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Control of ion-channel functions by analogues of natural toxins

Planned Research

Project AreaChemical Biology using bioactive natural products as specific ligands: identification of molecular targets and regulation of bioactivity
Project/Area Number 23102015
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionNagoya University

Principal Investigator

Nishikawa Toshio  名古屋大学, 生命農学研究科, 教授 (90208158)

Co-Investigator(Kenkyū-buntansha) Konoki Kei-ichi  東北大学, 大学院農学研究科, 准教授 (40292825)
Adachi Masaatsu  名古屋大学, 大学院生命農学研究科, 助教 (80432251)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥43,290,000 (Direct Cost: ¥33,300,000、Indirect Cost: ¥9,990,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2013: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2012: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywordsテトロドトキシン / サキシトキシン / 阻害剤 / 電位依存性ナトリウムチャネル / サブタイプ選択性 / 有機合成 / サブタイプ選択的 / パッチクランプ法 / チリキトキシン / バッチクランプ法 / ブロモ環化反応 / グアニジン
Outline of Final Research Achievements

Tetrodotoxin, a puffer fish toxin, inhibits voltage-gated sodium channel (VSGC), a key protein of neurotransmission, however, dose not show subtype selectivity. Purpose of this research is to find a new subtype selective inhibitor of VGSCs, by synthesizing a dozen analogues of TTX. However, slight modification of TTX decreases the inhibitory activity of VGSC. On the other hand, we found that crambesin B carboxylic acid, a marine natural product, exhibits potent inhibition comparable to TTX for the first time.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (159 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (35 results) (of which Peer Reviewed: 35 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (118 results) (of which Int'l Joint Research: 8 results,  Invited: 20 results) Book (2 results) Remarks (4 results)

  • [Journal Article] Synthesis of a C-N Axially Chiral N-Aryl Isatin through Asymmetric Intramolecular N-Arylation.2015

    • Author(s)
      Nakazaki, A.; Miyagawa, K.; Miyata, N.; Nishikawa, T.
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 21 Issue: 21 Pages: 4603-4606

    • DOI

      10.1002/ejoc.201500593

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 1.5-dioxaspiro[3.4]octane through bromocation-induced cascade cyclization.2015

    • Author(s)
      Nakazaki, A.; Nakane, Y.; Ishikawa, Y.; Nishikawa, T.
    • Journal Title

      Heterocycles

      Volume: 91 Issue: 6 Pages: 1157-1163

    • DOI

      10.3987/com-15-13208

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multifunctionality of the N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin, a Puffer Fish Toxin2015

    • Author(s)
      Toshio Nishikawa, Daisuke Urabe, Masaatsu Adachi, Minoru Isobe
    • Journal Title

      Synlett

      Volume: 26 Issue: 14 Pages: 1930-1939

    • DOI

      10.1055/s-0034-1380781

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Unexpected Metal-Free Transformation of gem-Dibromomethylenes to Ketones under Acetylation Conditions.2015

    • Author(s)
      Kimura, R.; Sawayama, Y.; Nakazaki, A.; Miyamoto, K.; Uchiyama, M.; Nishikawa, T.
    • Journal Title

      Chem. Asian J.

      Volume: 10 Issue: 4 Pages: 1035-1041

    • DOI

      10.1002/asia.201403277

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Asymmetric Synthesis of 3-Azide-4-fluoro-L-phenylalanine.2015

    • Author(s)
      Adachi, M.; Nakajima, M.; Isobe, M.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: XX Issue: 5 Pages: 0-0

    • DOI

      10.1080/09168451.2014.997185

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereocontrolled Synthesis of ABC-tricycle of Solanoeclepin A.2015

    • Author(s)
      Adachi, M.; Torii, M.; Nishikawa, T.
    • Journal Title

      Synlett

      Volume: 26 Issue: 07 Pages: 965-969

    • DOI

      10.1055/s-0034-1380399

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from N-Aryl-3-Chlorooxindoles Bearing Axial Chirality via Nucleophilic Substitution.2015

    • Author(s)
      Nakazaki, A.; Miyagawa, K.; Nishikawa, T.
    • Journal Title

      Synlett

      Volume: 26 Issue: 08 Pages: 0-0

    • DOI

      10.1055/s-0034-1380266

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 5- and 8-Deoxytetrodotoxin.2014

    • Author(s)
      Satake, Y.; Adachi, M.; Tokoro, S.; Yotsu-Yamashita, M.; Isobe, M.; Nishikawa, T.
    • Journal Title

      Chem. Asian. J.

      Volume: 9 Issue: 7 Pages: 1922-1932

    • DOI

      10.1002/asia.201402202

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of 5,6,11-Trideoxytetrodotoxin2014

    • Author(s)
      Adachi, M.; Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T.
    • Journal Title

      Chemistry Letters

      Volume: 43 Issue: 11 Pages: 1719-1721

    • DOI

      10.1246/cl.140684

    • NAID

      130004677596

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A New Deprotection Procedure of MTM Ether.2014

    • Author(s)
      Adachi, M.; Hashimoto, H.; Sakakibara, R.; Imazu, T.; Nishikawa, T.
    • Journal Title

      Synlett

      Volume: 25 Issue: 17 Pages: 2498-2502

    • DOI

      10.1055/s-0034-1379027

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of gambierol and its analogs for their inhibition of human Kv1.2 and cytotoxicity2014

    • Author(s)
      K. Konoki, Y. Suga, H. Fuwa, M. Yotsu-Yamashita, M. Sasaki
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 25 Issue: 3 Pages: 514-518

    • DOI

      10.1016/j.bmcl.2014.12.022

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channel.2014

    • Author(s)
      Nakazaki, A.; Ishikawa, Y.; Sawayama, Y.; Yotsu-Yamashita, M.; Nishikawa, T.
    • Journal Title

      Org. Biomol. Chem.

