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Continued development of a comprehensive computational platform for Systems Biology

Planned Research

Project AreaEstablishment of Integrative Multi-level Systems Biology and its Applications
Project/Area Number 22136003
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionOkinawa Institute of Science and Technology Graduate University

Principal Investigator

KITANO Hiroaki  沖縄科学技術大学院大学, 統合オープンシステムユニット, 教授 (80500256)

Research Collaborator MATSUOKA Yukiko  システムバイオロジー研究機構, シニアリサーチャー
GHOSH Samik  システムバイオロジー研究機構, シニアリサーチャー
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥110,240,000 (Direct Cost: ¥84,800,000、Indirect Cost: ¥25,440,000)
Fiscal Year 2014: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2013: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2012: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥21,060,000 (Direct Cost: ¥16,200,000、Indirect Cost: ¥4,860,000)
Fiscal Year 2010: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
Keywordsシグナル伝達 / ゲノム / 情報工学 / シミュレーション工学 / 循環器 / システムズバイオロジー / 生理学的モデル / 多階層モデル / システム創薬 / 心臓モデル / 代謝循環モデル / システムバイオロジー / ソフトウェア基盤 / 国際標準 / 細胞モデル
Outline of Final Research Achievements

Development of the project-wide software platform is the mission of the group. Based on cellular level modeling that is relatively well established, we have expanded our platform to be able to create multi-scale physiological model for drug effect predictions. PhysioDesigner modeling software, PHML description language, and Flint simulation core have been developed and widely distributed. In parallel, we have delved into molecular interactions for broad-coverage high precision docking simulation using machine learning and parallel execution of multiple docking strategies. Furthermore, Garuda alliance was formed and the official version of Garuda Platform was released, and now widely used by pharmaceutical companies. Combined together, we have accomplished our initial commitment of platform development, and we consider it is very successful.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (157 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (28 results) (of which Peer Reviewed: 28 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (88 results) (of which Invited: 34 results) Book (17 results) Remarks (13 results) Patent(Industrial Property Rights) (11 results) (of which Overseas: 5 results)

  • [Journal Article] Oscillation of cAMP and Ca(2+) in cardiac myocytes: a systems biology approach2015

    • Author(s)
      Kamide T, Okumura S, Ghosh S, Shinoda Y, Mototani Y, Ohnuki Y, Jin H, Cai W, Suita K, Sato I, Umemura M, Fujita T, Yokoyama U, Sato M, Furutani K, Kitano H, Ishikawa Y
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 65(2) Issue: 2 Pages: 195-200

    • DOI

      10.1007/s12576-014-0354-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] システム制御学のもたらす変革~人間の認知限界を突破するために~2015

    • Author(s)
      北野宏明
    • Journal Title

      実験医学

      Volume: 33 Pages: 100-108

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Software Platform for Systems Biology2014

    • Author(s)
      浅井義之, 安部武志, 松岡由紀子, Samik Ghosh, 北野宏明
    • Journal Title

      Drug Delivery System

      Volume: 29 Issue: 5 Pages: 386-396

    • DOI

      10.2745/dds.29.386

    • NAID

      130004874238

    • ISSN
      0913-5006, 1881-2732
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生物学者のためのシステムサイエンス入門(第6回)2014

    • Author(s)
      北野宏明
    • Journal Title

      QIAGEN eyes

      Volume: 11 Pages: 7-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 情報プラットフォームと人工知能の登場2014

    • Author(s)
      北野宏明
    • Journal Title

      実験医学

      Volume: 32 Pages: 2981-2988

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] モデル構築におけるロバストネスとノイズ2014

    • Author(s)
      北野宏明
    • Journal Title

      実験医学

      Volume: 32 Pages: 2302-2311

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生物学者のためのシステムサイエンス入門(第5回)2014

    • Author(s)
      北野宏明
    • Journal Title

      QIAGEN eyes

      Volume: 10 Pages: 7-9

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 役立つモデルを作るのに必要なこと2014

    • Author(s)
      北野宏明
    • Journal Title

      実験医学

      Volume: 32 Pages: 1797-1802

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腫瘍内遺伝的多様性の数理2014

    • Author(s)
      北野宏明
    • Journal Title

      SURGERY FRONTIER

      Volume: 21 Pages: 72-74

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physiome.jp におけるモデルデータベースとモデリング・シミュレーションプラットフォームとの連携2014

    • Author(s)
      浅井義之, 野村泰伸, 北野宏明
    • Journal Title

      計測と制御

      Volume: 53 Pages: 426-431

    • NAID

      130005457952

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Versatile Platform for Multilevel Modeling of Physiological Systems: SBML-PHML Hybrid Modeling and Simulation2014

    • Author(s)
      Asai Y, Abe T, Oka H, Okita M, Hagihara K, Ghosh S, Matsuoka Y, Kurachi Y, Nomura T, Kitano H
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 3 Issue: 0 Pages: 50-58

    • DOI

      10.14326/abe.3.50

    • NAID

      130005001705

    • ISSN
      2187-5219
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] システムバイオロジーをオープニング・ゲームに使う~細胞老化研究の事例2014

    • Author(s)
      11.北野宏明
    • Journal Title

      実験医学

      Volume: 32 Pages: 1288-1294

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling of rifampicin-induced CYP3A4 activation dynamics for the prediction of clinical drug-drug interactions from in vitro data2013

    • Author(s)
      Fumiyoshi Yamashita, Yukako Sasa, Shuya Yoshida, Akihiro Hisaka, Yoshiyuki Asai, Hiroaki Kitano, Mitsuru Hashida, Hiroshi Suzuki
    • Journal Title

      PLoS One

      Volume: 8(9) Issue: 9 Pages: 1-11

    • DOI

      10.1371/journal.pone.0070330

    • NAID

      120005343920

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Harnessing Diversity towards the Reconstructing of Large Scale Gene Regulatory Networks2013

