Dysfunction of planar cell polarity signaling and its relationship with ciliopathies and cancer invasion and metastasis

• Project Area: Regulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
• Project/Area Number: 23112007
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kobe University
• Principal Investigator: MINAMI YASUHIRO 神戸大学, 医学(系)研究科(研究院), 教授 (70229772)
• Co-Investigator(Kenkyū-buntansha): MASHIMA Ryuichi 東京大学, 医科学研究所, 助教 (00401365) ; TEZUKA Toru 東京大学, 医科学研究所, 助教 (50312319)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥174,590,000 (Direct Cost: ¥134,300,000、Indirect Cost: ¥40,290,000); Fiscal Year 2015: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000); Fiscal Year 2014: ¥32,370,000 (Direct Cost: ¥24,900,000、Indirect Cost: ¥7,470,000); Fiscal Year 2013: ¥34,190,000 (Direct Cost: ¥26,300,000、Indirect Cost: ¥7,890,000); Fiscal Year 2012: ¥33,930,000 (Direct Cost: ¥26,100,000、Indirect Cost: ¥7,830,000); Fiscal Year 2011: ¥41,730,000 (Direct Cost: ¥32,100,000、Indirect Cost: ¥9,630,000)
• Keywords: 上皮管腔組織破綻 / 平面細胞極性シグナル / 繊毛シグナル / 非古典的Wntシグナル / アダプター分子 / 癌の浸潤・進展 / 上皮管腔組織形成 / 組織炎症 / 線毛シグナル / 上皮管腔組織の破綻 / 繊毛関連症候群・炎症 / 癌の浸潤 / エピジェネティック制御 / 上皮間葉転換 / 癌の浸潤転移 / 繊毛関連症候群 / 頂底極性シグナル / Wnt5a-Rorシグナル

Outline of Final Research Achievements

The epithelial tubular tissues are fundamental and functionally important structures in multicellular organisms, and it is one of the most important issues to clarify the molecular mechanisms underlying the formation and disruption of these epithelial tubular structures. In this research project, we have focused on the planar cell polarity (PCP) signaling, and have tried to elucidate possible relationships between abnormalities of this signaling and anomalies of epithelial tubular tissues (including the kidney), ciliopathies, and cancer progression. As a result, we have shown that dysfunction of PCP signaling results in various anomalies, including congenital anomalies of kidney and urinary tract (CAKUT), and that aberrant activation of this signaling in various types of cancer cells contributes to their progression through expression of proteins, required for the formation of the primary cilia.

Research Products

• [Int'l Joint Research] Harvard University(米国)
• [Journal Article] Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis. (2016)
  • Author(s): Takiguchi, G., Nishita, M., Kurita, K., Kakeji, Y., Minami, Y.
  • Journal Title: Cancer Sci. Volume: 107 Issue: 3 Pages: 290-297
  • DOI: 10.1111/cas.12871
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Essential role of Wnt5a-Ror1/Ror2 signaling in metanephric mesenchyme and ureteric bud formation. (2016)
  • Author(s): Qi X, Okinaka Y, Nishita M, Minami Y.
  • Journal Title: Genes to Cells Volume: 21 Issue: 4 Pages: 325-334
  • DOI: 10.1111/gtc.12342
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice. (2016)
  • Author(s): Diaz-Horta, O., Abad, C., Sennaroglu, L., Foster II, J., DeSmidt, A., Bademci, G., Tokgoz-Yilmaz, S., Duman, D., Cengiz, F. B., Grati, M., Fitoz, S., Liu, X-Z., Farooq, A., Imtiaz, F., Currall, B. B., Morton, C. C., Nishita, M., Minami, Y., Lu, Z., Walz, K., Tekin, M.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Insight into the role of Wnt5a-induced signaling in normal and cancer cells. (2015)
  • Author(s): Endo, M., Nishita, M., Fujii, M., Minami, Y.
  • Journal Title: Int. Rev. Cell Mol. Biol. Volume: 314 Pages: 117-148
  • DOI: 10.1016/bs.ircmb.2014.10.003
  • ISBN: 9780128022832
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis. (2015)
  • Author(s): Sato, A., Kayama, H., Shojima, K., Matsumoto, S., Koyama, H., Minami, Y., Nojima, S., Morii, E., Honda, H., Takeda, K., Kikuchi, A.
