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Bioinformatic and statistical genetic analysis of cancer

Planned Research

Project AreaIntegrative Systems Understanding of Cancer for Advanced Diagnosis, Therapy and Prevention
Project/Area Number 22134008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

TSUNODA Tatsuhiko  独立行政法人理化学研究所, 統合生命医科学研究センター, グループディレクター (10273468)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Akihiro  独立行政法人理化学研究所, 統合医科学研究センター, 副チームリーダー (30525853)
MIYA Fuyuki  独立行政法人理化学研究所, 統合医科学研究センター, リサーチアソシエイト (50415311)
JOHNSON Todd  独立行政法人理化学研究所, 統合医科学研究センター, リサーチアソシエイト (90392042)
Co-Investigator(Renkei-kenkyūsha) NAKAGAWA Hidewaki  独立行政法人理化学研究所, 統合医科学研究センター, チームリーダー (50361621)
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥97,240,000 (Direct Cost: ¥74,800,000、Indirect Cost: ¥22,440,000)
Fiscal Year 2014: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2013: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2012: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2011: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2010: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Keywords癌 / ゲノム / 統計数学 / 遺伝学 / オミックス解析 / 次世代シークエンサー / 予測 / オーダーメイド医療 / 情報工学 / 肝臓がん / 遺伝子 / 遺伝統計学 / クロマチン制御遺伝子 / がんゲノム / 多様性 / コピー数多型 / 構造多型 / 日本人ゲノム / 国際がんゲノムコンソーシアム / ゲノムワイド関連解析
Outline of Final Research Achievements

We aimed to realize the optimum therapy for each cancer patient by understanding cancer through comprehensive -omic analysis and by considering each patient’s predisposition, state, and environment. For that, we established: analysis methodology of newest -omic analysis, e.g. next-generation sequencing, clarification of the relationship between -omic and clinical data, identification of disease markers, a solution for the causal relationship between -omic layers, and development of a prediction methodology for diagnosis and drug response. With these methodologies, we achieved: the first comprehensive analysis of a Japanese individual’s genome, whole genome analysis of 27 hepatocellular carcinoma samples, whole genome analysis of 30 intrahepatic cholangiocarcinoma samples, identification of driver mutations and genes involved in carcinogenesis, and construction of a new system for clarifying the mechanisms of cancer development and for cancer risk prediction.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (77 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (35 results) (of which Peer Reviewed: 33 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (41 results) (of which Invited: 14 results) Remarks (1 results)

  • [Journal Article] Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity2015

    • Author(s)
      Fujimoto A, Furuta M, Shiraishi Y, Shigemizu D, Abe T, Boroevich KA, Nakano K, Yamamoto Y, Tanaka H, Shibuya T, Shibata T, Kubo M, Chayama K, Miyano S, Tsunoda T, Nakagawa H, 他
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6120-6120

    • DOI

      10.1038/ncomms7120

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] WHSC1 Promotes Oncogenesis through Regulation of NIMA-related-kinase-7 in Squamous Cell Carcinoma of the Head and Neck2015

    • Author(s)
      Saloura V, Cho HS, Kyiotani K, Alachkar H, Zuo Z, Nakakido M, Tsunoda T, Seiwert T, Lingen M, Licht J, Nakamura Y, Hamamoto R
    • Journal Title

      Molecular Cancer Research

      Volume: 13 Issue: 2 Pages: 293-304

    • DOI

      10.1158/1541-7786.mcr-14-0292-t

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 数理科学・計算科学とゲノム2015

    • Author(s)
      角田 達彦
    • Journal Title

      血管医学

      Volume: 16 Pages: 85-91

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers2014

    • Author(s)
      Shiraishi Y, Fujimoto A, Furuta M, Chayama K, Tsunoda T, Miyano S, and Nakagawa H, 他
    • Journal Title

      PLoS One

      Volume: 9 Issue: 12 Pages: e114263-e114263

    • DOI

      10.1371/journal.pone.0114263

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort2014

    • Author(s)
      Shigemizu D, Abe T, Morizono T, Johnson TA, Boroevich KA, Hirakawa Y, Ninomiya T, Kiyohara Y, Kubo M, Nakamura Y, Maeda S, Tsunoda T
    • Journal Title

