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Integrative simulation of electrophysiological activities in the heart reflecting multi-level data

Planned Research

Project AreaEstablishment of Integrative Multi-level Systems Biology and its Applications
Project/Area Number 22136011
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Complex systems
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

NAKAZAWA Kazuo  独立行政法人国立循環器病研究センター, 研究所, 室長 (50198058)

Co-Investigator(Kenkyū-buntansha) HARAGUCHI Ryo  国立循環器病研究センター, 情報統括部, 室長 (00393215)
SHIMIZU Wataru  日本医科大学, 大学院医学研究科, 大学院教授 (50399606)
ASHIHARA Takashi  滋賀医科大学, 医学部, 助教 (80396259)
IKEDA Takanori  東邦大学, 医学部, 教授 (80256734)
IJIRI Takashi  理化学研究所, 光量子工学研究領域, 基礎科学特別研究員 (30550347)
Co-Investigator(Renkei-kenkyūsha) AIBA Takeshi  国立循環器病研究センター, 病院, 医長 (40574348)
NAMBA Tunetoyo  姫路獨協大学, 医療保健学部臨床工学科, 教授 (70331866)
YAMAGUCHI Takeshi  金沢大学, 医薬保健研究域医学系, 助教 (60532182)
SUGIMACHI Masaru  国立循環器病研究センター, 研究所, 部長 (40250261)
YOKOTA Hideo  理化学研究所, 生物情報基盤構築チーム, チームヘッド (00261206)
Research Collaborator SHIBATA Nitaro  新宿三井ビルクリニック, 院長
Project Period (FY) 2010-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥58,240,000 (Direct Cost: ¥44,800,000、Indirect Cost: ¥13,440,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Keywords不整脈 / シミュレーション
Outline of Final Research Achievements

Introducing experimental multilevel data based from the ion channel level to the organ morphology level, many functional simulation studies were conducted for a comprehensive understanding of the electrophysiological phenomena in the heart. Actually, to incorporate various experimental multilevel data into a heart model and execute simulations according to the purpose are difficult tasks. It is important to optimize a model as much as possible for an effective and comprehensible simulation. As the consequences, the importance of inhomogeneity of the cells in the sinus node, the validity of the ablation surgery for chronic atrial fibrillation and so on were indicated. In addition, by applying the technique of computer graphics, a real time beating heart simulator executable on a general-purpose PC was developed.

Report

(6 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (150 results)

All 2015 2014 2013 2012 2011 2010 Other

All Journal Article (43 results) (of which Peer Reviewed: 22 results,  Open Access: 1 results,  Acknowledgement Compliant: 6 results) Presentation (85 results) (of which Invited: 4 results) Book (11 results) Remarks (11 results)

  • [Journal Article] FSKイオンチャネルモデルを用いた心臓興奮伝播の機能的シミュレーション2015

    • Author(s)
      中沢一雄, 稲田慎, 原口亮, 相庭武司, 井尻敬, 池田隆徳, 芦原貴司
    • Journal Title

      生体医工学

      Volume: 53(3)

    • NAID

      130005106900

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] ヒトiPS細胞由来心筋細胞シートの不整脈研究への応用可能性:in silico 不整脈学の観点から2015

    • Author(s)
      芦原貴司, 黒川洵子, 諫田泰成, 原口亮, 稲田慎, 中沢一雄, 堀江稔
    • Journal Title

      生体医工学

      Volume: 53(3)

    • NAID

      130005106893

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] コンピュータシミュレーションによるプルキンエ起源の心室性不整脈発生機序の検討2015

    • Author(s)
      稲田慎, Daniel T. Harrell, 原口亮, 芦原貴司, 蒔田直昌, 中沢一雄
    • Journal Title

      生体医工学

      Volume: 53(3)

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Shape Mataching 法による心臓拍動のビジュアルシミュレーション2015

    • Author(s)
      井尻敬, 芦原貴司, 梅谷信行, 小山裕己, 五十嵐健夫, 原口亮, 横田秀夫, 中沢一雄
    • Journal Title

      生体医工学

      Volume: 53(3)

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Importance of gradients in membrane properties and electrical coupling in sinoatrial node pacing2014

    • Author(s)
      InadaS, Zhang H, TellezJO, ShibataN, Nakazawa K, Kamiya K, Kodama I, Mitsui K, Dobrzynski H, Boyett MR, Honjo H
    • Journal Title

      PLoS ONE

      Volume: 4 Issue: 4 Pages: e94565-e94565

    • DOI

      10.1371/journal.pone.0094565

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 基礎研究 コンピュータシミュレーションによる洞結節不均一構造重要性の検討2014

    • Author(s)
      稲田慎, 中沢一雄
    • Journal Title

      循環器病研究の進歩

      Volume: 35(1) Pages: 69-80

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Importance of clinical analysis in this era of new technology of molecular genetic screening2014

    • Author(s)
      Shimizu W
    • Journal Title

      J Am Coll Cardio

      Volume: 64(1) Issue: 1 Pages: 80-82

    • DOI

      10.1016/j.jacc.2014.04.023

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and Genetic Diagnosis for Inherited Cardiac Arrhythmias2014

    • Author(s)
      Shimizu W
    • Journal Title

      Journal of Nippon Medical School

      Volume: 81 Issue: 4 Pages: 203-210

    • DOI

      10.1272/jnms.81.203

    • NAID

      130004725094

    • ISSN
      1345-4676, 1347-3409
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 三次元心臓モデルのリアルタイム形状変形を実現するマルチタッチインタラクションシステムの技術開発2014

