| Budget Amount *help |
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
On the guidance of the constructed screening systems for searching anti-cancer and anti-tuberculosis substances from the extract library of marine medicinal resources, we succeeded in the isolation of several bioactive natural products, which are expected to be medicinal seeds. We then engaged in the total synthesis and analog synthesis of the bioactive natural products to supply sufficient amount for further biological analysis and structure-activity relationship study.
Furthermore, we explored new methods to promote the generality of the method for identifying target molecule of bioactive compound. Through the target identification study of the isolated bioactive natural products by using the designed new probe molecules, the Mycobacterium transformed with a genomic DNA library, and the phage display method, we could clarify the several responsible molecules expected as new drug targets for Cancer and Tuberculosis.
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