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Development of new synthetic methods and molecules using organocatalyst

Planned Research

Project AreaAdvanced Molecular Transformations by Organocatalysts
Project/Area Number 23105010
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTohoku University

Principal Investigator

Hayashi Yujiro  東北大学, 理学研究科, 教授 (00198863)

Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥86,710,000 (Direct Cost: ¥66,700,000、Indirect Cost: ¥20,010,000)
Fiscal Year 2015: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords有機触媒 / 不斉合成 / 不斉触媒反応 / 天然物合成 / 全合成 / ワンポット反応 / 有機合成化学 / タミフル / 天然物 / 不斉反応 / エナミン / マイケル反応 / 触媒反応 / インフルエンザ
Outline of Final Research Achievements

Diphenylprolinol silyl ether, which can be conveniently synthesized from proline, was found to be effective for reactions involving enamine and iminium salt as intermediates, such as Mannich reaction, Michael reaction, epoxidation reaction, aldol reaction, 3 + 2 cycloaddition reaction, cyclopropanation reaction, and Diels-Alder reaction. These reactions can construct asymmetric quaternary carbons centers, which are difficult to be synthesized. Also, we developed a cross-aldol reaction of glyoxal, alkynyl aldehyde, chloral, and dichloroacetaldehyde catalyzed by diarylprolinol having CF3 group on aromatic ring. In addition, total syntheses of RQN-18690A (18-Deoxyherboxidiene) and N 7,10-epimer of Amphidinolide N, and one-pot syntheses of Tamiflu and Baclofen were accomplished.

Report

(6 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (117 results)

All 2017 2016 2015 2014 2013 2012 2011 Other

All Int'l Joint Research (1 results) Journal Article (44 results) (of which Peer Reviewed: 41 results,  Acknowledgement Compliant: 16 results,  Open Access: 1 results) Presentation (64 results) (of which Int'l Joint Research: 16 results,  Invited: 38 results) Book (8 results)

  • [Int'l Joint Research] ETH-Zurich(スイス)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Formal Synthesis of Ezetimibe Using a Proline-mediated Asymmetric, Three-component Mannich Reaction2016

    • Author(s)
      Y. Shimazaki, S. Koshino, Y. Hayashi
    • Journal Title

      Chem. Lett.

      Volume: 18 Issue: 1 Pages: 30-32

    • DOI

      10.1246/cl.150916

    • NAID

      130005118756

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step2016

    • Author(s)
      Y. Hayashi, D. Okamura, D. Sakamoto
    • Journal Title

      Org. Lett.

      Volume: 18 Issue: 1 Pages: 4-7

    • DOI

      10.1021/acs.orglett.5b02839

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Pot economy and one-pot synthesis2016

    • Author(s)
      Y. Hayashi
    • Journal Title

      Chem. Sci.

      Volume: 7 Issue: 2 Pages: 866-880

    • DOI

      10.1039/c5sc02913a

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Total Synthesis of 7,10-Epimer of the Proposed Structure of Amphidinolide N, Part I: Synthesis of the C1-C13 Subunit2016

    • Author(s)
      K. Ochiai, S. Kuppusamy, Y. Yasui, T. Okano, Y. Matsumoto, N. R. Gupta, Y. Takahashi, T. Kubota, J. Kobayashi, Y. Hayashi
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Issue: 10 Pages: 3282-3286

    • DOI

      10.1002/chem.201504674

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of 7,10-Epimer of the Proposed Structure of Amphidinolide N, Part II: Synthesis of C17-C29 Subunit and Completion of the Synthesis2016

    • Author(s)
      K. Ochiai, S. Kuppusamy, Y. Yasui, K. Harada, N. R. Gupta, Y. Takahashi, T. Kubota, J. Kobayashi, Y. Hayashi
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Issue: 10 Pages: 3287-3291

    • DOI

      10.1002/chem.201504675

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 16O/18O Exchange of Aldehydes and Ketones caused by H218O in the Mechanistic Investigation of Organocatalyzed Michael, Mannich, and Aldol reactions2016

    • Author(s)
      Y. Hayashi, T. Mukaiyama, M. Benohoud, N. R Gupta, T. Ono, S. Toda
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Issue: 17 Pages: 5868-5872

    • DOI

      10.1002/chem.201600280

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The DFT Calculation with NBO Analysis of E/Z Enamines Derived from α-Alkoxyaldehyde with Pyrrolidine2016

    • Author(s)
      T. Mukaiyama, T. Uchimaru, Y. Hayashi
    • Journal Title

      Bull. Chem. Soc. Jpn.

      Volume: 89 Issue: 4 Pages: 455-459

    • DOI

      10.1246/bcsj.20150382

    • NAID

      130005144946

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric Aldol Reaction of Dichloroacetaldehyde Catalyzed by Diarylprolinol2016

    • Author(s)
      Y. Hayashi, D. Nakamura, Y. Yasui, K. Iwasaki, H. Chiba
    • Journal Title

      Adv. Synth. Catal.