      Volume: 12 Issue: 1 Pages: 53-56

    • DOI

      10.1039/c3ob42017e

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog.2014

    • Author(s)
      Adachi, M.; Imazu, T.; Sakakibara, R.; Satake, Y.; Isobe, M.; Nishikawa, T.
    • Journal Title

      Chem. Eur. J.

      Volume: 20 Issue: 5 Pages: 1247-1251

    • DOI

      10.1002/chem.201304110

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereocontrolled Total Synthesis of Polygalolide A.2013

    • Author(s)
      Yamada, H.; Adachi, M.; Isobe, M.; Nishikawa, T.
    • Journal Title

      Chem. Asian. J.

      Volume: 8 Issue: 7 Pages: 1428-1435

    • DOI

      10.1002/asia.201300362

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First Identification of 5,11-Dideoxytetrodotoxin in Marine Animals, and Characterization of Major Fragment Ions of Tetrodotoxin and Its Analogs by High Resolution ESI-MS/MS2013

    • Author(s)
      Mari Yotsu-Yamashita, Yuka Abe, Yuta Kudo, Raphael Ritson-Williams, Valerie J. Paul, Keiichi Konoki, Yuko Cho, Masaatsu Adachi, Takuya Imazu, Toshio Nishikawa, Minoru Isobe
    • Journal Title

      Marine Drugs

      Volume: 11 Issue: 8 Pages: 2799-2813

    • DOI

      10.3390/md11082799

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Tetrodotoxin, a Classic but Still Fascinating Natural Product.2013

    • Author(s)
      Nishikawa, T.; Isobe, M.
    • Journal Title

      Chem. Rec.

      Volume: 13 Issue: 3 Pages: 286-302

    • DOI

      10.1002/tcr.201200025

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereocontrolled Synthesis of the Oxathiabicylo[3.3.1]nonane Core Structure of Tagetitoxin.2013

    • Author(s)
      Yamada, H.; Adachi, M.; Isobe, M.; Nishikawa, T.
    • Journal Title

      Chem. Commun.

      Volume: 49 Issue: 95 Pages: 11221-11223

    • DOI

      10.1039/c3cc46949b

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structural Study on a Naturally Occurring Terphenyl Quinone2013

    • Author(s)
      Nakazaki, A.; Huang, W.-Y.; Koga, K.; Yingyongnarongkul, B.; Boonsombat, J.; Sawayama, Y.; Tsujimoto, T.; Nishikawa, T.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 7 Pages: 1529-1532

    • DOI

      10.1271/bbb.130199

    • NAID

      10031190464

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The binding of okadaic acid analogues to recombinant OABP2.1 originally isolated from the marine sponge Halichondria okadai2013

    • Author(s)
      Keiichi Konoki, Tatsuya Onoda, Sachie Furumochi, Yuko Cho, Mari Yotsu-Yamashita, Takeshi Yasumoto
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 23 Issue: 21 Pages: 5833-5835

    • DOI

      10.1016/j.bmcl.2013.08.099

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: Identification of pharmacophoric elements2013

    • Author(s)
      H. Fuwa, M. Kawakami, K. Noto, T. Muto, Y. Suga, K. Konoki, M. Yotsu-Yamashita, and M. Sasaki
    • Journal Title

      Chem. Eur.J.

      Volume: 19 Issue: 25 Pages: 8100-8110

    • DOI

      10.1002/chem.201300664

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Improved Synthesis of (-)-5,11 -Dideoxytetrodotoxin.2013

    • Author(s)
      Adachi, M.; Imazu, T.; Isobe, M.; Nishikawa, T.
    • Journal Title

      J. Org. Chem.

      Volume: 78 Issue: 4 Pages: 1699-1705

    • DOI

      10.1021/jo302773f

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Tetracyclic Indoline and Indolenine Derivatives Having beta-Lactam Using Amphiphilic Reactivity of 2-Methylindolenine2013

    • Author(s)
      Nakazaki, A.; Hara, Y.; Kajii, S.; Nishikawa, T.
    • Journal Title

      Heterocycles

      Volume: 87 Issue: 3 Pages: 611-625

    • DOI

      10.3987/com-12-12657

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Acylation of Okadaic Acid in the Presence of Various Bivalves’ Extracts2013

    • Author(s)
      Keiichi Konoki, Tatsuya Onoda, Ryuichi Watanabe, Yuko Cho, Shinnosuke Kaga, Toshiyuki Suzuki and Mari Yotsu-Yamashita
    • Journal Title

      Marine Drugs

      Volume: 11 Issue: 2 Pages: 300-315

    • DOI

      10.3390/md11020300

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic Studies on Pactamycin, a Potent Antitumor Antibiotic2012

    • Author(s)
      Matsumoto, N.; Tsujimoto, T.; Nakazaki, A.; Isobe, M.; Nishikawa, T.
    • Journal Title

      RSC Advances

      Volume: 2 Issue: 25 Pages: 9448-9462

    • DOI

      10.1039/c2ra21060f

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives2012

    • Author(s)
      Nakazaki, A.; Mori, A.; Kobayashi, S.; Nishikawa, T.
    • Journal Title

      Tetrahedron Lett.

      Volume: 53 Issue: 52 Pages: 7131-7134

    • DOI

      10.1016/j.tetlet.2012.10.092

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A New Synthetic Route to the Skeleton of Saxitoxin, a Naturally Occurring Blocker of Voltage-Gated Sodium Channels2012

    • Author(s)
      Sawayama, Y.; Nishikawa, T.
    • Journal Title

      Journal of Synthetic Organic Chemistry, Japan

      Volume: 70 Issue: 11 Pages: 1178-1186

    • DOI

      10.5059/yukigoseikyokaishi.70.1178

    • NAID

      10031131197

    • ISSN
      0037-9980, 1883-6526
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereocontrolled Synthesis of an Indole Moiety of Sespendole and Stereochemical Assignment of the Side Chain2012

    • Author(s)
      Adachi, M.; Higuchi, K.; Thasana, N.; Yamada, H.; Nishikawa, T.
    • Journal Title

      Org.Lett.