    • Author(s)
      小山裕己, 五十嵐健夫, 井尻敬, 稲田慎, 黒嵜健一, 白石公, 中沢一雄
    • Journal Title

      医療情報学

      Volume: 34(5) Pages: 221-232

    • NAID

      130005148399

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence and prognosis of patients with lone and paroxysmal atrial tachyarrhythmias showing Brugada-type electrocardiograms after class IC antiarrhythmic drug administration but no risk-stratifying factors2013

    • Author(s)
      Atsuko Abe,Tadashi Fujino,Shunji Fukunaga,Hitomi Yuzawa, Hideyuki Sato,Takeya Suzuki, Kenzaburo Kobayashi, Yoshifumi Okano, Kentaro Nakamura, Satoru Yusu, Hideaki Yoshino, Takashi Ashihara, Kazuo Nakazawa, Takanori Ikeda
    • Journal Title

      Journal of Arrhythmia

      Volume: 29(2) Issue: 2 Pages: 138-142

    • DOI

      10.1016/j.joa.2012.12.011

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features of Brugada syndrome2013

    • Author(s)
      Wataru Shimizu
    • Journal Title

      Journal of Arrhythmia

      Volume: 29(2) Issue: 2 Pages: 65-70

    • DOI

      10.1016/j.joa.2013.01.009

    • NAID

      130004415131

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Journal Article] Update of Diagnosis and Management of Inherited Cardiac Arrhythmias2013

    • Author(s)
      Wataru Shimizu
    • Journal Title

      Circulation Journal

      Volume: 77 Issue: 12 Pages: 2867-2872

    • DOI

      10.1253/circj.CJ-13-1217

    • NAID

      10031203564

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2013 Annual Research Report
  • [Journal Article] Double tachycardia after slow pathway ablation for atrioventricular nodal tachycardia: what is the mechanism?2013

    • Author(s)
      Makimoto H
    • Journal Title

      J Cardiovasc Electrophysiol

      Volume: 24 Issue: 2 Pages: 233-236

    • DOI

      10.1111/jce.12004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of cilostazol in a patient with recurrent ventricular fibrillation associated with early repolarization syndrome2013

    • Author(s)
      Iguchi K
    • Journal Title

      Heart Rhythm

      Volume: 10 Issue: 4 Pages: 604-606

    • DOI

      10.1016/j.hrthm.2012.11.001

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 心拍制御メカニズムの解明を目指した心房心室間興奮伝導シミュレーション2013

    • Author(s)
      小野多佳子
    • Journal Title

      電子情報通信学会技術研究報告

      Volume: MBE2012-88 Pages: 1-6

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 不整脈診断のためのコンピュータシミュレーション解析2013

    • Author(s)
      芦原貴司
    • Journal Title

      循環器内科

      Volume: 73

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 連載「モデル解析の視点」:第5回「プルキンエ線維は電気的除細動の成否に関与するのかしないのか?」2013

    • Author(s)
      芦原貴司
    • Journal Title

      心電図

      Volume: 33

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 第III部 心電図・不整脈との格闘:コンピュータモデリング:心電学・不整脈学領域のシミュレーション2013

    • Author(s)
      芦原貴司
    • Journal Title

      日本心電学会30周年記念誌

      Volume: in press

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome2012

    • Author(s)
      Hiro Kawata
    • Journal Title

      Heart Rhythm

      Volume: 9 Issue: 1 Pages: 77-83

    • DOI

      10.1016/j.hrthm.2011.08.017

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical impact of the number of extrastimuli in programmed electrical stimulation in patients with Brugada type 1 electrocardiogram2012

    • Author(s)
      Hisaki Makimoto
    • Journal Title

      Heart Rhythm

      Volume: 9 Issue: 2 Pages: 242-248

    • DOI

      10.1016/j.hrthm.2011.09.053

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics and risk of arrhythmia recurrences in patients with idiopathic ventricular fibrillation associated with early repolarization.2012

    • Author(s)
      Watanabe H
    • Journal Title

      Int J Cardiol.

      Volume: 159 Issue: 3 Pages: 238-40

    • DOI

      10.1016/j.ijcard.2012.05.091

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seasonal and Circadian Distributions of Cardiac Events in Genotyped Patients With Congenital Long QT Syndrome2012

    • Author(s)
      Takigawa M
    • Journal Title

      Circulation Journal

      Volume: 76 Issue: 9 Pages: 2112-2118

    • DOI

      10.1253/circj.CJ-12-0213

    • NAID

      10030696408

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological Blockade of <I>I</I><SUB>Ks</SUB> Destabilizes Spiral-Wave Reentry Under <I>&beta;</I>-Adrenergic Stimulation in Favor of Its Early Termination2012

    • Author(s)
      Kato S, Ashihara T, et al.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 119 Issue: 1 Pages: 52-63

    • DOI

      10.1254/jphs.12008FP

    • NAID

      10030760299

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Kinematic Approach for Efficient and Robust Simulation of the Cardiac Beating Motion2012

    • Author(s)
      Ijiri T, Ashihara T, Umetani N, Igarashi T, Haraguchi R, Yokota H, Nakazawa K
    • Journal Title

      PloS One

      Volume: 7(5) Issue: 5 Pages: 1-9

    • DOI

      10.1371/journal.pone.0036706

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation : Implications for electrogram-based catheter ablation2012

    • Author(s)
      Ashihara T, Haraguchi R, Nakazawa K, Namba T, Ikeda T, Nakazawa Y, Ozawa T, Ito M, Horie M, Trayanova NA
    • Journal Title