      Volume: 358 Issue: 14 Pages: 2345-2351

    • DOI

      10.1002/adsc.201501111

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene)2016

    • Author(s)
      Y. Matsumoto, K. Hibino, M. Yonaga, H. Kakeya, Y. Hayashi
    • Journal Title

      Org. Lett.

      Volume: 18 Issue: 14 Pages: 3382-3385

    • DOI

      10.1021/acs.orglett.6b01524

    • NAID

      130007722910

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Diels-Alder Reaction of α-Substituted and β,β-Disubstituted α,β-Enals via Diarylprolinol Silyl Ether for the Construction of All-Carbon Quaternary Stereocenters2016

    • Author(s)
      Y. Hayashi, B. P. Bondzic, T. Yamazaki, Y. Gupta, S. Ogasawara, T. Taniguchi, K. Monde
    • Journal Title

      Chem. Eur. J.

      Volume: 22 Issue: 44 Pages: 15874-15880

    • DOI

      10.1002/chem.201602345

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time Economical Total Synthesis of (-)-Oseltamivir2016

    • Author(s)
      Y. Hayashi, S. Ogasawara
    • Journal Title

      Org. Lett.

      Volume: 18 Issue: 14 Pages: 3426-3429

    • DOI

      10.1021/acs.orglett.6b01595

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric Organocatalyzed Epoxidation of 2-Oxoindoline-3-ylidene Acetaldehydes2015

    • Author(s)
      T. Mukaiyama, K. Ogata, T. Ono, Y. Hayashi
    • Journal Title

      ChemCatChem

      Volume: 7 Issue: 1 Pages: 155-159

    • DOI

      10.1002/cctc.201402811

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric Aldol Reaction of Chloral Catalyzed by Diarylprolinol2015

    • Author(s)
      Y. Hayashi, S. Watanabe, Y. Yasui, S. Umemiya
    • Journal Title

      ChemCatChem

      Volume: 7 Issue: 11 Pages: 1646-1649

    • DOI

      10.1002/cctc.201500282

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Aldol Reaction of α,α-Disubstituted Acetaldehydes Catalyzed by Diphenylprolinol Silyl Ether for the Construction of Quaternary Stereogenic Centers2015

    • Author(s)
      Yujiro Hayashi, Hiroki Shomura, Qianqian Xu, Martin J. Lear, Itaru Sato
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 2015 Issue: 20 Pages: 4316-4319

    • DOI

      10.1002/ejoc.201500585

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Formal [3+2] Cycloaddition Reaction of Succinaldehyde and Nitro­alkene Catalyzed by Diphenylprolinol Silyl Ether2015

    • Author(s)
      S. Umemiya, Y. Hayashi
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 20 Issue: 20 Pages: 4320-4324

    • DOI

      10.1002/ejoc.201500623

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Reaction Mechanisms via Iminium Ion Intermediates: The Different Reactivity of Diphenylprolinol Silyl Ether and Trifluoromethyl-Substituted Diarylprolinol Silyl Ether2015

    • Author(s)
      H. Gotoh, T. Uchimaru, Y. Hayashi
    • Journal Title

      Chem. Eur. J.

      Volume: 21 Issue: 35 Pages: 12337-12346

    • DOI

      10.1002/chem.201500326

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric Nitrocyclopropanation of α-Substituted α,β-Enals Catalyzed by Diphenylprolinol Silyl Ether for the Construction of All-Carbon Quaternary Stereogenic Centers2015

    • Author(s)
      Hayashi Y., Yamazaki T., Nakanishi Y., Ono T., TaniguchiT., Monde K., Uchimaru T.
    • Journal Title

      Eur.J. Org. Chem.

      Volume: 2015 Issue: 26 Pages: 5747-5754

    • DOI

      10.1002/ejoc.201500838

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric Aldol Reaction of Formaldehyde Catalyzed by Diarylprolinol2014

    • Author(s)
      Yusuke Yasui, Meryem Benohoud, Itaru Sato, Yujiro Hayashi
    • Journal Title

      Chem. Lett.

      Volume: 43 Issue: 4 Pages: 556-558

    • DOI

      10.1246/cl.131199

    • NAID

      130004868084

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diphenylprolinol Silyl Ether Catalyzed Asymmetric Michael Reaction of Nitroalkanes and β,β-Disubstituted α,β-Unsaturated Aldehydes for the Construction of All-Carbon Quaternary Stereogenic Centers2014

    • Author(s)
      Yujiro Hayashi, Yuya Kawamoto, Masaki Honda, Daichi Okamura, Shigenobu Umemiya, Yuka Noguchi, Takasuke Mukaiyama, Itaru Sato
    • Journal Title

      Chem. Eur. J.

