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Organ malformations as results of accumulated polarity disruptions in epithelial tubular structures during organogenesis and histogenesis

Planned Research

Project AreaRegulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
Project/Area Number 23112006
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionShimane University

Principal Investigator

Otani Hiroki  島根大学, 医学部, 教授 (20160533)

Co-Investigator(Kenkyū-buntansha) HATTA Toshihisa  金沢医科大学, 医学部, 教授 (20238025)
UDAGAWA Jun  滋賀医科大学, 医学部, 教授 (10284027)
Research Collaborator HASHIMOTO Ryuju  
NAITO Kanta  
MATSUMOTO Akihiro  
FURUYA Motohide  
OGAWA Noriko  
INOUE Takayuki  
RAFIQ Ashiq Mahmood  
JAHAN Esrat  
MOTOYA Tomoyuki  
NITTA Tetsuya  
KURAMOTO Junko  
HIRANO Satoru  
ZHANG Qinghua  
LIANG Shuai  
DEREJE Getachew Regassa  
KANEDA Ryo  
SAEKI Yuko  
TAKEDA Yumiko  
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥96,330,000 (Direct Cost: ¥74,100,000、Indirect Cost: ¥22,230,000)
Fiscal Year 2015: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2013: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2012: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2011: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Keywords上皮管腔組織 / 極性 / 器官形成 / 組織形成 / 形態学 / 数理解析 / ノックアウトマウス / Ror2 / Wnt11 / Wnt5a / 組織学 / 胚操作 / Ror2 / Wnt11 / Wnt5a / 電子顕微鏡
Outline of Final Research Achievements

Basic morphological data on developing epithelial tubular structures were obtained applying mathematical methods as standards to evaluate abnormal development, and findings including those in Ror2 knockout mice were reported. We proved interkinetic nuclear migration (INM), a regulatory mechanism of stem cell proliferation/differentiation reported in the neural epithelium, in the developing epithelium of multiple organs of three germ-layer origins. We showed that INM is a general strategy for the regulated proliferation/differentiation of progenitor cells in the epithelial tubular structures, and also suggested a link between INM defects and malformation of organs.
We improved the exo-utero development method, an experimental analysis of organ histogenesis, and published the report and review papers. We also developed a kit for producing cleared biological specimens and method for producing cleared biological specimens for fine and effective 3-D observation.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (83 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (31 results) (of which Peer Reviewed: 31 results,  Open Access: 10 results,  Acknowledgement Compliant: 5 results) Presentation (45 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Interkinetic nuclear migration in the mouse embryonic ureteric epithelium: Possible implication for congenital anomalies of the kidney and urinary tract2016

    • Author(s)
      Motoya T, Ogawa N, Nitta T, Rafiq AM, Jahan E, Furuya M, Matsumoto A, Udagawa J, Otani H
    • Journal Title

      Congenit Anom

      Volume: in press Issue: 3 Pages: 127-134

    • DOI

      10.1111/cga.12150

    • NAID

      130008079235

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Statistical analyses in trials for the comprehensive understanding of organogenesis and histogenesis in humans and mice2016

    • Author(s)
      Hiroki Otani, Jun Udagawa and Kanta Naito
    • Journal Title

      Journal of Biochemistry

      Volume: 未定 Issue: 6 Pages: 553-561

    • DOI

      10.1093/jb/mvw020

    • NAID

      40020869341

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1,2 and 52015

    • Author(s)
      Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 4 Pages: 1-17

    • DOI

      10.1371/journal.pone.0123232

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] In utero and exo utero fetal surgery on histogenesis of organs in animals2015

    • Author(s)
      Jahan E, Rafiq AM, Otani H
    • Journal Title

      World J Surg Proced

      Volume: 5 Issue: 2 Pages: 198-207

    • DOI

      10.5412/wjsp.v5.i2.198

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of nutritional factors at the early life stages in the pathogenesis and clinical course of type 1 diabetes2015

    • Author(s)
      Kagohashi Y, Otani H
    • Journal Title

      Biomed Res Int

      Volume: 2015 Pages: 1-9

    • DOI

      10.1155/2015/382165

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The suppression of maternal-fetal leukemia inhibitory factor signal relay pathway by maternal immune activation impairs brain development in mice2015

    • Author(s)
      Tsukada T, Simamura E, Shimada H, Arai T, Higashi N, Akai T, Iizuka H, Hatta T
    • Journal Title

      PLOS ONE

      Volume: 4 Issue: 6 Pages: 1-14

    • DOI

      10.1371/journal.pone.0129011

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional structure of seminiferous tubules in the adult mouse.2015

    • Author(s)
      4.Nakata H, Wakayama T, Sonomura T, Honma S, Hatta T, Iseki S.
    • Journal Title

      J Anat.