      Circ Res

      Volume: 110 Issue: 2 Pages: 275-284

    • DOI

      10.1161/circresaha.111.255026

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk stratification for serious arrhythmic events using nonsustained ventricular tachycardia and heart rate turbulence detected by 24-hour Holter electrocardiograms in patients with left ventricular dysfunction.2012

    • Author(s)
      Miwa Y, Yoshino H, Hoshida K, Miyakoshi M, Tsukada T, Yusu S, Ikeda T
    • Journal Title

      Ann Noninvasive Electrocardiol

      Volume: 17 Issue: 3 Pages: 1-8

    • DOI

      10.1111/j.1542-474x.2012.00522.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of late potentials for 24 hours between Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy using a novel signal-averaging system based on Holter ECG.2012

    • Author(s)
      Abe A, Kobayashi K, Yuzawa H, Sato H, Fukunaga S, Fujino T, Okano Y, Yamazaki J, Miwa Y, Yoshino H, Ikeda T
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 5 Issue: 4 Pages: 789-95

    • DOI

      10.1161/circep.111.969865

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irregular wide QRS complex tachycardia without structural heart disease2012

    • Author(s)
      Kobayashi K
    • Journal Title

      Journal of Arrhythmia

      Volume: 28 Issue: 5 Pages: 307-309

    • DOI

      10.1016/j.joa.2012.05.008

    • NAID

      130002129503

    • ISSN
      1880-4276, 1883-2148
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts2012

    • Author(s)
      Yamazaki M, Ashihara T, et al.
    • Journal Title

      Heart Rhythm

      Volume: 9 Issue: 1 Pages: 107-114

    • DOI

      10.1016/j.hrthm.2011.08.013

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 連載「モデル解析の視点」:第4回「トンネル伝播仮説で電気的除細動の強度-反応曲線を説明できるか?」2012

    • Author(s)
      芦原貴司
    • Journal Title

      心電図

      Volume: 32 Pages: 443-447

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 連載「モデル解析の視点」:第3回「心室壁内部の分極を可視化して電気的除細動のメカニズムに迫る」2012

    • Author(s)
      芦原貴司
    • Journal Title

      心電図

      Volume: 32 Pages: 363-366

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 連載「モデル解析の視点」:第2回「電気的除細動において心室壁の内部は分極するのかしないのか?」2012

    • Author(s)
      芦原貴司
    • Journal Title

      心電図

      Volume: 32 Pages: 249-252

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 連載「モデル解析の視点」:第1回「電気的除細動では心臓全体が脱分極してリセットされるのか?」2012

    • Author(s)
      芦原貴司
    • Journal Title

      心電図

      Volume: 32 Pages: 161-164

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Phenotypical manifestations of mutations in genes encoding subunits of cardiac potassium channels2011

    • Author(s)
      Shimizu W
    • Journal Title

      Circ Res

      Volume: 109 Pages: 97-109

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular screening of long-QT syndrome : risk is there or rare?2011

    • Author(s)
      Aiba T
    • Journal Title

      Heart Rhythm

      Volume: 8 Issue: 3 Pages: 420-421

    • DOI

      10.1016/j.hrthm.2010.12.002

    • Related Report
      2011 Annual Research Report
  • [Journal Article] システムバイオロジーと遺伝性不整脈2011

    • Author(s)
      芦原貴司
    • Journal Title

      循環器内科

      Volume: 70 Pages: 483-492

    • Related Report
      2011 Annual Research Report
  • [Journal Article] バイドメインモデルによる電気的除細動メカニズムの研究2011

    • Author(s)
      芦原貴司
    • Journal Title

      医学のあゆみ

      Volume: 238 Pages: 229-236

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Usefulness of heart rate turbulence for predicting cardiac events in patients with nonischemic dilated cardiomyopathy2011

    • Author(s)
      Ikeda T
    • Journal Title

      J Electrocardiol

      Volume: 44 Issue: 6 Pages: 669-672

    • DOI

      10.1016/j.jelectrocard.2011.08.003

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] イオンチャネルモデルを用いた心筋組織に置ける興奮伝播シミュレーションーフィラメント解析による抗不整脈機構の検討2011

    • Author(s)
      稲田慎
    • Journal Title

      医学のあゆみ

      Volume: 238 Pages: 223-228

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Roles of Subcellular Na+ Channel Distributions in the Mechanism of Cardiac Conduction2011

    • Author(s)
      Tsumoto K
    • Journal Title

      Biophysical Journal

      Volume: 100(3) Pages: 554-563

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MR画像からの心臓形状構築システムの開発2011

    • Author(s)
      稲田慎
    • Journal Title

      電子情報通信学会技術研究報告.MI,医用画像

      Volume: 110(364) Pages: 143-146

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 心臓モデリングとコンピュータシミュレーションが導く不整脈研究の世界2010

    • Author(s)
      中沢一雄
    • Journal Title

      心臓

      Volume: 42(Suppl.4) Pages: 208-215

    • NAID

      130002146701

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 心臓再同期療法(CRT)と電気的逆リモデリング2010

    • Author(s)
      相庭武司
    • Journal Title

      心電図

      Volume: 30(3) Pages: 235-245

    • NAID

      130000432012

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遺伝性不整脈の現状と展望2015

    • Author(s)
      清水 渉
    • Organizer
      第29回日本医学会総会 2015 (関西)
    • Place of Presentation
      国立京都国際会館(京都市左京区宝ヶ池)
    • Year and Date
      2015-04-11 – 2015-04-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 医療における計算科学 ~循環器診療支援に向けて~2014