      Volume: 20 Issue: 38 Pages: 12072-12082

    • DOI

      10.1002/chem.201403588

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric Aldol Reaction of α-Acetoxyimino Aldehydes and its Application in the Synthesis of Substituted 1,2-Oxazine Derivatives2014

    • Author(s)
      Y. Yasui, K. Ogata, I. Sato, Y. Hayashi
    • Journal Title

      Adv. Synth. Catal.

      Volume: 356 Issue: 14-15 Pages: 3106-3118

    • DOI

      10.1002/adsc.201400294

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Asymmetric Organocatalyzed Michael Addition of Nitrometane to 2-Oxoindoline-3-ylidene acetaldehyde and Three “One-pot” Sequential Synthesis of (-)-Horsfiline and (-)-Coerulescine2014

    • Author(s)
      T. Mukaiyama, K. Ogata, I. Sato, Y. Hayashi
    • Journal Title

      Chem. Eur. J.

      Volume: 20 Issue: 42 Pages: 13583-13588

    • DOI

      10.1002/chem.201403932

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Theoretical and Experimental Study of the Effects of Silyl Substituents in Enantioselective Reactions Catalyzed by Diphenylprolinol Silyl Ether2014

    • Author(s)
      Hayashi, Y.; Okamura, D.; Yamazaki, T.; Ameda, Y.; Gotoh, H.; Tsuzuki, S.; Uchimaru, T. Seebach, D
    • Journal Title

      Chem. Eur. J

      Volume: 20 Issue: 51 Pages: 17077-17088

    • DOI

      10.1002/chem.201403514

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Asymmetric Catalytic Mannich Reaction Catalyzed by Organocatalyst - A Personal Account -2014

    • Author(s)
      Yujiro Hayashi
    • Journal Title

      J. Synth. Org. Chem., Jpn.

      Volume: 72 Pages: 1228-1238

    • NAID

      130004749121

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] ポットエコノミーを指向した効率的天然物合成2014

    • Author(s)
      石川勇人、林 雄二郎
    • Journal Title

      ファインケミカル

      Volume: 43 Pages: 6-14

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] ここまでできる!短工程合成2014

    • Author(s)
      林 雄二郎、佐藤格
    • Journal Title

      化学(化学同人)

      Volume: 69 Pages: 64-65

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 有機触媒の医薬品合成への応用2014

    • Author(s)
      林 雄二郎
    • Journal Title

      ファインケミカル

      Volume: 43 Pages: 58-67

    • Related Report
      2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Asymmetric Mannich Reaction of α-Keto Imines Catalyzed by Diarylprolinol Silyl Ether2013

    • Author(s)
      Y. Hayashi, D. Sakamoto, H. Shomura, D. Hashizume
    • Journal Title

      Chem. Eur. J.

      Volume: 19 Issue: 12 Pages: 7678-7681

    • DOI

      10.1002/anie.201209380

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stoichiometric Reactions of Enamines Derived from Diphenylprolinol Silyl Ethers with Nitro Olefins and Lessons for the Corresponding Organocatalytic Conversions- a Survey2013

    • Author(s)
      D. Seebach, X. Sun, M.-O. Ebert, W. B. Schweizer, N. Purkayastha, A. K. Beck, J. Duschmale, H. Wennemers, T. Mukaiyama, M. Benohoud, Y. Hayashi, M. Reiher
    • Journal Title

      Helv. Chim. Acta

      Volume: 96 Pages: 799-852

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Aldol Reaction of Glyoxal Catalyzed by Diarylprolinol2013

    • Author(s)
      Y. Hayashi, M. Kojima
    • Journal Title

      ChemCatChem

      Volume: 5 Issue: 10 Pages: 2883-2885

    • DOI

      10.1002/cctc.201300247

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diarylprolinol in an Asymmetric, Direct Cross-Aldol Reaction with Alkynyl Aldehydes2013

    • Author(s)
      Yujiro Hayashi, Masahiro Kojima, Yusuke Yasui, Yuta Kanda, Takasuke Mukaiyama, Hiroki Shomura, Daichi Nakamura, Leni Ritmaleni, Itaru Sato
    • Journal Title

      ChemCatChem

      Volume: 5 Issue: 10 Pages: 2887-2892

    • DOI

      10.1002/cctc.201300390

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Formal [3 + 2] Cycloaddition Reaction of Succinaldehyde via Diarylprolinol-mediated Domino Aldol - Acetalization Reaction for the Construction of Tetrahydrofuran2013

    • Author(s)
      Y. Hayashi, K. Nishino, I. Sato
    • Journal Title

      Chem. Lett.

