| Budget Amount *help |
¥116,740,000 (Direct Cost: ¥89,800,000、Indirect Cost: ¥26,940,000)
Fiscal Year 2015: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2014: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2013: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2012: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2011: ¥27,950,000 (Direct Cost: ¥21,500,000、Indirect Cost: ¥6,450,000)
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| Outline of Final Research Achievements |
The present study was designed to investigate whether the arrangement of calcium phosphate mineral crystals in the matrix scaffold affects the cellular activity around the crystals, including the differentiation from the precursor cells, in the mineralized tissue formation. It was apparent that the differentiation of mouse bone marrow derived stromal cells is controlled by the chemical environment associated with the crystals, that the differentiation of murine bone marrow derived mesenchymal stem cells is controlled by the crystal phase and the amount of strain of the matrix around the cells, and that the tissue formation, including the formation of the mineralized tissue and the bone-related non-mineralized tissue, is controlled by the dispersion condition of the crystals in the matrix scaffold material. The presence and the characteristics of the mineral crystals could be a factor to control the mineralized tissue formation.
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