| Project Area | Advanced Molecular Transformations by Organocatalysts |
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| Project/Area Number |
23105007
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MIYABE Hideto 兵庫医療大学, 薬学部, 教授 (10289035)
KOBAYASHI Yusuke 京都大学, 大学院薬学研究科, 助教 (90509275)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥114,270,000 (Direct Cost: ¥87,900,000、Indirect Cost: ¥26,370,000)
Fiscal Year 2015: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
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| Keywords | 有機触媒 / 不斉反応 / 水素結合 / ハロゲン結合 / ルイス塩基 / ルイス酸 / 天然物合成 / 複素環化学 / ベンゾチアジアジン触媒 / スルホン酸アミド触媒 / アミノチオ尿素 / ボロン酸 / ヨードイミダゾリウム塩 / リン酸触媒 / ２元触媒 / アミノ酸誘導体 / α,β－不飽和カルボン酸 / ボロン酸触媒 / NHC触媒 / β,β二置換不飽和アルデヒド / セミピナコール転位反応 / Nakadomarin A / caprazamycin A / 水素結合供与触媒 / 光励起触媒 / アルドール反応 / マイケル付加 / ラジカル付加 / エポキシ化 / 水素結合供与分子 / 合成化学 / アレン化合物 / 反応機構 / カルベン触媒 / チオ尿素触媒 / ヒドラジノ化反応 / 不斉Neber反応 / 二置換アレン合成 / ペタシス反応 / ヒドロキシチオ尿素触媒 |
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| Outline of Final Research Achievements |
With an aim of developing innovative organocatalysts, we designed new organocatalysts bearin a Lewis base or Lewis acid moiety such as aminothioureas, benzothiadiazines, NHC’s, phosphoric acids, halogen-bond donors. After many screening of these catalysts, a wide range of asymmetric reactions have been developed: (1) bifunctional aminothioureas (Neber reaction and aldol reaction), (2) benzothiadiazines (epoxidation, synthesis of allenoates, oxa-Michael addition), (3) TEMPO-promoted aerobic oxidation, (4) NHC-catalysts (thioesterification, synthesis of 3,3-disubstituted indoline-2-thiones), (5) phosphoric acids (anti-α,β-diamino acid derivatives), (6) halogen-bond donor catalysts (semi-pinacol rearrangement, direct dehydroxylative coupling reaction of alcohols with organosilanes), (7) arylboronic acids (hetero-Michael addition to α,β-unsaturated carboxylic acids), (8) total synthesis of nakadomarin A, caprazamycin A, and beraprost.
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