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Chemical target identification and its biological study using bead technology.

Planned Research

Project AreaChemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity
Project/Area Number 23102002
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTokyo Medical University (2013-2015)
Tokyo Institute of Technology (2011-2012)

Principal Investigator

Handa Hiroshi  東京医科大学, 医学部, 教授 (80107432)

Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥65,130,000 (Direct Cost: ¥50,100,000、Indirect Cost: ¥15,030,000)
Fiscal Year 2015: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Keywords天然物リガンド / 分散性磁性ビーズ / アフィニティ精製 / 標的タンパク質 / 生体内作用機構 / 固定化 / 質量分析 / 高分散性磁性ビーズ / 作用メカニズム
Outline of Final Research Achievements

To immobilize various type of bioactive natural products on Handa beads effectively, we established the method that utilize reliable esterification and click reaction with azide and acetylene. We successfully prepared various bioactive natural product-immobilized Handa beads. (bioactive natural products: erythromycin derivative, vitamin K2, salicylic acid and others)
Through affinity purification with the bioactive natural product-immobilized Handa beads and biochemical analyses of the specific binding proteins to the bioactive natural product, we identified target proteins (Bak for vitamin K2; ferrochelatase for salicylic acid) for the bioactive natural products and elucidated mechanisms of action of the bioactive natural products. Additionally, exceptional results were achieved by research collaboration.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report

Research Products

(109 results)

All 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article (30 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 30 results,  Open Access: 10 results,  Acknowledgement Compliant: 8 results) Presentation (53 results) (of which Int'l Joint Research: 5 results,  Invited: 34 results) Book (19 results) Remarks (1 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance.2017

    • Author(s)
      Kabe Y, Nakane T, Koike I, Yamamoto T, Sugiura Y, Harada E, Sugase K, Shimamura T, Ohmura M, Muraoka K, Yamamoto A, Uchida T, Iwata S, Yamaguchi Y, Krayukhina E, Noda M, Handa H, Ishimori K, Uchiyama S, Kobayashi T, Suematsu M.
    • Journal Title

      Nature communications

      Volume: 7 Pages: 11030-11030

    • DOI

      10.1038/ncomms11030

    • NAID

      130007529314

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Glutamine triggers acetylation-dependent degradation of glutamine synthetase via the thalidomide receptor cereblon.2016

    • Author(s)
      Thang Van Nguyen, J. Eugene Lee1, Michael J. Sweredoski, Seung-Joo Yang, Seung-Je Jeon, Joseph S. Harrison, Jung-Hyuk Yim, Sang Ghil Lee, Handa H., Brian Kuhlman, Ji-Seon Jeong, Justin M. Reitsma, Chul-Seung Park, Sonja Hess, and Raymond J. Deshaies
    • Journal Title

      Mol. Cell

      Volume: 61,6 Pages: 809-820

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors.2016

    • Author(s)
      Klaeger, S., Gohlke, B., Perrin, J., Gupta, V., Heinzlmeir, S., Helm, D., Qiao, H., Bergamini, G., Handa, H., Savitski, M, M., Bantscheff, M., Medard, G., Preissner, R. and Kuster, B.
    • Journal Title

      ACS Chem.Biol.

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines.2016

    • Author(s)
      Mukai S, Moriya S, Hiramoto M, Kazama H, Kokuba H, Che XF, Yokoyama T, Sakamoto S, Sugawara A, Sunazuka T, Omura S, Handa H, Itoi T, Miyazawa K.
    • Journal Title

      Int. J. Clin. Oncol.

      Volume: 48 Pages: 1848-1858

    • DOI

      10.3892/ijo.2015.3237

    • NAID

      120005845877

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] CTCF regulates NELF, DSIF and P-TEFb recruitment during transcription.2015

    • Author(s)
      Laitem, C., Zaborowska, J., Tellier, M., Yamaguchi, Y., Qingfu, C., Egloff, S., Handa, H. and Murphy, S.
    • Journal Title

      Transcription

      Volume: 6 Pages: 79-90

    • DOI

      10.1080/21541264.2015.1095269

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of the Human Transcription Elongation Factor Rtf1: Evidence for Non-overlapping Functions of Rtf1 and the Paf1 Complex.2015

    • Author(s)
      Cao, Q. F., C., Yamamoto, J., Isobe, T., Tateno, S., Murase, Y., Chen, Y., Handa, H. and Yamaguchi, Y.
    • Journal Title

      Mol. Cell Biol.