    • Author(s)
      中沢一雄
    • Organizer
      LIFE2014(生活生命支援医療福祉工学系学会連合大会2014)
    • Place of Presentation
      ルスツリゾート(北海道虻田郡留寿都村)
    • Year and Date
      2014-09-24 – 2014-09-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Investigating excitation conduction in the atrioventricular node and Purkinje network using computer simulation2014

    • Author(s)
      Shin Inada
    • Organizer
      The 9th Tawara-Aschoff Symposium
    • Place of Presentation
      東京プリンスホテル(東京都港区)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Evaluation excitation conduction between sinoatrial node and right atrium with a safety factor - A simulation study -2014

    • Author(s)
      Shin Inada
    • Organizer
      第29回日本不整脈学会/第31回日本心電学会合同学術大会
    • Place of Presentation
      ザ・プリンスパークタワー東京(東京都港区)
    • Year and Date
      2014-07-22 – 2014-07-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] コンピュータシミュレーションによる多階層生体機能学から循環器診療支援に向けて2014

    • Author(s)
      中沢一雄
    • Organizer
      第4回小児循環器遠隔医療研究会
    • Place of Presentation
      岡山コンベンションセンター(岡山市北区)
    • Year and Date
      2014-07-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Ventricular arrhythmia induced by the Purkinje network with reduced gap junction conductance -A simulation study-2014

    • Author(s)
      Shin Inada
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] Applicability of human iPS cell-derived myocardial sheet to the study of arrhythmias: A simulation study2014

    • Author(s)
      Takashi Ashihara
    • Organizer
      第53回日本生体医工学会大会
    • Place of Presentation
      仙台国際センター(仙台市青葉区)
    • Year and Date
      2014-06-24 – 2014-06-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] A simulation study of ventricular arrhythmias generated from the Purkinje network with gap junction mutation2014

    • Author(s)
      Shin Inada, Daniel T. Harrell, Ryo Haraguchi, Takashi Ashihara, Naomasa Makita, Kazuo Nakazawa
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
  • [Presentation] echnological Development of Heart Simulators for Various Computer Platforms in the Medical and Health-care Fields2014

    • Author(s)
      Kazuo Nakazawa, Shin Inada, Ryo Haraguchi, Takashi Ashihara, Isao Shiraishi, Ken-ichi Kurosaki, Suzu Kanzaki, Takeo Igarashi, Takashi Ijiri, Yuki Koyama, Takanori Ikeda
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Sciety
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] 構造的リモデリング下の心房筋における興奮伝播のシミュレーション2013

    • Author(s)
      芦原貴司
    • Organizer
      第 90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] Simulation study of excitation conduction in human atrioventricular node using action potential models constructed from messenger RNA data2013

    • Author(s)
      Inada S
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] A theoretical study on the mechanism of complex fractionated atrial electrograms with continuous deflection during chronic atrial fibrillation.2013

    • Author(s)
      Ashihara T
    • Organizer
      The 77th Annual Scientific Meeting of Japanese Circulation Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2013-03-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] コンピュータシミュレーションによる致死性不整脈発現の評価:心室較差と線維走向ねじれによる催不整脈性作用に着目して2013

    • Author(s)
      原口亮,芦原貴司,稲田慎,池田隆徳,中沢一雄
    • Organizer
      第33回日本ホルター・ノンインベイシブ心電学研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 心房細動に対するチャネル遮断薬のレートコントロール効果に関するシミュレーション研究―Ca2+ブロックとK+ブロックの比較―2013

    • Author(s)
      小野多佳子,稲田慎,柴田仁太郎,原口亮,Mark R. Boyett, Halina Dobrzynski, 三井和幸,中沢一雄
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] 虚血心筋における細胞内Na+チャネル分布リモデリングのI群抗不整脈薬による催不整脈増強作用2013

    • Author(s)
      津元国親,芦原貴司,原口亮,中沢一雄,倉智嘉久
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトips細胞分化心筋シートの薬効評価への応用可能性:in silico不整脈学の観点から2013

    • Author(s)
      芦原貴司,原口亮,中沢一雄,伊藤誠,堀江稔
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] 心房細動に対するジギタリスおよびベータ遮断によるレートコントロール機序のコンピュータシミュレーションによる検討2013

    • Author(s)
      稲田慎,小野多佳子,柴田仁太郎,原口亮,芦原貴司,Halina Dobrzynski, Mark R. Boyett, 三井和幸,池田隆徳,中沢一雄
    • Organizer
      第30回日本心電学会学術集会
    • Place of Presentation
      青森
    • Related Report
      2013 Annual Research Report
  • [Presentation] Multi-scale simulation studies of excitation conduction from the sinoatrial node to the ventricles in the heart,2013

    • Author(s)
      Shin Inada, Daniel T. Harrell, Takako Ono, Ryo Haraguchi, Takashi Ashihara, Halina Dobrzynski, Haruo Honjo, Nitaro Shibata, Takanori Ikeda, Kazuyuki Mitsui, Naomasa Makita, Itsuo Kodama, Mark R. Boyett, Kazuo Nakazawa
    • Organizer
      The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] eentrant beat in the Purkinje network associated with gap junction mutation - A simulation study -2013

    • Author(s)
      Shin Inada, Daniel T. Harrell, Ryo Haraguchi, Takashi Ashihara, Naomasa Makita, Kazuo Nakazawa
    • Organizer
      The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Rotational anisotropy prevents transition of tachycardia to fibrillation in ventricles under the large transmural dispersion of depolarisation - A simulation study -2013

