| Budget Amount *help |
¥97,760,000 (Direct Cost: ¥75,200,000、Indirect Cost: ¥22,560,000)
Fiscal Year 2015: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
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| Outline of Final Research Achievements |
We investigated the regulation of critical period plasticity by chondroitin sulfate (CS) and keratan sulfate (KS) proteoglycans included in perineuronal nets in the visual cortex. The analysis using transgenic mice, in which the enzyme responsible for the sulfation of CS at the 6 position was overexpressed, demonstrated that the transition of CS from 6S dominant to 4S dominant forms was involved in the regulation of terminating the critical period. This regulation was mediated by the modulation of the maturation of parvalbumin neurons and T-type Ca2+ channel-dependent long-term potentiation (T-LTP). In addition, we found that low-sulfated KS was involved in the regulation of T-LTP and the potentiation of nondeprived eye responses following monocular deprivation. These results suggest that these sugar chains with specific sulfation patterns regulate the critical period plasticity.
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