      Volume: 35 Pages: 3459-3470

    • DOI

      10.1128/mcb.00601-15

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Myeloid disease: Another action of a thalidomide derivative2015

    • Author(s)
      Takumi Ito, Hiroshi Handa
    • Journal Title

      Nature(News & Views)

      Volume: 523 Pages: 167-168

    • DOI

      10.1038/nature14628

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SV40 VP1 major capsid protein in its self-assembled form allows VP1 pentamers to coat various types of artificial beads in vitro regardless of their sizes and shapes2015

    • Author(s)
      M.-A. Kawano, K. Doi, H. Fukuda, Y. Kita, K. Imai, T. Inoue, T. Enomoto, M. Matsui, M. Hatakeyama, Y. Yamaguchi, H. Handa
    • Journal Title

      Biotechnology Reports

      Volume: 5 Pages: 105-111

    • DOI

      10.1016/j.btre.2014.12.008

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structure of the human cereblon-DDB1- lenalidomide complex reveals basis for responsiveness to thalidomide analogs2014

    • Author(s)
      P. Chamberlain, A. Lopez-Girona, K. Miller, G. Carmel, B. Pagarigan, B. Chie-Leon, E. Rychak, L. Corral, Y. Ren, M. Wang, M. Riley, S. Delker, T. Ito, H. Ando, T. Mori, Y. Hirano, H. Handa, T. Hakoshima, T. Daniel, B. Cathers
    • Journal Title

      Nature Structural & Molecular Biology

      Volume: 21 Pages: 803-809

    • DOI

      10.1038/nsmb.2874

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitins2014

    • Author(s)
      A. Perez-Perarnau, S. Preciado, C. M. Palmeri, C. Moncunill-Massaguer, D. Iglesias-Serret, D. M. Gonzalez-Girones, M. Miguel, S. Karasawa, S. Sakamoto, A. M. Cosialls, C. Rubio-Patino, J. Saura-Esteller, R. Ramón, L. Caja, I. Fabregat, G. Pons, H. Handa, F. Albericio, J. Gil, R. Lavilla
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 53 Pages: 10150-10154

    • DOI

      10.1002/anie.201405758

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DSIF and NELF interact with Integrator to specify the correct post-transcriptional fate of snRNA genes2014

    • Author(s)
      J. Yamamoto, Y. Hagiwara, K. Chiba, T. Isobe, T. Narita, H. Handa, Y. Yamaguchi
    • Journal Title

      Nature Communications

      Volume: 5 Pages: 4263-4263

    • DOI

      10.1038/ncomms5263

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata2014

    • Author(s)
      M. Takemoto, Y. Kawamura, M. Hirohama, Y. Yamaguchi, H. Handa, H. Saitoh, Y. Nakao, M. Kawada, K. Khalid, H. Koshino, K. Kimura, A. Ito, M. Yoshida
    • Journal Title

      J. Antibiot.

      Volume: 67 Pages: 335-338

    • DOI

      10.1038/ja.2013.142

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Magnetically promoted rapid immunoreactions using functionalized fluorescent magnetic beads: a proof of principle2014

    • Author(s)
      S. Sakamoto, K. Omagari, Y. Kita, Y. Mochizuki, Y. Naito, S. Kawata, S. Matsuda, O. Itano, H. Jinno, H. Takeuchi, Y. Yamaguchi, Y. Kitagawa, H. Handa
    • Journal Title

      Clinical Chem.

      Volume: 60 Pages: 610-620

    • DOI

      10.1373/clinchem.2013.211433

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN)2014

    • Author(s)
      A. K. Gandhi, J. Kang, C. G. Havens, T. Conklin, Y. Ning, L. Wu, T. Ito, H. Ando, M. F. Waldman, A. Thakurta, A. Klippel, H. Handa, T.O. Daniel, P. H. Schafer, R. Chopra
    • Journal Title

      British Journal of Haematology

      Volume: 164 Pages: 811-821

    • DOI

      10.1111/bjh.12708

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chimeric SV40 virus-like particles induce specific cytotoxicity and protective immunity against influenza A virus without the need of adjuvants2014

    • Author(s)
      M.-A. Kawano, K. Morikawa, T. Suda, N. Ohno, S. Matsushita, T. Akatsuka, H. Handa, M. Matsui
    • Journal Title

      Virology

      Volume: 448 Pages: 159-167

    • DOI

      10.1016/j.virol.2013.10.010

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Silk gland factor-2, involved in fibroin gene transcription, consists of LIM homeodomain, LIM-interacting, and single-stranded DNA-binding proteins2013

