| Budget Amount *help |
¥51,870,000 (Direct Cost: ¥39,900,000、Indirect Cost: ¥11,970,000)
Fiscal Year 2015: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Arenes and heteroarenes have been widely used in the structure of various drug candidates. The development of new methodology for the C-H functionalization of aromatic molecules is considered to be one of the most important subjects in medicinal oriented organic synthesis. Many kind of transition metalcatalyzed reactions have been employed for the selective modification of aromatic molecules, but the comtamination of heavy metals in the precursors of drug syntheses is strictly regulated. In this project, develpment of organocatalytic systems for selective C-H functionalization of aromatic molecules was investigated without using transition metal catalyzed processes. Especially, new deprotonative functionalizations were achieved by using in situ generated amide base catalyst.
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