      Volume: 14 Pages: 114-117

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Concise Synthesis of a Highly Strained Cyclobutane in Solanoeclepin A by Radical Cyclization2012

    • Author(s)
      Komada, T.; Adachi, M.; Nishikawa, T
    • Journal Title

      Chem. Lett.

      Volume: 41 Issue: 3 Pages: 287-289

    • DOI

      10.1246/cl.2012.287

    • NAID

      130004426518

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Chirality Determines Critical Roles for Bioluminescence in Symplectin-Dehydrocoelenterazine System2011

    • Author(s)
      Kongjinda, V.; Nakashima, Y.; Tani, N.; Kuse, M.; Nishikawa, T.; Yu, C.-H.; Harada, N.; Isobe, M.
    • Journal Title

      Chem. Asian J.

      Volume: 6 Issue: 8 Pages: 2080-2091

    • DOI

      10.1002/asia.201100089

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Polygalolode A2011

    • Author(s)
      Adachi, M.; Yamada, H.; Isobe, M.; Nishikawa, T.
    • Journal Title

      Org.Lett.

      Volume: 13 Pages: 6532-6535

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Synthetic Route to the Saxitoxin Skeleton : Synthesis of Decarbamoylα-Saxitoxinol, an Analogue of Saxitoxin Produced by the Cyanobacterium2011

    • Author(s)
      Sawayama, Y.; Nishikawa, T.
    • Journal Title

      Lyngbya wollei. Angew. Chem. Int. Ed.

      Volume: 50 Issue: 31 Pages: 7176-7178

    • DOI

      10.1002/anie.201102494

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A New Ring Expansion for a Chiral Hexahydroazulene Skeleton Possessing an Angular Methyl Group2011

    • Author(s)
      Adachi, M.; Komada, T.; Nishikawa, T
    • Journal Title

      J. Org. Chem.

      Volume: 76 Issue: 16 Pages: 6942-6945

    • DOI

      10.1021/jo201153h

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise Synthesis of Deformylflustrabromine, a Marine Indole Alkaloid, through a 2-Propynyl Dicobalt Hexacarbonyl Complex2011

    • Author(s)
      Isaji, H.; Nakazaki, A.; Isobe, M.; Nishikawa, T
    • Journal Title

      Chemistry Letters

      Volume: 40 Issue: 10 Pages: 1079-1081

    • DOI

      10.1246/cl.2011.1079

    • NAID

      130004426050

    • ISSN
      0366-7022, 1348-0715
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimization for simultaneous analysis of tetrodotoxin, 4-epitetrodotoxin, 4,9-anhydrotetrodotoxin and 5,6,11-trideoxytetrodotoxin by hydrophilic interaction liquid chromatography-tandem mass spectrometry2011

    • Author(s)
      Mari Yotsu-Yamashita, Jun-Ho Jang, Yuko Cho, Keiichi Konoki
    • Journal Title

      Forensic Toxicology

      Volume: 29 Issue: 1 Pages: 61-64

    • DOI

      10.1007/s11419-010-0106-x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel oxidized levuglandin D2 in marine red alga and mouse tissues2011

    • Author(s)
      Yoshikazu Kanai, Sadahiko Hiroki, Hiroyuki Koshino, Keiichi Konoki, Yuko Cho, Mirriam Cayme, Yasuo Fukuyo, Mari Yotsu-Yamashita
    • Journal Title

      Journal of Lipid Research

      Volume: 52 Issue: 12 Pages: 2245-2254

    • DOI

      10.1194/jlr.m017053

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Synthetic Study on Lycojapodine A.2016

    • Author(s)
      Wen-Yu Huang, Toshio Nishikawa, Atsuo Nakazaki
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] アプリシアトキシンの合成研究2016

    • Author(s)
      野倉吉彦、西川俊夫
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ジャガイモシスト線虫孵化促進物質ソラノエクレピンA右側部分の合成研究2016

    • Author(s)
      宮澤 悠、駒田武馬、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] エンドファイトが産生するアルカロイド、ペラミンの化学合成研究2016

    • Author(s)
      山本雄太、西川俊夫
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 8-epiテトロドトキシンの合成研究2016

    • Author(s)
      岩瀬翔太郎、堀田貴大、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] セスペンドール芳香環部分の光学活性体の合成研究2016

    • Author(s)
      植木佳織、樋口恵子、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inagami-Tamura EDLFの合成化学的研究: 光学活性体の合成ルートの確立2016

    • Author(s)
      橋本圭古、池田 藍、西川俊夫、中崎敦夫
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ジャガイモシスト線虫孵化促進物質ソラノエクレピンA左側部分の合成研究2016

    • Author(s)
      長谷川耕太、鳥居真衣、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2016年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] (+)-サキシトキシンの合成研究2016

    • Author(s)
      上野壮平、中崎敦夫、西川俊夫
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      京都
    • Year and Date
      2016-03-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthesis of biologically active steroid-derived compounds from an edible mushroom.2015

    • Author(s)
      Toshio Nishikawa, Yoshiki Nakane, Atsuo Nakazaki, Takuya Imazu, Shouta Tokoro, Ryo Sakakibara, Masaatsu Adachi, Keiichi Konoki, Mari Yotsu-Yamashita
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Synthesis and biological activities of guanidine-containing natural products.2015

    • Author(s)
      Toshio Nishikawa, Yoshiki Nakane, Atsuo Nakazaki, Takuya Imazu, Shouta Tokoro, Ryo Sakakibara, Masaatsu Adachi, Keiichi Konoki, Mari Yotsu-Yamashita
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Eight-step synthesis of chaxine B based on a proposed biosynthetic pathway.2015