  • Journal Title: Sci. Rep. Volume: 5 Issue: 1 Pages: 10536-10536
  • DOI: 10.1038/srep10536
  • Peer Reviewed / Open Access
• [Journal Article] The Wnt5a-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-γ in colitis. (2015)
  • Author(s): Sato, A., Kayama, H., Shojima, K., Matsumoto, S., Koyama, H., Minami, Y., Nojima, S., Morii, E., Honda, H., Takeda, K., Kikuchi, A.
  • Journal Title: Sci. Report Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Diabetic osteopenia by decreased β-catenin signaling is partly induced by epigenetic derepression of sFRP-4 gene (2014)
  • Author(s): Mori K, Kitazawa R, Kondo T, Mori M, Hamada Y, Nishida M, Minami Y, Haraguchi R, Takahashi Y, Kitazawa S.
  • Journal Title: PLoS One Volume: 9 Issue: 7 Pages: e102797-e102797
  • DOI: 10.1371/journal.pone.0102797
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Role of Wnt5a-Ror2 signaling in morphogenesis of the metanephric mesenchyme during ureteric budding (2014)
  • Author(s): Nishita M, Qiao S, Miyamoto M, Okinaka Y, Yamada M, Hashimoto R, Iijima K, Otani H, Hartmann C, Nishinakamura R, Minami Y
  • Journal Title: Mol Cell Biol Volume: 34 Issue: 16 Pages: 3096-3105
  • DOI: 10.1128/mcb.00491-14
  • Peer Reviewed / Open Access
• [Journal Article] Critical role of Frizzledl in age-related alterations of Wnt/β-catenin signal in myogenic cells during differentiation. (2014)
  • Author(s): Doi R, Endo M, Yamakoshi K, Y amanashi Y, Nishita M, Fukada SI. Minami Y.
  • Journal Title: Genes Cells. Volume: 19 Issue: 4 Pages: 287-296
  • DOI: 10.1111/gtc.12132
  • Peer Reviewed / Open Access
• [Journal Article] IL-6-accelerated calcification by induction of Ror2 in human adipose tissue-derived mesenchymal stem cells is STAT3-dependent. (2014)
  • Author(s): Fukuyo, S., Yamaoka, K., Sonomoto, K., Oshita, K., Okada, Y., Saito, K., Yoshida, Y., Kanazawa, T., Minami, Y., Tanaka, Y.
  • Journal Title: Rheumatology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Noncanonical Wnt5a enhances Wnt/-catenin signaling during osteogenesis. (2014)
  • Author(s): Okamoto, M., Udagawa, N., Yamashita, T., Nakamichi, Y., Uehara, S., Kato, H., Saito, N., Minami, Y., Takahashi, N., Kobayashi, Y.
  • Journal Title: Sci. report Volume: 4 Issue: 1 Pages: 4493-4493
  • DOI: 10.1038/srep04493
  • Peer Reviewed / Open Access
• [Journal Article] Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis. (2013)
  • Author(s): Li, X., Yamagata, K., Nishita, M., Endo, M., Arfian, N., Rikitake, Y., Emoto, N., Hirata, K., Tanaka, Y., Minami, Y.
  • Journal Title: Genes Cells Volume: 18 Issue: 7 Pages: 608-619
  • DOI: 10.1111/gtc.12064
  • Peer Reviewed
• [Journal Article] Dok adaptors play anti-inflammatory roles in pulmonary homeostasis. (2013)
  • Author(s): Mashima R, Arimura S, Kajikawa S, Oda H, Nakae S, Yamanashi Y.
  • Journal Title: Genes to Cells Volume: 18 Issue: 1 Pages: 56-65
  • DOI: 10.1111/gtc.12016
  • Peer Reviewed
• [Journal Article] Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition (EMT) of tubular epithelial cells during renal fibrosis. (2013)
  • Author(s): Li, X
  • Journal Title: Genes Cells Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex (2012)
  • Author(s): Endo M, Doi R, Nishita M, Minami Y
  • Journal Title: Journal of Cell Science Volume: (印刷中)(掲載確定) Pages: 2017-2029
  • DOI: 10.1242/jcs.097782
  • Peer Reviewed
• [Journal Article] Activation of Receptor Protein-Tyrosine Kinases from the Cytoplasmic Compartment (2012)
  • Author(s): Yamanashi Y, Tezuka T, and Yokoyama K.