    • Author(s)
      K. Ohno, J. Sawada, S. Takiya, M. Kimoto, A. Matsumoto, T. Tsubota, K. Uchino, C. C. Hui, H. Sezutsu, H. Handa, Y. Suzuki
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Pages: 31581-31591

    • DOI

      10.1074/jbc.m113.514471

    • NAID

      120005397912

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity2013

    • Author(s)
      V. Gupta, S. Liu, H. Ando, R. Ishii, S. Tateno, Y. Kaneko, M. Yugami, S. Sakamoto, Y. Yamaguchi, O. Nureki, H. Handa
    • Journal Title

      Mol. Pharmacol.

      Volume: 84 Pages: 824-833

    • DOI

      10.1124/mol.113.087940

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing2013

    • Author(s)
      H. Miyazaki, K. Higashimoto, Y. Yada, T. A. Endo, J. Sharif, T. Komori, M. Matsuda, Y. Koseki, M. Nakayama, H. Soejima, H. Handa, H. Koseki, S. Hirose, K. Nishioka
    • Journal Title

      PLoS Genet

      Volume: 9

    • DOI

      10.1371/journal.pgen.1003897

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo identification of sentinel lymph nodes using MRI and size-controlled and monodispersed magnetite nanoparticles2013

    • Author(s)
      S. Iida, K. Imai, S. Matsuda, O. Itano, M. Hatakeyama, S. Sakamoto, D. Kokuryo, K. Okabayashi, T. Endo, Y. Ishii, H. Hasegawa, I. Aoki, H. Handa, Y. Kitagawa
    • Journal Title

      J. Magn. Reson. Imaging

      Volume: 38 Pages: 1346-1355

    • DOI

      10.1002/jmri.24108

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Viral protein-coating of magnetic nanoparticles using simian virus 40 VP12013

    • Author(s)
      T. Enomoto, M.-A. Kawano, H. Fukuda, W. Sawada, T. Inoue, K. C. Haw, Y. Kita, S. Sakamoto, Y. Yamaguchi, T. Imai, M. Hatakeyama, S. Saito, A. Sandhu, M. Matsui, I. Aoki, H. Handa
    • Journal Title

      J Biotechnol.

      Volume: 167 Pages: 8-15

    • DOI

      10.1016/j.jbiotec.2013.06.005

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin K2 covalently binds to Bak and induces Bak-mediated apoptosis.2013

    • Author(s)
      Karasawa S, Azuma M, Kasama T, Sakamoto S, Kabe Y, Imai T, Yamaguchi Y, Miyazawa K, Handa H
    • Journal Title

      Mol. Pharmacol.

      Volume: 83 Pages: 613-620

    • DOI

      10.1124/mol.112.082602

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vesnarinone Suppresses TNF α mRNA Expression by Inhibiting Valosin-containing Protein2013

    • Author(s)
      Hotta K, Nashimoto A, Yasumura E, Suzuki M, Azuma M, Iizumi Y, Shima D, Nabeshima R, Hiramoto M, Okada A, Sakata-Sogawa K, Tokunaga M, Ito T, Ando H, Sakamoto S, Kabe Y, Aizawa S, Imai T, Yamaguchi Y, Watanabe H, Handa H
    • Journal Title

      Mol. Pharmacol.

      Volume: Vol.83 Pages: 11-15

    • DOI

      10.1124/mol.112.081935

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tools and methodologies capable of isolating and identifying a target molecule for a bioactive compound2012

    • Author(s)
      Sakamoto, S., Hatakeyama, M., Ito, T. and Handa, H.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 20 Pages: 1990-2001

    • DOI

      10.1016/j.bmc.2011.12.022

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission.2012

    • Author(s)
      Okuda-Ashitaka E, Minami T, Tsubouchi S, Kiyonari H, Iwamatsu A, Noda T, Handa H and Ito S
    • Journal Title

      J. Biol. Chem

      Volume: 287 Pages: 10403-10413

    • DOI

      10.1074/jbc.m111.271866

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deciphering the mystery of thalidomide teratogenicity2012

    • Author(s)
      Ito, T. and Handa, H.
    • Journal Title

      Congenital Anomalies

      Volume: 52 Issue: 1 Pages: 1-7

    • DOI

      10.1111/j.1741-4520.2011.00351.x

    • ISSN
      0914-3505
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide.2012