    • Author(s)
      Yuushi Hiratra, Toshio Nishikawa
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Asymmetric synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channels, and its analogues.2015

    • Author(s)
      Yoshiki Nakane, Yuki Ishikawa, Atsuo Nakazaki, Toshio Nishikawa
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015 (Pacifichem 2015)
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ジャガイモシスト線虫孵化促進物質ソラノエクレピンAの右側部分の合成研究2015

    • Author(s)
      宮澤 悠、駒田武馬、安立昌篤、西川俊夫
    • Organizer
      第46回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      津
    • Year and Date
      2015-11-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Biomimetic Synthesis of Biologically Active Steroidal Natural Products.2015

    • Author(s)
      Toshio Nishikawa
    • Organizer
      ICCEOCA-10/ARNCEOCA-1
    • Place of Presentation
      Taiwan
    • Year and Date
      2015-11-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Syntheses of Guanidine-containing Natural Products Aiming at development of Ion-channel Blockers.2015

    • Author(s)
      Toshio Nishikawa
    • Organizer
      10th AFMC International Medicinal Chemistry Symposium (AIMECS2015)
    • Place of Presentation
      ICC JEJU, KOREA
    • Year and Date
      2015-10-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] エンドファイトが産生するペラミンの合成研究2015

    • Author(s)
      山本雄太、西川俊夫
    • Organizer
      2015年度日本農芸化学会中部・関西支部合同大会
    • Place of Presentation
      富山
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Inagami-Tamura EDLF (Endogenous Digitalis-Like Factor) の合成化学的研究2015

    • Author(s)
      橋本圭古、池田 藍、西川俊夫、中崎敦夫
    • Organizer
      2015年度日本農芸化学会中部・関西支部合同大会
    • Place of Presentation
      富山
    • Year and Date
      2015-09-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] クランベシンBカルボン酸とその誘導体の合成研究2015

    • Author(s)
      中根嘉祈、中崎敦夫、石川裕生、澤山裕介、山下まり、西川俊夫
    • Organizer
      第57回天然有機化合物討論会
    • Place of Presentation
      横浜
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Syntheses of Biologically Active natural products by Means of Cascade Reactions.2015

    • Author(s)
      Toshio Nishikawa
    • Organizer
      The 6th Japanese-Sino Symposium on Organic Chemistry for Young Scientists
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2015-09-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biomimetic Synthesis of Biologically Active Steroidal Natural Products.2015

    • Author(s)
      Toshio Nishikawa
    • Organizer
      Kick-off Symposium on Advanced Research Network for Cutting-Edge Organic Chemistry in Asia
    • Place of Presentation
      Tohoku University, Japan
    • Year and Date
      2015-08-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ナトリウムチャネル阻害剤の創製を目指したグアニジン系天然物の合成2015

    • Author(s)
      西川俊夫、中崎敦夫、中根嘉祈、石川裕生、安立昌篤、橋本穂果、今津拓也、所聖太、榊原良、此木敬一、千葉雪絵、山下まり
    • Organizer
      日本ケミカルバイオロジー学会 第10回年会
    • Place of Presentation
      仙台
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 生合成仮説に基づいたチャキシン B の7 段階合成2015

    • Author(s)
      平田裕嗣、西川俊夫
    • Organizer
      新規素材探索研究会第14回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 天然物合成と構造決定2015

    • Author(s)
      西川俊夫
    • Organizer
      静岡大学講演会
    • Place of Presentation
      静岡
    • Year and Date
      2015-04-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Total Synthesis of Chiriquitoxin, an Analogue of Tetrodotoxin Isolated from the Skin of a Dart Frog.2015

    • Author(s)
      Masaatsu Adachi
    • Organizer
      日本化学会第95春季年会:日本化学会アジア国際シンポジウム
    • Place of Presentation
      船橋
    • Year and Date
      2015-03-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 6-epiテトロドトキシンの合成研究2015

    • Author(s)
      橋本穂果、今津拓也、榊原 良、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] クランベシンBカルボン酸とその誘導体の不斉合成2015

    • Author(s)
      中根嘉祈、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分子内不斉N-アリール化を利用したC-N軸性キラリティを有するオキシインドールの合成2015

    • Author(s)
      宮川敬太朗、西川俊夫、中崎敦夫
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] 電位依存性ナトリウムチャネルのサブタイプを識別するテトロドトキシン類縁体の探索2015

    • Author(s)
      千葉雪絵、塚本匡顕、長由扶子、安立昌篤、榊原良、所聖太、中崎敦夫、石川裕生、西川俊夫、山下まり、此木敬一
    • Organizer
      日本農芸化学会2015年度大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-03-26 – 2015-03-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthetic studies on (+)-saxitoxin.2014

    • Author(s)
      Sohei Ueno, Atsuo Nakazaki, Toshio Nishikawa
    • Organizer
      名古屋大学博士課程教育リーディングプログラム グリーン自然科学国際教育研究プログラム 年次報告会2014
    • Place of Presentation
      名古屋
    • Year and Date
      2014-12-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthetic Study on Lycojapodine A.2014

    • Author(s)
      Wen-Yu Huang, Toshio Nishikawa, Atsuo Nakazaki
    • Organizer
      名古屋大学博士課程教育リーディングプログラム グリーン自然科学国際教育研究プログラム 年次報告会2014
    • Place of Presentation
      名古屋
    • Year and Date
      2014-12-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] Stereocontrolled asymmetric synthesis of crambescin B carboxylic acid, a potent inhibitor of voltage-gated sodium channels.2014

    • Author(s)
      Atsuo Nakazaki, Yoshiki Nakane, Yuki Ishikawa, Yusuke Sawayama and Toshio Nishikawa
    • Organizer
      The 9th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-9)/ The 5th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-5)
    • Place of Presentation
      Petaling Jaya, Malaysia
    • Year and Date
      2014-12-01 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthesis of Guanidine-containing Natural Products by Means of Cascade Bromocylization.2014