      Volume: 42 Issue: 10 Pages: 1294-1296

    • DOI

      10.1246/cl.130544

    • NAID

      10031201343

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Remote 1,6-Stereocontrol by Iminium-mediated Organocatalytic Events2013

    • Author(s)
      M. J. Lear, Y. Hayashi
    • Journal Title

      ChemCatChem

      Volume: 5 Issue: 12 Pages: 3499-3501

    • DOI

      10.1002/cctc.201300590

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-Pot Synthesis of (-)-Oseltamivir and Mechanistic Insights into the Organocatalyzed Michael Reaction2013

    • Author(s)
      T. Mukaiyama, H. Ishikawa, H. Koshino, Y. Hayashi
    • Journal Title

      Chem. Eur. J

      Volume: 19 Issue: 52 Pages: 17789-17800

    • DOI

      10.1002/chem.201302371

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organocatalyst-Mediated Dehydrogenation of Aldehydes to α,β-Unsaturated Aldehydes, and Oxidative and Enantioselective Reaction of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether2013

    • Author(s)
      Y. Hayashi , T. Itoh, H. Ishikawa
    • Journal Title

      Adv. Synth. Catal

      Volume: 355 Issue: 18 Pages: 3661-3669

    • DOI

      10.1002/adsc.201300919

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxoaldehyde as an electrophile2012

    • Author(s)
      Yujiro Hayashi, Yusuke Yasui, Masahiro Kojima, Tsuyoshi Kawamura and Hayato Ishikawa
    • Journal Title

      Chem、Commun

      Volume: 48 Issue: 38 Pages: 4570-4572

    • DOI

      10.1039/c2cc31230a

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organocatalytic 1,4-Addition Reaction of α,β-γ,δ-Diunsaturated Aldehyde versus 1,6-Addition Reaction2012

    • Author(s)
      Y. Hayashi, D. Okamura, S. Umemiya, T. Uchimaru
    • Journal Title

      ChemCatChem

      Volume: 7 Issue: 7 Pages: 959-962

    • DOI

      10.1002/cctc.201200161

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-pot High-Yielding Synthesis of the DPP4-Selective Inhibitor ABT-341 by a Four-Component Coupling Mediated by a Diphenylprolinol Silyl Ether2011

    • Author(s)
      Hayato Ishikawa
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 50 Issue: 12 Pages: 2824-2827

    • DOI

      10.1002/anie.201006204

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-Pot Synthesis of Chiral α-Substituted β,γ-Epoxy Aldehyde Derivatives through an Asymmetric Aldol Reaction of Chloroacetaldehyde2011

    • Author(s)
      Yujiro Hayahsi
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 50 Issue: 12 Pages: 2804-2807

    • DOI

      10.1002/anie.201005577

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric One-Pot Four-Component Coupling Reaction: Synthesis of Substituted Tetrahydropyrans Catalyzed by Diphenylprolinol Silyl Ether2011

    • Author(s)
      H. Ishikawa
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 50 Issue: 16 Pages: 3774-3779

    • DOI

      10.1002/anie.201005386

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative and Enantioselective Cross-Coupling of Aldehydes and Nitromethane Catalyzed by Diphenylprolinol Silyl Ether2011

    • Author(s)
      Y. Hayashi
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 50 Issue: 17 Pages: 3920-3924

    • DOI

      10.1002/anie.201006885

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Mannich Reaction of Imines Derived from Aliphatic and Aromatic Aldehydes Catalyzed by Diarylprolinol Silyl Ether2011

    • Author(s)
      T. Urushima
    • Journal Title

      Chem. Eur. J.

      Volume: 17 Issue: 30 Pages: 8273-8276

    • DOI

      10.1002/chem.201101077

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of (-)-Oseltamivir using a microreactor in the Curtius rearrangement2011

    • Author(s)
      H. Ishikawa
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 2011 Issue: 30 Pages: 6020-6031

    • DOI

      10.1002/ejoc.201100074

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-pot Synthesis of Chiral Aziridines by a Domino Reaction by Using Desulfonylative Formation on the N-Tosyl Imine of Chloroacetaldehyde with an Asymmetric Mannich Reaction as a Key Step2011

    • Author(s)
      Y. Hayashi
    • Journal Title

      Chem. Eur. J.

      Volume: 17 Issue: 42 Pages: 11715-11718

    • DOI

      10.1002/chem.201101668

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organocatalytic, Enantioselective Intramolecular [6+2] Cycloaddition Reaction for the Formation of Tricyclopentanoids and Insight on Its Mechanism from a Computational Study2011

    • Author(s)
      Uchimaru, T.
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133 Issue: 50 Pages: 20175-20185

    • DOI

      10.1021/ja108516b

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Asymmetric construction of a steroidal structure using diphenylprolinol silyl ether mediated asymmetric Michael reaction2017

    • Author(s)
      越野晴太郎, 林雄二郎
    • Organizer
      日本化学会 第97春季年会
    • Place of Presentation
      慶応義塾大学日吉キャンパス
    • Year and Date
      2017-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] The Asymmetric Construction of 1,3-Dimethyl Unit via Successive Michael Reaction of Nitroalkane Catalyzed by Diphenylprolinol Silyl Ether2017