    • Author(s)
      Takeshi Hase, Samik Ghosh, Ryota Yamanaka, Hiroaki Kitano
    • Journal Title

      PLOS Computational Biology

      Volume: 9(11) Issue: 11 Pages: e1003361-e1003361

    • DOI

      10.1371/journal.pcbi.1003361

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology2013

    • Author(s)
      Kun-Yi Hsin, Samik Ghosh and Hiroaki Kitano
    • Journal Title

      PLOS ONE

      Volume: 8(12) Issue: 12 Pages: e83922-e83922

    • DOI

      10.1371/journal.pone.0083922

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adding Protein Context to the Human Protein-Protein Interaction Network to Reveal Meaningful Interactions2013

    • Author(s)
      Martin H. Schaefer, Tiago J. S. Lopes, Nancy Mah, Jason E. Shoemaker, Yukiko Matsuoka, Jean-Fred Fontaine, Caroline Louis-Jeune, Amie J. Eisfeld, Gabriele Neumann, Carol Perez-Iratxeta, Yoshihiro Kawaoka, Hiroaki Kitano, Miguel A. Andrade-Navarro
    • Journal Title

      PLOS Computational Biology

      Volume: 9 Issue: 1 Pages: 1-1

    • DOI

      10.1371/journal.pcbi.1002860

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of dosage-sensitive genes in Saccharomyces cerevisiae using the genetic tug-of-war method2013

    • Author(s)
      Koji Makanae, Reiko Kintaka, Takashi Makino, Hiroaki Kitano and Hisao Moriya
    • Journal Title

      Genome Research

      Volume: 23 Issue: 2 Pages: 300-311

    • DOI

      10.1101/gr.146662.112

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A framework for mapping, visualisation and automatic model creation of signal-transduction networks2012

    • Author(s)
      Carl-Fredrik Tiger, Falko Krause, Gunnar Cedersund, Robert Palmer, Edda Klipp, Stefan Hohmann, Hiroaki Kitano and Marcus Krantz
    • Journal Title

      Molecular Systems Biology

      Volume: 8 Issue: 1 Pages: 578-578

    • DOI

      10.1038/msb.2012.12

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Software support for SBGN maps: SBGN-ML and LibSBGN2012

    • Author(s)
      Martijn P. van Iersel, Alice C. Villéger, Tobias Czauderna, Sarah E. Boyd, Frank T. Bergmann, Augustin Luna, Emek Demir, Anatoly Sorokin, Ugur Dogrusoz, Yukiko Matsuoka, Akira Funahashi, Mirit I. Aladjem, Huaiyu Mi, Stuart L. Moodie, Hiroaki Kitano, Nicolas Le Novère, and Falk Schreiber
    • Journal Title

      Bioinformatics

      Volume: 28(15) Issue: 15 Pages: 2016-2021

    • DOI

      10.1093/bioinformatics/bts270

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTen: a web-based platform for identifying enriched cell types from heterogeneous microarray data2012

    • Author(s)
      Jason E Shoemaker, Tiago JS Lopes, Samik Ghosh, Yukiko Matsuoka, Yoshihiro Kawaoka and Hiroaki Kitano
    • Journal Title

      BMC Genomics

      Volume: 13(1) Issue: 1 Pages: 460-460

    • DOI

      10.1186/1471-2164-13-460

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Integrated network analysis reveals a novel role for the cell cycle in 2009 pandemic influenza virus-induced inflammation in macaque lungs2012

    • Author(s)
      Jason E Shoemaker, Satoshi Fukuyama, Amie J Eisfeld, Yukiko Muramoto, Shinji Watanabe, Tokiko Watanabe, Yukiko Matsuoka, Hiroaki Kitano and Yoshihiro Kawaoka
    • Journal Title

      BMC Systems Biology

      Volume: 6 Issue: 1 Pages: 117-117

    • DOI

      10.1186/1752-0509-6-117

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Social engineering for virtual 'big science' in systems biology2011

    • Author(s)
      Hiroaki Kitano, Samik Ghosh, Yukiko Matsuoka
    • Journal Title

      Nature Chemical Biology

      Volume: 7 Issue: 6 Pages: 323-326

    • DOI

      10.1038/nchembio.574

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Software for systems biology : from tools to integrated platforms2011

    • Author(s)
      Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Kun-Yi Hsin, Hiroaki Kitano
    • Journal Title

      Nature Reviews Genetics

      Volume: 12 Issue: 12 Pages: 821-832

    • DOI

      10.1038/nrg3096

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Large-Scale Analysis of Network Bistability for Human Cancers2010

    • Author(s)
      Tetsuya Shiraishi, Shinako Matsuyama, Hiroaki Kitano
    • Journal Title

      PLoS Computational Biology

      Volume: 6(7)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A comprehensive molecular interaction map of the budding yeast cell cycle2010

    • Author(s)
      Kazunari Kaizu, Samik Ghosh, Yukiko Matsuoka, Hisao Moriya, Yuki Shimizu-Yoshida, Hiroaki Kitano
    • Journal Title

      Molecular Systems Biology

      Volume: 6 Pages: 415-415

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] システムバイオロジーにおける情報基盤2010

    • Author(s)
      北野宏明、松岡由紀子、Samik Ghosh
    • Journal Title

      計測と制御

      Volume: 49(8) Pages: 507-512

    • NAID

      10026585732

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 細胞シミュレータCellDesignerの設計と実装2010

    • Author(s)
      船橋啓、松岡由紀子、上樂明也、瀧沢大夢、広井賀子、Samik Ghosh、菊池紀広、北野宏明
    • Journal Title

      計測と制御

      Volume: 49(8) Pages: 531-536

    • NAID

      10026585798

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Connecting the dots : role of standardization and technology sharing in biological simulation2010

