, T., Tsutsui, T., Sugimoto, M., Osaki, M., Okada, F., Igarashi, K., Hiratake, J., Homma, T., Conrad, M., Fujii, J., Soga, T., Bannai, S., Sato, H.
  • Journal Title: J. Biol. Chem. Volume: 290 Issue: 14 Pages: 8778-8788
  • DOI: 10.1074/jbc.m114.625053
  • Peer Reviewed / Open Access
• [Journal Article] Decreased miR122 in hepatocellular carcinoma leads to chemoresistance with increased arginine (2015)
  • Author(s): Kishikawa, T., Otsuka, M., Tan, P.S., Ohno, M., Sun, X., Yoshikawa, T., Shibata, C., Takata, A., Kojima, K., Takehana, K., Ohishi, M., Ota, S., Noyama, T., Kondo, Y., Sato, M., Soga, T., Hoshida, Y., Koike, K.
  • Journal Title: Oncotarget Volume: 6 Pages: 8339-8352
  • Peer Reviewed / Open Access
• [Journal Article] Development of quantitative method for determination of γ-glutamyl peptides by capillary electrophoresis tandem mass spectrometry: An efficient approach avoiding matrix effect (2014)
  • Author(s): Hirayama, A., Igarashi, K., Tomita, M., Soga, T.
  • Journal Title: J Chromatogr A. Volume: 1369 Pages: 161-169
  • DOI: 10.1016/j.chroma.2014.10.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Thymidine phosphorylase activates NFκB and stimulates the expression of angiogenic and metastatic factors in human cancer cells (2014)
  • Author(s): Tabata, S., Ikeda, R., Yamamoto, M., Shimaoka, S., Mukaida, N., Takeda, Y., Yamada, K., Soga, T., Furukawa, T., Akiyama, S.
  • Journal Title: Oncotarget Volume: 5 Pages: 10473-10485
  • Peer Reviewed / Open Access
• [Journal Article] Hydroxyproline, a Serum Biomarker Candidate for Gastric Ulcer in Rats: A Comparison Study of Metabolic Analysis of Gastric Ulcer Models Induced by Ethanol, Stress, and Aspirin (2014)
  • Author(s): Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., and Soga, T.
  • Journal Title: Biomark. Insights. Volume: 9 Pages: 61-66
  • DOI: 10.4137/bmi.s15918
  • Peer Reviewed / Open Access
• [Journal Article] Reconstruction of insulin signal flow from phosphoproteome and metabolome data (2014)
  • Author(s): Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K.I., Kashikura, K., Endo, K., Ikeda, K., Soga, T., Kuroda, S.
  • Journal Title: Cell Rep. Volume: 8 Issue: 4 Pages: 1171-1183
  • DOI: 10.1016/j.celrep.2014.07.021
  • NAID: 120005537752
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metabolome analysis based on capillary electrophoresis-mass spectrometry (2014)
  • Author(s): Hirayama, A., Wakayama, M., Soga, T.
  • Journal Title: Trends Anal. Chem. Volume: 61 Pages: 215-222
  • DOI: 10.1016/j.trac.2014.05.005
  • Peer Reviewed / Open Access
• [Journal Article] Necrosis-Driven Systemic Immune Response Alters SAM Metabolism through the FOXO-GNMT Axis (2014)
  • Author(s): Obata F, Kuranaga E, Tomioka K, Ming M, Takeishi A, Chen CH, Soga T, Miura M
  • Journal Title: Cell Rep. Volume: 7 Issue: 3 Pages: 821-833
  • DOI: 10.1016/j.celrep.2014.03.046
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation (2014)
  • Author(s): Ohka, F., Ito, M., Ranjit, M., Senga, T., Motomura, A., Motomura, K., Saito, K., Kato, K., Kato, Y., Wakabayashi, T., Soga, T., Natsume, A.
  • Journal Title: Tumor Biol. Volume: 35 Issue: 6 Pages: 5911-5920
  • DOI: 10.1007/s13277-014-1784-5
  • Peer Reviewed / Open Access
• [Journal Article] Metabolomic Analysis of the Effects of Omeprazole and Famotidine on Aspirin-induced Gastric Injury (2014)
  • Author(s): Takeuchi, K., Ohishi, M., Endo, K., Suzumura, K., Naraoka, H., Ohata, T., Seki, J., Miyamae, Y., Honma, M., Soga, T.
  • Journal Title: Metabolomics Volume: 10 Issue: 5 Pages: 995-1004
  • DOI: 10.1007/s11306-014-0627-0
  • Peer Reviewed / Open Access
• [Journal Article] Rare insights into cancer biology (2014)
  • Author(s): Adam, J., Yang, M., Soga, T., Pollard, P.J.