    • Author(s)
      Lopez-Girona A, Mendy D, Ito T et al.
    • Journal Title

      Leukemia

      Volume: 26 Pages: 2326-2335

    • DOI

      10.1038/leu.2012.119

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A.2012

    • Author(s)
      Ito, Y., Ito, T., Karasawa, S., Enomoto, T., Nashimoto, A., Hase, Y., Sakamoto, S., Ito, T., Mimori, T., Matsumoto, Y., Yamaguchi, Y., Handa, H.
    • Journal Title

      Plos ONE

      Volume: 7(12)

    • DOI

      10.1371/journal.pone.0050481

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of NIPSNAP1 as a nocistatin-interacting protein involving pain transmission2012

    • Author(s)
      Okuda-Ashitaka
    • Journal Title

      J.Biol.Chem.

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A two-step ligand exchange reaction generates highly water-dispersed magnetic nanoparticles for biomedical applications2011

    • Author(s)
      畠山士
    • Journal Title

      J.Mater.Chem.

      Volume: 21 Pages: 5959-5966

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-performance affinity purification for identification of 15-deoxy-Δ12,14-PGJ2 interacting factors using magnetic nanobeads2011

    • Author(s)
      前川尚也
    • Journal Title

      Biomed.Chromatogr.

      Volume: 25 Pages: 466-471

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Cereblon (CRBN), the common target of multiple pharmacological actions of thalidomide and its derivatives2016

    • Author(s)
      Hiroshi Handa
    • Organizer
      UCLA CTSI Seminar Series
    • Place of Presentation
      UCLA David Geffen School of Medicine
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] セレブロン~IMiDsのターゲット~2016

    • Author(s)
      半田宏
    • Organizer
      第10回臨床骨髄腫研究会
    • Place of Presentation
      メルキュールホテル札幌
    • Year and Date
      2016-02-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] サリドマイド標的因子セレブロン同定から新たな多発性骨髄腫治療薬の開発2016

    • Author(s)
      半田宏
    • Organizer
      文部科学省 私立大学戦略的研究基盤形成支援事業 第一回進捗状況報告会
    • Place of Presentation
      東京医科大学 第二看護棟
    • Year and Date
      2016-01-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 抗体標識蛍光磁気ビーズによる転移がん迅速診断システムの構築2016

    • Author(s)
      坂本聡、半田宏
    • Organizer
      AMDAプロジェクト キックオフミーティング
    • Place of Presentation
      東京大学 (農学部フードサイエンス棟中島董一郎記念ホール)
    • Year and Date
      2016-01-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Elucidation of the molecular mechanisms of action of bioactive natural products using high performance affinity beads2015

    • Author(s)
      Satoshi Sakamoto, Yuki Yamaguchi, Takumi Ito, Hiroshi Handa
    • Organizer
      PACIFICHEM2015(新学術国際シンポジウム)
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, USA
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Bio chemical analyses of CRBN, the target protein for immunomodulatory drugs(IMiDs).2015

    • Author(s)
      Satoshi Sakamoto, Takumi Ito, Yuki Yamaguchi, Hideki Ando, Hiroshi Handa
    • Organizer
      PACIFICHEM2015(新学術国際シンポジウム)
    • Place of Presentation
      Hilton Hawaiian Village (Mid-Pacific Center) Honolulu, Hawaii, USA
    • Year and Date
      2015-12-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cereblon(CRBN), the common target of multiple pharmacological actions of thaildomide and its derivatives.2015

    • Author(s)
      Hiroshi Handa
    • Organizer
      New developments of zebrafish research
    • Place of Presentation
      National Institute of Genetics
    • Year and Date
      2015-11-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] セレブロン~IMiDsのターゲット~2015

    • Author(s)
      半田宏
    • Organizer
      第6回Bay area hematology congress
    • Place of Presentation
      ヨコハマグランドインターコンチネンタルホテル
    • Year and Date
      2015-11-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] セレブロン~IMiDsのターゲット~2015

    • Author(s)
      半田宏
    • Organizer
      Okayama IMiDs Conference
    • Place of Presentation
      ホテルグランヴィア岡山
    • Year and Date
      2015-11-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Discovery of a target of immunomodulatory drugs(IMiDs)免疫調整薬(IMiDs)のターゲットの発見2015

    • Author(s)
      半田宏
    • Organizer
      第77回日本血液学会学術集会シンポジウム6「多発性骨髄腫の新規治療薬の感受性あるいは耐性を決定する機序、因子」
    • Place of Presentation
      石川県立音楽堂
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] サリドマイド催奇性のターゲットから創薬へ2015