    • Author(s)
      戸田駿介、林雄二郎
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学日吉キャンパス
    • Year and Date
      2017-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 4-hydroxydiphenylprolinol as an active catalyst in asymmetric aldol reaction2017

    • Author(s)
      UMEKUBO, Nariyoshi; TAKAHASHI, Kazuki; IWASAKI, Kotaro; CHIBA, Hiroaki; HAYASHI, Yujiro
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学日吉キャンパス
    • Year and Date
      2017-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Enantioselective Total Synthesis of Beraprost2017

    • Author(s)
      梅宮茂伸,坂本大輔,河内元希,林雄二郎
    • Organizer
      日本化学会 第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス
    • Year and Date
      2017-03-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthetic Study of Latanoprost2017

    • Author(s)
      河内元希, 梅宮茂伸, 林雄二郎
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学日吉キャンパス
    • Year and Date
      2017-03-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 呼吸器疾患治療薬ベラプロストの合成2017

    • Author(s)
      坂本大輔,梅宮茂伸,河内元希,林雄二郎
    • Organizer
      理学・生命科学 2研究科合同シンポジウム2017
    • Place of Presentation
      東北大学理学研究科合同C棟
    • Year and Date
      2017-02-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Synthesis of 1,3-syn-diol by asymmetric aldol / oxy-Michael reaction2016

    • Author(s)
      Y. Hayashi, T. Saitoh, H. Arase, G. Kawauchi
    • Organizer
      15th Symposium on Chemical Approaches to Chirality
    • Place of Presentation
      東京理科大学神楽坂キャンパス
    • Year and Date
      2016-11-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pot-Economy and Time-Economy in the Synthesis of Biologically Active Molecules2016

    • Author(s)
      Y. Hayashi
    • Organizer
      10th International Symposium on Integrated Synthesis (ISONIS-10)
    • Place of Presentation
      Awaji Yumebutai International Confernece Center, Awaji Island
    • Year and Date
      2016-11-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 有機触媒で如何に簡単に有用物質を作れるか?2016

    • Author(s)
      林雄二郎
    • Organizer
      日本化学会 第6回CSJ化学フェスタ2016
    • Place of Presentation
      タワーホール舟堀(東京)
    • Year and Date
      2016-11-16
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Pot-Economy and Time-Economy in the Synthesis of Biologically Active Molecules2016

    • Author(s)
      Y. Hayashi
    • Organizer
      Satellite International Mini Symposium on Middile Molecular Strategy in Sendai
    • Place of Presentation
      Katahira-campus, Tohoku University, Sendai
    • Year and Date
      2016-09-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 4-ヒドロキシジフェニルプロリノールを用いた不斉アルドール反応2016

    • Author(s)
      楳窪成祥、高橋和暉、岩崎孝太郎、千葉浩亮、林雄二郎
    • Organizer
      第33回有機合成化学セミナー
    • Place of Presentation
      北海道ヒルトンニセコビレッジ
    • Year and Date
      2016-09-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pot-economy and Time Economy in the Synthesis of Biologically Active Molecules2016

    • Author(s)
      Y. Hayashi
    • Organizer
      Advances in Organic Chemistry - Smolenice 2016
    • Place of Presentation
      Smolenice, Slovakia
    • Year and Date
      2016-09-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] オセルタミビルの超迅速60分ワンポット合成2016

    • Author(s)
      小笠原新、林雄二郎
    • Organizer
      日本プロセス化学会2016サマーシンポジウム
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Year and Date
      2016-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pot-economy in the total synthesis of biologically active molecules2016

    • Author(s)
      Y. Hayashi
    • Organizer
      Stereochemistry Gordon Research Conference
    • Place of Presentation
      Salve Regina University, Newport, RI, USA
    • Year and Date
      2016-07-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Formal synthesis of ezetimibe using a proline-mediated, asymmetric, three-component Mannich reaction2016

    • Author(s)
      島崎泰治, 越野晴太郎, 林雄二郎
    • Organizer
      20th International Symposium on Homogeneous Catalysis
    • Place of Presentation
      京都テルサ
    • Year and Date
      2016-07-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 有機分子触媒を用いた不斉反応の機構解明にH218Oを用いることの危険性2016

    • Author(s)
      戸田駿介、向山貴祐、Meryem Benohoud、Nishant R. Gupta、小野剛、林雄二郎
    • Organizer
      第51回天然物化学談話会
    • Place of Presentation
      湯沢東映ホテル、新潟
    • Year and Date
      2016-07-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有機分子触媒を用いた不斉反応の機構解明にH218Oを用いることの危険性2016