  • Journal Title: Oncogene Volume: 33 Issue: 20 Pages: 2547-2556
  • DOI: 10.1038/onc.2013.222
  • Peer Reviewed / Open Access
• [Journal Article] メタボロミクス (2014)
  • Author(s): 平山明由、曽我朋義
  • Journal Title: 生体の科学 Volume: 65 Pages: 408-409
• [Journal Article] はじめに (2014)
  • Author(s): 曽我朋義
  • Journal Title: 医学のあゆみ Volume: 246 Pages: 285-285
• [Journal Article] メタボローム解析技術とがんの代謝解析への応用 (2014)
  • Author(s): 平山明由、曽我朋義
  • Journal Title: 実験医学 Volume: 32 Pages: 1205-1209
• [Journal Article] Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol (2014)
  • Author(s): Cheng, K., Lee, B., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., Soga, T., Tomita, M., Palsson, B. O. & Robert, M.
  • Journal Title: Nat. Commun. Volume: 5 Issue: 1 Pages: 3233-3233
  • DOI: 10.1038/ncomms4233
  • Peer Reviewed
• [Journal Article] Differences in the fatty acid metabolism of visceral adipose tissue in postmenopausal women (2014)
  • Author(s): Yamatani, H., Takahashi, K., Yoshida, T., Soga, T., Kurachi, H.
  • Journal Title: Menopause Volume: 21 Issue: 2 Pages: 170-176
  • DOI: 10.1097/gme.0b013e318296431a
  • Peer Reviewed
• [Journal Article] Metabolomic profiling of sodium fluoride-induced cytotoxicity in an oral squamous cell carcinoma cell line (2014)
  • Author(s): Sakagami, H., Sugimoto, M., Tanaka, S., Onuma, H., Ota, S., Kaneko, M., Soga, T., Tomita, M.
  • Journal Title: Metabolomics Volume: 10 Issue: 2 Pages: 270-279
  • DOI: 10.1007/s11306-013-0576-z
  • Peer Reviewed
• [Journal Article] 総論 がんとメタボローム：オーバービュー (2014)
  • Author(s): 曽我朋義
  • Journal Title: 細胞 The CELL Volume: 46 Pages: 2-4
• [Journal Article] オンコメタボライト-フマル酸によるがんの代謝制御 (2014)
  • Author(s): 曽我朋義
  • Journal Title: 細胞工学 Volume: 33 Pages: 133-138
• [Journal Article] A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia (2013)
  • Author(s): Adam, J., Yang, M., Bauerschmidt, C., Kitagawa, M., O’Flaherty, L., Maheswaran, P., O¨ zkan, G., Sahgal, N., Baban, D., Kato, K., Saito, K., Iino, K., Igarashi, K., Stratford, M., Pugh, C., Tenant, D., Ludwig, C., Davies, B., Ratcliffe, P. J., El-Bahrawy, M., Ashrafian, H., Soga, T., and Pollard, P. J.
  • Journal Title: Cell Rep. Volume: 3 Issue: 5 Pages: 1440-1448
  • DOI: 10.1016/j.celrep.2013.04.006
  • Peer Reviewed
• [Journal Article] The selective control of glycolysis, gluconeogenesis and glycogenesis by temporal insulin patterns (2013)
  • Author(s): Noguchi, R., Kubota, H., Yugi, K., Toyoshima, Y., Komori, Y., Soga, T., Kuroda, S.
  • Journal Title: Mol Syst Biol. Volume: 9 Issue: 1 Pages: 664-664
  • DOI: 10.1038/msb.2013.19
  • Peer Reviewed
• [Journal Article] Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors (2013)
  • Author(s): Uema, N., Ooshio, T., Harada, K., Naito, M., Naka, K., Hoshii, T., Tadokoro, Y., Ohta, K., Ali, M.A., Katano, M., Soga, T., Nakanuma, Y., Okuda, A., Hirao, A.
  • Journal Title: Am. J. Pathol. Volume: 183 Issue: 2 Pages: 592-603
  • DOI: 10.1016/j.ajpath.2013.04.018
  • Peer Reviewed
• [Journal Article] Autophagy protects kidney proximal tubule epithelial cells from mitochondrial metabolic stress (2013)
  • Author(s): Kimura, T., Takahashi, A., Takabatake, Y., Namba, T, Yamamoto, T., Kaimori, J.Y., Matsui, I., Kitamura, H., Niimura, F., Matsusaka T., Soga, T., Rakugi, H., Isaka, Y.