    • Author(s)
      Toshio Nishikawa
    • Organizer
      The international Symposium on Natural Products Chemistry and Chemical Biology 2014
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 天然毒を貯蔵する生物が獲得した解毒機構2014

    • Author(s)
      此木敬一
    • Organizer
      第2回天然物化学研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] gem-ジブロモメチレンのケトンへの新奇変換反応2014

    • Author(s)
      木村梨乃、澤山裕介、中崎敦夫、西川俊夫
    • Organizer
      第106回有機合成シンポジウム2014年【秋】
    • Place of Presentation
      東京
    • Year and Date
      2014-11-06 – 2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthesis and Biological Activities of Guanidine-containing Natural Products.2014

    • Author(s)
      Toshio Nishikawa
    • Organizer
      The 3rd International Symposium on Chemical Biology of Natural products : Target ID and Regulation of Bioactivity
    • Place of Presentation
      Osaka
    • Year and Date
      2014-10-28 – 2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Synthetic Study on Lycojapodine A.2014

    • Author(s)
      Wen-Yu Huang, Toshio Nishikawa, Atsuo Nakazaki
    • Organizer
      日本農芸化学会中部支部第171回例会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] イリドイド類の合成研究2014

    • Author(s)
      宮澤 悠、安立昌篤、室岡孝信、宮崎雅雄、西川俊夫
    • Organizer
      日本農芸化学会中部支部第171回例会
    • Place of Presentation
      名古屋
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 含グアニジン天然物の全合成研究2014

    • Author(s)
      西川俊夫
    • Organizer
      平成26年度日本農芸化学会関西支部 京都府立大学 生命分子化学科•鴨叡会セミナー 有機化学•天然物化学セミナー
    • Place of Presentation
      京都
    • Year and Date
      2014-09-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ヘテロ環天然物の全合成研究―天然物合成は新反応発見の場(きっかけ)となるか?―2014

    • Author(s)
      西川俊夫
    • Organizer
      神戸大学有機化学講演会
    • Place of Presentation
      神戸
    • Year and Date
      2014-08-01
    • Related Report
      2014 Annual Research Report
  • [Presentation] (+)-saxitoxinの合成研究2014

    • Author(s)
      上野壮平、中崎敦夫、西川俊夫
    • Organizer
      第49回天然物化学談話会
    • Place of Presentation
      岡山
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] イリドイド類の合成研究2014

    • Author(s)
      宮澤 悠、安立昌篤、室岡孝信、宮崎雅雄、西川俊夫
    • Organizer
      第49回天然物化学談話会
    • Place of Presentation
      岡山
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 光学活性体クランベシンBカルボン酸の合成研究2014

    • Author(s)
      中根嘉祈、中崎敦夫、西川俊夫
    • Organizer
      第49回天然物化学談話会
    • Place of Presentation
      岡山
    • Year and Date
      2014-07-02 – 2014-07-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] 含グアニジン天然物の全合成研究―新規イオンチャネル阻害剤の開発を目指して―2014

    • Author(s)
      西川俊夫
    • Organizer
      第25回記念万有仙台シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ジャガイモシスト線虫孵化促進物質の化学合成2014

    • Author(s)
      西川俊夫
    • Organizer
      公益財団法人山田科学振興財団2014年度研究交歓会成果発表会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-31
    • Related Report
      2014 Annual Research Report
  • [Presentation] グアニジン天然物の合成と新規イオンチャネル阻害剤の開発2014

    • Author(s)
      西川俊夫、安立昌篤、此木敬一
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第6回領域公開シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2014-05-28 – 2014-05-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Asymmetric Synthesis of Crambescin B Caroxylic Acid, A Potent Inhibitor of Voltage-Gated Sodium Channels.2014

    • Author(s)
      Yoshiki Nakane, Atsuo Nakazaki, Yuki Ishikawa, Yusuke Sawayama, Toshio Nishikawa
    • Organizer
      IGER international Symposium on Chemical Science in Asia
    • Place of Presentation
      Nagoya
    • Year and Date
      2014-05-26 – 2014-05-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Syntheses of Guanidine-Containing Natural products by Means of Cascade Boromocyclization.2014

    • Author(s)
      Toshio Nishikawa
    • Organizer
      The International Startup Symposium of CUTTING-EDGE ORGANIC CHEMISTRY IN ASIA (III)
    • Place of Presentation
      Hsinchu, Taiwan
    • Year and Date
      2014-04-19 – 2014-04-21
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] サキシトキシン骨格の新規構築法の開発2014

    • Author(s)
      上野壮平、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] gem-ジブロモメチレンからケトンへの新規変換条件2014

    • Author(s)
      木村梨乃、澤山裕介、西川俊夫
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 光親和性標識基を導入したガンビエロール単純化類縁体の合成と生物活性評価2014

    • Author(s)
      廣田一晃、菅悠人、此木敬一、山下まり、不破春彦、佐々木誠
    • Organizer
      日本化学会第94春季年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] イチイTaxus cuspidata由来α、βチューブリンの発現とタキソール結合性の評価2014

    • Author(s)
      工藤佑馬、長由扶子、山下まり、此木敬一
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] ホタテ貝中で進行する下痢性貝毒オカダ酸のアシル化機構2014

    • Author(s)
      此木敬一、古用幸愛、小野田竜也、長由扶子、山下まり
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] MTMエーテルの新しい脱保護法の開発2014

    • Author(s)
      橋本穂果、今津拓也、榊原 良、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多環多官能性天然物の合成戦略2013

    • Author(s)
      西川俊夫
    • Organizer
      日本薬学会シンポジウム「新しい分子構築戦略ー効率的な生物活性分子の合成に向けてー」日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 5,11-ジデオキシテトロドトキシンの全合成2013

    • Author(s)
      今津拓也、安立昌篤、磯部 稔、西川俊夫
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] 連続環化反応によるSaxitoxin骨格の合成研究2013