    • Author(s)
      戸田駿介、向山貴祐、Meryem Benohoud、Nishant R. Gupta、小野剛、林雄二郎
    • Organizer
      第27回万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-06-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 有機触媒を用いた天然物の短工程ポット合成2016

    • Author(s)
      林雄二郎
    • Organizer
      岐阜大学工学部 セミナー
    • Place of Presentation
      岐阜大学工学部
    • Year and Date
      2016-06-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Formal synthesis of ezetimibe using a proline-mediated, asymmetric, three-component Mannich reaction2016

    • Author(s)
      越野晴太郎, 島崎泰治, 林雄二郎
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      同志社大学 京田辺キャンパス
    • Year and Date
      2016-03-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pot-economy and Organocatalysis in total synthesis2015

    • Author(s)
      Y. Hayashi
    • Organizer
      PacificChem 2015
    • Place of Presentation
      Hilton Hawaiian Village, Hawaii, USA
    • Year and Date
      2015-12-18
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Formal synthesis of eze1mibe using a proline-mediated, asymmetric, three-component Mannich reac1on2015

    • Author(s)
      越野晴太郎, 島崎泰治, 林雄二郎
    • Organizer
      14th Symposium on Chemical Approaches to Chirality
    • Place of Presentation
      東京理科大学森戸記念館
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Organocatalyst and pot-economy in total synthesis of biologically active compounds2015

    • Author(s)
      Y. Hayashi
    • Organizer
      14th International Conference on the Chemistry of Antibiotics and other Bioactive Compounds
    • Place of Presentation
      The San Luis Resort, Galveston Island, Texas, USA
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 有機触媒を用いた生物活性化合物の短工程合成2015

    • Author(s)
      林 雄二郎
    • Organizer
      第9回北里化学シンポジウム、平成27年度AKPS研究集会
    • Place of Presentation
      北里大学 白金キャンパス
    • Year and Date
      2015-09-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] プロスタグランジン類の合成研究2015

    • Author(s)
      梅宮茂伸、坂本大輔、林雄二郎
    • Organizer
      第32回有機合成化学セミナー
    • Place of Presentation
      ニューウェルシティ湯河原
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pot Economy in Total Synthesis2015

    • Author(s)
      Y. Hayashi
    • Organizer
      Dominocat first Symposium
    • Place of Presentation
      RWTH Aachen University, Aachen, Germany
    • Year and Date
      2015-09-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pot Economy in Total Synthesis2015

    • Author(s)
      Y. Hayashi
    • Organizer
      Gordon Research Conference Natural Products
    • Place of Presentation
      Proctor Academy, NH, USA
    • Year and Date
      2015-07-26
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 医薬品合成における有機触媒の重要性2015

    • Author(s)
      林 雄二郎
    • Organizer
      第31回創薬セミナー、日本薬学会 創薬セミナー委員会主催
    • Place of Presentation
      大津プリンスホテル、滋賀
    • Year and Date
      2015-07-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Total Synthesis of Prostaglandin E1 Methyl Ester by Three One-pot Operations2015

    • Author(s)
      Y. Hayashi, S. Umemiya
    • Organizer
      The 3rd International Symposium of Process Chemistry
    • Place of Presentation
      Kyoto International Conference Center, Kyoto
    • Year and Date
      2015-07-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Pot-Synthesis of medicinally important organic compound by organocatalyst2015

    • Author(s)
      Y. Hayashi
    • Organizer
      The 39th Naito Conference on The Chemistry of Organocatalysts
    • Place of Presentation
      Chateraise Gateaux Kingdom, Sapporo, Japan
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ジフェニルプロリノールシリルエーテル触媒を用いる形式的不斉[3+2]付加環化反応2015

    • Author(s)
      梅宮茂伸、河内元希、林雄二郎
    • Organizer
      シンポジウム モレキュラー・キラリティー2015
    • Place of Presentation
      早稲田大学 西早稲田キャンパス
    • Year and Date
      2015-06-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] Oxidative Amidation of Nitroalkanes with Amine Nucleophiles using O2 and Iodine Sources: Mechanistic Insights2015

    • Author(s)
      Jing Li, Martin J. Lear, 川本雄也、梅宮茂伸、Alice R. Wong, Eunsang Kwon, 佐藤格、林雄二郎
    • Organizer
      第26回 万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2015-06-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] Organocatalyst in Asymmetric Aldol Reaction2014

    • Author(s)
      Y. Hayashi
    • Organizer
      The 9th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-9) and The 5th New Phase International Conference on Cutting-Edge Organic Chemistry in Asia (NICCEOCA-5)
    • Place of Presentation
      Eastin Hotel, Petaling Jaya, Malaysia
    • Year and Date
      2014-12-03
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 酸素を用いるNef反応の開発とプロスタグランジン合成への応用2014