  • Journal Title: Autophagy Volume: 9 Issue: 11 Pages: 1876-1886
  • DOI: 10.4161/auto.25418
  • Peer Reviewed
• [Journal Article] Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis (2013)
  • Author(s): Karasawa, T., Saito, T., Ueno, Y., Sugimoto, M., Soga, T.
  • Journal Title: Int J Med Sci. Volume: 10 Issue: 11 Pages: 1575-1577
  • DOI: 10.7150/ijms.6436
  • Peer Reviewed
• [Journal Article] Dynamics of serum metabolites in patients with chronic hepatitis C receiving pegylated interferon plus ribavirin: A metabolomics analysis (2013)
  • Author(s): Saito, T., Sugimoto, M., Igarashi, K., Saito, K., Shao, L., Katsumi, T., Tomita, K., Sato, C., Ishii, R., Okumoto, K., Nishise, Y., Watanabe, H., Tomita, M., Ueno, Y., Soga, T.
  • Journal Title: Metabolism Volume: 62 Issue: 11 Pages: 1577-1586
  • DOI: 10.1016/j.metabol.2013.07.002
  • Peer Reviewed
• [Journal Article] Persistent overexpression of phosphoglycerate mutase, a glycolytic enzyme, modifies energy metabolism and reduces stress resistance of heart in mice (2013)
  • Author(s): Okuda, J., Niizuma, S., Shioi, T., Kato, T., Inuzuka, Y., Kawashima, T., Tamaki, Y., Kawamoto, A., Tanada, Y., Iwanaga, Y., Narazaki, M., Matsuda, T., Adachi, S., Soga, T., Takemura, G., Kondoh, H., Kita, T., Kimura, T.
  • Journal Title: PLoS ONE Volume: 8 Issue: 8 Pages: e72173-e72173
  • DOI: 10.1371/journal.pone.0072173
  • Peer Reviewed
• [Journal Article] Oncometabolites: Linking Altered Metabolism with Cancer (2013)
  • Author(s): Yang, M., Soga, T., and Pollard, P. J.
  • Journal Title: J. Clin. Invest. Volume: 123 Issue: 9 Pages: 3652-3658
  • DOI: 10.1172/jci67228
  • Peer Reviewed
• [Journal Article] Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact (2013)
  • Author(s): Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H.
  • Journal Title: Am J Pathol. Volume: 182 Issue: 5 Pages: 1800-1810
  • DOI: 10.1016/j.ajpath.2013.01.048
  • Peer Reviewed
• [Journal Article] がんの代謝-ワーブルグ効果の今日的な解釈 (2013)
  • Author(s): 曽我朋義
  • Journal Title: 腫瘍内科 Volume: 11 Pages: 717-724
• [Journal Article] Cancer metabolism: key players in metabolic reprogramming (2013)
  • Author(s): Soga, T.
  • Journal Title: Cancer Sci. Volume: 104 Issue: 3 Pages: 275-281
  • DOI: 10.1111/cas.12085
  • Peer Reviewed
• [Journal Article] Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency (2013)
  • Author(s): Ternette N.
  • Journal Title: Cell Rep. Volume: 3 Issue: 3 Pages: 689-700
  • DOI: 10.1016/j.celrep.2013.02.013
  • Peer Reviewed
• [Journal Article] Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. (2013)
  • Author(s): Takubo K
  • Journal Title: Cell Stem Cell Volume: 12 Issue: 1 Pages: 49-61
  • DOI: 10.1016/j.stem.2012.10.011
  • Peer Reviewed
• [Journal Article] Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry (2013)
  • Author(s): Kami, K.; Fujimori, T.; Sato, H.; Sato, M.; Yamamoto, H.; Ohashi, Y.; Sugiyama, N.; Ishihama, Y..; Onozuka, H.; Ochiai, A.; Esumi, H.; Soga, T.; Tomita, M.
  • Journal Title: Metabolomics Volume: 9 (2) Issue: 2 Pages: 444-453
  • DOI: 10.1007/s11306-012-0452-2
  • Peer Reviewed
• [Journal Article] mTORC1is essential for leukemia propagation but not stem cell self-renewal. (2012)
  • Author(s): Hoshii. T
  • Journal Title: J Clin Invest. Volume: 122 Issue: 6 Pages: 2114-2129
  • DOI: 10.1172/jci62279
  • Peer Reviewed
• [Journal Article] Human blood metabolite timetable indicates internal body time (2012)
  • Author(s): Kasukawa T, Sugimoto M, Hida A, Minami Y, Mori M, Honma S, Honma K, Mishima K, Soga T, Ueda HR
  • Journal Title: Proc.Natl. Acad. Sci. U.S.A Volume: 109(37) Issue: 37 Pages: 15036-41
  • DOI: 10.1073/pnas.1207768109
  • Peer Reviewed
• [Journal Article] Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis (2012)
  • Author(s): Hirata Y, Ikeda K, shimotohno K, et al.,
  • Journal Title: PLoS Pathog Volume: PLoS Pathog Issue: 8 Pages: e1002860-e1002860
  • DOI: 10.1371/journal.ppat.1002860
  • Peer Reviewed
• [Journal Article] Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis (2012)
  • Author(s): Hirayama, A.