      Volume: 227 Issue: 5 Pages: 686-694

    • DOI

      10.1111/joa.12375

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A single-neuron tracing study of arkypallidal and prototypic neurons in healthy rats2015

    • Author(s)
      Fujiyama F, Nakano T, Matsuda W, Furuta T, Udagawa J, Kaneko T
    • Journal Title

      Brain Struct. Funct.

      Volume: published online Issue: 9 Pages: 1-8

    • DOI

      10.1007/s00429-015-1152-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidermis-dermis junction as a novel location for bone marrow-derived cells to reside in response to ionizing radiation2015

    • Author(s)
      Okano J, Kojima H, Katagi M, Nakae Y, Terashima T, Nakagawa T, Kurakane T, Okamoto N, Morohashi K, Maegawa H, Udagawa J
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: - Issue: 4 Pages: 695-701

    • DOI

      10.1016/j.bbrc.2015.04.094

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of prolactin-induced protein on human skin: new insight into the digestive action of this aspartic peptidase on the stratum corneum and its induction of keratinocyte proliferation.2015

    • Author(s)
      Sugiura S, Tazuke M, Ueno S, Sugiura Y, Kato I, Miyahira Y, Yamamoto Y, Sato H, Udagawa J, Uehara M, Sugiura H
    • Journal Title

      J Invest Dermatol

      Volume: 135 Issue: 3 Pages: 776-785

    • DOI

      10.1038/jid.2014.448

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 胎児プログラミングと脳の形成2015

    • Author(s)
      宇田川 潤
    • Journal Title

      最新医学

      Volume: 70 Pages: 39-46

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒト・マウスの器官形成と組織形成における正常と異常2015

    • Author(s)
      大谷 浩
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 50 Pages: 1153-1155

    • NAID

      120006888783

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fetal jaw movement affects Ihh signaling in mandibular condylar cartilage development: The possible role of Ihh as mechanotransduction mediator2014

    • Author(s)
      Jahan E, Matsumoto A, Rafiq AM, Hashimoto R, Inoue T, Udagawa J, Sekine J, Otani H
    • Journal Title

      Archives of Oral Biology

      Volume: 59 Issue: 10 Pages: 1108-1118

    • DOI

      10.1016/j.archoralbio.2014.06.009

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Statistical analysis with dilatation for development process of human fetuses2014

    • Author(s)
      Naito K, Notsu A, Udagawa J, Otani H
    • Journal Title

      Stat Methods Med Res

      Volume: - Issue: 1 Pages: 176-200

    • DOI

      10.1177/0962280214543405

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding2014

    • Author(s)
      Nishita M, Qiao S, Miyamoto M, Okinaka Y, Yamada M, Hashimoto R, Iijima K, Otani H, Hartmann C, Nishinakamura R, Minami Y
    • Journal Title

      Mol Cell Biol

      Volume: 34 Issue: 16 Pages: 3096-3105

    • DOI

      10.1128/mcb.00491-14

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of chronic administration of arachidonic acid on lipid profiles and morphology in the skeletal muscles of aged rats2014

    • Author(s)
      Inoue T, Hashimoto M, Katakura M, Tanabe Y, Al Mamun A, Matsuzaki K, Otani H, Shido O
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids

      Volume: 91 Issue: 4 Pages: 119-127

    • DOI

      10.1016/j.plefa.2014.07.015

    • NAID

      120006938650

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo analysis of Arg-Gly-Asp sequence/integrin α5β1-mediated signal involvement in embryonic enchondral ossification by exo utero development system2014

    • Author(s)
      Inoue T, Hashimoto R, Matsumoto A , Jahan E, Rafiq AM , Udagawa J, Hatta T, Otani H
    • Journal Title

