| Budget Amount *help |
¥122,720,000 (Direct Cost: ¥94,400,000、Indirect Cost: ¥28,320,000)
Fiscal Year 2015: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2012: ¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
Fiscal Year 2011: ¥27,430,000 (Direct Cost: ¥21,100,000、Indirect Cost: ¥6,330,000)
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| Outline of Final Research Achievements |
We studied the design and fabrication method of microfluidic chip integrating microactuator and microsensor to measure the multi-parameter of cell. We developed the precise measurement method of probe position with a sub-pixel level of resolution using the phase detection of moire fringe. And we developed the microfluidic chip having multi fluorescence sensor pillars for measuring several physiological parameters such as pH, temperature, and Calcium ions. By using these technologies, we measured the stiffness of cell and spheroid in high-speed, and time-course variation of physiological conditions was measured in the chip. Moreover, we developed rapid fabrication method of multilayer tubular tissue as a model artery, and constructed the perfusion culture environment. By using this model artery and culture system, we found the long-term mechanical stimulus to model artery is effective to form the elastic fiber.
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