    • Author(s)
      梅宮茂伸、西野健太郎、佐藤格、林雄二郎
    • Organizer
      第106回有機合成シンポジウム
    • Place of Presentation
      早稲田大学国際会議場
    • Year and Date
      2014-11-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Pot-Economy in Total Synthesis2014

    • Author(s)
      林 雄二郎
    • Organizer
      4th RSC/SCI symposium on Challenges in Catalysis for Pharmaceuticals and Fine Chemicals
    • Place of Presentation
      Burlington House, London UK
    • Year and Date
      2014-11-05
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Metal-free catalyzed synthetic transformations2014

    • Author(s)
      林 雄二郎
    • Organizer
      ISCHIA Advanced School of Organic Chemistry
    • Place of Presentation
      Ischia Island (Napoli), Italy
    • Year and Date
      2014-09-24
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Organocatalyst in Asymmetric Aldol Reaction2014

    • Author(s)
      林 雄二郎
    • Organizer
      CHIRALITY 2014 (26th International Symposium on Chiral Discrimination, ISCD-26)
    • Place of Presentation
      Prague, Czech Republic
    • Year and Date
      2014-07-28
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] タミフルのワンポット合成2014

    • Author(s)
      林 雄二郎
    • Organizer
      第4回公開シンポジウム(分子活性化 - 有機分子触媒合同シンポジウム)
    • Place of Presentation
      北海道大学学術交流会館
    • Year and Date
      2014-06-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] ニトロアルカンとβ,β-二置換アクロレインとの有機触媒による マイケル反応を用いた不斉四級炭素構築法2014

    • Author(s)
      林雄二郎 、川本雄也 、本田真崎 、岡村大地 、野口柚華 、向山貴祐、佐藤格
    • Organizer
      万有仙台シンポジウム
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2014-06-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] ジアリールプロリノールを触媒とするジクロロアセトアルデヒドの不斉クロスアルドール反応2014

    • Author(s)
      林雄二郎,渡邊翔也,中村大地,安井祐介,佐藤 格
    • Organizer
      モレキュラーキラリティ2014
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] ニトロアルカンとβ,β-二置換アクロレインとの有機触媒によるマイケル反応を用いた不斉四級炭素構築法2014

    • Author(s)
      林 雄二郎,川本雄也,本田真崎,岡村大地,野口柚華,向山貴祐,佐藤 格
    • Organizer
      モレキュラーキラリティ2014
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] ジアリールプロリノールを触媒とするアルキニルアルデヒドの不斉アルドール反応2014

    • Author(s)
      林 雄二郎,小島正裕,安井祐介,神田悠太,向山貴祐,正村宏樹,中村大地,Ritmaleni,佐藤 格
    • Organizer
      モレキュラーキラリティ2014
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Diphenylprolinol silyl ether catalyzed asymmetric Michael reaction of nitroalkanes and β,β-disubstituted α,β-unsaturated aldehydes for the construction of all-carbon quaternary stereogenic centers2014

    • Author(s)
      林 雄二郎
    • Organizer
      IGER International Symposium on Chemical Science in Asia
    • Place of Presentation
      Noyori Conference Hall, Nagoya University
    • Year and Date
      2014-05-27
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 医薬品の超短工程合成 ―One-Pot反応の応用―

    • Author(s)
      林 雄二郎
    • Organizer
      BioJapan 2013, World Business Forum
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 有機触媒を用いたプロスタグランジンの3ポット合成

    • Author(s)
      林 雄二郎
    • Organizer
      第31回メディシナルケミストリーシンポジウム、日本薬学会医薬化学部会主催
    • Place of Presentation
      アステールプラザ 広島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] One-pot reaction in total synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      Gordon Research Conference on High-Throughput Chemistry & Chemical Biology
    • Place of Presentation
      Colby-Sawyer College in New London, NH, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Pot-Economy in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      Jokichi Takamine, 130 Years of Glasgow-Japan Collaboration symposium
    • Place of Presentation
      University of Glasgow, Glasgow, Scottland
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Pot-Economy in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      XXXIV Biennial Meeting of The Spanish Royal Society of Chemistry
    • Place of Presentation
      Santander, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Pot-Economy in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      International Symposium for the 70th Anniversary of the Tohoku Branch of the Chemical Society of Japan
    • Place of Presentation
      Tohoku University, Sendai
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 有機触媒による反応のデザイン

    • Author(s)
      林 雄二郎
    • Organizer
      有機合成夏期セミナー「明日の有機合成化学」
    • Place of Presentation
      大阪科学技術センター
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 有機触媒とone-pot合成

    • Author(s)
      林 雄二郎
    • Organizer
      日本化学会関東支部主催講演会「進化する有機分子触媒-その最先端と展望-」
    • Place of Presentation
      日本化学会7階ホール
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 有機触媒と医薬品合成