    • Author(s)
      半田宏
    • Organizer
      CSJ科学フェスタ
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] セレブロン~IMiDsのターゲット~2015

    • Author(s)
      半田宏
    • Organizer
      香川血液疾患フォーラム~Pomalidomide発売記念講演会~
    • Place of Presentation
      ロイヤルパークホテル高松
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] IMiDsの多彩な薬理作用~標的分子探索研究の進歩~2015

    • Author(s)
      半田宏
    • Organizer
      Fukuoka IMiDs Forum
    • Place of Presentation
      ヒルトン福岡シーホーク
    • Year and Date
      2015-08-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] IMiDsの多彩な薬理作用~標的分子探索研究の進歩~2015

    • Author(s)
      半田宏
    • Organizer
      Tokyo 3M Forum 2015
    • Place of Presentation
      東京ドームホテル
    • Year and Date
      2015-07-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Basic aspects concerning the mechanisms of actions of immunomodulatory drugs(IMiDs)in multiple myeloma2015

    • Author(s)
      Hiroshi Handa
    • Organizer
      The 20th Congress of EHA-JSH Joint Symposium(Multiple Myeloma)
    • Place of Presentation
      Messezentrum Vienna:Wien
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 分子標的探索と生物学的評価2015

    • Author(s)
      半田宏、坂本聡
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー~分子標的と活性制御~」第8回公開シンポジウム
    • Place of Presentation
      東北大学
    • Year and Date
      2015-06-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] IMiDsの多彩な薬理作用~標的分子探索研究の進歩~2015

    • Author(s)
      半田宏
    • Organizer
      最新医学セミナー
    • Place of Presentation
      宮崎大学医学部
    • Year and Date
      2015-04-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] サイエンスと知財2015

    • Author(s)
      半田宏
    • Organizer
      第一回知的財産プロデューサー等連絡会議講演会
    • Place of Presentation
      共同通信会館
    • Year and Date
      2015-04-07
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] アフィニティビーズを利用した生物活性物質標的タンパク質の単離・同定・評価2015

    • Author(s)
      坂本 聡、山口雄輝、半田 宏
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] セレブロン -IMiDs標的分子研究の最前線-2015

    • Author(s)
      半田 宏
    • Organizer
      セルジーン講演会
    • Place of Presentation
      ヨコハマ グランド インターコンチネンタルホテル
    • Year and Date
      2015-02-28
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ケミカルで知り、ケミカルで動かす -サリドマイド催奇性のターゲットの発見から創薬への展開-2015

    • Author(s)
      半田 宏
    • Organizer
      サントリー生命科学財団セミナー
    • Place of Presentation
      サントリー生命科学財団
    • Year and Date
      2015-02-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] サリドマイド催奇性のターゲットの発見から創薬への展開 -ケミカルで知り、ケミカルで動かす-2015

    • Author(s)
      半田 宏
    • Organizer
      埼玉医科大学 ゲノム医学研究センターセミナー
    • Place of Presentation
      埼玉医科大学
    • Year and Date
      2015-01-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] E3ユビキチンリガーゼの基質認識レセプターCRBNとポマリドマイド依存的な基質Aiolosの生化学的解析2014

    • Author(s)
      片山美樹、伊藤拓水、安藤秀樹、山口雄輝、半田 宏
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] IMiDsの多彩な薬理作用 ~標的分子探索研究の進歩~2014

    • Author(s)
      半田 宏
    • Organizer
      第76回日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-10-31 – 2014-11-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Screening and Evaluation of Natural Product Targets2014

    • Author(s)
      半田 宏、坂本 聡
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー ~分子標的と活性制御~」第3回国際シンポジウム
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2014-10-28 – 2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] ケミカルで生命の謎を知る!2014

    • Author(s)
      半田 宏
    • Organizer
      東京医科大学 第48回医科学フォーラム
    • Place of Presentation
      東京医科大学 教育研究棟
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] セレブロン ~サリドマイド催奇性から創薬への展開~2014

    • Author(s)
      半田 宏
    • Organizer
      セルジーン血液腫瘍フォーラム
    • Place of Presentation
      京都国際ホテル
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大学のシーズ研究から実用化に向けて -大学における基礎研究の重要性-2014

    • Author(s)
      半田 宏
    • Organizer
      信州大学 医学部 メディカル・ヘルスイノベーション講座 第8回定例講演会
    • Place of Presentation
      信州地域技術メディカル展開センター
    • Year and Date
      2014-09-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] IMiDsのセレブロンを介した多様な薬理作用2014