      PLoS One

      Volume: 9 Issue: 3 Pages: e92549-e92549

    • DOI

      10.1371/journal.pone.0092549

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] がん研究におけるゲノムビッグデータ解析と臨床応用2014

    • Author(s)
      角田 達彦
    • Journal Title

      実験医学

      Volume: 32 Pages: 2046-2051

    • Related Report
      2014 Annual Research Report
  • [Journal Article] A practical method to detect SNVs and indels from whole genome and exome sequencing data.2013

    • Author(s)
      Shigemizu D, Fujimoto A, Akiyama S, Abe T, Nakano K, Boroevich KA, Yamamoto Y, Furuta M, Kubo M, Nakagawa H, Tsunoda T.
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 2161-2161

    • DOI

      10.1038/srep02161

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated molecular analysis of clear-cell renal cell carcinoma.2013

    • Author(s)
      Sato Y, Yoshida K
    • Journal Title

      Nature Genet.

      Volume: 45 Issue: 8 Pages: 860-867

    • DOI

      10.1038/ng.2699

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.2013

    • Author(s)
      Kogure M, Takawa M, Saloura V, Sone K, Piao L, Ueda K, Ibrahim R, Tsunoda T, Sugiyama M, Atomi Y, Nakamura Y, Hamamoto R.
    • Journal Title

      Neoplasia

      Volume: 15 Issue: 11 Pages: 1251-1261

    • DOI

      10.1593/neo.131436

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition.2013

    • Author(s)
      Kogure M, Takawa M, Cho HS, Toyokawa G, Hayashi K, Tsunoda T, Kobayashi T, Daigo Y, Sugiyama M, Atomi Y, Nakamura Y, Hamamoto R.
    • Journal Title

      Cancer Letters

      Volume: 336 Issue: 1 Pages: 76-84

    • DOI

      10.1016/j.canlet.2013.04.009

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and microarray analyses of human hepatocytes from xenogeneic host livers.2013

    • Author(s)
      Tateno C, Miya F, Wake K, Kataoka M, Ishida Y, Yamasaki C, Yanagi A, Kakuni M, Wisse E, Verheyen F, Inoue K, Sato K, Kudo A, Arii S, Itamoto T, Asahara T, Tsunoda T, Yoshizato K.
    • Journal Title

      Laboratory investigation

      Volume: 93 Issue: 1 Pages: 54-71

    • DOI

      10.1038/labinvest.2012.158

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.2013

    • Author(s)
      Kang D, Cho HS, Toyokawa G, Kogure M, Yamane Y, Iwai Y, Hayami S, Tsunoda T, Field HI, Matsuda K, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R.
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 52 Issue: 2 Pages: 126-139

    • DOI

      10.1002/gcc.22012

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C2013

    • Author(s)
      Nakano R, Maekawa T, Abe H, Hayashida Y, Ochi H, Tsunoda T, Kumada H, Kamatani N, Nakamura Y, Chayama K
    • Journal Title

      The Journal of General Virology

      Volume: 94 Issue: 1 Pages: 81-89

    • DOI

      10.1099/vir.0.044396-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.2012

    • Author(s)
      Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, Aoki M, Hosono N, Kubo M, Miya F, Arai Y, Takahashi H, Shirakihara T, Nagasaki M, Shibuya T, Nakano K, Watanabe-Makino K, Tanaka H, Nakamura H, Kusuda J, Ojima H, Shimada K, Okusaka T, Ueno M, Shigekawa Y, Kawakami Y, Arihiro K, Ohdan H, Gotoh K, Ishikawa O, Ariizumi S, Yamamoto M, Yamada T, Chayama K, Kosuge T, Yamaue H, Kamatani N, Miyano S, Nakagama H, Nakamura Y, Tsunoda T, Shibata T, Nakagawa H
    • Journal Title

      Nature Genetic

      Volume: 44 Issue: 7 Pages: 760-764

    • DOI

      10.1038/ng.2291

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression2012

    • Author(s)
      M. Takawa, H. S. Cho, S. Hayami, G. Toyokawa, M. Kogure, Y. Yamane, Y. Iwai, K. Maejima, K. Ueda, A. Masuda, N. Dohmae, H. I. Field, T. Tsunoda, T. Kobayashi, T. Akasu, M. Sugiyama, S. Ohnuma, Y. Atomi, B. A. Ponder, Y. Nakamura, and R. Hamamoto
    • Journal Title