    • Author(s)
      船橋啓、松岡由紀子、上樂明也、瀧沢大夢、広井賀子、Samik Ghosh、菊池紀広、北野宏明
    • Journal Title

      Drug Discovery Today

      Volume: 15 Pages: 1024-1031

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Day AI Wins Nobel Prize: Toward Advanced Intelligence that Transforms the Way We do Biomedical Research2015

    • Author(s)
      Kitano, H.
    • Organizer
      MIME-FIT Workshop: Challenges and Future Directions in Systems Medicine and Health ICT
    • Place of Presentation
      Clayton Campus, Monash University, Australia
    • Year and Date
      2015-03-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The Day AI Wins Nobel Prize: Toward Advanced Intelligence that Transforms the Way We do Biomedical Research2015

    • Author(s)
      Kitano, H.
    • Organizer
      2015 Hunter Meeting
    • Place of Presentation
      Crown Plaza Hunter Valley, Lovedale, Australia
    • Year and Date
      2015-03-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Disruptive Innovation in Computational Platform for Systems Biology2015

    • Author(s)
      Kitano, H.
    • Organizer
      Grant-in-Aid for Scientific Research on Innovative Area “HD-Physiology” The Final HD-Physiology Report Meeting
    • Place of Presentation
      Osaka University Nakanoshima Center
    • Year and Date
      2015-03-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] PhysioDesigner 1.2 (poster)2015

    • Author(s)
      Yoshiyuki Asai, Takeshi Abe and Hiroaki Kitano
    • Organizer
      Grant-in-Aid for Scientific Research on Innovative Area “HD-Physiology” The Final HD-Physiology Report Meeting
    • Place of Presentation
      Osaka University Nakanoshima Center
    • Year and Date
      2015-03-04 – 2015-03-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Flint and Flint K3: Simulations of Biophysiological models (poster)2015

    • Author(s)
      Takeshi Abe, Yoshiyuki Asai, Masao Okita, Miho Nagai, Ken-ichi Hagihara and Hiroaki Kitano.
    • Organizer
      Grant-in-Aid for Scientific Research on Innovative Area “HD-Physiology” The Final HD-Physiology Report Meeting
    • Place of Presentation
      Osaka University Nakanoshima Center
    • Year and Date
      2015-03-04 – 2015-03-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Combining machine learning systems and multiple docking simulations for network pharmacology (poster)2015

    • Author(s)
      Kun-Yi Hsin, Yukiko Matsuoka, Samik Ghosh and Hiroaki Kitano.
    • Organizer
      High Definition Physiology symposium
    • Place of Presentation
      Osaka University Nakanoshima Center
    • Year and Date
      2015-03-04 – 2015-03-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] The day AI wins Nobel Prize2015

    • Author(s)
      Kitano, H.
    • Organizer
      AAAI Workshop on “Beyond the Turing Test”
    • Place of Presentation
      Hyatt Regency in Austin, Texas, USA
    • Year and Date
      2015-01-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] In-silico approach in assessing anti-influenza agents and their targets using comprehensive pathway map (FluMap) (poster)2015

    • Author(s)
      Kun-Yi Hsin, Yukiko Matsuoka and Hiroaki Kitano.
    • Organizer
      4th Negative Strand Virus-Japan
    • Place of Presentation
      Raguna Garden Hotel, Ginowan, Okinawa
    • Year and Date
      2015-01-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] PhysioDesignerによる多階層モデリング2014

    • Author(s)
      浅井義之, 北野宏明
    • Organizer
      ネットワークが創発する知能研究会」・「データ指向構成マイニングとシミュレーション研究会」合同秋合宿2014
    • Place of Presentation
      沖縄科学技術大学院大学 (沖縄県恩納村)
    • Year and Date
      2014-12-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Galaxyを迅速に活用するための仮想環境の構築 (poster)2014

    • Author(s)
      芦崎晃一, 山中遼, 大田達郎, 油谷浩幸, 北野宏明
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Garuda Platform: An integrated software solution for data-driven medical sciences2014

    • Author(s)
      Kitano, H.
    • Organizer
      World Health Summit 2014
    • Place of Presentation
      Federal Foreign Office, Berlin, Germany
    • Year and Date
      2014-10-20
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] A framework for simulation of neural network models driven by experimental spike timing data2014

    • Author(s)
      Yoshiyuki Asai, Hiroaki Kitano and Alessandro E.P. Villa.
    • Organizer
      Neural Coding 2014
    • Place of Presentation
      Versailles Cedex, France
    • Year and Date
      2014-10-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of multilevel neural network modeling integrating spike train data on PhysioDesigner2014

    • Author(s)
      Asai, Y., Abe, T., Li, L., Oka, H., Kurachi, Y. and Kitano, H.
    • Organizer
      Advances in Neuroinformatics 2014 (AINI2014)
    • Place of Presentation
      RIKEN, Wako, Saitama, Japan
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Systems Biology and Applications2014

    • Author(s)
      Kitano, H.
    • Organizer
      ICSB 2014
    • Place of Presentation
      Melbourne Convention and Exhibition Centre
    • Year and Date
      2014-09-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Systems Drug Discovery and Software Platform2014

    • Author(s)
      Kitano, H.
    • Organizer
      ICSB 2014
    • Place of Presentation
      Melbourne Convention and Exhibition Centre
    • Year and Date
      2014-09-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Using molecular simulations for network pharmacology (poster)2014

    • Author(s)
      Hsin, KY., Ghosh, S. and Kitano, H
    • Organizer
      EuroQSAR 2014-20th European Symposium
    • Place of Presentation
      St. Petersburg, Russia
    • Year and Date
      2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Interoperability between multilevel modeling platform PhysioDesigner and with databases in Physiome.jp and Dynamic Brain Platform through Garuda platform (poster)2014