  • Journal Title: J Biochem Volume: (n press) Issue: 4 Pages: 353-359
  • DOI: 10.1093/jb/mvs013
  • NAID: 10031166074
  • Peer Reviewed
• [Journal Article] 非古典的Wntシグナルによる極性と幹細胞性維持の制御 (2012)
  • Author(s): 遠藤光晴
  • Journal Title: 生体の科学（特集：細胞極性の制御） Volume: 63 Pages: 224-228
• [Journal Article] Analysis of Wnt/Planar cell polarity pathway in cultured cells (2012)
  • Author(s): Endo, M., Nishita, M., Minami, Y.
  • Journal Title: Methods Mol.Biol. Volume: 839 Pages: 201-214
• [Journal Article] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP)-13 expression (2012)
  • Author(s): Yamagata, K., Li, X., Ikegaki, S., Oneyama, C., Okada, M., Nishita, M., Minami, Y.
  • Journal Title: J.Biol.Chem. Volume: 287 Pages: 1588-1599
  • Peer Reviewed
• [Journal Article] Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex (2012)
  • Author(s): Endo, M., Doi, R., Nishita, M., Minami, Y.
  • Journal Title: J.Cell Sci. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis (2012)
  • Author(s): Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
  • Journal Title: Nat.Med. Volume: (印刷中) Issue: 3 Pages: 405-12
  • DOI: 10.1038/nm.2653
  • Peer Reviewed
• [Journal Article] Wnt signaling gradients establish planar cell polarity by inducing Vangl 2 phosphorylation through Ror2 (2011)
  • Author(s): Gao, B., Song, H., Bishop, K., Eliott, G., Garrett, L., English, M.A., Andre, P., Robinson, J., Sood, R., Minami, Y., Economedes, A.N., Yang, Y.
  • Journal Title: Dev.Cell Volume: 20 Pages: 163-176
  • Peer Reviewed
• [Journal Article] Critical role of Wnt5a-Ror2 signaling in motility and invasiveness of epidermoid carcinoma cells following Snail-mediated epithelial-mesenchymal transition (2011)
  • Author(s): Ren, D., Minami, Y., Nishita, M.
  • Journal Title: Genes Cells Volume: 16 Issue: 3 Pages: 304-315
  • DOI: 10.1111/j.1365-2443.2011.01487.x
  • Peer Reviewed
• [Journal Article] Non-canonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer (2011)
  • Author(s): Takahashi, S., Watanabe, T., Okada, M., Inoue, K., Ueda, T., Takada, I., Watabe, T., Yamamoto, Y., Fukuda, T., Nakamura, T., Akimoto, C., T., Fujimura, T., Hoshino, M., Imai, Y., Metzger, D., Miyazono, K., Minami, Y., Chambon, P., Kitamura, T., Matsumoto, T., Kato, S.
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Pages: 4938-4943
  • Peer Reviewed
• [Presentation] Crucial role of the Ror-family rcceptor tyosine kinases in regulating tissue stem cells (2016)
  • Author(s): Koki Kamizaki, Ryosuke Doi, Takeshi Saji, Mitsuharu Endo, Motoi Kanagawa, So-ichiro Fukada, Tatsushi Toda, Makoto Hayashi, Yasuhiro Minami
  • Organizer: 環太平洋創薬・新規治療標的同定ネットワーク、Kick-off Symposium
  • Place of Presentation: 神戸大学医学部（神戸・兵庫県）
  • Year and Date: 2016-03-22
  • Int'l Joint Research
• [Presentation] Identification of substrates for Ror2 receptor tyrosine kinase, which regulate invasion of osteosarcoma cells (2016)
  • Author(s): Makoto Hayashi, Takeshi Saji, Michiru Nishita, Mitsuharu Endo, Yasuhiro Minami
  • Organizer: 第１０回日米癌合同会議
  • Place of Presentation: Maui (Hawaii, U.S.A.)
  • Year and Date: 2016-02-19
  • Int'l Joint Research
• [Presentation] Wnt5a-Ror2シグナルは繊毛タンパク質IFT20の発現誘導を介してがん細胞の浸潤を制御する (2015)
  • Author(s): 西田 満、西尾 忠、 紙崎 孝基、王 志超、榎本 真宏、玉田 紘太、内匠 透、Victor W. Hsu、Gregory J. Pazour、南 康博
  • Organizer: 第３８回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場（兵庫県）
  • Year and Date: 2015-12-04
• [Presentation] 受容体型チロシンキナーゼRor2は静止期のアストロサイトが増殖を再開するために必要である (2015)
  • Author(s): 遠藤 光晴、小林 千穂、疋田 壮舞、グリジャハン オブリカスム、稲垣 貴彦、南 康博
  • Organizer: 第３８回日本分子生物学会年会
  • Place of Presentation: 神戸国際会議場（兵庫県）
  • Year and Date: 2015-12-02
• [Presentation] Novel role for Wnt5a-Ror2 signaling in regulating polarity and structure of the Golgi apparatus in osteosarcoma cells. (2015)
  • Author(s): Michiru Nishita, Yasuhiro Minami
  • Organizer: University of Washington-Kobe University Joint Symposium on Cell Signaling
  • Place of Presentation: University of Washington, Seattle, U.S.A.
