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Mode-of-action of endogenous factor controlling biological phenomena

Planned Research

Project AreaChemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity
Project/Area Number 23102012
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTohoku University

Principal Investigator

UEDA Minoru  東北大学, 理学研究科, 教授 (60265931)

Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥86,710,000 (Direct Cost: ¥66,700,000、Indirect Cost: ¥20,010,000)
Fiscal Year 2015: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords天然物リガンド / コロナチン / 立体異性体 / 天然物化学 / 植物科学 / ケミカルバイオロジー / ジャスモン酸グルコシド / 就眠運動 / イオンチャネル / 活性酸素 / ウワバゲニン / 天然物 / 標的同定 / 作用機構 / 天然物ケミカルバイオロジー / コンパクト分子プローブ / 標的タンパク質
Outline of Final Research Achievements

Our most important achievement is to show that a stereoisomer of natural products is most useful for tuning the target selectivity. Usually, natural product have plural target and functions as a multi-biofunctional molecule. natural product behave like a bunch of keys, not a canonical lock-and-key. We can reduce the side reactions in the body by using a stereoisomer of natural products. We demonstrated the successful example of target tuning of natural products in plant hormone mimicking natural product, coronatine.

Report

(6 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (36 results)

All 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article (15 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (19 results) (of which Int'l Joint Research: 1 results,  Invited: 16 results) Book (1 results) Remarks (1 results)

  • [Journal Article] A Novel Nuclear Receptor Ligand, Digoxigenin, is a Selective Antagonist of Liver-X-receptors2017

    • Author(s)
      H. Oishi, Y. Takaoka, T. Nishimaki-Mogami, H. Saito, M. Ueda
    • Journal Title

      Chem. Lett.

      Volume: 46 Issue: 3 Pages: 313-314

    • DOI

      10.1246/cl.161071

    • NAID

      130005436551

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Dual function of coronatine as a bacterial virulence factor against plants: possible COI1 JAZ independent role2016

    • Author(s)
      S. Egoshi, Y. Takaoka, H. Saito, Y. Nukadzuka, K. Hayashi, Y. Ishimaru, H. Yamakoshi, K. Dodo, M. Sodeoka, M. Ueda
    • Journal Title

      RSC Adv.

      Volume: 6 Issue: 23 Pages: 19404-19412

    • DOI

      10.1039/c5ra20676f

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ディビジョントピックス 天然物の標的選択性を立体異性体で制御する2016

    • Author(s)
      上田 実
    • Journal Title

      化学と工業

      Volume: 69 Pages: 236-236

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 生物の謎に挑む天然物ケミカルバイオロジー2016

    • Author(s)
      上田 実
    • Journal Title

      化学工業(特集 ケミカルバイオロジーの新展開)

      Volume: 67 Pages: 682-686

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The jasmonate-responsive GTR1 transporter is required for gibberellin-mediated stamen development in Arabidopsis2015

    • Author(s)
      H. Saito, T. Oikawa, S. Hamamoto, Y. Ishimaru, T. Utsumi, J. Chen, M. Kanamori, Y. Sasaki-Sekimoto, M. Shimojima, S. Masuda, Y. Kamiya, M. Seo, N. Uozumi, M. Ueda, H. Ohta, A
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 6095-6095

    • DOI

      10.1038/ncomms7095

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functional importance of the sugar moiety of jasmonic acid glucoside for bioactivity and target affinity2015

    • Author(s)
      M. Ueda, G. Yang, Y. Nukadzuka, Y. Ishimaru, S. Tamura, Y. Manabe,
    • Journal Title

      Org. Biomol. Chem.

      Volume: 13 Pages: 55-58

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 〓probe and its efficiency in affinity labeling of a target protein for jasmonate2013

    • Author(s)
      Tamura S, Inomata S, Ebine M, Genji T, Iwakura I, Mukai M, Shoji M, Sugai T, Ueda M
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 23 Issue: 1 Pages: 188-193

    • DOI

      10.1016/j.bmcl.2012.10.124

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fabrication of Pure Nanodrugs of Podophyllotoxin Dimer and Their Anticancer Activity2013

    • Author(s)
      Y. Ikuta, Y. Koseki, T. Murakami, M. Ueda, H. Oikawa, H. Kasai
    • Journal Title

      Chem. Lett.