    • Author(s)
      Asai, Y., Kuwae, K., Li, L., Kitano, H., Wagatsuma, H. and Yamaguchi, Y.
    • Organizer
      Neuroinformatics2014
    • Place of Presentation
      Leiden, Netherlands
    • Year and Date
      2014-08-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fly to the future of biology2014

    • Author(s)
      Ghosh, S. and Kitano, H
    • Organizer
      ISMB 2014
    • Place of Presentation
      John B. Hynes Memorial Convention Center, Boston, USA
    • Year and Date
      2014-07-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] システム毒性学の戦略とプラットフォーム技術2014

    • Author(s)
      北野宏明
    • Organizer
      第41回日本毒性学会学術年会 シンポジウム:毒性オミクス-遺伝子発現ネットワークを標的とした、治療、毒性、及びそれらの評価の新動向-
    • Place of Presentation
      神戸コンベンションセンター
    • Year and Date
      2014-07-02
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Physiome.jpのモデルデータベースならびにツール連携の開発2014

    • Author(s)
      浅井義之, 安部武志, Li, L., 岡秀樹, 野村泰伸, 北野宏明
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] PhysioDesignerによる多階層生体機能モデリングサポート技術の進展2014

    • Author(s)
      浅井義之, 安部武志, Li, Li, 岡秀樹, 倉智嘉久, 北野宏明
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター (宮城県仙台市)
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 多階層生体機能学のさらなる発展2014

    • Author(s)
      北野宏明
    • Organizer
      多階層生体機能学シンポジウム
    • Place of Presentation
      ナレッジキャピタルコングレコンベンションセンター (大阪府)
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] フィジオームを指向した階層的モデリング/シミュレーション基盤2014

    • Author(s)
      浅井義之, 安部武志 , 北野宏明
    • Organizer
      公益社団法人 日本薬剤学会第29年会
    • Place of Presentation
      大宮ソニックシティビル (埼玉県)
    • Year and Date
      2014-05-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The 2nd PhysioDesigner tutorial2014

    • Author(s)
      Asai, Y., T. Abe, L. Li and H. Kitano
    • Organizer
      The 2nd PhysioDesigner tutorial
    • Place of Presentation
      Osaka University Nakanoshima center, Osaka, Japan
    • Year and Date
      2014-04-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Multiscale disease systems modelling2014

    • Author(s)
      Kitano, H.
    • Organizer
      7th Noordwijkerhout Symposium on Pharmacokinetics, Pharmacodynamics and Systems Pharmacology: “SYSTEMS PHARMACOLOGY IN DRUG DISCOVERY AND DEVELOPMENT”
    • Place of Presentation
      NH Conference Centre Leeuwenhorst, Noordwijkerhout, the Netherlands
    • Year and Date
      2014-04-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Frontiers of Systems Biology and Software Platform2014

    • Author(s)
      Kitano, H.
    • Organizer
      Seminar at L’OREAL Research & Innovation
    • Place of Presentation
      L’OREAL Research & Innovation, Aulnay-sous-Bois, France.
    • Year and Date
      2014-04-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Garuda platformを介したDynamic Brain platformとモデリング開発・シミュレーション環境をつなぐ連携システム開発2014

    • Author(s)
      浅井義之・桑江健・北野宏明・我妻広・ 山口陽子
    • Organizer
      ニューロコンピューティング研究会(NC)
    • Place of Presentation
      九州工業大学 (福岡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Systems Drug Design and Software Platform for Adverse Drug Effects: Application to TKI Cardiotoxicity2014

    • Author(s)
      Kitano, H.
    • Organizer
      American Society for Clinical Pharmacology and Therapeutics (ASCPT) 2014 Annual Meeting
    • Place of Presentation
      Atlanta Marriott Marquis (Atlanta, Georgia, USA)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] システム・バイオロジーの展開と今後の可能性2014

    • Author(s)
      北野宏明
    • Organizer
      第75回冠循環談話会
    • Place of Presentation
      東京国際フォーラム (東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] HD-Physiology Project -A Japanese Flagship Physiological Modeling Project-2013

    • Author(s)
      Kitano, H.
    • Organizer
      The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
    • Place of Presentation
      丸の内 MY PLAZA HALL (東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Flint K3: Cloud-based simulation service powered by Flint (poster)2013

    • Author(s)
      Yoshiyuki Asai, Takeshi Abe, Masao Okita, Tomohiro Okuyama, Ken-ichi Hagihara, Yoshihisa Kurachi, Hiroaki Kitano.
    • Organizer
      The 2nd HD-Physiology International Symposium 2013
    • Place of Presentation
      丸の内 MY PLAZA HALL (東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A versatile platform for multilevel modeling of physiological systems: Template/instance2013

    • Author(s)
      Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Masao Okita, Tomohiro Okuyama, Ken-ichi Hagihara, Samik Ghosh, Yukiko Matsuoka, Yoshihisa Kurachi, Hiroaki Kitano.
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology
    • Place of Presentation
      Osaka International Convention Center (Osaka, Japan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Systems biology and systems biomedicine: integrative systems sciences and biomedical sciences2013

    • Author(s)
      Kitano, H.
    • Organizer
      35th Annual International Conference of the IEEE Engineering in Medicine and Biology
    • Place of Presentation
      Osaka International Convention Center (Osaka, Japan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] HD-Physiology Project -A Japanese Flagship Physiological Modeling Project-2013

    • Author(s)
      Kitano, H.
    • Organizer
      ICSU bio-unions satellite symposium: Multi-Scale Systems Biology
    • Place of Presentation
      Chicheley Hall (Chicheley, UK)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Systems Biology Platform for Drug Discovery2013

    • Author(s)
      Kitano, H.
    • Organizer
      Talk at Imperial College London
    • Place of Presentation
      Imperial College (London, UK)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] PhysioDesigner for Multilevel Neural System Modeling (poster)2013