      Cancer research

      Volume: 72(13) Issue: 13 Pages: 3217-27

    • DOI

      10.1158/0008-5472.can-11-3701

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reproducibility, performance, and clinical utility of a genetic risk prediction model for prostate cancer in Japanese.2012

    • Author(s)
      赤松秀輔
    • Journal Title

      Plos One

      Volume: 7 Issue: 10 Pages: 46454-46454

    • DOI

      10.1371/journal.pone.0046454

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway2012

    • Author(s)
      Kosuke Yoshihara
    • Journal Title

      Clinical Cancer Research

      Volume: 18 Issue: 5 Pages: 1374-1385

    • DOI

      10.1158/1078-0432.ccr-11-2725

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin D receptor, conferring prostate cancer2012

    • Author(s)
      Ha Nguyen H, 他
    • Journal Title

      Human Molecular Genetics

      Volume: 21 Issue: 9 Pages: 2076-2085

    • DOI

      10.1093/hmg/dds025

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] hzAnalyzer : Detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets2011

    • Author(s)
      T.A.Johnson, Y.Niimura, H.Tanaka, Y.Nakamura, T.Tsunoda
    • Journal Title

      Genome Biology

      Volume: 12 Issue: 3

    • DOI

      10.1186/gb-2011-12-3-r21

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inferring Haplotypes of Copy Number Variations From High-Throughput Data With Uncertainty2011

    • Author(s)
      M.Kato, S.Yoon, N.Hosono, A.Leotta, J.Sebat, T.Tsunoda, M.Q.Zhang
    • Journal Title

      G3 : Genes, Genomes, Genetics

      Volume: 1 Issue: 1 Pages: 35-42

    • DOI

      10.1534/g3.111.000174

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers2011

    • Author(s)
      Miki D, Ochi H, Hayes CN, Abe H, Yoshima T, Aikata H, Ikeda K, KumadaH, Toyota J, Morizono T, Tsunoda T, Kubo M, Nakamura Y, Kamatani N, Chayama K
    • Journal Title

      Nat Genet

      Volume: 43 Issue: 8 Pages: 797-800

    • DOI

      10.1038/ng.876

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese2011

    • Author(s)
      K.Kiyotani, T.Mushiroda, T.Tsunoda, T.Morizono, N.Hosono, M.Kubo, Y.Tanigawara, CK.Imamura, DA.Flockhart, F.Aki, K.Hirata, Y.Takatsuka, M.Okazaki, S.Ohsumi, T.Yamakawa, M.Sasa, Y.Nakamura, H.Zembutsu
    • Journal Title

      Human Molecular Genetics

      Volume: (オンライン出版済) Issue: 7 Pages: 1665-1672

    • DOI

      10.1093/hmg/ddr597

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility2011

    • Author(s)
      V.Kumar, K.Matsuo, A.Takahashi, N.Hosono, T.Tsunoda, N.Kamatani, S.Y.Kong, H.Nakagawa, R.Cui, C.Tanikawa, M.Seto, Y.Morishima, M.Kubo, Y.Nakamura, K.Matsuda
    • Journal Title

      Journal of Human Genetics

      Volume: 56 Issue: 6 Pages: 436-439

    • DOI

      10.1038/jhg.2011.35

    • NAID

      10030659704

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population2011

    • Author(s)
      R.Cui, Y.Okada, S.G.Jang, J.L.Ku, J.G.Park, Y.Kamatani, N.Hosono, T.Tsunoda, V.Kumar, C.Tanikawa, N.Kamatani, R.Yamada, M.Kubo, Y.Nakamura, K.Matsuda
    • Journal Title

      Gut

      Volume: 60 Issue: 6 Pages: 799-805

    • DOI

      10.1136/gut.2010.215947

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility2011

    • Author(s)
      S.Chung, H.Nakagawa, M.Uemura, L.Piao, K.Ashikawa, N.Hosono, R.Takata, S.Akamatsu, T.Kawaguchi, T.Morizono, T.Tsunoda, Y.Daigo, K.Matsuda, N.Kamatani, Y.Nakamura, M.Kubo
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 1 Pages: 245-252