    • Author(s)
      Ryo Haraguchi, Takashi Ashihara, Shin Inada, Takanori Ikeda, Kazuo Nakazawa
    • Organizer
      The 2nd HD Physiology International Symposium: Multi-Level Systems Biology
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Simulation studies of tachyarrhythmias in a 3-D ventricular wall model: implications for electrophysiological heterogeneity and rotational anisotropy2013

    • Author(s)
      Ryo Haraguchi, Takashi Ashihara, Shin Inada, Takanori Ikeda, Kazuo Nakazawa
    • Organizer
      35th Annual International IEEE EMBS Conference
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Simulation study of complex action potential conduction in atrioventricular node2013

    • Author(s)
      Shin Inada, Takako Ono, Nitaro Shibata, Michiaki Iwata, Ryo Haraguchi, Takashi Ashihara, Kazuyuki Mitsui, Mark R. Boyett, Halina Dobrzynski, Kazuo Nakazawa
    • Organizer
      35th Annual International IEEE EMBS Conference
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Simulation study of ventricular rate control therapy during atrial fibrillation using one-dimensional cable model with two conduction pathways2013

    • Author(s)
      Shin Inada, Takako Ono, Nitaro Shibata, Michiaki Iwata, Ryo Haraguchi, Takashi Ashihara, Atsuko Abe, Takanori Ikeda, Kazuyuki Mitsui, Mark R. Boyett, Halina Dobrzynski, Kazuo Nakazawa
    • Organizer
      0th International Congress on Electrocardiology
    • Place of Presentation
      Glasgow, United Kingdom
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional properties of complex fractionated atrial electrograms during atrial fibrillation can be explained by structural remodeling:: A simulation study2013

    • Author(s)
      Takashi Ashihara, Ryo Haraguchi, Shin Inada, Kazuo Nakazawa, Takanori Ikeda, T. Ozawa, Makoto Ito, Natalia Trayanova, Minoru Horie
    • Organizer
      40th International Congress on Electrocardiology
    • Place of Presentation
      Glasgow, United Kingdom
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional properties of complex fractionated atrial electrograms during atrial fibrillation can be explained by structural remodeling: A computational study2012

    • Author(s)
      Ashihara T
    • Organizer
      AHA 84th Scientific Sessions
    • Place of Presentation
      Los Angeles
    • Year and Date
      2012-11-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] 慢性心房細動における種々のComplex Fractionated Atrial Electrogramは構造的リモデリングの進展で説明できるか?2012

    • Author(s)
      芦原貴司
    • Organizer
      第28回心電情報処理ワー クショップ
    • Place of Presentation
      熱海
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] リアルタイム3次元心臓拍動シミュレータ2012

    • Author(s)
      井尻 敬
    • Organizer
      経済産業省デジタルコンテンツEXPO 2012
    • Place of Presentation
      東京
    • Year and Date
      2012-10-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 致死性不整脈の数理:バイドメインモデルによる電気的除細動メカニズムの理論的研究2012

    • Author(s)
      芦原貴司
    • Organizer
      GCOEシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-10-24
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 心室線維走向ねじれは心室較 差増大による催不整脈性を抑制する:3次元心室壁モデルによるシミュレーション研 究2012

    • Author(s)
      原口 亮
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-10-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心外膜面局所冷却による除細動の可能性:3次元心室壁モデルを用いたシミュレーションによる検討2012

    • Author(s)
      稲田 慎
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-10-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] 慢性心房細動におけるComplex Fractionated Atrial Electrogramは機能的か?:シミュレーションによる理論的検討2012

    • Author(s)
      芦原貴司
    • Organizer
      第29回日本心電学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2012-10-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Rotational anisotropy prevents transition of tachycardia to fibrillation in ventricles under the large transmural dispersion of repolarization2012

    • Author(s)
      Haraguchi R
    • Organizer
      The 5th APHRS,The 8th APAFS
    • Place of Presentation
      Taipei
    • Year and Date
      2012-10-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] Function of dual conduction pathway in atrioventricular node during Wenckebach periodicity: a simulation study2012

    • Author(s)
      Inada S
    • Organizer
      The 5th APHRS,The 8th APAFS
    • Place of Presentation
      Taipei
    • Year and Date
      2012-10-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mechanisms of CFAE-targeted ablation for chronic AF: A simulation study2012

    • Author(s)
      Ashihara T
    • Organizer
      The 5th APHRS,The 8th APAFS
    • Place of Presentation
      Taipei
    • Year and Date
      2012-10-03
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Application of biological simulations to the studies of ventricular defibrillation2012

    • Author(s)
      Ashihara T
    • Organizer
      The 5th APHRS,The 8th APAFS
    • Place of Presentation
      Taipei
    • Year and Date
      2012-10-03
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Dual conduction pathway in atrioventricular node acts as important roles to generate Wenckebach periodicity - A simulation study -2012

    • Author(s)
      Inada S
    • Organizer
      8th Tawara-Aschoff-Meeting
    • Place of Presentation
      Munich
    • Year and Date
      2012-08-29
    • Related Report
      2012 Annual Research Report
  • [Presentation] Epicardial cooling increases opportunity of spiral wave termination: a simulation study2012

    • Author(s)
      Inada S
    • Organizer
      ESC congress 2012
    • Place of Presentation
      Munich
    • Year and Date
      2012-08-25
    • Related Report
      2012 Annual Research Report
  • [Presentation] 持続性心房細動におけるComplex Fractionated Atrial Electrogram領域の電位 的特徴に関する理論的研究2012