  • Journal Title: Analyst Volume: 137 Issue: 21 Pages: 5026-5033
  • DOI: 10.1039/c2an35492f
  • Peer Reviewed
• [Journal Article] Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy. (2012)
  • Author(s): Hirayama A
  • Journal Title: Anal Bioanal Chem. Volume: 404(10) Issue: 10 Pages: 3101-9
  • DOI: 10.1007/s00216-012-6412-x
  • Peer Reviewed
• [Journal Article] The emerging role of fumarate as an oncometabolite (2012)
  • Author(s): Yang, M.
  • Journal Title: Front. Oncol. Volume: 2 Pages: 85-85
  • DOI: 10.3389/fonc.2012.00085
  • Peer Reviewed
• [Journal Article] がんの代謝研究の最前線-Warburgを超えて- (2012)
  • Author(s): 曽我朋義
  • Journal Title: 実験医学増刊 Volume: 30 Pages: 12-22
• [Journal Article] メタボローム解析によるがんのフマル酸呼吸の解明 (2012)
  • Author(s): 紙健次郎
  • Journal Title: 実験医学増刊 Volume: 30 Pages: 73-80
• [Journal Article] メタボローム解析によるがんの代謝解析 (2012)
  • Author(s): 平山明由
  • Journal Title: 実験医学増刊 Volume: 30 Pages: 203-208
• [Journal Article] がん組織に特異的な代謝変化 (2012)
  • Author(s): 平山明由
  • Journal Title: 医学のあゆみ Volume: 241 Pages: 445-449
• [Journal Article] メタボローム解析に基づくがん特異的代謝の解明 (2012)
  • Author(s): 平山明由
  • Journal Title: 実験医学増刊 Volume: 30 Pages: 25-30
• [Journal Article] Profiling of the Charged Metabolites of Traditional Herbal Medicines Using Capillary Electrophoresis time-of-flight Mass Spectrometry (2012)
  • Author(s): Iino, K.
  • Journal Title: Metabolomics Volume: 8 Issue: 1 Pages: 99-108
  • DOI: 10.1007/s11306-011-0290-7
  • Peer Reviewed
• [Journal Article] Bioinfomatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis (2012)
  • Author(s): Sugimoto, M.
  • Journal Title: Curr.Bioinf. Volume: 7 Issue: 1 Pages: 96-108
  • DOI: 10.2174/157489312799304431
  • Peer Reviewed
• [Journal Article] Non-targeted metabolite profiling in activated macrophage secretion (2011)
  • Author(s): Sugimoto, M.
  • Journal Title: Metabolomics Volume: (In press) Issue: 4 Pages: 624-633
  • DOI: 10.1007/s11306-011-0353-9
  • Year and Date: 2011-08-24
  • Peer Reviewed
• [Journal Article] MMDB : Mouse multiple tissue metabolome database (2011)
  • Author(s): Sugimoto, M., et al.
  • Journal Title: Nucleic Acids Res Volume: 2011 Issue: D1 Pages: 1-6
  • DOI: 10.1093/nar/gkr1170
  • Peer Reviewed
• [Journal Article] Serum Metabolomics Reveals Y-glutamyl Dipeptides as Biomarkers for discrimination among Different Forms of Liver Disease (2011)
  • Author(s): Soga, T.
  • Journal Title: J.Hepatol. Volume: 55 Issue: 4 Pages: 896-905
  • DOI: 10.1016/j.jhep.2011.01.031
  • Peer Reviewed
• [Journal Article] Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway : Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling (2011)
  • Author(s): Adam, J.
  • Journal Title: Cancer Cell Volume: 20 Issue: 4 Pages: 524-537
  • DOI: 10.1016/j.ccr.2011.09.006
  • Peer Reviewed
• [Journal Article] Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway (2011)
  • Author(s): Deng, L.
  • Journal Title: J.Virol. Volume: 85 Issue: 17 Pages: 8556-8568
  • DOI: 10.1128/jvi.00146-11
  • Peer Reviewed
• [Journal Article] Use of Serum and Urine Metabolome Analysis for the Detection of Metabolic Changes in Patients with Stage 1-2 Chronic Kidney Disease (2011)
  • Author(s): Hayashi, K.
