| Budget Amount *help |
¥116,610,000 (Direct Cost: ¥89,700,000、Indirect Cost: ¥26,910,000)
Fiscal Year 2015: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2014: ¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2013: ¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2012: ¥21,320,000 (Direct Cost: ¥16,400,000、Indirect Cost: ¥4,920,000)
Fiscal Year 2011: ¥33,020,000 (Direct Cost: ¥25,400,000、Indirect Cost: ¥7,620,000)
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| Outline of Final Research Achievements |
Parkinson’s disease (PD) may be caused by mitochondrial and autophagy lysosome pathway dysfunction, which are probably affected by both genetic predisposition and environmental factors. The discovery of gene including CHCHD2 and the function of PINK1 and Parkin, which associated with the mitochondria, also enhanced the understanding of cellular functions. Kufor-Rakeb syndrome (KRS) was originally described in association with an autosomal recessive form of early-onset parkinsonism. The causative gene for KRS has been identified as ATP13A2, which encodes a lysosomal type 5 P-type ATPase whose physiological function in mammalian cells remains unknown. We recently showed that KRS/PARK9-linked mutations lead to several lysosomal alterations, including reduced proteolytic processing of a lysosomal enzyme.
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