    • Author(s)
      芦原貴司
    • Organizer
      第27回日本不整脈学会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2012-07-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] コンピュタシミュレーションによるウェンケバッハ現象の成因の検討 ―多重房室伝導路の役割―2012

    • Author(s)
      稲田慎
    • Organizer
      第32回日本ホルター・ノンインベイシブ心電学研究会
    • Place of Presentation
      新潟
    • Year and Date
      2012-06-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] 致死的不整脈防御機構としての心室較差および線維走向ねじれの電気生理学的意義2012

    • Author(s)
      原口亮
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心室冷却による除細動の可能性:シミュレーションによる検討2012

    • Author(s)
      稲田 慎
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 不整脈臨床医はマルチスケールシミュレー ションに何を求めるのか?2012

    • Author(s)
      芦原貴司
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] 心臓拍動計算のための異方性弾性を考慮したShape Matching法2012

    • Author(s)
      井尻 敬
    • Organizer
      第51回日本生体医工学 会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-05-10
    • Related Report
      2012 Annual Research Report
  • [Presentation] Theoretical basis of optimal strategy for CFAE-targeted ablation during chronic atrial fibrillation2012

    • Author(s)
      Ashihara T
    • Organizer
      Heart Rhythm 2012 Scientific Sessions
    • Place of Presentation
      Boston
    • Year and Date
      2012-05-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] Na+チャネルの細胞内再分布による催不整脈性の変化:Phase-2リエントリーとの関連において2012

    • Author(s)
      Tsumoto K
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Theoretical studies on the mechanisms of electrogram-based catheter ablation for chronic atrial fibrillation2012

    • Author(s)
      Ashihara T
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Phase-2 reentry associated with subcellular sodium channel remodeling : A possible mechanism of fibrillation induction in Brugada syndrome2012

    • Author(s)
      Tsumoto K
    • Organizer
      第76回日本循環器学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンピュータ不整脈学が拓く新しい薬効評価法の意義2012

    • Author(s)
      芦原貴司
    • Organizer
      第85回日本薬理学会年会:シンポジウム23「心機能評価法の新展開Frontiers in heart research」
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of subcellular sodium channel distribution in the mechanism of cardiac conduction2012

    • Author(s)
      Tsumoto K
    • Organizer
      第1回国際シンポジウム新学術領域研究「多階層生体機能学HD Physiology」
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2012-01-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms of electrogram-based catheter ablation for chronic atrial fibrillation2012

    • Author(s)
      Takashi Ashihara
    • Organizer
      第1回国際シンポジウム新学術領域研究「多階層生体機能学HD Physiology
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2012-01-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of Ca2+ channel blocker and beta-blocker on ventricular rate during atrial fibrillation2012

    • Author(s)
      Inada S
    • Organizer
      The 1^<st> HD Physiology Internatinal Symposium
    • Place of Presentation
      The University of Tokyo (Tokyo)
    • Year and Date
      2012-01-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ハイパーフォーマンスコンピューティングが拓く不整脈研究2012

    • Author(s)
      中沢一雄
    • Organizer
      第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2012-01-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Shape Matching法を用いた心臓拍動の計算手法2011

    • Author(s)
      井尻敬
    • Organizer
      第34回生物機械システム研究会
    • Place of Presentation
      大阪大学(大阪)
    • Year and Date
      2011-12-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Transmural Dispersion fo Repolarization Determines Scroll Wave Behavior During Ventricular Tachyarrhythmias-A Simulation Study2011

    • Author(s)
      Haraguchi R
    • Organizer
      The 4^<th> Global COE International Symposium on Phsiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
    • Place of Presentation
      千里阪急ホテル(大阪)
    • Year and Date
      2011-11-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] カテーテルアブレーションで慢性心房細動を停止できるか:In silicoによるCFAE標的アブレーションの検討2011

    • Author(s)
      芦原貴司
    • Organizer
      第27回心電情報処理ワークショップ
    • Place of Presentation
      石和温泉(山梨県笛吹)
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光学マッピングを用いた局所低温除細動における最適冷却領域の検討2011

    • Author(s)
      荒船龍彦
    • Organizer
      第27回心電情報処理ワークショップ
    • Place of Presentation
      石和温泉(山梨県笛吹)
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 循環器領域における生体システム学:コンピュータ不整脈学2011

    • Author(s)
      芦原貴司
    • Organizer
      文部科学省戦略的大学連携支援事業:広域大学連携による臨床医工学・情報学高度人材育成システムの構築
    • Place of Presentation
      大阪大学中之島センター(大阪)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心筋ナトリウムチャネルの細胞内分布変化が興奮伝導に及ぼす影響:in silico研究2011

    • Author(s)
      津元国親
    • Organizer
      第104回近畿生理学談話会
    • Place of Presentation
      大阪医科大学(大阪)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of subcellular sodium channel distribution on the initiation of hase-2 reentry : A possible mechanism of fibrillation induction in Brugada syndrome2011

    • Author(s)
      Tsumoto K
    • Organizer
      4th APHRS (Asia-Pacific Heart Rhythm Society)
    • Place of Presentation
      Hilton Fukuoka Sea Hawk (Fukuoka)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Rotational anisotropy prevents transition of tachycardia to fibrillation in the ventricular wall model with large transmural dispersion of repolarization : A simulation study2011

    • Author(s)
      Haraguchi R
    • Organizer
      4th APHRS (Asia-Pacific Heart Rhythm Society)
    • Place of Presentation
      Hilton Fukuoka Sea Hawk (Fukuoka)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Noninvasive Risk Stratification for Sudden Death in Patients with Asymptomatic Brugada-Type Electrocardiograms2011