    • Author(s)
      Yoshiyuki Asai, Hideki Oka, Li Li, Takeshi Abe, Yoshihisa Kurachi and Hiroaki Kitano.
    • Organizer
      Neuroinformatics2013
    • Place of Presentation
      Karolinska Institutet (Sweden)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Systems Drug Discovery and Integrated Software Platform2013

    • Author(s)
      Kitano, H.
    • Organizer
      Talk at ETH Zurich IMSB
    • Place of Presentation
      ETH Zurich IMSB (Zurich, Switzerland)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Multilevel modeling using SBML and PHML on PhysioDesigner (poster)2013

    • Author(s)
      Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Yukiko Matsuoka, Ghosh Samik, Yoshihisa Kurachi, Hiroaki Kitano
    • Organizer
      ICSB2013
    • Place of Presentation
      Copenhagen (Denmark)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Systems Biology and Software Platform2013

    • Author(s)
      Kitano, H.
    • Organizer
      Nature Publishing Group Asian Academic Publishing team meeting
    • Place of Presentation
      Sheraton Miyako Hotel (Tokyo)
    • Related Report
      2013 Annual Research Report
  • [Presentation] PhysioDesigner and Flint: a platform for multilevel modeling of physiological systems and simulation (poster)2013

    • Author(s)
      Asai, Yoshiyuki; Abe, Takeshi; Oka, Hideki; Okita, Masao; Okuyama, Tomohiro; Hagihara, Ken-ichi; Kurachi, Yoshihisa; Kitano, Hiroaki.
    • Organizer
      ICCB2013
    • Place of Presentation
      Leuven (Belgium)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Garuda Platform: An integrated inter-operability for biomedical software and data resources2013

    • Author(s)
      Kitano, H.
    • Organizer
      COMBINE 2013
    • Place of Presentation
      Institut Curie (Paris, France)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Versatile Platform for Multilevel Modeling of Physiological Systems: SBML-PHML Hybrid Modeling and Simulation (poster)2013

    • Author(s)
      Yoshiyuki Asai, Takeshi Abe, Hideki Oka, Masao Okita, Ken-ichi Hagihara, Samik Ghosh, Yukiko Matsuoka, Yoshihisa Kurachi, Taishin Nomura, Hiroaki Kitano
    • Organizer
      生体医工学シンポジウム2013
    • Place of Presentation
      九州大学 (福岡)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多階層生体機能学:モデル創薬から臨床推論サポートまで2013

    • Author(s)
      北野宏明
    • Organizer
      金沢医科大学 第15回KMU研究推進セミナー
    • Place of Presentation
      金沢医科大学病院 (石川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] システム創薬の現状と今後の展望2013

    • Author(s)
      北野宏明
    • Organizer
      アスビオファーマ社内セミナー
    • Place of Presentation
      アスビオファーマ株式会社 (東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] システムズバイオロジーのための京コンピュータへの期待2013

    • Author(s)
      北野宏明 (北野宏明)
    • Organizer
      第4回スーパーコンコンピュータ「京」と創薬・医療の産学連携セミナー -HPCI計算生命科学推進プログラム-
    • Place of Presentation
      フクラシア東京ステーション
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Systems Drug Design and Software Platform for drug efficacy and adverse effects prediction2013

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      FDA Workshop: Systems Pharmacology for the Prediction of Tyrosine Kinase Inhibitor non-QT Cardiotoxicity
    • Place of Presentation
      FDA White Oak Campus, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Systems biomedicine and their computational platforms2012

    • Author(s)
      Kitano, H
    • Organizer
      Seminar at IMCS
    • Place of Presentation
      Institute of Molecular and Cell Biology (Singapore)(招待講演)
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Systems biomedicine and their computational platforms2012

    • Author(s)
      Kitano, H
    • Organizer
      HGM2012
    • Place of Presentation
      Sydney Convention & Exhibition Centre (Australia)(招待講演)
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Garuda Overview/Garuda use case challenge : Yeast Signaling pathway curation2012

    • Author(s)
      Kitano, H
    • Organizer
      Garada Seven Workshop
    • Place of Presentation
      沖縄科学技術大学院大学・シーサイドハウス
    • Year and Date
      2012-02-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] HD-Physiology Project Overview2012

    • Author(s)
      Kitano, H
    • Organizer
      The 1^<st> HD Physiology International Symposium
    • Place of Presentation
      東京大学・武田ホール(招待講演)
    • Year and Date
      2012-01-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Will engineering play the lead role in drug discovery in 2030?2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      BioMelbourne breakfast
    • Place of Presentation
      Cinema 1, Melbourne, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Software Platform for Systems Drug Discovery2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      Bio-IT World Asia Conference 2012
    • Place of Presentation
      Marina Bay Sands, Singapore
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Systems Drug Design and Garuda Software Platform.2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      Network Biology SIG: On the Analysis and Visualization of Network in Biology (NetBio SIG), ISMB 2012
    • Place of Presentation
      Long Beach Convention Center, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] HD-Physiology, Garuda, and Computational drug side-effects prediction2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      Talk at FDA
    • Place of Presentation
      FDA, Silver Spring, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Biological Robustness2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      Seminar at University of Toronto
    • Place of Presentation
      University of Toronto, Canada
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Systems Biology powered by Artificial Intelligence2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      PRICAI-2012: 12th Pacific Rim International Conference on Artificial Intelligence
    • Place of Presentation
      Pullman Hotel, Kuching, Malaysia (via skype)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] VPH in industrial research2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      VPH 2012
    • Place of Presentation
      Savoy Place, London, UK
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] システム創薬とGarudaプラットフォームの概要2012

    • Author(s)
      北野宏明 (北野宏明)
    • Organizer
      BioJapan 2012
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Systems biomedicine and their computational platforms2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      FOSBE 2012
    • Place of Presentation
      Institute for Advanced Biosciences, Keio University
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] システムバイオロジー概論2012

