| Budget Amount *help |
¥86,710,000 (Direct Cost: ¥66,700,000、Indirect Cost: ¥20,010,000)
Fiscal Year 2015: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Outline of Final Research Achievements |
Diphenylprolinol silyl ether, which can be conveniently synthesized from proline, was found to be effective for reactions involving enamine and iminium salt as intermediates, such as Mannich reaction, Michael reaction, epoxidation reaction, aldol reaction, 3 + 2 cycloaddition reaction, cyclopropanation reaction, and Diels-Alder reaction. These reactions can construct asymmetric quaternary carbons centers, which are difficult to be synthesized. Also, we developed a cross-aldol reaction of glyoxal, alkynyl aldehyde, chloral, and dichloroacetaldehyde catalyzed by diarylprolinol having CF3 group on aromatic ring. In addition, total syntheses of RQN-18690A (18-Deoxyherboxidiene) and N 7,10-epimer of Amphidinolide N, and one-pot syntheses of Tamiflu and Baclofen were accomplished.
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