      J Bone Miner Res

      Volume: 印刷中 Issue: 7 Pages: 1554-1563

    • DOI

      10.1002/jbmr.2166

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of sugar chain recognition by galectins and its involvement in disease-associated glycosylation.2014

    • Author(s)
      Arikawa T, Simamura E, Shimada H, Nakamura T, Hatta T, Shoji H.
    • Journal Title

      Congenit Anom

      Volume: 印刷中 Issue: 2 Pages: 77-81

    • DOI

      10.1111/cga.12055

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The roles of retinoic acid signaling in normal and abnormal development of the palate2014

    • Author(s)
      Okano J, Udagawa J, Shiota K
    • Journal Title

      Congenital Anomalies

      Volume: 印刷中 Issue: 2 Pages: 69-76

    • DOI

      10.1111/cga.12049

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上皮管腔組織の器官形成と組織形成の解析2013

    • Author(s)
      大谷 浩
    • Journal Title

      島根医学

      Volume: 33 Pages: 170-179

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological changes in the developing heart of human fetuses2013

    • Author(s)
      Liang S, Tanabe K, Niu Y, Otani H
    • Journal Title

      Shimane J Med Sci

      Volume: 30 Pages: 1-10

    • NAID

      110009669749

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] fect of leptin dministration on myelination in ob/ob mouse cerebrum after birth2013

    • Author(s)
      Hashimoto R, Matsumoto A, Udagawa J, Hioki K, Otani H
    • Journal Title

      Neuroreport

      Volume: 24 Issue: 1 Pages: 22-29

    • DOI

      10.1097/wnr.0b013e32835ba875

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histological changes in the developing heart of human fetuses2013

    • Author(s)
      Liang S
    • Journal Title

      Shimane J Med Sci

      Volume: 30

    • NAID

      110009669749

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression pattern of Galectin 4in rat placentation.2012

    • Author(s)
      Arikawa T,Simamura E,Shimada H,NishiN,TatsunoT,IshigakiY,TomosugiN,YamashiroC,HataT,TakegamiT,MogamiH,YamaguchiK,NakamuraT,OtaniH,HattaT,ShojiH.
    • Journal Title

      Placenta

      Volume: 33 Issue: 10 Pages: 885-887

    • DOI

      10.1016/j.placenta.2012.07.013

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interkinetic nuclear migration during early development of midgut and ureteric epithelia.2012

    • Author(s)
      YamadaM,UdagawaJ,HashimatoR,MatsumotoA,HattaT,OtaniH.
    • Journal Title

      Anat Sci Int

      Volume: 88 Issue: 1 Pages: 31-37

    • DOI

      10.1007/s12565-012-0156-8

    • NAID

      10031167942

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mathematical analysis of mandibular morphogenesis by micro-CT-based mouse and alizarin red S-stained-based human studies during development2012

    • Author(s)
      Rafiq AM, Udagawa J, Lundh T, Jahan E, Matsumoto A, Sekine J, Otani H.
    • Journal Title

      Anat Rec

      Volume: 295 Issue: 2 Pages: 313-327

    • DOI

      10.1002/ar.21535

    • URL

      http://onlinelibrary.wiley.com/doi/10.1002/ar.21535/abstract

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of melanocortins on fetal development2011

    • Author(s)
      Simamura E, Shimada H, Shoji H, Otani H, Hatta T.
    • Journal Title

      Congenit Anom

      Volume: 51(2) Issue: 2 Pages: 47-54

    • DOI

      10.1111/j.1741-4520.2011.00316.x

    • URL

      http://onlinelibrary.wiley.com/doi/10.1111/j.1741-4520.2011.00316.x/full

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adrenocorticotropic tumor cells transplanted into mouse embryos affect pancreatic histogenesis2011

    • Author(s)
      Kawamoto M, Udagawa J, Hashimoto R, Matsumoto A, Yamada M, Nimura M, Otani H.
    • Journal Title

      Congenit Anom

      Volume: 51 Issue: 2 Pages: 62-69

    • DOI

      10.1111/j.1741-4520.2010.00313.x

    • URL

      http://onlinelibrary.wiley.com/doi/10.1111/j.1741-4520.2010.00313.x/full

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cross-and triple-ratios of human body parts during development2011