    • Author(s)
      北野宏明 (北野宏明)
    • Organizer
      第6回KASTシステムバイオロジー講座
    • Place of Presentation
      かながわサイエンスパーク
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Systems Toxicology2012

    • Author(s)
      Kitano, H (Kitano, H)
    • Organizer
      An invited talk at DSTO, Defence Science and Technology Organisation (DSTO), Department of Defence, Australian Government
    • Place of Presentation
      Melbourne, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Data-Driven Network-Based Biomarker Discovery2012

    • Author(s)
      北野宏明 (北野宏明)
    • Organizer
      第35会 日本分子生物学会年会 バイオテクノロジーセミナー
    • Place of Presentation
      福岡国際会議場
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Systems Drug Design2011

    • Author(s)
      Kitano, H
    • Organizer
      Lecture at Fudan University
    • Place of Presentation
      Fudan University, Shanghai, China(招待講演)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Systems Drug Design2011

    • Author(s)
      Kitano, H
    • Organizer
      Lecture at Chinese Academy of Sciences
    • Place of Presentation
      Chinese Academy of Sciences, Shanghai, China(招待講演)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] HD-Physiology Project and the Garuda Alliance Software and Resource Platform2011

    • Author(s)
      Kitano, H
    • Organizer
      The 4^<th> Global COE International Symposium on Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
    • Place of Presentation
      大阪・千里中央ホテル(招待講演)
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Garuda Goals2011

    • Author(s)
      Kitano, H
    • Organizer
      Garuda Six Workshop
    • Place of Presentation
      Pavilion Skip, Luxembourg
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] How networks can be used to find diagnostic and therapeutic candidates2011

    • Author(s)
      Kitano, H
    • Organizer
      International Conference on Systems Biology 2011 (ICSB2011)
    • Place of Presentation
      University of Heidelberg, Germany(招待講演)
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Garuda Vision and Goals2011

    • Author(s)
      Kitano, H
    • Organizer
      Garuda Five Workshop
    • Place of Presentation
      University of Heidelberg
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Act Beyond Borders2011

    • Author(s)
      Kitano, H
    • Organizer
      International Conference on Systems Biology 2011 (ICSB2011)
    • Place of Presentation
      Rosengarten Conference Center, Mannheim, Germany(招待講演)
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Integrated experimental and computational analysis for the dynamics of Tamoxifen resistance in MCF-7 cell lines2011

    • Author(s)
      Kang, H.; Ghosh, S.; Suzuki, K.; Matsuoka, Y.; Kitano, H
    • Organizer
      International Conference on Systems Biology 2011 (ICSB2011)
    • Place of Presentation
      Rosengarten Conference Center, Mannheim, Germany(poster presentation)
    • Year and Date
      2011-08-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] システムバイオロジーの起源と展開(Origin and progress of systems biology)2011

    • Author(s)
      Hiroaki Kitano
    • Organizer
      NC-BIO合同研究会
    • Place of Presentation
      琉球大学50周年記念館(招待講演)
    • Year and Date
      2011-06-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] A modeling/simulation platform for multi-level physiological functions2011

    • Author(s)
      Yoshiyuki Asai, Yoshiyuki Kido, Hideki Oka, Taishin Nomura, Hiroaki Kitano
    • Organizer
      新学術領域研究全体会議
    • Place of Presentation
      大阪大学中之島センター
    • Year and Date
      2011-06-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Towards an integrated platform for biophysical modeling2011

    • Author(s)
      Hiroaki Kitano, Yoshiyuki Asai, Kun-Yi Hsin, Sami Ghosh, Yukuko Matsuoka
    • Organizer
      新学術領域研究全体会議
    • Place of Presentation
      大阪大学中之島センター
    • Year and Date
      2011-06-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] An Open Platform toward Large-scale Multilevel Modeling and Simulation of Physiological Systems2011

    • Author(s)
      Yoshiyuki Asai, Hideki Oka, Takeshi Abe, Masao Okita, Ken-ichi Hagihara, Taishin Nomura, Hiroaki Kitano
    • Organizer
      The 11th IEEE/IPSJ International Symposium on Applications and the Internet (SAINT2011)
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2011-06-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Towards a simulation platform for multi-level neuronal networks2011

    • Author(s)
      Yoshiyuki Asai, Hideki Oka, Taishin Nomura, Hiroaki Kitano
    • Organizer
      The 3rd International Conference on Cognitive Neurodynamics (3rd ICCN)
    • Place of Presentation
      北海道ニセコ町ヒルトンニセコヴィレッジ
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Systems Drug Discovery and Platform Design2011

    • Author(s)
      Hiroaki Kitano
    • Organizer
      15^<th> Human Genome Meeting : Genomics of Human Diversity and Heritable Disorders
    • Place of Presentation
      Dubai International Convention & Exhibition Centre, Dubai, UAE(招待講演)
    • Year and Date
      2011-03-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Systems Medicine and Systems Drug Design as the Grand Challenge in 21st Century2011

    • Author(s)
      Hiroaki Kitano
    • Organizer
      BioComplexity Symposium : Systems Biology Approach to Systems Drug Discovery and Systems Medicine
    • Place of Presentation
      NUHS Tower Block, Singapore(招待講演)
    • Year and Date
      2011-02-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] システムバイオロジーと創薬・医療応用2011

    • Author(s)
      北野宏明
    • Organizer
      「生命をはかる」研究会第33回研究会
    • Place of Presentation
      東陽テクニカ(招待講演)
    • Year and Date
      2011-02-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] iPathways-biological pathways on your palm!2011

    • Author(s)
      Ghosh, S.; Matsuoka, Y.; Kitano, H
    • Organizer
      International Conference on Systems Biology 2011 (ICSB2011)
    • Place of Presentation
      Rosengarten Conference Center, Mannheim, Germany(poster presentation)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Systems Drug Design2010

