| Project Area | Establishment of Integrative Multi-level Systems Biology and its Applications |
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| Project/Area Number |
22136011
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
NAKAZAWA Kazuo 独立行政法人国立循環器病研究センター, 研究所, 室長 (50198058)
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| Co-Investigator(Kenkyū-buntansha) |
HARAGUCHI Ryo 国立循環器病研究センター, 情報統括部, 室長 (00393215)
SHIMIZU Wataru 日本医科大学, 大学院医学研究科, 大学院教授 (50399606)
ASHIHARA Takashi 滋賀医科大学, 医学部, 助教 (80396259)
IKEDA Takanori 東邦大学, 医学部, 教授 (80256734)
IJIRI Takashi 理化学研究所, 光量子工学研究領域, 基礎科学特別研究員 (30550347)
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| Co-Investigator(Renkei-kenkyūsha) |
AIBA Takeshi 国立循環器病研究センター, 病院, 医長 (40574348)
NAMBA Tunetoyo 姫路獨協大学, 医療保健学部臨床工学科, 教授 (70331866)
YAMAGUCHI Takeshi 金沢大学, 医薬保健研究域医学系, 助教 (60532182)
SUGIMACHI Masaru 国立循環器病研究センター, 研究所, 部長 (40250261)
YOKOTA Hideo 理化学研究所, 生物情報基盤構築チーム, チームヘッド (00261206)
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| Research Collaborator |
SHIBATA Nitaro 新宿三井ビルクリニック, 院長
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥58,240,000 (Direct Cost: ¥44,800,000、Indirect Cost: ¥13,440,000)
Fiscal Year 2014: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2013: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2012: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
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| Keywords | 不整脈 / シミュレーション |
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| Outline of Final Research Achievements |
Introducing experimental multilevel data based from the ion channel level to the organ morphology level, many functional simulation studies were conducted for a comprehensive understanding of the electrophysiological phenomena in the heart. Actually, to incorporate various experimental multilevel data into a heart model and execute simulations according to the purpose are difficult tasks. It is important to optimize a model as much as possible for an effective and comprehensible simulation. As the consequences, the importance of inhomogeneity of the cells in the sinus node, the validity of the ablation surgery for chronic atrial fibrillation and so on were indicated. In addition, by applying the technique of computer graphics, a real time beating heart simulator executable on a general-purpose PC was developed.
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