| Budget Amount *help |
¥154,050,000 (Direct Cost: ¥118,500,000、Indirect Cost: ¥35,550,000)
Fiscal Year 2015: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2014: ¥28,470,000 (Direct Cost: ¥21,900,000、Indirect Cost: ¥6,570,000)
Fiscal Year 2013: ¥30,160,000 (Direct Cost: ¥23,200,000、Indirect Cost: ¥6,960,000)
Fiscal Year 2012: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2011: ¥37,180,000 (Direct Cost: ¥28,600,000、Indirect Cost: ¥8,580,000)
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| Outline of Final Research Achievements |
The cellular and molecular mechanisms governing the formation and the maintenance of epithelial architecture remains unclear. By using the mammary gland as a model, we have succeeded in clarifying the positive role of a polarity protein, aPKC, on stem cell proliferation. Interestingly, the same protein play a negative role on proliferation of luminal precursor cells. we further explored the mechanism; aPKC regulates different transcription factors positively, and negatively in each cases. These results seems to explain part of the mechanism for different mammary cancer types and can be used as a diagnostic marker.
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