    • Author(s)
      Lundh T, Udagawa J, Hanel S-V, Otani H.
    • Journal Title

      Anat Rec

      Volume: 294 Issue: 8 Pages: 1360-1369

    • DOI

      10.1002/ar.21426

    • URL

      http://onlinelibrary.wiley.com/doi/10.1002/ar.21426/abstract

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and morphometric study on sphenoid and basioccipital ossification in normal human fetuses2011

    • Author(s)
      Zhang Q, Wang H, Udagawa J, Otani H.
    • Journal Title

      Congenit Anom

      Volume: 51 Issue: 3 Pages: 138-148

    • DOI

      10.1111/j.1741-4520.2011.00322.x

    • NAID

      50008084975

    • URL

      http://onlinelibrary.wiley.com/doi/10.1111/j.1741-4520.2011.00322.x/full

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stage-specific changes in the levels of granulocyte-macrophage colony-stimulating factor and its receptor in the biological fluid and organ of mouse fetuses2011

    • Author(s)
      Matsumoto A, Hatta T, Ono A, Hashimoto R, Otani H.
    • Journal Title

      Congenit Anom

      Volume: 51 Issue: 4 Pages: 183-186

    • DOI

      10.1111/j.1741-4520.2011.00337.x

    • URL

      http://onlinelibrary.wiley.com/doi/10.1111/j.1741-4520.2011.00337.x/full

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Interkinetic nuclear migration in the developing endoderm- and mesoderm-origin epithelial tubular structures2016

    • Author(s)
      Otani H, Motoya T, Ogawa N, Nitta T, Rafiq AM, Jahan E, Kaneda R, Furuya M, Matsumoto A, Udagawa J, Hatta T
    • Organizer
      第121回日本解剖学会全国学術集会
    • Place of Presentation
      ビックパレット福島(郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] GFPマウス胎仔の透明化による心臓発生過程の立体画像化2016

    • Author(s)
      吉村衣里子,杉原諒,三浦公実,島田ひろき,東伸明,三谷真弓,狩山信生,有川智博,東海林博樹,八田稔久
    • Organizer
      第121回日本解剖学会全国学術集会
    • Place of Presentation
      ビックパレット福島(郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス胎仔尿管の伸長過程における上皮細胞核の再配置2015

    • Author(s)
      元矢 知志、新田 哲哉、Rafiq Ashiq Mahmood、Jahan Esrat、小川 典子、古屋 智英、松本 暁洋、宇田川 潤、大谷 浩
    • Organizer
      日本解剖学会第70回中国・四国支部学術集会
    • Place of Presentation
      愛媛大学城北キャンパス南加記念ホール(松山市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス腸管の発生過程における腸管上皮細胞数とInterkinetic nuclear migration (INM)の解析2015

    • Author(s)
      新田哲哉、小川典子、倉本純子、元矢知志、古屋智英、Rafiq Ashiq Mahmood、Jahan Esrat、松本 暁洋、大谷 浩
    • Organizer
      日本解剖学会第70回中国・四国支部学術集会
    • Place of Presentation
      愛媛大学城北キャンパス南加記念ホール(松山市)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] Role of microRNA in histogenesis of the cerebrum in mouse embryos2015

    • Author(s)
      Hashimoto R, Kihara I, Matsumoto A, Otani H
    • Organizer
      45th Annual Meeting Neuroscience 2015
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Cell polarity-associated mechanisms in normal and abnormal organogenesis and histogenesis of epithelial tubular structures2015

    • Author(s)
      Otani H, Udagawa J, Hatta T, Minami Y
    • Organizer
      The Second International Meeting for Epithelial Tubulology
    • Place of Presentation
      北海道大学医学部フテラホール(札幌市)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マイクロRNAのマウス胎仔大脳の組織形成における役割2015

    • Author(s)
      橋本龍樹、松本暁洋、大谷 浩
    • Organizer
      第55回日本先天異常学会学術集会、第38回日本小児遺伝学会学術集会合同開催
    • Place of Presentation
      パシフィコ横浜会議センター(横浜市)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス尿管の発生過程におけるInterkinetic nuclear migrationおよびConvergent extensionの解析2015