    • Author(s)
      上野壮平、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] クロイソカイメン中でオカダ酸およびオカダ酸結合タンパク質OABP2を生産する生物の探索2013

    • Author(s)
      小濱 真実、岡田 華弥、西谷 豪、長 由扶子、山下まり、此木 敬一
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] 下痢性貝毒貯蔵生物における自己耐性機構の探索2013

    • Author(s)
      小野田 竜也、渡邊 龍一、長 由扶子、加賀 新之助、鈴木 敏之、山下 まり、此木 敬
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthetic Studies on Nitrogen-Containing Natural Products.2013

    • Author(s)
      Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Shouta Tokoro, Takuya Imazu, Yoshiki Satake, Minoru Isobe
    • Organizer
      Pure and Applied Chemistry International Conference 2013
    • Place of Presentation
      Bangsaen Beach, Thailand
    • Year and Date
      2013-01-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthetic studies toward saxitoxin skeleton by a cascade cyclization reaction.2013

    • Author(s)
      Sohei Ueno, Atsuo Nakazaki, Toshio Nishikawa
    • Organizer
      Thieme Chemistry - Nagoya Symposium 2013
    • Place of Presentation
      Nagoya
    • Related Report
      2013 Annual Research Report
  • [Presentation] イオンチャネル阻害剤の合成研究2013

    • Author(s)
      西川俊夫、中崎敦夫、石川裕生、澤山裕介
    • Organizer
      新学術領域研究(研究領域提案型)天然物ケミカルバイオロジー~分子標的と活性制御~第4回公開シンポジウム
    • Place of Presentation
      つくば
    • Related Report
      2013 Annual Research Report
  • [Presentation] テトロドトキシンの全合成研究 -フグ毒の謎を追って-2013

    • Author(s)
      西川俊夫
    • Organizer
      理研シンポジウム 未来に繋ぐ天然物合成化学
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヘテロ環天然物の合成研究2013

    • Author(s)
      西川俊夫
    • Organizer
      平成25年度有機合成化学協会東海支部 若手研究者のためのセミナー
    • Place of Presentation
      三重
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Synthesis of guanidine-containing natural products.2013

    • Author(s)
      Toshio Nisikawa
    • Organizer
      ACP Lectureship Tour
    • Place of Presentation
      Nanyang Technological University, National University of Singapore, Singapore
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 矢毒カエル毒チリキトキシンの全合成2013

    • Author(s)
      安立昌篤、今津拓也、榊原 良、佐竹佳樹、磯部 稔、西川俊夫
    • Organizer
      第55回天然有機化合物討論会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Crambescin Bカルボン酸の合成2013

    • Author(s)
      石川裕生、澤山裕介、中崎敦夫、西川俊夫
    • Organizer
      第43回複素環化学討論会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Nav安定発現系の構築とTTX関連化合物の結合性評価2013

    • Author(s)
      千葉雪絵、長由扶子、安立昌篤、榊原 良、所 聖太、今津拓也、磯部 稔、西川俊夫、山下まり、此木敬一
    • Organizer
      日本農芸化学会東北支部第148回大会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthesis of Marine Toxins Aiming at Developing Ion-Channel Inhibitors2013

    • Author(s)
      Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Takuya Imazu, Yoshiki Satake, Shouta Tokoro, Atsuo Nakazaki, Yuuki Ishikawa, Yusuke Sawayama, Minoru Isobe, Keiichi Konoki, Yukie Chiba, Mari Yotsu-Yamashita
    • Organizer
      The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Annual Research Report
  • [Presentation] カスケード型ブロモ環化反応を用いたサキシトキシン骨格の効率的構築法の開発2013

    • Author(s)
      上野壮平、中崎敦夫、西川俊夫
    • Organizer
      第44回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      浜松
    • Related Report
      2013 Annual Research Report
  • [Presentation] MTM基の新しい脱保護法に関する研究2013

    • Author(s)
      橋本穂果、今津拓也、榊原 良、安立昌篤、西川俊夫
    • Organizer
      第44回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      浜松
    • Related Report
      2013 Annual Research Report
  • [Presentation] gem-ジブロモメチレンを用いた新規反応の開発2013

    • Author(s)
      木村梨乃、澤山裕介、西川俊夫
    • Organizer
      第44回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      浜松
    • Related Report
      2013 Annual Research Report
  • [Presentation] クロイソカイメンおよびホタテ貝による下痢性貝毒の蓄積機構2013

    • Author(s)
      此木敬一
    • Organizer
      日本農芸化学会東北支部第148回大会
    • Place of Presentation
      岩手
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Physiological Function Acquired by Diarrheic Shellfish Poisoning-Accumulating Species2013

    • Author(s)
      Keiichi Konoki
    • Organizer
      The 2nd International Symposium on Chemical Biology of Natural Products: Target ID and Regulation of Bioactivity
    • Place of Presentation
      Yokohama
    • Related Report
      2013 Annual Research Report
  • [Presentation] Collective Synthesis of Tetrodotoxin and its Analogus.2012

    • Author(s)
      Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Shouta Tokoro, Takuya Imazu, Yoshiki Satake, Minoru Isobe
    • Organizer
      The 7th International Conference on Cutting-Edge Organic Chemistry in Asia and The 3rd New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7/NICCEOCA-3)
    • Place of Presentation
      Singapore
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of Guanidine-Containing Natural Products.2012

    • Author(s)
      Toshio Nishikawa
    • Organizer
      International Symposium on Natural Products Chemistry and Chemical Biology 2012
    • Place of Presentation
      Hangzhou, China
    • Year and Date
      2012-11-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Synthesis of Marine Toxins Aiming at Developing Ion-Channel Inhibitors. The 1st International Symposium on Chemical Biology of Natural Products2012

