| Budget Amount *help |
¥58,240,000 (Direct Cost: ¥44,800,000、Indirect Cost: ¥13,440,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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| Outline of Final Research Achievements |
For understanding of physiological system, it is essential to validate in silico physiological and pathological platform by biological experiments. The following two themes in this 5-year project were carried out; (i) the development of new synthetic methods capable of efficiently producing chemical compounds and (ii) the supply of chemical compounds utilized in biological experiments to validate the platform. During this project, we succeeded in developing a number of new synthetic methods applicable to an easy access to chemical compounds with unique skeletons as well as the synthesis of the derivatives with structural variations. In addition, collaborative researches with many groups in the project “HD physiology” were performed through the supply of the chemical compounds synthesized by us. These results could not only contribute to the progress of the “HD physiology” project but also give practical and useful information for drug-discovery research.
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