    • Author(s)
      元矢知志、新田哲哉、Rafiq Ashiq Mahmood、Jahan Esrat、小川 典子、古屋 智英、松本 暁洋、宇田川 潤、大谷 浩
    • Organizer
      第55回日本先天異常学会学術集会、第38回日本小児遺伝学会学術集会合同開催
    • Place of Presentation
      パシフィコ横浜会議センター(横浜市)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス腸管の発生過程における腸管上皮細胞数とInterkinetic nuclear migration (INM) の変化2015

    • Author(s)
      新田哲哉、小川典子、倉本純子、元矢知志、古屋智英、Rafiq Ashiq Mahmood、Jahan Esrat、松本 暁洋、大谷 浩
    • Organizer
      第55回日本先天異常学会学術集会、第38回日本小児遺伝学会学術集会合同開催
    • Place of Presentation
      パシフィコ横浜会議センター(横浜市)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] 器官形成期マウス胚の気管・食道上皮におけるinterkinetic nuclear migrationの解析2015

    • Author(s)
      兼田 稜、橋本龍樹、荒内亮輔、古屋智英、佐藤文夫、宇田川 潤、大谷 浩
    • Organizer
      第55回日本先天異常学会学術集会、第38回日本小児遺伝学会学術集会合同開催
    • Place of Presentation
      パシフィコ横浜会議センター(横浜市)
    • Year and Date
      2015-07-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Interkinetic nuclear migration in the mouse embryonic ureteric epithelium2015

    • Author(s)
      Motoya T, Ogawa N, Nitta T, Rafiq A M, Jahan E, Furuya M, Matsumoto A, Udagawa J, Otani H
    • Organizer
      第120回日本解剖学会全国学術集会、第92回日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 尿管上皮発生におけるInterkinetic nuclear migrationの解析2014

    • Author(s)
      新田哲哉、元矢知志、Rafiq AM、Jahan E、小川典子、古屋智英、松本暁洋、宇田川 潤、大谷 浩
    • Organizer
      第54回日本先天異常学会学術集会
    • Place of Presentation
      麻布大学(相模原市)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウス胎児の腸管上皮における細胞数の計測2014

    • Author(s)
      倉本純子、平野 了、元矢知志、八田稔久、大谷 浩
    • Organizer
      第54回日本先天異常学会学術集会
    • Place of Presentation
      麻布大学(相模原市)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 器官形成期マウス胚の気管上皮におけるInterkinetic nuclear migrationの解析2014

    • Author(s)
      兼田 稜、橋本龍樹、金山加代、荒内亮輔、古屋智英、佐藤文夫、宇田川 潤、大谷 浩
    • Organizer
      第54回日本先天異常学会学術集会
    • Place of Presentation
      麻布大学(相模原市)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Mesiation of Wnt/PCP-JNK signal pathway in NTDs happening and preventing NTDs with taurine2014

    • Author(s)
      Zhang Qinghua, Zhang Li, 大谷 浩
    • Organizer
      第54回日本先天異常学会学術集会
    • Place of Presentation
      麻布大学(相模原市)
    • Year and Date
      2014-07-26 – 2014-07-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] ヒト・マウスの器官形成と組織形成における正常と異常2014

    • Author(s)
      大谷 浩
    • Organizer
      第50回日本周産期・新生児医学会学術集会
    • Place of Presentation
      シェラトン・グランデ・トーキョーベイ・ホテル(浦安市)
    • Year and Date
      2014-07-13 – 2014-07-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 無眼球症ラット:胎生期における眼杯と水晶体の消失過程の解析2014

    • Author(s)
      日野広大、瀧 公介、原澤俊也、岩本壮太郎、川野純一、工藤 基、宇田川潤
    • Organizer
      第119回日本解剖学会全国学術集会
    • Place of Presentation
      自治医科大学(下野市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 生後マウス大脳におけるperoxisomeproliferator-activated receptorを介したレプチンの髄鞘化に対する作用についての解析2013

    • Author(s)
      橋本龍樹
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス胎仔の脳組織形成における顆粒球・マクロファージコロニー刺激因子の作用の解析2013

    • Author(s)
      松本暁洋
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 子宮外発生法を用いた軟骨内骨化における軟骨細胞増殖,分化・肥大,細胞死調節因子のin vivo解析2013