    • Author(s)
      Ikeda T
    • Organizer
      4th APHRS (Asia-Pacific Heart Rhythm Society)
    • Place of Presentation
      Hilton Fukuoka Sea Hawk (Fukuoka)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stability of ventricular fibrillation is altered by wall deformation after the onset of fibrillation2011

    • Author(s)
      Inada S
    • Organizer
      4th APHRS (Asia-Pacific Heart Rhythm Society)
    • Place of Presentation
      Hilton Fukuoka Sea Hawk (Fukuoka)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Simulation study of effect of antiarrhythmic drugs on ventricular rate during atrial fibrillation2011

    • Author(s)
      Inada S
    • Organizer
      4th APHRS (Asia-Pacific Heart Rhythm Society)
    • Place of Presentation
      Hilton Fukuoka Sea Hawk (Fukuoka)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanisms of complex fractionated electrogram-targeted ablation in a model for chronic atrial fibrillation2011

    • Author(s)
      Ashihara T
    • Organizer
      4th APHRS (Asia-Pacific Heart Rhythm Society)
    • Place of Presentation
      Hilton Fukuoka Sea Hawk (Fukuoka)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] コンピュータシミュレーションコンピュータ心電図の進歩:オーバービュー2011

    • Author(s)
      芦原貴司
    • Organizer
      日本心電学会:特別企画II
    • Place of Presentation
      ヒルトン福岡シーホーク(福岡)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] An Efficient, Robust Framework For Simulating the Beating Heart2011

    • Author(s)
      Takashi Ijiri
    • Organizer
      23rd Conference of the Society for Medical Innovation and Technology
    • Place of Presentation
      Tel Aviv, Israel
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of fibroblasts/myofibroblasts in the mechanisms of CFAEs during chronic atrial fibrillation and CFAE-targeted catheter ablation : A simulation study2011

    • Author(s)
      Ashihara T
    • Organizer
      第75回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2011-08-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 理論不整脈学からみた慢性心房細動アブレーションとその展望2011

    • Author(s)
      芦原貴司
    • Organizer
      第4回AEC関西
    • Place of Presentation
      阪急ターミナルビル(大阪)
    • Year and Date
      2011-06-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] 致死的不整脈防御機構としての心室較差の電気生理学的意義~シミュレーションによる検討~2011

    • Author(s)
      原口亮
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学(東京)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 幾何制約に基づく運動計算手法を用いた実時間心臓拍動シミュレーション2011

    • Author(s)
      井尻敬
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学(東京)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 心室筋厚と心室細動の持続性との関係:シミュレーションによる検討2011

    • Author(s)
      稲田慎
    • Organizer
      第50回日本生体医工学会大会
    • Place of Presentation
      東京電機大学(東京)
    • Year and Date
      2011-04-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Autonomic Nerve System and Electrophysiological Risk Stratification Indices : Overview2011

    • Author(s)
      Ikeda T
    • Organizer
      36th ISCE (International Society of Computerized Electrocardiography)
    • Place of Presentation
      Dolce Hayes Mansion (San Jose)
    • Year and Date
      2011-04-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Heart Rate Turbulence and Late Potentials Related to Autonomic Nerve System2011

    • Author(s)
      Ikeda T
    • Organizer
      36th ISCE (International Society of Computerized Electrocardiography)
    • Place of Presentation
      Dolce Hayes Mansion (San Jose)
    • Year and Date
      2011-04-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] QT measures and T wave altemans2011

    • Author(s)
      Ikeda T
    • Organizer
      60th ACC (American College of Cardiology)
    • Place of Presentation
      New Orleans
    • Year and Date
      2011-04-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] リアルタイムリエントリ旋回中心認識と局所冷却手法による除細動メカニズムの解明2010

    • Author(s)
      荒船龍彦
    • Organizer
      第26回心電情報処理ワークショップ
    • Place of Presentation
      福島・ホテルリステル猪苗代
    • Year and Date
      2010-10-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心筋ナトリウムチャネルの細胞内局在の興奮伝導への影響2010

    • Author(s)
      津元国親
    • Organizer
      第27回日本心電学会学術集会
    • Place of Presentation
      大分全日空ホテル
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラットPurkinje線維の電子顕微鏡観察2010

    • Author(s)
      山口豪
    • Organizer
      第27回日本心電学会学術集会
    • Place of Presentation
      大分全日空ホテル
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] フィードバック刺激を用いた局所低温除細動治療メカニズムの解明2010

    • Author(s)
      荒船龍彦
    • Organizer
      第27回日本心電学会学術集会
    • Place of Presentation
      Iichiko総合文化センター
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性心房細動に対するCFAE標的アブレーションのメカニズムに関するin silico研究:線維芽細胞の役割に着目して2010

    • Author(s)
      芦原貴司
    • Organizer
      第27回日本心電学会学術集会
    • Place of Presentation
      大分全日空ホテル
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] カルシウム/カルモジュリン及びカルモジュリンキナーゼIIと心筋Naチャネル機能2010

    • Author(s)
      相庭武司
    • Organizer
      第27回日本心電学会学術集会
    • Place of Presentation
      Iichiko総合文化センター
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of fibroblasts in the mechanisms of complex fractionated atrial electrograms and catheter ablation during chronic atrial fibrillation2010

    • Author(s)
      Ashihara T
    • Organizer
      The 3rd Asia-Pacific Heart Rhythm Society Scientific Session (APHRS 2010) in conjunction with The 4th Asia-Pacific Atrial Fibrillation Symposium (APAFS2010)
    • Place of Presentation
      Jeju Island
    • Related Report
      2010 Annual Research Report
  • [Presentation] Potential influences of cardiac autonomic nerves on cardiac events in patients with ion channelopathy2010

