| Budget Amount *help |
¥51,870,000 (Direct Cost: ¥39,900,000、Indirect Cost: ¥11,970,000)
Fiscal Year 2015: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2014: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2012: ¥11,570,000 (Direct Cost: ¥8,900,000、Indirect Cost: ¥2,670,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Natural products having a fused seven membered ring often elicit fascinating biological activities and pose considerable challenges to synthetic community. In order to enrich the strategic latitude for assembling medicinally relevant cycloheptanoid and hydroazulenoid structures, we have developed enantioselective routes to versatile cycloheptanoid chiral building block, namely, 4-hydroxy-cyclohept-2-en-1-one and 8-oxabicyclo[3.2.1]oct-3-en-2-one, driven by the use of organocatalysis. To facilitate a multistep synthetic transformations involving alcohol oxidations, we have also developed a series of nitroxyl radical-type organocatalysts that offer highly efficient and selective oxidation alcohols under eco-friendly reaction conditions.
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