    • Author(s)
      Toshio Nishikawa, Masaatsu Adachi, Ryo Sakakibara, Takuya Imazu, Yoshiki Satake, Minoru Isobe
    • Organizer
      Target ID and Regulation of Bioactivity
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] Self-defence mechanism of diarrhetic shellfish poisoning toxins-accumulating species、The 1st International Symposium on Chemical Biology of Natural Products2012

    • Author(s)
      Keiichi Konoki
    • Organizer
      Target ID and Regulation of Bioactivity
    • Place of Presentation
      Kyoto
    • Year and Date
      2012-10-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] 5,11-ジデオキシテトロドトキシンの全合成2012

    • Author(s)
      今津拓也、安立昌篤、磯部 稔、西川俊夫
    • Organizer
      日本農芸化学会中部支部第165回例会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-27
    • Related Report
      2012 Annual Research Report
  • [Presentation] 質量分析を用いたイチイ中のタキソール結合タンパク質の探索2012

    • Author(s)
      工藤佑馬、阿部晃大、長由扶子、山下まり、此木敬一
    • Organizer
      日本農芸化学会東北支部会第147回大会
    • Place of Presentation
      弘前
    • Year and Date
      2012-10-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] 植物毒素Tagetitoxinの合成研究2012

    • Author(s)
      山田ひと美、安立昌篤、西川俊夫
    • Organizer
      第29回有機合成化学セミナー
    • Place of Presentation
      静岡
    • Year and Date
      2012-09-05
    • Related Report
      2012 Annual Research Report
  • [Presentation] ホタテ貝中の下痢性貝毒変換酵素の探索2012

    • Author(s)
      此木敬一、小野田竜也、長由扶子、加賀新之助、渡邉龍一、鈴木敏之、山下まり
    • Organizer
      第59回毒素シンポジウム
    • Place of Presentation
      帯広
    • Year and Date
      2012-08-30
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] インドールアルカロイド セスペンドールの合成研究2012

    • Author(s)
      樋口恵子、Nopporn Thasana、山田ひと美、杉野公美、中崎敦夫、安立昌篤、西川俊夫
    • Organizer
      第47回天然化学物談話会
    • Place of Presentation
      熊本
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] 5,11-ジデオキシテトロドトキシンの合成2012

    • Author(s)
      今津拓也、安立昌篤、西川俊夫
    • Organizer
      第47回天然化学物談話会
    • Place of Presentation
      熊本
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] 環状グアニジン化合物の合成研究2012

    • Author(s)
      上野壮平、中崎敦夫、西川俊夫
    • Organizer
      第47回天然物化学談話会
    • Place of Presentation
      熊本
    • Year and Date
      2012-07-04
    • Related Report
      2012 Annual Research Report
  • [Presentation] サブタイプ選択的Na+チャネル阻害剤創製を目指したテトロドトキシン類縁体の合成研究2012

    • Author(s)
      西川俊夫、安立昌篤、此木敬一
    • Organizer
      新学術領域研究「天然物ケミカルバイオロジー:分子標的と活性制御」第2回領域公開シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-06-17
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヘテロ環天然物の全合成研究 ---天然物合成は新反応発見の場(きっかけ)となるか?2012

    • Author(s)
      西川俊夫
    • Organizer
      広島大学大学院理学研究科 特別講演会
    • Place of Presentation
      東広島
    • Year and Date
      2012-06-15
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 環状グアニジン骨格を有する海産天然物クランベシンBの合成研究2012

    • Author(s)
      石川裕生、澤山裕介、中崎敦夫、西川俊夫
    • Organizer
      新規素材探索研究会第11回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-08
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthetic Studies on Guanidine-Containing Natural Products.2012

    • Author(s)
      Toshio Nishikawa
    • Organizer
      ACP Lectureship Tour
    • Place of Presentation
      Hong-Kong
    • Year and Date
      2012-04-24
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] イオンチャネル阻害剤の創製を目指した海産天然毒の化学合成2012

    • Author(s)
      西川俊夫
    • Organizer
      シンポジウム4SY09「天然物ケミカルバイオロジー」日本農芸化学会2012年度大会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗腫瘍抗生物質パクタマイシンの合成研究2012

    • Author(s)
      松本信之、辻本恭、中崎敦夫、西川俊夫
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] インドールアルカロイドsespendole芳香環部分の合成研究と立体化学の決定2012

    • Author(s)
      樋口恵子、Nopporn Thasana、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 植物毒素Tagetitoxinの合成研究2012

    • Author(s)
      山田ひと美、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 8-デオキシテトロドトキシンの立体制御合成2012

    • Author(s)
      所聖太、安立昌篤、磯部稔、西川俊夫
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] ソラノエクレピンA右側部分の合成研究2012

    • Author(s)
      駒田武馬、安立昌篤、西川俊夫
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海産アルカロイドチャルテリンCの合成研究2012

    • Author(s)
      原由香里、梶井重男、中崎敦夫、磯部稔、西川俊夫
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] テトロドトキシンおよびチリキトキシンの合成研究2012

    • Author(s)
      榊原良、安立昌篤、佐竹佳樹、磯部稔、西川俊夫
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 紅藻からの新規プロスタグランジン代謝物の単離、構造決定とマウス組織中での同定2012

    • Author(s)
      金井良和、廣木禎彦、越野広雪、此木敬一、長由扶子、Cayme Mirriam、福代康夫、山下まり
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] クロイソカイメン中のオカダ酸、オカダ酸結合タンパク質の定量および局在2012

    • Author(s)
      松浦宏樹、小濱真実、福沢世傑、橘和夫、長由扶子、山下まり、此木敬
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] クロイソカイメン細胞の培養およびオカダ酸結合タンパク質OABP2.1の局在2012

    • Author(s)
      小濱真実、松浦宏樹、西谷豪、伊東久美子、大和田修一、長由扶子、山下まり、此木敬
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海洋性カロテノイド、フコキサンチンのヒドロキシル基修飾体の細胞毒性とタンパク質結合体の作製2012