    • Author(s)
      Shimizu W
    • Organizer
      The 3rd Asia-Pacific Heart Rhythm Society Scientific Session (APHRS 2010) in conjunction with The 4th Asia-Pacific Atrial Fibrillation Symposium (APAFS2010)
    • Place of Presentation
      Jeju Island
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cellular and molecular mechanism of Brugada syndrome2010

    • Author(s)
      Shimizu W
    • Organizer
      The 3rd Asia-Pacific Heart Rhythm Society Scientific Session (APHRS 2010) in conjunction with The 4th Asia-Pacific Atrial Fibrillation Symposium (APAFS2010)
    • Place of Presentation
      Jeju Island
    • Related Report
      2010 Annual Research Report
  • [Presentation] Genotype-phenotype aspects of the long QT syndrome2010

    • Author(s)
      Shimizu W
    • Organizer
      The 3rd Asia-Pacific Heart Rhythm Society Scientific Session (APHRS 2010) in conjunction with The 4th Asia-Pacific Atrial Fibrillation Symposium (APAFS2010)
    • Place of Presentation
      Jeju Island
    • Related Report
      2010 Annual Research Report
  • [Presentation] 3次元心室モデルによる心臓不整脈のシミュレーション研究について2010

    • Author(s)
      原口亮
    • Organizer
      第25回生体・生理工学シンポジウム[オーガナイズドセッション:心臓電気活動の可視化解析および臨床応用]
    • Place of Presentation
      岡山
    • Related Report
      2010 Annual Research Report
  • [Book] Electrical Diseases of the Heart (Second edition): Genetics, Mechanisms, Treatment, Prevention, Part IV. Clinical rhythmology: Diagnostic methods and tools2013

    • Author(s)
      Shimizu W
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Book] Electrical Diseases of the Heart (Second edition): Genetics, Mechanisms, Treatment, Prevention, Part III. Secondary Hereditary and Acquired Cardiac Channelopathies, and Sudden Cardiac Death2013

    • Author(s)
      Shimizu W
    • Publisher
      Springer
    • Related Report
      2012 Annual Research Report
  • [Book] 心不全をマスターする:病態を理解して治療できる医師になろう, 堀江 稔:III.心不全を治療する:心不全における不整脈を管理する2013

    • Author(s)
      芦原貴司
    • Publisher
      文光堂
    • Related Report
      2012 Annual Research Report
  • [Book] 不整脈概論:専門医になるためのエッセンシャルブック, 植込み型心電用データレコーダ2013

    • Author(s)
      芦原貴司
    • Publisher
      メジカルビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] 不整脈学, 不整脈の実験モデル:不整脈のシミュレーション2012

    • Author(s)
      芦原貴司
    • Publisher
      南江堂
    • Related Report
      2012 Annual Research Report
  • [Book] シミュレーション辞典, 仮想心臓シミュレーション2012

    • Author(s)
      中沢一雄
    • Total Pages
      5
    • Publisher
      コロナ社
    • Related Report
      2012 Annual Research Report
  • [Book] 成り立ちから理解する心電図波形:心筋の活動電位を読み解く, 心室細動2012

    • Author(s)
      芦原貴司
    • Publisher
      秀潤社
    • Related Report
      2012 Annual Research Report
  • [Book] Diagnostic evaluation of Long QT syndrome. in : Cardiac electrophysiology clinics, Long QT syndrome(Priori SG (ed))2012

    • Author(s)
      Shimizu W
    • Total Pages
      9
    • Publisher
      Elsevier
    • Related Report
      2011 Annual Research Report
  • [Book] Electrical Diseases of the Heart (Second edition) : Genetics, Mechanisms, Treatment, Prevention, Part IV. Clinical rhythmology : Diagnostic methods and tools2012

    • Author(s)
      Shimizu W
    • Publisher
      Springer(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] Electrical Diseases of the Heart (Second edition) : Genetics, Mechanisms, Treatment, Prevention, Part III. Secondary Hereditary and Acquired Cardiac Channelopathies, and Sudden Cardiac Death2012

    • Author(s)
      Shimizu W
    • Publisher
      Springer(in press)
    • Related Report
      2011 Annual Research Report
  • [Book] シミュレーション辞典「仮想心臓シミュレーション」2012

    • Author(s)
      中沢一雄
    • Total Pages
      1
    • Publisher
      コロナ社
    • Related Report
      2011 Annual Research Report
  • [Remarks] 仮想心臓(バーチャルハート)による不整脈現象のシミュレーションと可視化の研究

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_001.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 仮想心臓(バーチャルハート)を応用した致死性不整脈の誘発性・持続性の解析

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_007.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] プルキンエ線維起源不整脈に関するシミュレーション研究

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_010.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 仮想心臓(バーチャルハート)による不整脈現象のシミュレーションと可視化の研究

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_001.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 仮想心臓(バーチャルハート)を応用した致死性不整脈の誘発性・持続性の解析

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_007.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] (A) 仮想心臓(バーチャルハート)による不整脈現象のシミュレーションと可視化の研究

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_001.html

    • Related Report
      2012 Annual Research Report
  • [Remarks] (B) 仮想心臓(バーチャルハート)を応用した致死性不整脈の誘発性・持続性の解析

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_007.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_001.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_007.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_001.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.ncvc.go.jp/res/divisions/biomedical_system/bms_007.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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