| Budget Amount *help |
¥118,820,000 (Direct Cost: ¥91,400,000、Indirect Cost: ¥27,420,000)
Fiscal Year 2015: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2014: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2013: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2012: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥35,230,000 (Direct Cost: ¥27,100,000、Indirect Cost: ¥8,130,000)
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| Outline of Final Research Achievements |
Functions and action mechanisms of gangliosides that are highly expressed in nervous systems have been analyzed using glycolipid-deficient mutant mice with focus on their regulatory functions in lipid rafts. Using neuron-specific transgenic mice of B4galnt1, it was shown that gangliosides play roles in neurons for maintenance of the integrity of nervous tissues. Analysis of St8sia1 knockout mice revealed that b-series gangliosides are essential in the secretion of leptin from adipocytes, and that a-series gangliosides are crucial for the sensitivity of leptin receptor in hypothalamus. It was also demonstrated that GD2/GD3 ebhances malignant properties of gliomas by forming a molecular complex with PDGFRalpha and Yes in a mouse glioma model.
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