  • Journal Title: Nephro-Urol.Mon. Volume: 3 Pages: 164-171
  • Peer Reviewed
• [Journal Article] Analysis of liver metabolism in a rat model of heart failure (2011)
  • Author(s): Kato T, Niizuma S, Inuzuka Y, Kawashima T, Okuda J, Kawamoto A, Tamaki Y, Iwanaga Y, Soga T, Kita T, Kimura T, Shioi T.
  • Journal Title: Int J Cardiol Volume: (In press) Issue: 3 Pages: 130-136
  • DOI: 10.1016/j.ijcard.2011.07.056
  • Peer Reviewed
• [Journal Article] Disruption of HIF-1α in Hepatocytes Impairs Glucose Metabolism in Diet-induced Obesity Mice (2011)
  • Author(s): Ochiai, D.
  • Journal Title: Biochem.Biophys.Res.Commun Volume: 415 Issue: 3 Pages: 445-449
  • DOI: 10.1016/j.bbrc.2011.10.089
  • Peer Reviewed
• [Journal Article] Transcriptional Regulation of Organic Anion Transporting Polypeptide SLCO4C1 as a New Therapeutic Modality to Prevent Chronic Kidney Disease (2011)
  • Author(s): Suzuki, T.
  • Journal Title: J.Pharm.Sci. Volume: 100 Issue: 9 Pages: 3696-3707
  • DOI: 10.1002/jps.22641
  • Peer Reviewed
• [Journal Article] Sex-dependent Hepatic Transcripts and Metabolites in the Development of Glucose Intolerance and Insulin Resistance in Zucker Diabetic Fatty Rats (2011)
  • Author(s): Gustavsson, C.
  • Journal Title: J.Mol.Endcrinol. Volume: 47 Issue: 2 Pages: 129-143
  • DOI: 10.1530/jme-11-0007
  • Peer Reviewed
• [Journal Article] Autophagy Protects the Proximal Tubule from Degeneration and Acute Ischemic Injury (2011)
  • Author(s): Kimura, T.
  • Journal Title: J.Am.Soc.Nephrol. Volume: 22 Issue: 5 Pages: 902-913
  • DOI: 10.1681/asn.2010070705
  • Peer Reviewed
• [Journal Article] Positive Autoregulation Delays the Expression Phase of Mammalian Clock Gene Per2 (2011)
  • Author(s): Ogawa, Y.
  • Journal Title: PLoS ONE Volume: 6 Issue: 4 Pages: e18663-e18663
  • DOI: 10.1371/journal.pone.0018663
  • Peer Reviewed
• [Journal Article] CE-MSメタボローム測定法 (2011)
  • Author(s): 平山明由
  • Journal Title: Diabetes Frontier Volume: 22 Pages: 673-678
• [Journal Article] 新規酸化ストレスマーカーγ-グルタミルジペプチドによる肝疾患スクリーニング (2011)
  • Author(s): 曽我朋義
  • Journal Title: 酸化ストレスと肝疾患 Volume: 7 Pages: 115-123
• [Journal Article] メタボローム解析による癌代謝特性の包括的解明 (2011)
  • Author(s): 平山明由
  • Journal Title: 細胞工学 Volume: 30 Pages: 25-29
• [Journal Article] CE-MS法によるメタボローム解析と医薬への応用 (2011)
  • Author(s): 曽我朋義
  • Journal Title: 遺伝子医学MOOK Volume: 19号 Pages: 66-70
• [Journal Article] CE-MSメタボロミクスの最新動向 (2010)
  • Author(s): 曽我朋義
  • Journal Title: ぶんせき Volume: Vol461No.11 Pages: 585-590
  • NAID: 10027314690
• [Presentation] メタボロミクスによるオンコメタボライトの発がんの機序解析 (2015)
  • Author(s): 曽我朋義
  • Organizer: 日本薬学会第135年会シンポジウム
  • Place of Presentation: 神戸学院大学(兵庫県神戸市）
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] CE-MSメタボロミクスとがんの代謝研究 (2014)
  • Author(s): 曽我朋義
  • Organizer: よこはまNMR研究会第51回ワークショップ
  • Place of Presentation: 理化学研究所横浜事業所 交流棟ホール（神奈川県横浜市）
  • Year and Date: 2014-12-04
  • Invited
• [Presentation] オンコメタボライトとがんの代謝 (2014)
  • Author(s): 曽我朋義
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-11-26
  • Invited
