| Budget Amount *help |
¥102,050,000 (Direct Cost: ¥78,500,000、Indirect Cost: ¥23,550,000)
Fiscal Year 2014: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2013: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2012: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2011: ¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2010: ¥28,210,000 (Direct Cost: ¥21,700,000、Indirect Cost: ¥6,510,000)
|
|---|
| Outline of Final Research Achievements |
Homeostasis for blood concentrations of various small molecules is one of the most important mechanisms to maintain life. In the present study, we focused on this system which is emerged by the cooperation of multi-organs, aiming to achieve the integrated comprehension of the systems behaviors. In the first half of the study period, we have built novel mathematical models to describe the behavior of small molecules in the body, using drug molecules as models. In the second half of the study, we extended the target ranges to various endogenous small molecules, including highly lipophilic compounds such as cholesterol and fat-soluble vitamins, inorganic salts such as phosphate and calcium, and urate. We have elucidated molecular mechanisms for regulating the behavior of these compounds in the body, and have integrated the information to the multi-organ models.
|