    • DOI

      10.1111/j.1349-7006.2010.01737.x

    • NAID

      10029289301

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone Lysine Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1 Is Involved in Human Carcinogenesis through Regulation of the Wnt Pathway2011

    • Author(s)
      G.Toyokawa, H.S.Cho, K.Masuda, Y.Yamane, M.Yoshimatsu, S.Hayami, M.Takawa, Y.Iwai, Y.Daigo, E.Tsuchiya, T.Tsunoda, H.I.Field, J.D.Kelly, D.E.Neal, Y.Maehara, B.A.Ponder, Y.Nakamura, R.Hamamoto
    • Journal Title

      Neoplasia

      Volume: 13 Issue: 10 Pages: 887-898

    • DOI

      10.1593/neo.11048

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G(1)/S transition in cancer cells via transcriptional regulation of the HOXA1 gene2011

    • Author(s)
      Cho HS, Toyokawa G, Daigo Y, Hayami S, Masuda K, Ikawa N, Yamane Y, Maejima K, Tsunoda T, Field HI, Kelly JD, Neal DE, Ponder BA, Maehara Y, Nakamura Y, Hamamoto R
    • Journal Title

      Int J Cancer

      Volume: (in press) Issue: 3

    • DOI

      10.1002/ijc.26501

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 62011

    • Author(s)
      Toyokawa G, Cho H-S, Iwai Y, Yoshimatsu M, Takawa M, Hayami S, Maejima K, Shimizu N, Tanaka H, Tsunoda T, Field H, Kelly J, Neal D, Ponder B, Maehara Y, Nakamura Y, Hamamoto R
    • Journal Title

      Cancer Prev.Res.

      Volume: 4 Issue: 12 Pages: 2051-2061

    • DOI

      10.1158/1940-6207.capr-11-0290

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Expression of EHMT2 Is Involved in the Proliferation of Cancer Cells through Negative Regulation of SIAH12011

    • Author(s)
      H.S.Cho, J.D.Kelly, S.Hayami, G.Toyokawa, M.Takawa, M.Yoshimatsu, T.Tsunoda, H.I.Field, D.E.Neal, B.A.Ponder, Y.Nakamura, R.Hamamoto
    • Journal Title

      Neoplasia

      Volume: 13 Issue: 8 Pages: 676-684

    • DOI

      10.1593/neo.11512

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting response of bladder cancers to gemcitabine and carboplatin neoadjubant chemotherapy through genome-wide gene expression profiling2011

    • Author(s)
      Y.Kato, H.Zembutsu, R.Takata, F.Miya, T.Tsunoda, W.Obara, T.Fujioka, Y.Nakamura
    • Journal Title

      Experimental and Therapeutic Medicine

      Volume: 2 Issue: 1 Pages: 47-56

    • DOI

      10.3892/etm.2010.166

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers2011

    • Author(s)
      M.Yoshimatsu, G.Toyokawa, S.Hayami, M.Unoki, T.Tsunoda, H.I.Field, J.D.Kelly, D.E.Neal, Y.Maehara, B.A.Ponder, Y.Nakamura, R.Hamamoto
    • Journal Title

      International Journal of Cancer

      Volume: 128 Issue: 3 Pages: 562-573

    • DOI

      10.1002/ijc.25366

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers2011

    • Author(s)
      S.Hayami, J.D.Kelly, H.S.Cho, M.Yoshimatsu, M.Unoki, T.Tsunoda, H.I.Field, D.E.Neal, H.Yamaue, B.A.J.Ponder, Y.Nakamura, R.Hamamoto
    • Journal Title

      International Journal of Cancer

      Volume: 128 Issue: 3 Pages: 574-586

    • DOI

      10.1002/ijc.25349

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing.2010

    • Author(s)
      A.Fujimoto, H.Nakagawa, N.Hosono, K.Nakano, T.Abe, K.A.Boroevich, M.Nagasaki, R.Yamaguchi, T.Shibuya, M.Kubo, S.Miyano, Y.Nakamura, T.Tsunoda.
    • Journal Title