    • Author(s)
      林 雄二郎
    • Organizer
      第2回大塚有機合成シンポジウム
    • Place of Presentation
      大塚製薬株式会社
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 有機触媒を起点とした生物活性化合物の合成

    • Author(s)
      林 雄二郎
    • Organizer
      第93回日本化学会春季年会
    • Place of Presentation
      立命館大学 琵琶湖・草津キャンパス
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Organocatalyst in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      ISCHIA Advanced School of Organic Chemistry
    • Place of Presentation
      Ischia Island (Napoli), Italy
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Organocatalyst in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      Organocatalysis in Rome CA, Workshop Organized with the support of COST-ORCA (OrganoCAtalysis)
    • Place of Presentation
      Sapienza University of Rome, Italy
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Organocatalyst in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      the 7th International Conference on cutting-edge organic chemistry in Asia and the 3rd new phase international conference on cutting-edge organic chemistry in Asia (ICCEOCA-7/NICCEOCA-3)
    • Place of Presentation
      Nayang Technological University, Singapore
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Asymmetric Aldol Reaction Catalyzed by Diarylprolinol

    • Author(s)
      林 雄二郎
    • Organizer
      First Japan-USA Organocatalytic Symposium
    • Place of Presentation
      Hawaii Prince Hotel Waikiki, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 有機触媒を用いた合成反応

    • Author(s)
      林 雄二郎
    • Organizer
      日本化学会 第5回関東支部大会、特別企画講演
    • Place of Presentation
      東京農工大学 小金井キャンパス
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] DPP4阻害活性を有するABT-341のOne-Pot合成

    • Author(s)
      林 雄二郎
    • Organizer
      日本プロセス化学会2011ウインターシンポジウムJSPC優秀賞受賞記念講演
    • Place of Presentation
      日本プロセス化学会、東京大学安田講堂
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Organocatalyst in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      Woodward lecture series
    • Place of Presentation
      Harvard University, MA, USA
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Diphenylprolinol silyl ether as an effective organocatalyst and its application to the one-pot synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      Novartis Chemistry Lecture
    • Place of Presentation
      Novartis Inc, Cambridge, MA, USA
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Organocatalyst in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium (AIMECS11)
    • Place of Presentation
      Keio Plaza Hotel, Tokyo, Japan
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Practical Asymmetric Synthesis Using Organocatalyst

    • Author(s)
      林 雄二郎
    • Organizer
      9th Symposium on Chemical Approaches to Chirality
    • Place of Presentation
      Ieno-hikari Kaikan, Chiral Research Center of TUS, Tokyo
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Organocatalyst in Total Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      Novartis Chemistry Lecture
    • Place of Presentation
      Novartis Inc, Basel, Switzerland
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Diphenylprolinol silyl ether in "One-Pot" Synthesis

    • Author(s)
      林 雄二郎
    • Organizer
      Novartis Chemistry Lecture
    • Place of Presentation
      Novartis Inc., Emeryville, CA, USA
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Book] イミニウム塩を活性種とする求核触媒、in 「有機分子触媒の化学」2016

    • Author(s)
      林 雄二郎
    • Publisher
      化学同人
    • Related Report
      2015 Annual Research Report
  • [Book] 有用物質合成(医薬品等)への応用、in 「有機分子触媒の化学」2016

    • Author(s)
      林 雄二郎、石川勇人
    • Publisher
      化学同人
    • Related Report
      2015 Annual Research Report
  • [Book] “Comprehensive Organic Synthesis” second edition2014

    • Author(s)
      N. Mase, Y. Hayashi
    • Publisher
      Elsevier
    • Related Report
      2014 Annual Research Report
  • [Book] Asymmetric Synthesis II: More Methods and Applications2013

    • Author(s)
      H. Ishikawa, Y. Hayashi
    • Total Pages
      4
    • Publisher
      Wiley
    • Related Report
      2013 Annual Research Report
  • [Book] Sustainable Catalysis2013

    • Author(s)
      H. Gotoh, Y. Hayashi
    • Total Pages
      29
    • Publisher
      John Wiley & Sons, Inc
    • Related Report
      2013 Annual Research Report
  • [Book] Asymmetric Organocatalysis 1: Lewis Base and Acid Catalysts2012

    • Author(s)
      M. Benohoud, Y. Hayashi
    • Total Pages
      61
    • Publisher
      George Thieme Verlag KG
    • Related Report
      2012 Annual Research Report
  • [Book] Water in Organic Synthesis2012

    • Author(s)
      M. Benohoud, Y. Hayashi
    • Total Pages
      47
    • Publisher
      George Thieme Verlag KG
    • Related Report
      2012 Annual Research Report
  • [Book] Modern Tools for the Synthesis of Complex Bioactive Molecules2012

    • Author(s)
      M. Shoji, Y. Hayashi
    • Total Pages
      23
    • Publisher
      A John Wiley & Sons, Inc.
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-01   Modified: 2019-07-29  

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