| Budget Amount *help |
¥76,180,000 (Direct Cost: ¥58,600,000、Indirect Cost: ¥17,580,000)
Fiscal Year 2015: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2014: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2013: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000)
Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2011: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
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| Outline of Final Research Achievements |
In this study, we focused on tissue stem cells that provide various epithelial cells forming tubule structures. In our previous studies, we have developed a method to prospectively isolate hepatic stem cells residing in the developing mouse liver, called hepatoblasts, and thus, we sought to elucidate molecular mechanisms underlying maintenance and differentiation of hepatoblasts. Our analyses revealed essential roles of transcription factors and microRNAs in regulation of the differentiation and proliferation of hepatoblasts. Moreover, we unveiled a mechanism that regulates initiation of hepatocyte proliferation in liver regeneration, succeeded in inducing conversion of mouse fibroblasts to hepatocyte-like cells, found that intrahepatic cholangiocarcinoma and the ductular reaction caused in the chronically injured liver arise from hepatocytes by Notch-mediated cell-fate conversion, and succeeded in constructing a three-dimensional dynamic model of intrahepatic bile duct formation.
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