      Nature Genetics

      Volume: 42 Pages: 931-936

    • NAID

      40019159184

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] International network of cancer genome projects.2010

    • Author(s)
      The International Cancer Genome Consortium.
    • Journal Title

      Nature

      Volume: 464 Pages: 993-998

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Population-genetic nature of copy number variations in the human genome.2010

    • Author(s)
      M.Kato, T.Kawaguchi, S.Ishikawa, T.Umeda, R.Nakamichi, M.H.Shapero, K.W.Jones, Y.Nakamura, H.Aburatani, T.Tsunoda.
    • Journal Title

      Human Molecular Genetics

      Volume: 19 Pages: 761-773

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Analysis of mutational landscape and genetic heterogeneity in liver cancer with whole genome sequencing2014

    • Author(s)
      Fujimoto A, Furuta M, Shiraishi Y, Chayama K, Miyano S, Tsunoda T, and Nakagawa H, 他
    • Organizer
      American Society of Human Genetics
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Medical Science Mathematics for Cancer Genome Analysis2014

    • Author(s)
      Tsunoda T
    • Organizer
      Japanese Cancer Association
    • Place of Presentation
      パシフィコ横浜, Yokohama
    • Year and Date
      2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 全ゲノムビッグデータ解析によるオーダーメイド医療2014

    • Author(s)
      角田 達彦
    • Organizer
      富士通 知創薬コンソーシアム
    • Place of Presentation
      汐留シティセンター, 東京
    • Year and Date
      2014-04-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Whole Genome Big Data Analysis for Complex Diseases2014

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      3rd Global COE Workshop between BGI and University of Tokyo – Advances in Medical Genomics
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Big data for personalized medicine: whole-genome analysis of BioBank and cancer samples2014

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      英国大使館 日英 ビッグデータ研究 ワークショップ
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Comprehensive analysis of genetic variation by whole genome sequencing2014

    • Author(s)
      藤本明洋, 十時泰, 宮野悟, 角田逹彦, 柴田龍弘, 中川英刀
    • Organizer
      金沢国際がん生物学&アカデミア創薬シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Whole Genome Approach Is Revolutionizing Medicine2013

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      The 10th International Workshop on Advanced Genomics
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Whole genome sequencing and comprehensive mutation analysis of liver cancer2013

    • Author(s)
      Tatsuhiko Tsunoda
    • Organizer
      SNUCRI & SNUCH Cancer Symposium
    • Place of Presentation
      Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 全ゲノムとエクソームシークエンス解析2013

    • Author(s)
      角田 達彦
    • Organizer
      日本人類遺伝学会第58回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 次世代シークエンサーによるがんの全ゲノム解析と解釈2013

    • Author(s)
      角田 達彦
    • Organizer
      日本癌学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 肝がん全ゲノム解析から判明した 変異のパターンと腫瘍内遺伝的多様性2013

    • Author(s)
      藤本明洋, 白石 友一, 古田 繭子, 後藤 邦仁, 中村 透, 平野 聡, 山本 雅一, 山上 裕機, 茶山 一彰, 宮野 悟, 角田 達彦, 中川 英刀
    • Organizer
      日本遺伝学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 全ゲノムシークエンス解析による遺伝的多様性の統合的理解2013

    • Author(s)
      藤本明洋, 中川英刀, 角田達彦
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Comprehensive analysis of genetic variation by whole genome sequencing2013

    • Author(s)
      藤本明洋, 十時泰, 宮野悟, 角田逹彦, 柴田龍弘, 中川英刀
    • Organizer
      CBI学会2013年大会・生命医薬情報学連合大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 全ゲノム/全エクソームシークエンスデータからのSNVs,Indels を同定する実用的手法の開発2013

    • Author(s)
      重水大智, 藤本明洋, 秋山真太郎, 阿部哲雄, 中野かおる, Keith Boroevich, 山本裕二郎, 古田繭子, 久保充明, 中川英刀, 角田達彦
    • Organizer
      日本人類遺伝学会 第58回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 日本人における全ゲノム間の関連についての網羅的eQTL解析2013