    • Author(s)
      半田 宏
    • Organizer
      Shinjuku Myeloma Conference
    • Place of Presentation
      国際医療研究センター
    • Year and Date
      2014-07-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Idenification of a primary target of thalidomide teratogenecity: towards the debelopment of new drugs.2014

    • Author(s)
      Hiroshi Handa
    • Organizer
      RNA Biology
    • Place of Presentation
      McGovern Institute,MIT Bldg. USA
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 抗炎症薬サリチル酸の生体内作用機構の解析2014

    • Author(s)
      坂本 聡、Vipul Gupta、劉 舒捷、安藤秀樹、舘野峻平、金子裕生、湯上真人、石井亮平、濡木 理、山口雄輝、半田 宏
    • Organizer
      第9回日本ケミカルバイオロジー学会
    • Place of Presentation
      大阪大学会館
    • Year and Date
      2014-06-11 – 2014-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子標的探索と生物学的評価2014

    • Author(s)
      半田 宏、坂本 聡
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー ~分子標的と活性制御~」第6回公開シンポジウム
    • Place of Presentation
      名古屋大学 坂田・平田ホール
    • Year and Date
      2014-05-28 – 2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] IMiDsの作用機序 -近年の報告から-2014

    • Author(s)
      半田 宏
    • Organizer
      Therapeutic strategies for Multiple Myeloma 2014
    • Place of Presentation
      ホテル日航福岡
    • Year and Date
      2014-04-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Expansion from chemical target identification to drug discovery2014

    • Author(s)
      Hiroshi Handa
    • Organizer
      Thalidomide Embryopathy Conference
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 機能性磁性ビーズの作製と医療への応用2013

    • Author(s)
      半田 宏
    • Organizer
      信州大学メディカル・ヘルスイノベーション講座 第一回大会
    • Place of Presentation
      信州大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 分子標的探索と生物学的評価2013

    • Author(s)
      半田 宏、坂本 聡
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー~分子標的と活性制御~」第4回公開シンポジウム
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] ケミカルで知り、ケミカルで動かす2013

    • Author(s)
      半田 宏
    • Organizer
      核酸制御(陽進堂)共同研究講座 設立記念シンポジウム
    • Place of Presentation
      大阪大学 吹田キャンパス 銀杏会館
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Identification of a target of thalidomide teratogenicity2013

    • Author(s)
      Hiroshi Handa
    • Organizer
      35th Naito Conference "The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Encounter with Celgene2013

    • Author(s)
      Hiroshi Handa
    • Organizer
      Vice President Dinner Meeting at Celgene
    • Place of Presentation
      Morris Museum, Morristown, New Jersey, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] サリドマイド催奇性の原因因子の発見から創薬への展開2013

    • Author(s)
      半田 宏
    • Organizer
      信州大学臨床検査部講演
    • Place of Presentation
      信州大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Screening and Biological Evaluation of the Molecular Targets2013

    • Author(s)
      半田 宏、坂本 聡
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー」第2回国際シンポジウム
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] サリドマイド催奇性の原因因子の発見から創薬への展開2013

    • Author(s)
      半田 宏
    • Organizer
      第40回日本臓器保存生物医学会学術集会
    • Place of Presentation
      東京医科大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ケミカルによる生命の謎への挑戦 -サリドマイド催奇性の原因因子の発見-2013

    • Author(s)
      半田 宏
    • Organizer
      九州大学 生体防御医学研究所セミナー
    • Place of Presentation
      九州大学 馬出病院キャンパス
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Expansion from chemical target identification to drug discovery2012

    • Author(s)
      半田 宏
    • Organizer
      The 1st International Symposium oh Chemical Biology of Natural Products:Target ID and Regulation of Bioactivity(天然物ケミカルバイオロジー第1回国際シンポジウム)
    • Place of Presentation
      京都センチュリーホテル(京都府)
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Expansion from chemical target identification to drug discovery by the beads technology - CRBN is a target for next generation thalidomide drugs-2012

    • Author(s)
      半田 宏、坂本 聡
    • Organizer
      The 1st International Symposium oh Chemical Biology of Natural Products:Target ID and Regulation of Bioactivity(天然物ケミカルバイオロジー第1回国際シンポジウム)
    • Place of Presentation
      京都センチュリーホテル(京都府)
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] 化合物ターゲットから創薬への展開2012