      Volume: 48 Issue: 8 Pages: 900-901

    • DOI

      10.1246/cl.130224

    • NAID

      10031189289

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective construction of cis-decalin framework via radical domino cyclization2013

    • Author(s)
      Eriko Suzuki, Minoru Ueda, Sigeru Ohba, Takeshi Sugai, Mitsuru Shoji
    • Journal Title

      Tetrahedron Letters

      Volume: 54 Issue: 12 Pages: 1589-1592

    • DOI

      10.1016/j.tetlet.2013.01.050

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Construction of cis-Decalin Framework via Radical Domino Cyclization,2013

    • Author(s)
      E. Suzuki, M. Ueda, S. Ohba, T. Sugai, M. Shoji
    • Journal Title

      Tetrahedron Lett.

      Volume: 54 Pages: 1589-1592

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hybrid Stereoisomers of Compact Molecular Probes Based on Jasmonic Acid Glucoside: Syntheses and Biological Evaluations,2012

    • Author(s)
      M. Ueda, G. Yang, Y. Ishimaru, S. Tamura, T. Itabashi, K. Kiyota, S. Kuwahara, S. Inomata, M. Shoji, T. Sugai
    • Journal Title

      Bioorg. Med. Chem.,

      Volume: 20 Pages: 5832-5843

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Creation of Pure Nanodrugs and Their Anticancer Properties2012

    • Author(s)
      H. Kasai, T. Murakami, Y. Ikuta, Y. Koseki, K. Baba, H. Oikawa, H. Nakanishi, M. Okada, M. Shoji, M. Ueda, H. Imahori, M. Hashida
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 51 Pages: 10315-10318

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cassia obtusifolia MetE as a Cytosolic Target for Potassium Isolespedezate, a Leaf-Opening Factor of Cassia plants : Target Exploration by a Compact Molecular-Probe Strategy2011

    • Author(s)
      Ueda, M.Manabe, Y.Otsuka, Y.Kanzawa, N.
    • Journal Title

      Chem Asian J

      Volume: 6 Issue: 12 Pages: 3286-97

    • DOI

      10.1002/asia.201100392

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The high-performance of 3XFLAG for target purification of bioactive metabolite : a tag combined with highly effective linker structure2011

    • Author(s)
      M.Ueda, Y.Manabe, M.Mukai
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 21 Issue: 5 Pages: 1359-1362

    • DOI

      10.1016/j.bmcl.2011.01.038

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 12-Hydroxyjasmonic Acid Glucoside is a COI1-JAZs Independent Activator of Leaf Closing Movement in Samanea saman2011

    • Author(s)
      Y.Nakamura, A.Mithofer, E.Kombrink, W.Boland, S.Hamamoto, N.Uozumi, K.Tohma, M.Ueda
    • Journal Title

      Plant Physiology

      Volume: 155 Issue: 3 Pages: 1226-1236

    • DOI

      10.1104/pp.110.168617

    • NAID

      130006997012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 植物生理活性物質のケミカルバイオロジー2016

    • Author(s)
      上田 実
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-09-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Chemical Biology of Plant Natural Products2016

    • Author(s)
      上田 実
    • Organizer
      The First A3 Roundtable Meeting on Chemical Probe Research Hub
    • Place of Presentation
      福岡レオパレス
    • Year and Date
      2016-09-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical Biology of Coronatine; the effect on the guard cell2015

    • Author(s)
      上田 実
    • Organizer
      第56回日本植物生理学会年会
    • Place of Presentation
      東京農業大学
    • Year and Date
      2015-03-16 – 2015-03-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 植物の生物現象を制御するジャスモン酸誘導体の新たな機能2014

    • Author(s)
      上田 実
    • Organizer
      第51回植物化学シンポジウム
    • Place of Presentation
      東北大学
    • Year and Date
      2014-11-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 天然植物毒素コロナチンの気孔 開口作用解明を目指した植物孔辺細胞の in vivo ラマンイメージング2014