• [Presentation] メタボロミクスとがんの代謝研究 (2014)
  • Author(s): 曽我朋義
  • Organizer: 北海道大学遺伝子病制御研究所金沢大学がん進展制御研究所ジョイントシンポジウム2014
  • Place of Presentation: 北海道大学医学部学友会館フラテ（北海道札幌市）
  • Year and Date: 2014-10-27
  • Invited
• [Presentation] オンコメタボライト-フマル酸によるがんの代謝制御 (2014)
  • Author(s): 曽我朋義
  • Organizer: 第87回日本生化学会大会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2014-10-16
  • Invited
• [Presentation] CE-MSメタボロミクスによるがん研究 (2014)
  • Author(s): 曽我朋義
  • Organizer: 日本分析化学会第63年会
  • Place of Presentation: 広島大学東広島キャンパス（広島県東広島市）
  • Year and Date: 2014-09-17
  • Invited
• [Presentation] メタボロミクスとがんの代謝 (2014)
  • Author(s): 曽我朋義
  • Organizer: CREATE 2014
  • Place of Presentation: ロイヤルパークホテル（東京都中央区）
  • Year and Date: 2014-07-25
  • Invited
• [Presentation] オンコメタボライト-フマル酸によるがんのエピジェネティック制御 (2014)
  • Author(s): 曽我朋義
  • Organizer: 第2回がんと代謝研究会
  • Place of Presentation: 東京理科大学葛飾キャンパス講堂（東京都葛飾区）
  • Year and Date: 2014-07-10
  • Invited
• [Presentation] メタボロミクスによるがんの代謝研究 (2014)
  • Author(s): 曽我朋義
  • Organizer: 第61回日本生化学会近畿支部例会
  • Place of Presentation: 京都産業大学神山ホール（京都府京都市）
  • Year and Date: 2014-05-17
  • Invited
• [Presentation] メタボロミクスによるがんの代謝解析 (2013)
  • Author(s): 曽我朋義
  • Organizer: がんと代謝シンポジウム2013
  • Place of Presentation: 慶應義塾大学信濃町キャンパス北里記念医学図書館講堂
  • Year and Date: 2013-01-17
  • Invited
• [Presentation] CE-MSメタボロミクスによる医薬研究 (2012)
  • Author(s): 曽我朋義
  • Organizer: 疾患メタボロミクスシンポジウム
  • Place of Presentation: 大阪大学吹田キャンパス銀杏会館
  • Year and Date: 2012-12-18
  • Invited
• [Presentation] メタボロミクスとがんの代謝 (2012)
  • Author(s): 曽我朋義
  • Organizer: 第85回日本生化学大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-12-14
  • Invited
• [Presentation] メタボロミクスによるがんの代謝解析 (2012)
  • Author(s): 曽我朋義
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-12-12
  • Invited
• [Presentation] CE-MSメタボロミクスによるがんの代謝解析 (2012)
  • Author(s): 曽我朋義
  • Organizer: 第32回キャピラリー電気泳動シンポジウム
  • Place of Presentation: 産業技術総合研究所関西センター
  • Year and Date: 2012-11-08
  • Invited
• [Presentation] Biomedical Research by CE-MS Metabolomics (2012)
  • Author(s): Tomoyoshi Soga
  • Organizer: 4th International Conference on Foundations of Systems Biology in Enginnering 2012
  • Place of Presentation: Institute for Advanced Biosciences, Keio University, Tsuruoka
  • Year and Date: 2012-10-23
  • Invited
• [Presentation] CE-MS Metabolomics and Biomedical Research (2012)
  • Author(s): Tomoyoshi Soga
  • Organizer: New Frontiers of Metabololism Research in Biomedical Sciences
  • Place of Presentation: Ichijyo Hall, The University of Tokyo
  • Year and Date: 2012-09-28
  • Invited
• [Presentation] メタボローム解析によるがん研究 (2012)
  • Author(s): 曽我朋義
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: さっぽろ芸文館
  • Year and Date: 2012-09-20
  • Invited
• [Presentation] メタボロミクスと生命科学 (2012)
  • Author(s): 曽我朋義
  • Organizer: 日本プロテオーム学会2012年大会
  • Place of Presentation: 日本科学未来館
  • Year and Date: 2012-07-26
  • Invited
• [Presentation] メタボロミクスとがんの代謝 (2012)
  • Author(s): 曽我朋義
  • Organizer: 第16回日本がん分子標的治療学会
  • Place of Presentation: 北九州市西日本総合展示場
  • Year and Date: 2012-06-29
