| Budget Amount *help |
¥121,290,000 (Direct Cost: ¥93,300,000、Indirect Cost: ¥27,990,000)
Fiscal Year 2015: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2014: ¥26,260,000 (Direct Cost: ¥20,200,000、Indirect Cost: ¥6,060,000)
Fiscal Year 2013: ¥29,640,000 (Direct Cost: ¥22,800,000、Indirect Cost: ¥6,840,000)
Fiscal Year 2012: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Fiscal Year 2011: ¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
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| Outline of Final Research Achievements |
We have newly developed heparin-immobilized temperature-responsive cell culture surface (TRCS), further modifying the surfaces with growth factor to fabricate hepatic-cells sheet. We have demonstrated that hepatic-cells sheet was readily fabricated with growth-factor and heparin complex immobilized surface, maintaining physiological function characteristic of hepatic-tissue for longer period. Micro-patterned TRCS was also developed, being applied to fabricate nerve-tissue. The surface would be expected as base technology for fabrication of nerve-tissue. A facile method of preparation of TRCS without special equipment and reagents were newly developed. We also innovated robotics to create robot, which attained precise and multiple micro-contacting, and devise to transplant and/or carry cell-sheet easily for short time. Rapid and convenient method for fabricating soft-tissue such as hepatic and nerve tissues would be attained, combing those techniques.
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