    • Author(s)
      Hiroaki Kitano
    • Organizer
      Systems Biology at the Interface of Metabolism and Signal Transduction
    • Place of Presentation
      VU University Amsterdam, The Netherlands(招待講演)
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] システム創薬-がんのシステム的理解と創薬への応用-2010

    • Author(s)
      北野宏明
    • Organizer
      神奈川科学技術アカデミー(KAST)教育講座システムバイオロジー講座2010
    • Place of Presentation
      神奈川科学技術アカデミー(KAST),神奈川県(招待講演)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Systems Robustness and Systems Failures in Biology, Medicine, and Engineering2010

    • Author(s)
      Hiroaki Kitano
    • Organizer
      A*STAR Scientific Conference 2010
    • Place of Presentation
      A*STAR, Singapore(招待講演)
    • Year and Date
      2010-11-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Systems Biology and Drug Discovery2010

    • Author(s)
      Hiroaki Kitano
    • Organizer
      National University of Singapore, Biochemistry Seminar
    • Place of Presentation
      National University of Singapore(招待講演)
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] An Open-flow Paradigm for Curation and Enrichment of Biological Pathways2010

    • Author(s)
      Samik Ghosh, Yukiko Matsuoka, Hiroaki Kitano
    • Organizer
      International Conference of Systems Biology (ICSB2010)
    • Place of Presentation
      Edinburgh International Conference Centre, UK
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] PathText : Integrating Text Mining Resources with Biological Pathway Visualizations2010

    • Author(s)
      Brian Kemper, Takuya Matsuzaki, Yukiko Matsuoka, Yoshimasa Tsuruoka, Hiroaki Kitano, Jun'ichi Tsujii, Sophia Ananiadou
    • Organizer
      International Conference of Systems Biology (ICSB2010)
    • Place of Presentation
      Edinburgh International Conference Centre, UK
    • Year and Date
      2010-10-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] Systems drug discovery and software platform for healthcare research and services2010

    • Author(s)
      Hiroaki Kitano
    • Organizer
      InCoB (International Conference on Bioinformatics)
    • Place of Presentation
      東京・早稲田大学(招待講演)
    • Year and Date
      2010-09-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hitting Robustness2010

    • Author(s)
      Hiroaki Kitano
    • Organizer
      16^<th> World Congress on Basic and Clinical Pharmacology (WorldPharma 2010)
    • Place of Presentation
      Bella Center Copenhagen, Denmark(招待講演)
    • Year and Date
      2010-07-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Rationale of Garuda and introduction to Garuda-2 workshop2010

    • Author(s)
      Hiroaki Kitano
    • Organizer
      Garuda Two Workshop
    • Place of Presentation
      Manchester Interdisciplinary Biocentre, UK
    • Year and Date
      2010-07-05
    • Related Report
      2010 Annual Research Report
  • [Book] Dr.北野のゼロから始めるシステムバイオロジー2015

    • Author(s)
      北野宏明
    • Total Pages
      191
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] Modeling and Simulation Using CellDesigner. Transcription Factor Regulatory Networks. Methods in Molecular Biology2014

    • Author(s)
      Matsuoka, Y., A. Funahashi, S. Ghosh and H. Kitano
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] システム論的アプローチとは? [実験医学2014年1月号]2014

    • Author(s)
      北野宏明
    • Publisher
      株式会社 羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] システムバイオロジーと創薬-実例を交えて [実験医学2014年3月号]2014

    • Author(s)
      北野宏明
    • Publisher
      株式会社 羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 生物学者のためのシステムサイエンス入門(第4回)[QIAGEN eyes]2014

    • Author(s)
      北野宏明
    • Publisher
      QIAGEN
    • Related Report
      2013 Annual Research Report
  • [Book] The Grand Challenge of Systems Biomedicine [World Health Summit Yearbook 2013]2014

    • Author(s)
      Kitano, H
    • Publisher
      Janssen Global Services, LLC
    • Related Report
      2013 Annual Research Report
  • [Book] 生物学者のためのシステムサイエンス入門(第1回)[QIAGEN eyes]2013

    • Author(s)
      北野宏明
    • Publisher
      QIAGEN
    • Related Report
      2013 Annual Research Report
  • [Book] 生物学者のためのシステムサイエンス入門(第2回)[QIAGEN eyes]2013

    • Author(s)
      北野宏明
    • Publisher
      QIAGEN
    • Related Report
      2013 Annual Research Report
  • [Book] システムバイオロジーとは何か? [実験医学2013年11月号]2013

    • Author(s)
      北野宏明
    • Publisher
      株式会社 羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 生物学者のためのシステムサイエンス入門(第3回)[QIAGEN eyes]2013

    • Author(s)
      北野宏明
    • Publisher
      QIAGEN
    • Related Report
      2013 Annual Research Report
  • [Book] Toward an integrated software platform for systems pharmacology [Biopharmaceutics & Drug Disposition]2013

    • Author(s)
      Samik Ghosh; Yukiko Matsuoka; Yoshiyuki Asai; Kun-Yi Hsin; Hiroaki Kitano.
    • Publisher
      John Wiley & Sons, Ltd.
    • Related Report
      2013 Annual Research Report
  • [Book] 実験医学2013年1月号, 31, 12013

    • Author(s)
      北野宏明
    • Publisher
      がんの多様性の数理
    • Related Report
      2012 Annual Research Report
  • [Book] Cancer Systems Biology: A Robustness-Based Approach. HANDBOOK OF SYSTEMS BIOLOGY CONCEPTS AND INSIGHTS2012

    • Author(s)
      Hiroaki Kitano (Hiroaki Kitano)
    • Publisher
      Academic Press
    • Related Report
      2012 Annual Research Report
  • [Book] Springer2012