    • Author(s)
      宮冬樹, 森園隆, 阿部哲雄, 久保充明, 角田達彦
    • Organizer
      日本人類遺伝学会 第58回大会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 全ゲノムシークエンスによる肝臓がんの変異と遺伝的多様性の解析2013

    • Author(s)
      藤本明洋, 白石友一, 古田繭子, 後藤邦仁, 中村透, 平野聡, 山本雅一, 山上裕機, 茶山一彰, 宮野悟, 角田達彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Whole genome sequencing reveals past population history and signature of natural selection in the Japanese population2013

    • Author(s)
      Akihiro Fujimoto, Tetuo Abe, Keith A Boroevich, Kaoru Nakano, Aya Sasaki, Rina Kitada, Hiroko Tanaka, Yusuke Nakamura, Satoru Miyano, Michiaki Kubo, Hidewaki Nakagawa, Tatsuhiko Tsunoda
    • Organizer
      American Society of Human Genotics
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 全ゲノム・全エクソームシークエンスデータからSNV/Indelを同定する実用的手法の開発2013

    • Author(s)
      重水大智, 藤本 明洋, 秋山 真太郎, 阿部 哲雄, 中野 かおる, Boroevich Keith, 山本 裕二郎, 古田 繭子, 久保 充明, 中川 英刀, 角田 達彦
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Genome-wide cis-and trans-eQTL analysis using next generation sequencer in Japanese population.2013

    • Author(s)
      Fuyuki Miya, Takashi Morizono, Michiaki Kubo, Tatsuhiko Tsunoda
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Supercomputing accelerates genomic medicine2012

    • Author(s)
      T.Tsunoda
    • Organizer
      Biosupercomputing Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-12-04
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 次世代シーケンサーを用いた日本人における全ゲノム網羅的eQTL解析2012

    • Author(s)
      宮 冬樹, 阿部 哲雄, 森園 隆, 秋山 真太郎, 久保 充明, 角田 達彦
    • Organizer
      日本人類遺伝学会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genome medicine's milestones and future2012

    • Author(s)
      T.Tsunoda
    • Organizer
      International Conference on Bioinformatics
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2012-10-03
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 腎炎明細細胞癌の全ゲノム解析2012

    • Author(s)
      奥野 友介, 佐藤 悠佑, 前川 滋克, 佐藤 亜以子, 鈴木 啓道, 藤本 明洋, 白石 友一, 千葉 健一, 田中 洋子, 本間 之夫, 角田 達彦, 宮野 悟, 小川 誠司.
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] リプルネガティブ乳がんのエクソーム解析. 第71回日本癌学会学術総会2012

    • Author(s)
      清谷 一馬, 藤本 明洋, 小松 正人, 吉丸 哲郎, 松尾 泰佑, 角田 達彦, 三好 康雄, 笹 三徳, 片桐 豊雅
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 局所浸潤性膀胱癌に対するネオアジュバント療法感受性予測前向き試験2012

    • Author(s)
      加藤 陽一郎, 前佛 均, 高田 亮, 岩崎 一洋, 小原 航, 角田 達彦, 中村 祐輔, 藤岡 知昭
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genome-wide association study and whole-genome sequence analysis2011

    • Author(s)
      T.Tsunoda
    • Organizer
      JAPANESE-FINNISH JOINT SYMPOSIUM
    • Place of Presentation
      Helsinki, Finland(招待講演)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] A genome-wide association study identified a novel susceptibility locus for hepatocellular carcinoma in chronic hepatitis C virus carriers2011

    • Author(s)
      D.Miki, H.Ochi, C.Hayes, H.Abe, T.Yoshima, Y.Hayashida, H.Aikata, K.Ikeda, H.Kumada, J.Toyota, T.Tsunoda, M.Kubo, Y.Nakamura, N.Kamatani, K.Chayama
    • Organizer
      Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      San Francisco
    • Year and Date
      2011-11-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] COMPREHENSIVE WHOLE-GENOME SEQUENCE ANALYSIS OF CANCER2011

    • Author(s)
      T.Tsunoda
    • Organizer
      Cancer Genomics and Epigenomics: Towards Personalized Cancer Medicine
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-10-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 疾患の未解明の遺伝力の問題に対する日本とアジアでのアプローチ2011

