| Co-Investigator(Kenkyū-buntansha) |
INANOBE Atsushi 大阪大学, 大学院医学系研究科, 准教授 (00270851)
ASAI Yoshiyuki 沖縄科学技術大学院大学, オープンバイオロジーユニット, グループリーダー (00415639)
FURUTANI Kazuharu 大阪大学, 大学院医学系研究科, 助教 (40452437)
TSUMOTO Kunichika 大阪大学, 大学院医学系研究科, 助教 (70353331)
NOMURA Taishin 大阪大学, 基礎工学研究科, 教授 (50283734)
SASAKI Hiroyuki 帝京平成大学, 健康医療スポーツ学部, 教授 (60170693)
AitHaddou Rachid 大阪大学, 臨床医工学融合研究教育センター, 特任講師 (50506574)
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| Budget Amount *help |
¥182,390,000 (Direct Cost: ¥140,300,000、Indirect Cost: ¥42,090,000)
Fiscal Year 2014: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
Fiscal Year 2013: ¥35,620,000 (Direct Cost: ¥27,400,000、Indirect Cost: ¥8,220,000)
Fiscal Year 2012: ¥37,310,000 (Direct Cost: ¥28,700,000、Indirect Cost: ¥8,610,000)
Fiscal Year 2011: ¥36,920,000 (Direct Cost: ¥28,400,000、Indirect Cost: ¥8,520,000)
Fiscal Year 2010: ¥43,420,000 (Direct Cost: ¥33,400,000、Indirect Cost: ¥10,020,000)
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| Outline of Final Research Achievements |
We have defined a structured language, Physiological Hierarchy Markup language (PHML), for describing computational models in the field of systems biology and physiology. We have also developed a versatile open platform (PhysioDesigner and Flint) for multilevel modeling and simulation of physiological systems described by the PHML.
We have carried out experimental and simulation studies on the mechanism determining the rhythm of the heart beat and arrhythmias. Physiological or pharmacological changes of cardiac ion channels, such as G protein-gated potassium channel and hERG channel, in vitro, were measured, and the obtained data were integrated into theoretical model of cardiac action potential. This made it possible to predict the effects of these changes on the cardiac function. Through these studies, we have demonstrated that the ion channel function and regulation as well as its localization in the cardiomyocyte were crucial importance to predict changes in the cardiac function.
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