    • Author(s)
      半田 宏
    • Organizer
      生命医薬情報学連合大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Year and Date
      2012-10-14
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ビーズテクノロジーによる標的探索と生物学的評価2012

    • Author(s)
      半田 宏、坂本 聡
    • Organizer
      天然物ケミカルバイオロジー 第二回公開シンポジウム
    • Place of Presentation
      東京大学 弥生講堂(東京都)
    • Year and Date
      2012-06-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] サリドマイド催奇性の謎を解く2012

    • Author(s)
      半田 宏
    • Organizer
      山梨科学アカデミー交流大会
    • Place of Presentation
      ベルクラシック甲府(山梨県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 可塑剤ビスフェノールAの細胞障害作用機構の解析2012

    • Author(s)
      坂本 聡、伊藤雄気、梨本明宏、羽瀬康嘉、加部泰明、半田 宏
    • Organizer
      第6回日本ケミカルバイオロジー学会
    • Place of Presentation
      京都大学 百周年時計台記念館 百周年記念ホール・国際交流ホール(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] アフィニティビーズを利用した生理活性物質の標的タンパク質の同定と作用機構の解明2012

    • Author(s)
      坂本 聡
    • Organizer
      天然物ケミカルバイオロジー 第一回若手研究者ワークショップ
    • Place of Presentation
      東京医科歯科大学・M&Dタワー(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 「ケミカルによる生命の謎への挑戦」(Challenge to the mystery of life by chemical)2012

    • Author(s)
      半田 宏
    • Organizer
      日本糖鎖コンソーシアム(JCGG)シンポジウム
    • Place of Presentation
      東京コンファレンスセンター(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 天然物ケミカルバイオロジーの最先端 -ケミカルで知り、ケミカルで動かす-2012

    • Author(s)
      半田 宏
    • Organizer
      伊那谷アグリイノベーション推進機構設立準備会第2回シンポジウム
    • Place of Presentation
      飯田女子短期大学(長野県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 新規PGJ2標的因子の同定とその骨代謝制御機構の解明2011

    • Author(s)
      今井剛、前川尚也
    • Organizer
      日本ケミカルバイオテクノロジー
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Related Report
      2011 Annual Research Report
  • [Book] 医学のあゆみ「ユビキチン系の破綻と疾患」2016

    • Author(s)
      伊藤拓水、半田宏
    • Total Pages
      930
    • Publisher
      医歯薬出版(株)
    • Related Report
      2015 Annual Research Report
  • [Book] 磁気便覧2016

    • Author(s)
      畠山士、半田宏
    • Total Pages
      904
    • Publisher
      丸善出版(株)
    • Related Report
      2015 Annual Research Report
  • [Book] 東京医科大学大学雑誌2015

    • Author(s)
      半田宏
    • Total Pages
      320
    • Publisher
      東京医科大学医学会
    • Related Report
      2015 Annual Research Report
  • [Book] Organ Biology NO.21 Vol.22015

    • Author(s)
      伊藤拓水、安藤秀樹、半田宏
    • Total Pages
      273
    • Publisher
      (株)日本医学館
    • Related Report
      2014 Annual Research Report
  • [Book] IMiDs基礎と臨床20152015

    • Author(s)
      伊藤拓水、安藤秀樹、半田宏
    • Total Pages
      233
    • Publisher
      (株)メディカルレビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] 生物活性分子のケミカルバイオロジー:標的同定と作用機構- CSJカレントレビュー第19号(日本化学会編)2015

    • Author(s)
      坂本 聡、伊藤拓水、半田 宏
    • Total Pages
      189
    • Publisher
      化学同人
    • Related Report
      2014 Annual Research Report
  • [Book] 日本臨牀(特集:多発性骨髄腫の病態と最新治療-基礎と臨床の最新情報-)2015

    • Author(s)
      伊藤拓水、安藤秀樹、半田 宏
    • Total Pages
      182
    • Publisher
      日本臨牀社
    • Related Report
      2014 Annual Research Report
  • [Book] 多摩川技報2014

    • Author(s)
      寺田孝太郎、田中俊行、羽生尚広、本田孝行、半田 宏
    • Total Pages
      57
    • Publisher
      多摩川精機株式会社
    • Related Report
      2014 Annual Research Report
  • [Book] 実験医学増刊「驚愕の代謝システム」2014

    • Author(s)
      加部泰明、末松 誠、半田 宏
    • Total Pages
      206
    • Publisher
      羊土社
    • Related Report
      2014 Annual Research Report
  • [Book] マイクロ/ナノカプセルの調製、徐放性制御と応用事例2014