    • Author(s)
      角田達彦
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋(招待講演)
    • Year and Date
      2011-10-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 日本人と韓国人の肺腺癌発症に関連するTP63の一塩基多型の同定2011

    • Author(s)
      三木大樹, 久保充明, 角田達彦, 鎌谷直之, 茶山一彰, 高橋隆, 稲澤譲治, 中村祐輔, 醍醐弥太郎
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゲノムワイド関連解析による乳癌タモキシフェン治療反応性予測2011

    • Author(s)
      前佛均, 清谷一馬, 莚田泰誠, 角田達彦, 森園隆, 久保充明, 谷川原祐介, 今村知世, 平田公一, 大住省三, 山川卓, 笹三徳, 中村祐輔
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウイルス性肝細胞がんの全ゲノムシークエンス解析2011

    • Author(s)
      中川英刀, 藤本明洋, 角田達彦, 長崎正朗, 柴田龍弘, 十時泰, 上野昌樹, 川上由育, 山田晃正, 茶山一彰, 山上裕機, 宮野悟, 中村祐輔
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 網羅的遺伝子発現解析に基づいた浸潤性膀胱癌におけるCaGおよびM-VAC術前化学療法に対する反応性予測2011

    • Author(s)
      加藤陽一郎, 前佛均, 高田亮, 小原渉, 角田達彦, 中村祐輔, 藤岡知昭
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 日本人の前立腺癌発症に関連する遺伝子多型を組み合わせた発症リスク予測モデルの構築2011

    • Author(s)
      高田亮, 赤松秀輔, 中川英刀, 高橋篤, Nguyen Ha, 久保充明, 角田達彦, 鎌谷直之, 羽渕友則, 小川修, 中村祐輔, 藤岡知昭
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 全ゲノム解析の衝撃-疾患関連遺伝子研究の爆発的進展2011

    • Author(s)
      角田達彦
    • Organizer
      バイオスーパーコンピューティング・シンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2011-02-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 次世代シークエンサーを用いた日本人一個体の全ゲノムシークエンスと遺伝的多様性の包括的解析2010

    • Author(s)
      藤本明洋, 中川英刀, 細野直哉, 中野かおる, 阿部哲雄, 長崎正朗, 山口類, 渋谷哲朗, 久保充明, 宮野悟, 中村祐輔, 角田達彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 次世代シーケンサーとタイリングアレイの転写解析データの比較検証2010

    • Author(s)
      宮冬樹, 岡田洋平, 阿部哲雄, 森園隆, 鎌谷直之, 岡野栄之, 角田達彦
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analyzing contiguous homozygosity to quantify haplotype structure differences between case and control samples.2010

    • Author(s)
      T.Johnson, T.Tanaka, M.Kubo, Y.Nakamura, T.Tsunoda.
    • Organizer
      The American Society of Human Genetics 60th Annual Meeting (ASHG 2010)
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Whole genome sequencing and accurate variant calls of a Japanese individual using massively parallel sequencing.2010

    • Author(s)
      A.Fujimoto, H.Nakagawa, N.Hosono, K.Nakano, T.Abe, M.Nagasaki, R.Yamaguichi, T.Shibuya, M.Kubo, S.Miyano, Y.Nakamura, T.Tsunoda.
    • Organizer
      American Society of Human Genetics 60th Annual Meeting (ASHG 2010)
    • Place of Presentation
      Washigton DC, USA
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Analyzing contiguous homozygosity to quantify haplotype structure differences between case and control samples.2010

    • Author(s)
      Johnson A.Todd, 田中敏博, 久保充明, 中村祐輔, 角田達彦
    • Organizer
      日本人類遺伝学会第55回大会
    • Place of Presentation
      大宮市
    • Year and Date
      2010-10-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] 国際がんゲノムコンソーシアムにおける情報解析2010

    • Author(s)
      藤本明洋, 渋谷哲朗, 宮野悟, 中村祐輔, 中川英刀, 角田達彦
    • Organizer
      ゲノムテクノロジー第164委員会第34回研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.riken.jp/r-world/info/release/press/2010/101025

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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