    • Author(s)
      井上隆之
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      2013-03-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] 上皮管腔組織の器官形成と組織形成2013

    • Author(s)
      大谷 浩
    • Organizer
      第120回日本医学放射線学会中国四国地方会
    • Place of Presentation
      ニューウェルシティ出雲(出雲市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Leukemia inhibitory factorはinsulin-like growth factorを介してFibroblast growth factor 2の神経幹/前駆細胞の増殖作用を増強する2013

    • Author(s)
      島田ひろき、 島村英理子、 東海林博樹、 有川智博、東 伸明、八田稔久
    • Organizer
      第36回神経科学大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cell polarity-associated mechanisms in normal and abnormal organogenesis and histogenesis of epithelial tubular structures (Symposium)2013

    • Author(s)
      Otani H, Udagawa J, Hatta T, Minami Y
    • Organizer
      The First International Meeting for Epithelial Tubulology
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] DOHaD と組織形成:低栄養に関わらない疾病素因とは?(シンポジウム)2013

    • Author(s)
      大谷 浩
    • Organizer
      第53回日本先天異常学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 顆粒球・マクロファージコロニー刺激因子のマウス胎仔脳組織形成に及ぼす作用の解析2013

    • Author(s)
      松本暁洋、井上隆之、元矢知志、佐藤文夫、橋本龍樹、八田稔久、大谷 浩
    • Organizer
      第53回日本先天異常学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 子宮外発生法を用いた軟骨内骨化メカニズムのin vivo解析2013

    • Author(s)
      井上隆之、橋本龍樹、松本暁洋、Jahan Esrat、Rafiq Ashiq、宇田川潤、八田稔久、大谷 浩
    • Organizer
      第53回日本先天異常学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 35ゲージ針を用いたラット胎児脳室注入法2013

    • Author(s)
      島田ひろき、島村英理子、塚田剛史、 八田稔久
    • Organizer
      第53回日本先天異常学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多次元尺度構成法 (Multidimensional scaling MDS) による尿管上皮発生におけるInterkinetic nuclear migration (INM) の解析2013

    • Author(s)
      元矢知志、Rafiq Ashiq Mahmood、Jahan Esra、松本 暁洋、宇田川 潤、大谷 浩
    • Organizer
      日本解剖学会第68回中国・四国支部学術集会
    • Place of Presentation
      鳥取大学(米子市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラット胎児に関する組織細胞連続切片画像の高速自動整合と3次元再構築2012

    • Author(s)
      桶谷祐介
    • Organizer
      バイオイメージ・インフォマティクス ワークショップ2012
    • Place of Presentation
      理化学研究所 発生・再生科学総合研究センター(神戸市)
    • Year and Date
      2012-11-01
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of erythroblast differentiation by melanocortin receptors 1, 2 and 5-mediated signals2012

    • Author(s)
      島村英理子
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都国際会館(京都市)
    • Year and Date
      2012-10-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳児期マウス大脳の髄鞘化におけるneuropeptide Y (NPY) のY2受容体を介した作用2012

    • Author(s)
      橋本龍樹
    • Organizer
      第52回日本先天異常学会学術集会
    • Place of Presentation
      東京女子医科大学(東京都)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Wnt11ノックアウトマウスの小腸発生過程における組織形成異常2012

    • Author(s)
      平野 了
    • Organizer
      第52回日本先天異常学会学術集会
    • Place of Presentation
      東京女子医科大学(東京都)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Wnt11ノックアウトマウスの胎仔期及び新生仔期の大腸の形態学的解析2012

    • Author(s)
      Jahan E
    • Organizer
      第52回日本先天異常学会学術集会
    • Place of Presentation
      東京女子医科大学(東京都)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] 母体LIFシグナルの胎児大脳皮質radial gliaへの影響2012

    • Author(s)
      島村英理子
    • Organizer
      第52回日本先天異常学会学術集会
    • Place of Presentation
      東京女子医科大学(東京都)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] ガレクチンによる制御を介した胎盤形成・維持機構の解析2012

    • Author(s)
      有川智博
    • Organizer
      第52回日本先天異常学会学術集会
    • Place of Presentation
      東京女子医科大学(東京都)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Morphometric analysis of organ development in staged rat embryos with virtual serial slide library2012