  • Invited
• [Presentation] メタボロミクスによる新規酸化ストレスマーカーの発見と肝疾患診断 (2012)
  • Author(s): 曽我朋義
  • Organizer: 第三回レドックス・ライフイノベーションシンポジウム
  • Place of Presentation: 東京大学医学部教育研究棟(招待講演)
  • Year and Date: 2012-03-08
• [Presentation] CE-MS Metabolomic in Biomedical Research (2012)
  • Author(s): Tomoyoshi Soga
  • Organizer: 27^<th> International Symposium on MicroScale Bioseparations and Analyses, MSB2012
  • Place of Presentation: Starling Hotel and Conference Center, Geneva, Swissland(招待講演)
  • Year and Date: 2012-02-13
• [Presentation] メタボローム測定法の開発と生命科学への応用 (2012)
  • Author(s): 曽我朋義
  • Organizer: 第二回次世代バイオナノ研究会
  • Place of Presentation: サンポートホール高松(招待講演)
  • Year and Date: 2012-01-19
• [Presentation] Metabolomics in Biomedical Research (2011)
  • Author(s): Tomoyoshi Soga
  • Organizer: MBSJ 2011、第34回日本分子生物学会
  • Place of Presentation: Pacifico Yokohama(招待講演)
  • Year and Date: 2011-12-14
• [Presentation] 新規酸化ストレスマーカーγ-グルタミルジペプチドによる肝疾患スクリーニング (2011)
  • Author(s): 曽我朋義
  • Organizer: 第8回酸化ストレスと肝研究会
  • Place of Presentation: 博多エクセルホテル東急(招待講演)
  • Year and Date: 2011-11-27
• [Presentation] メタボロミクスによる新規肝臓疾患マーカーの発見 (2011)
  • Author(s): 曽我朋義
  • Organizer: 日本薬物動態学会第26回年会創薬と化学療法のためのバイオマーカー
  • Place of Presentation: 広島国際会議場(招待講演)
  • Year and Date: 2011-11-18
• [Presentation] CE-MSメタボロミクスによる疾患バイオマーカー探索 (2011)
  • Author(s): 曽我朋義
  • Organizer: 第6回メタボロームシンポジウム
  • Place of Presentation: 大阪大学コンベンションセンター(招待講演)
  • Year and Date: 2011-10-13
• [Presentation] Biomarker Discovery by CE-MS Metabolomics (2011)
  • Author(s): Tomoyoshi Soga
  • Organizer: The 59^<th> Annual Meeting of Japanese Association for Dental Research
  • Place of Presentation: International Conference Center Hiroshima(招待講演)
  • Year and Date: 2011-10-08
• [Presentation] メタボロミクスによるがんの代謝解明 (2011)
  • Author(s): 曽我朋義
  • Organizer: 第84回日本生化学会大会シンポジウム:がんの代謝制御
  • Place of Presentation: 国立京都国際会館(招待講演)
  • Year and Date: 2011-09-24
• [Presentation] メタボローム解析による新規バイオマーカー探索 (2011)
  • Author(s): 曽我朋義
  • Organizer: 日本分析化学会第60年会特別シンポジウム:最先端医療を支える分析化学
  • Place of Presentation: 名古屋大学東山キャンパスA会場(招待講演)
  • Year and Date: 2011-09-16
• [Presentation] CE-MSメタボローム測定法の開発と生命科学への応用 (2011)
  • Author(s): 曽我朋義
  • Organizer: 日本分析化学会第60年会電気泳動分析研究懇談会
  • Place of Presentation: 名古屋大学東山キャンパスJ会場(招待講演)
  • Year and Date: 2011-09-14
• [Presentation] メタボロミクスによる新規酸化ストレスマーカーの同定と肝臓疾患スクリーニング (2011)
  • Author(s): 曽我朋義
  • Organizer: 第14回Vitamin E Update Forum
  • Place of Presentation: 如水会館(招待講演)
  • Year and Date: 2011-08-30
• [Presentation] 最新のメタボローム測定法の開発と生命科学への応用 (2011)
  • Author(s): 曽我朋義
  • Organizer: 第38回日本トキシコロジー学会学術年会
  • Place of Presentation: パシフィコ横浜(招待講演)
  • Year and Date: 2011-07-11
• [Presentation] メタボロミクスによる新規バイオマーカーの発見 (2011)
  • Author(s): 曽我朋義
  • Organizer: オミックス医療研究会第2回オミックス定期講演会
  • Place of Presentation: 東京医科歯科大学歯学部特別講堂(招待講演)
  • Year and Date: 2011-07-07
• [Presentation] 最新のメタボローム解析によるがん研究 (2011)
  • Author(s): 曽我朋義
  • Organizer: 第17回癌治療増感研究会
  • Place of Presentation: 赤門鍼灸整専門学校(招待講演)
  • Year and Date: 2011-06-24