    • Author(s)
      江越脩祐、山越博幸、どど孝介、岩下利基、石丸泰寛、袖岡幹子、上田実
    • Organizer
      第56回天然有機化合物討論会
    • Place of Presentation
      高知・高知大学
    • Year and Date
      2014-10-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 天然物化学から天然物ケミカルバイオロジーへ:植物及び動植物配糖体リガンドを例として2014

    • Author(s)
      上田 実
    • Organizer
      神戸大学 学術講演会
    • Place of Presentation
      神戸大学(兵庫県・神戸市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] "Glycosylation Switching"による天然物リガンドの活性制御2013

    • Author(s)
      上田 実
    • Organizer
      日本化学会第93春期年会
    • Place of Presentation
      立命館大学
    • Year and Date
      2013-03-22
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 光親和性コンパクト分子プローブを用いた就眠物質結合タンパク質の検出と精製2013

    • Author(s)
      重永 美由希、源治 尚久、楊 剛強、石丸 泰寛、上田 実
    • Organizer
      新規素材探索研究会 第12回セミナー
    • Place of Presentation
      新横浜フジビューホテル(神奈川県・横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Glycosylation regulates function of endogenous ligands2013

    • Author(s)
      上田 実
    • Organizer
      天然物ケミカルバイオロジー第2回国際(第5回公開)シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 配糖体リガンドのケミカルバイオロジー2013

    • Author(s)
      上田 実
    • Organizer
      天然物ケミカルバイオロジー第4回公開シンポジウム
    • Place of Presentation
      つくば国際会議場(茨城県・つくば市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 配糖体型天然物リガンドのケミカルバイオロジーに見る活性制御の新戦略2012

    • Author(s)
      上田 実
    • Organizer
      後期(秋期)有機合成化学講習会
    • Place of Presentation
      日本薬学会長井記念館
    • Year and Date
      2012-11-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Chemical Biology of Glycoside Natural Products2012

    • Author(s)
      上田 実
    • Organizer
      The International Symposium on Chemical Biology of Natural Products
    • Place of Presentation
      沖縄
    • Year and Date
      2012-07-09
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 「植物の運動」の化学生物学2012

    • Author(s)
      上田 実
    • Organizer
      第12回学習院大学生命科学シンポジウム
    • Place of Presentation
      学習院大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 配糖体型天然物リガンドのケミカルバイオロジーに見る活性制御の新戦略2012

    • Author(s)
      上田 実
    • Organizer
      2012年生命医薬情報学連合大会
    • Place of Presentation
      船橋タワーホール
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 天然物ケミカルバイオロジー:配糖体リガンドの新しい機能2012

    • Author(s)
      上田 実
    • Organizer
      早稲田大学FBT生物学・化学・情報科学融合のための戦略的先進理工学研究基盤の形成
    • Place of Presentation
      早稲田大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 天然物ケミカルバイオロジー:生物現象と天然物リガンド2012

    • Author(s)
      上田 実
    • Organizer
      名古屋大学IGERグリーン自然科学レクチャー
    • Place of Presentation
      名古屋大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] “Glycosylation Switching”: Glycosylation regulates mode-of-action of bioactive natural products2012

    • Author(s)
      上田 実
    • Organizer
      3rd International Symposium on Creation of Functional Materials-Life Science and Materials
    • Place of Presentation
      筑波大学
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Chemical Biology of Naturally Occurring Glycosides: "Glycosylation Switching"2012

    • Author(s)
      上田 実
    • Organizer
      The International Symposium on Chemical Biology of Natural Products
    • Place of Presentation
      京都センチュリーホテル
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生理活性グリコシドの天然物ケミカルバイオロジー2011

    • Author(s)
      上田実
    • Organizer
      東北大学グローバルCOEシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Book] A. Volkov eds. “Plant Electrophysiology Signaling and Responses”2012

    • Author(s)
      Y. Ishimaru, S. Hamamoto, N. Uozumi, and M. Ueda
    • Publisher
      Springer-Verlag
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://chembiochem.jp/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-08-01   Modified: 2019-07-29  

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