    • Author(s)
      M.Uchishiba
    • Organizer
      第52回日本先天異常学会学術集会
    • Place of Presentation
      東京女子医科大学(東京都)
    • Year and Date
      2012-07-06
    • Related Report
      2012 Annual Research Report
  • [Presentation] Prenatal jaw movement affects molecular cascade in the mandibular condylar cartilage development2012

    • Author(s)
      Jahan E
    • Organizer
      Joint Meeting of the 45th Annual Meeting of the Japanese Society of Developmental Biologists the 64th Annual Meeting of the Japan Society for Cell Biology
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2012-05-28
    • Related Report
      2012 Annual Research Report
  • [Presentation] Fetal jaw movement affects molecular cascade in the development of mandibular condylar cartilage2012

    • Author(s)
      Esrat Jahan
    • Organizer
      第117回日本解剖学会全国学術集会
    • Place of Presentation
      山梨県、山梨大学
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 子宮外発生法を用いた筋腱結合部形成過程における細胞-細胞外マトリクス相互作用の実験的解析2012

    • Author(s)
      井上隆之
    • Organizer
      第117回日本解剖学会全国学術集会
    • Place of Presentation
      山梨県、山梨大学
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Preparation of Antibody Conjugated Silica-coated Zinc Oxide Nanoparticles2012

    • Author(s)
      Yoshikiyo K
    • Organizer
      5th International Symposium on Nanomedicine
    • Place of Presentation
      愛知県、名古屋大学
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cross- and triple-ratios of human body parts during development2011

    • Author(s)
      Lundh T
    • Organizer
      3rd Swedish Meeting on Mathematics in Biology
    • Place of Presentation
      Umea, Sweden
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Matemal-placental-fetal leukemia inhibitory factor signal pathway contributes stage-specific differentiation from fetal neural stem/progenitor cells to astrocytes2011

    • Author(s)
      Eriko Simamura
    • Organizer
      40^<th> Annual Meeting Neuroscience 2010
    • Place of Presentation
      Washington, D.C, USA
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロCTによるマウス胎仔発生におけるFGF発現部位の立体的観察2011

    • Author(s)
      松本暁洋
    • Organizer
      第9回医用分光学研究会
    • Place of Presentation
      島根県、島根大学
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラット母獣LIF投与は母胎間LIF-ACTH-LIFシグナルリレーを介して胎児脳におけるアストロサイト様細胞の分化を促進する2011

    • Author(s)
      島村英理子
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川県、パシフィコ横浜
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 知られざる先天異常-臓器の組織形成における個体差と疾病素因の関り-2011

    • Author(s)
      大谷浩
    • Organizer
      第34回日本小児遺伝学会学術集会
    • Place of Presentation
      神奈川県、パシフィコ横浜(特別講演)(招待講演)
    • Year and Date
      2011-08-11
    • Related Report
      2011 Annual Research Report
  • [Book] カラー版ラーセン人体発生学 第4版2013

    • Author(s)
      仲村 春和、大谷 浩(監訳)
    • Total Pages
      601
    • Publisher
      西村書店
    • Related Report
      2013 Annual Research Report
  • [Remarks] 島根大学医学部発生生物学ホームページ

    • URL

      http://shimane-u-developmental-biology.jp/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 島根大学医学部発生生物学ホームページ

    • URL

      http://shimane-u-developmental-biology.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://shimane-u-developmental-biology.jp/science/

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] Kit for producing cleared biological specimens and method for producing cleared biological specimens2015

    • Inventor(s)
      Toshihisa Hatta
    • Industrial Property Rights Holder
      Kanazawa Medical University
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-05-28
    • Related Report
      2015 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 透明化生物標本作製用キット及び透明化生物標本作製方法2015

    • Inventor(s)
      八田稔久
    • Industrial Property Rights Holder
      学校法人金沢医科大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-544550
    • Filing Date
      2015-04-20
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 透明化生物標本作製用キット及び透明化生物標本作製方法2013

    • Inventor(s)
      八田稔久、内芝舞実、東 伸明、島田ひろき、島村英理子
    • Industrial Property Rights Holder
      学校法人 金沢医科大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-10-30
    • Related Report
      2013 Annual Research Report
    • Overseas

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Published: 2011-08-01   Modified: 2019-07-29  

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