• [Presentation] CE-MS Metabolomics and Application to Biomedical Research (2011)
  • Author(s): Tomoyoshi Soga
  • Organizer: IUPAC International Congress on Analytical Sciences 2011
  • Place of Presentation: Kyoto International Conference Center(招待講演)
  • Year and Date: 2011-05-24
• [Presentation] 最新のメタボローム測定法の開発とがんのバイオマーカー・標的治療探索 (2011)
  • Author(s): 曽我朋義
  • Organizer: 第100回日本病理学会総会、がんトランスレーショナル研究の最先端と病理シンポジウム
  • Place of Presentation: パシフィコ横浜(招待講演)
  • Year and Date: 2011-04-30
• [Presentation] Capillary Electrophoresis Mass Spectrometry
  • Author(s): Tomoyoshi Soga
  • Organizer: Metabolomics 2013, 9th Annual International Conference of the Metabolomics Soceity
  • Place of Presentation: Scottish Exhibition & Conference Centre, Glasgow, Scotland, UK
  • Invited
• [Presentation] がん抑制遺伝子の変異とがんの代謝
  • Author(s): 曽我朋義
  • Organizer: 第36回日本分子生物学会
  • Place of Presentation: 神戸国際展示場
  • Invited
• [Presentation] CE-MSメタボロミクスによるオンコメタボライトの発がん機序解析
  • Author(s): 曽我朋義
  • Organizer: 第24回クロマトグラフィー科学会議、第33回キャピラリー電気泳動シンポジウム
  • Place of Presentation: 東京大学本郷キャンパス
  • Invited
• [Presentation] がん抑制遺伝子とがんの代謝
  • Author(s): 曽我朋義
  • Organizer: 第1回がんと代謝研究会
  • Place of Presentation: 鶴岡メタボロームキャンパスレクチャーホール
  • Invited
• [Presentation] Metabolomics and Cancer Metabolism
  • Author(s): 曽我朋義
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] メタボロミクスによるがんの代謝研究
  • Author(s): 曽我朋義
  • Organizer: 第8回メタボロームシンポジウム
  • Place of Presentation: 九州大学医学部百年講堂
  • Invited
• [Presentation] メタボロミクスによるがんの代謝解析
  • Author(s): 曽我朋義
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] メタボロミクスによるがんの創薬標的探索
  • Author(s): 曽我朋義
  • Organizer: 第53回日本臨床化学会年次学術集会
  • Place of Presentation: あわぎんホール、徳島
  • Invited
• [Presentation] メタボロミクスによるがんの創薬標的探索
  • Author(s): 曽我朋義
  • Organizer: 日本レチノイド研究会第24回学術集会
  • Place of Presentation: 星薬科大学百年記念館
  • Invited
• [Presentation] がん抑制遺伝子とがんの代謝
  • Author(s): 曽我朋義
  • Organizer: 第17回日本がん分子標的治療学会
  • Place of Presentation: 国立京都国際会館
  • Invited
• [Presentation] メタボロミクスによるがんの代謝解析
  • Author(s): 曽我朋義
  • Organizer: 千里ライフサイエンスセミナー
  • Place of Presentation: 千里ライフサイエンスセンタービル５Fライフホール
  • Invited
• [Book] Metabolomics: Methods and Protocols (2015)
  • Author(s): Bjerrum, J.T., Gall, G.L., Giskeodegard, G.F., Cao, M.D., Bathen, T.F., Yin, P., Zhou, L., Zhao, X., Xu, G., Yin, P., Emwas, A.-H.M., Al-Talla, Z.A., Kharbatia, N., Yang, Y., Wakayama, M., Hirayama, A., Soga, T., Vettukattil, R., Bylesjo, M., Rantalainen, M., Ramana, P., Adams, E., Augustijns, P., A.V., et.al.
  • Total Pages: 259
  • Publisher: Humana Press
• [Remarks] 慶應義塾大学先端生命科学研究所 Ｍａｊｏｒ Ｐｕｂｌｉｃａｔｉｏｎｓ
  • URL: http://www.iab.keio.ac.jp/en/content/blogcategory/34/118/
• [Remarks] メタボローム研究グループ 発表業績
  • URL: http://metabolome.iab.keio.ac.jp/
• [Remarks] 慶應義塾大学先端生命科学研究所 Major Publications
  • URL: http://www.iab.keio.ac.jp/en/content/view/435/118/
• [Remarks] メタボローム研究グループ 発表業績
  • URL: http://metabolome.iab.keio.ac.jp/index.php?Publications
• [Remarks] 慶應義塾大学先端生命科学研究所 publications
  • URL: http://www.iab.keio.ac.jp/en/content/blogcategory/34/118/