    • Author(s)
      野村駿、此木敬一、長由扶子、山下まり
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] 沖縄産シリケンイモリ(Cynops ensicauda popei)の新規テトロドトキシン類縁体の単離・構造決定、及びイモリとフグの毒組成比較2012

    • Author(s)
      工藤雄大、此木敬一、長由扶子、安元健、山下まり
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Target candidate for maitotoxin, the most toxic marine natural product2011

    • Author(s)
      Keiichi Konoki
    • Organizer
      International ERATO Symposium on Lipid Structures in and around Proteins
    • Place of Presentation
      吹田
    • Year and Date
      2011-11-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規テトロドトキシン類縁体の同定と各種海洋生物中の毒組成の比較2011

    • Author(s)
      阿部由佳、西川俊夫、磯部稔、小野寺健一、此木敬一、長由扶子、安元健、山下まり
    • Organizer
      日本農芸化学会東北支部会
    • Place of Presentation
      鶴岡
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] ホタテ貝(Patinopecten yessoensis)中のオカタ酸アシル化酵素の探索2011

    • Author(s)
      小野田竜也、渡邊龍一、長由扶子、鈴木敏之、山下まり, 此木敬一
    • Organizer
      日本農芸化学会東北支部会
    • Place of Presentation
      鶴岡
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 含グアニジン天然物の合成研究-イオンチャネル阻害剤の創製を目指して-2011

    • Author(s)
      西川俊夫
    • Organizer
      第356回東北大学大学院薬学研究科セミナー
    • Place of Presentation
      仙台(招待講演)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] テトロドトキシン類の化学合成とフグ毒の謎。『That's応用生命科学』有機化学、分子生物学、食品科学の最新研究から見る応用生命科学のいま2011

    • Author(s)
      西川俊夫
    • Organizer
      日本農芸化学会中部支部第161回例会
    • Place of Presentation
      岐阜(招待講演)
    • Year and Date
      2011-06-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗腫瘍抗生物質パクタマイシンの合成研究2011

    • Author(s)
      松本信之、辻本恭、中崎敦夫、西川俊夫
    • Organizer
      新規素材探索研究会第10回セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 含窒素生理活性天然物の合成イオンチャネルを阻害する天然毒素とその類縁体の化学合成-2011

    • Author(s)
      西川俊夫
    • Organizer
      新規素材探索研究会第10回セミナー
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] イオンチャネルを阻害する天然毒素とその類縁体の化学合成2011

    • Author(s)
      西川俊夫
    • Organizer
      平成22年度長瀬科学技術振興財団研究成果報告会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2011-04-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 薬用植物由来の多環性天然物polygalolide Aの全合成2011

    • Author(s)
      山田ひと美.安立昌篤、磯部稔、西川俊夫
    • Organizer
      第9回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Decarbamoyl-α-saxitoxinolの合成2011

    • Author(s)
      澤山裕介、西川俊夫
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] インドールアルカロイドsespendole芳香環部分の合成研究2011

    • Author(s)
      樋口恵子、Nopporn Thasana、杉野公美、中崎敦夫、安立昌篤、西川俊夫
    • Organizer
      第42回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      長野
    • Related Report
      2011 Annual Research Report
  • [Presentation] 8-デオキシテトロドトキシンの立体制御合成2011

    • Author(s)
      所聖太、安立昌篤、磯部稔、西川俊夫
    • Organizer
      第42回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      長野
    • Related Report
      2011 Annual Research Report
  • [Presentation] 糖アミノ酸C-マンノシルトリプトファン(C-Man-Trp)の合成研究2011

    • Author(s)
      三矢和志、中崎敦夫、久世雅樹、西川俊夫
    • Organizer
      第42回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      長野
    • Related Report
      2011 Annual Research Report
  • [Presentation] テトロドトキシンおよびチリキトキシンの合成研究2011

    • Author(s)
      榊原良、安立昌篤、佐竹佳樹、磯部稔、西川俊夫
    • Organizer
      第100回有機合成シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Total Synthesis of Polygalolide A2011

    • Author(s)
      Masaatsu Adachi, Hitomi Yamada, Minoru Isobe, Toshio Nishikawa
    • Organizer
      The 6th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-6), The 2nd New phase International Conference on Cutting-edge Organic Chemistry in Asia
    • Place of Presentation
      Hong Kong, P.R.China
    • Related Report
      2011 Annual Research Report
  • [Presentation] 沖縄産シリケンイモリ(Cynops ensicauda popei)の新規テトロドトキシン類縁体の単離と構造決定2011

    • Author(s)
      工藤雄大、此木敬一、長由扶子、安元健、山下まり
    • Organizer
      第53回天然有機化合物討論会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Book] カスケード型環化反応による天然物合成の効率化。特集 天然物の全合成、全合成の最先端研究I2016

    • Author(s)
      西川俊夫
    • Total Pages
      4
    • Publisher
      化学
    • Related Report
      2015 Annual Research Report
  • [Book] 天然物合成で活躍した反応-実験のコツとポイント2011

    • Author(s)
      大藪紀雄、西川俊夫
    • Total Pages
      2
    • Publisher
      化学同人
    • Related Report
      2011 Annual Research Report
  • [Remarks] 生物有機化学研究分野ホームページ

    • URL

      http://www.agr.nagoya-u.ac.jp/~organic/

    • Related Report
      2015 Annual Research Report
  • [Remarks] 名古屋大学大学院生命農学研究科 生物有機化学研究分野ホームページ

    • URL

      http://www.agr.nagoya-u.ac.jp/~organic/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 名古屋大学大学院生命農学研究科 生物有機化学研究分野ホームページ

    • URL

      http://www.agr.nagoya-u.ac.jp/~organic/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.agr.nagoya-u.ac.jp/~organic/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-08-01   Modified: 2019-07-29  

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