    • Author(s)
      Samik. Ghosh et al. (Samik Ghosh and Anshu Bhardwaj)
    • Publisher
      Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis. Systems Biology of Tuberculosis
    • Related Report
      2012 Annual Research Report
  • [Book] Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis(書籍タイトル:Systems Biology of Tubarculosis,)2012

    • Author(s)
      Samik Ghosh, Yukiko Matsuoka, Yoshiyuki Asai, Hiroaki Kitano, Anshu Bhardwaj, Vinod Scaria, Rohit Vashisht, Anup Shah, Anupam Kumar Mondal, Priti Vishnoi, Kumari Sonal, Akanksha Jain, Priyanka Priyadarshini, Kausik Bhattacharyya, Vikas Kumar, Anurag Passi, Pratibha Sharma, Open Source Drug Discovery Consortium, Samir Brahmachari
    • Publisher
      Springer(In press)
    • Related Report
      2011 Annual Research Report
  • [Book] Cancer Robustness and Therapy Strategies(書籍タイトル:Cancer Systems Biology, Bioinformatics and Medicine)2011

    • Author(s)
      Kitano, H
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report
  • [Book] システム創薬とソフトウエア プラットフォーム(書籍タイトル:遺伝子医学MOOK別冊「最新創薬インフォマティクス活用マニュアル」)2011

    • Author(s)
      松岡由希子, 浅井義之, Samik Ghosh, 北野宏明
    • Publisher
      株式会社メディカル ドゥ
    • Related Report
      2011 Annual Research Report
  • [Remarks] HD-Physiology Project

    • URL

      http://hd-physiology.jp

    • Related Report
      2014 Annual Research Report
  • [Remarks] PhysioDesigner

    • URL

      http://www.physiodesigner.org

    • Related Report
      2014 Annual Research Report
  • [Remarks] Flint

    • URL

      http://www.physiodesigner.org/simulation/flint/index.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] HD-Physiology Project

    • URL

      http://hd-physiology.jp

    • Related Report
      2013 Annual Research Report
  • [Remarks] PhysioDesigner

    • URL

      http://physiodesigner.org

    • Related Report
      2013 Annual Research Report
  • [Remarks] Flint K3

    • URL

      https://flintk3.org

    • Related Report
      2013 Annual Research Report
  • [Remarks] HD-Physiology

    • URL

      http://hd-physiology.jp/

    • Related Report
      2012 Annual Research Report
  • [Remarks] PhysioDesigner

    • URL

      http://www.physiodesigner.org/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://hd-physiology.jp/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://physiodesigner.org/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.garuda-alliance.org/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://hd-physiology.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://physiodesigner.org/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] INTERACTION PREDICTION DEVICE, INTERACTION PREDICTION METHOD AND PROGRAM2014

    • Inventor(s)
      Hiroaki Kitano 他
    • Industrial Property Rights Holder
      OIST, SBI
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-06-13
    • Related Report
      2014 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ソーシャルネットワークインターフェイスを使用した汎用シミュレーションシステム2014

    • Inventor(s)
      浅井義之 他
    • Industrial Property Rights Holder
      OIST, SBI
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-560177
    • Filing Date
      2014-12-15
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] ネットワークモデル統合装置、ネットワークモデル統合システム、ネットワークモデル統合方法、および、プログラム2013

    • Inventor(s)
      北野宏明, 松岡由希子, Samik Ghosh
    • Industrial Property Rights Holder
      OIST, SBI
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-159876
    • Filing Date
      2013-07-31
    • Acquisition Date
      2014-10-31
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 相互作用予測装置、相互作用予測方法、および、プログラム2013

    • Inventor(s)
      北野宏明, Kun-Yi Hsin, Samik Ghosh
    • Industrial Property Rights Holder
      OIST, SBI
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-06-13
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] General-Purpose Simulation System Using Social Network Interface2013

    • Inventor(s)
      浅井義之他
    • Industrial Property Rights Holder
      OIST, SBI
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-07-11
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] データ通信システム、データ解析装置、データ通信方法、および、プログラム2013

    • Inventor(s)
      北野宏明, Samik Ghosh, 松岡由希子
    • Industrial Property Rights Holder
      SBI, SBX, OIST
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-11-07
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 相互作用予測装置、相互作用予測方法、および、プログラム2012

    • Inventor(s)
      北野宏明, Kun-Yi Hsin, Samik Ghosh
    • Industrial Property Rights Holder
      システム・バイオロジー研究機構, 沖縄科学技術大学院大学学園
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-134261
    • Filing Date
      2012-06-13
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] データ通信システム、データ解析装置、データ通信方法、および、プログラム2012

    • Inventor(s)
      北野宏明, Samik Ghosh, 松岡由希子
    • Industrial Property Rights Holder
      沖縄科学技術大学院大学他
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-245326
    • Filing Date
      2012-11-07
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] General-Purpose Simulation System Using Social Network Interface2012

    • Inventor(s)
      Yoshiyuki Asai et al.
    • Industrial Property Rights Holder
      OIST; SBI; Osaka University
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-07-12
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ネットワークモデル統合装置、ネットワークモデル統合システム、ネットワークモデル統合方法、および、プログラム2010

    • Inventor(s)
      北野宏明, 松岡由希子, Samik Ghosh
    • Industrial Property Rights Holder
      OIST, SBI
    • Industrial Property Rights Type
      特許
    • Filing Date
      2010-10-01
    • Acquisition Date
      2013-08-09
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] ネットワークモデル統合装置、ネットワークモデル統合システム、ネットワークモデル統合方法、および、プログラム2010

    • Inventor(s)
      北野宏明、松岡由希子、サミック ゴーシュ
    • Industrial Property Rights Holder
      独立行政法人沖縄科学技術研究基盤整備機構、特定非営利活動法人システム・バイオロジー研究機構
    • Industrial Property Number
      2010-224308
    • Filing Date
      2010-10-01
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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