    • Author(s)
      坂本 聡、半田 宏
    • Total Pages
      510
    • Publisher
      株式会社技術情報協会
    • Related Report
      2014 Annual Research Report
  • [Book] Virus-like Particles in Vaccine Development2014

    • Author(s)
      M.-A. Kawano, M. Matsui, H. Handa
    • Total Pages
      15
    • Publisher
      Future Medicine Ltd
    • Related Report
      2013 Annual Research Report
  • [Book] サリドマイドの悲劇:その後の研究、キラル化学 -その起源から最新のキラル材料研究まで-(CSJカレントレビュー第13号)2013

    • Author(s)
      伊藤拓水、安藤秀樹、半田 宏
    • Total Pages
      3
    • Publisher
      株式会社化学同人
    • Related Report
      2013 Annual Research Report
  • [Book] セレブロン ~IMiDsの標的因子~(血液フロンティア)2013

    • Author(s)
      安藤秀樹、伊藤拓水、半田 宏
    • Total Pages
      5
    • Publisher
      株式会社医薬ジャーナル社
    • Related Report
      2013 Annual Research Report
  • [Book] バイオ医療応用に向けた高機能性磁性ビーズの開発2013

    • Author(s)
      半田 宏
    • Total Pages
      6
    • Publisher
      化学工業社
    • Related Report
      2012 Annual Research Report
  • [Book] 谷本学校 毒性質問箱 第14号2012

    • Author(s)
      羽生尚弘、伊藤拓水、安藤秀樹、山口雄輝、半田 宏
    • Total Pages
      7
    • Publisher
      株式会社サイエンティスト社
    • Related Report
      2012 Annual Research Report
  • [Book] 医学のあゆみ (ユビキチン修飾系の分子機構と疾患)2012

    • Author(s)
      伊藤拓水、半田宏
    • Total Pages
      5
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2012 Annual Research Report
  • [Book] ナノ微粒子を用いたサリドマイド標的タンパク質の同定2012

    • Author(s)
      羽生尚広、伊藤拓水、安藤秀樹、山口雄輝、半田 宏
    • Total Pages
      5
    • Publisher
      多摩川技報
    • Related Report
      2012 Annual Research Report
  • [Book] 磁性ビーズのバイオ・環境技術への応用展開《普及版》 第4章 磁気分離法のバイオ応用技術 1.創薬を指向したバイオスクリーニング技術の開発2012

    • Author(s)
      西尾広介、坂本 聡、宇賀 均、倉森見典、半田 宏
    • Total Pages
      10
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Annual Research Report
  • [Book] ナノ融合による先進バイオデバイス2011

    • Author(s)
      畠山士、半田宏
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Annual Research Report
  • [Remarks] 東京医科大学ナノ粒子先端医学応用講座ホームページ

    • URL

      http://www.tokyo-med.ac.jp/nanoparticle/

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 免疫賦活化剤およびその製造方法2015

    • Inventor(s)
      半田宏、川野雅章、加藤昌彦
    • Industrial Property Rights Holder
      半田宏、埼玉医科大学、シスメックス(株)
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-25
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 免疫誘導剤およびその製造方法2015

    • Inventor(s)
      半田宏、川野雅章、加藤昌彦
    • Industrial Property Rights Holder
      半田宏、埼玉医科大学、シスメックス(株)
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-11-30
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] ポリマー微粒子の製造方法2013

    • Inventor(s)
      半田 宏、坂本 聡、河田慎太郎
    • Industrial Property Rights Holder
      半田 宏、坂本 聡、河田慎太郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-071029
    • Filing Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 相乗的抗糖尿病治療薬剤2012

    • Inventor(s)
      今井 剛、半田 宏、山口雄輝
    • Industrial Property Rights Holder
      今井 剛、半田 宏、山口雄輝
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-05-10
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨、関節又は歯異常症の治療物質のスクリーニング方法2012

    • Inventor(s)
      今井 剛、半田 宏、山口雄輝
    • Industrial Property Rights Holder
      今井 剛、半田 宏、山口雄輝
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-140671
    • Filing Date
      2012-06-20
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] 骨粗鬆症治療薬のスクリーニング法2012

    • Inventor(s)
      今井剛、半田宏
    • Industrial Property Rights Holder
      東京工業大学
    • Industrial Property Number
      2012-027946
    • Filing Date
      2012-02-03
    • Related Report
      2011 Annual Research Report

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Published: 2011-07-31   Modified: 2019-07-29  

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