  • Year and Date: 2015-09-10
  • Int'l Joint Research / Invited
• [Presentation] Role of Wnt5a-Ror signaling in morphogenesis of the metanephric mesenchyme during ureteric budding (2015)
  • Author(s): Michiru Nishita, Sen Qiao, Xiaoyuan Qi, Mari Miyamoto, Yuka Okinaka, Makiko Yamada, Ryuju Hashimoto, Kazumoto Iijima, Hiroki Otani, Christine Hartmann, Ryuichi Nishinakamura, Yasuhiro Minami
  • Organizer: 新学術領域研究「上皮管腔組織形成」 第２回国際シンポジウム
  • Place of Presentation: 北海道大学（札幌、北海道）
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] Wnt5a-Ror2 signaling induces expression of the ciliary protein IFT20 to regulate the integrity of the Golgi apparatus and reorientation of the centrosome during tumor cell invasion (2015)
  • Author(s): Koki Kamizaki, Michiru Nishita, Tadashi Nishio, ZhiChao Wang, Masahiro Enomoto, Kota Tamada, Toru Takumi, Gregory J. Pazour, Yasuhiro Minami
  • Organizer: 新学術領域研究「上皮管腔組織形成」 第２回国際シンポジウム
  • Place of Presentation: 北海道大学（札幌、北海道）
  • Year and Date: 2015-08-23
  • Int'l Joint Research
• [Presentation] Role of NF-κB-mediated expression of Ror1 during skeletal muscle regeneration (2014)
  • Author(s): Koki Kamisaki, Ryosuke Doi, Suguru Kato, Soichiro Fukada, Motoi Kanagawa, Tatsushi, Mitsuharu Endo, Yasushiro Minami
  • Organizer: UNIVERSITY OF WASHINGTON-KOBE UNIVERSITY INTERNATIONAL SYMPOSIUM ON MEMBRANE BIOLOGY
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2014-12-15
• [Presentation] 受容体型チロシンキナーゼRor1による骨格筋再生制御 (2014)
  • Author(s): 加藤 英、土井 亮助、遠藤 光晴、深田 宗一郎、金川 基、戸田 達史、南 康博
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2014-11-27
• [Presentation] Role of Wnt5a-Ror2 signaling in patterning the metanephric mesenchyme during ureteric budding (2014)
  • Author(s): Michiru Nishita, Sen Qiao, Mari Miyamoto, Yuka Okinaka, Makiko Yamada, Ryuju Hashimoto, Kazumoto Iijima, Hiroki Otani, Christine Hartmann, Ryuichi Nishinakamura, Yasuhiro Minami
  • Organizer: Keystone Symposia "Developmental Pathways and Cancer: Wnt, Notch and Hedgehog(J7)"
  • Place of Presentation: Banff, Canada
• [Presentation] Roles of Wnt5a-Ror Signaling in Pathological Conditions (2014)
  • Author(s): Yasuhiro Minami
  • Organizer: UNIVERSITY OF WASHINGTON-KOBE UNIVERSITY SYMPOSIUM ON MEMBRANE BIOLOGY
  • Place of Presentation: UW, Seattle, U.S.A.
  • Invited
• [Presentation] 筋損傷・再生過程における受容体型チロシンキナーゼRor1の発現解析 (2013)
  • Author(s): 土井 亮助、遠藤 光晴、南 康博
  • Organizer: 第60回日本生化学会近畿支部例会
  • Place of Presentation: 大阪
• [Presentation] Roles of Wnt/PCP signaling in pathological conditions of epithelial tubular tissues (2013)
  • Author(s): Yasuhiro Minami, Kaoru Yamagata, Mitsuharu Endo, Hiroki Otani, Ryuichi Nishinakamura, Michiru Nishita
  • Organizer: First International Meeting for Epithelial Tubulology
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 炎症性サイトカインによりアストロサイトで発現誘導されるRor1受容体の機能解析 (2013)
  • Author(s): 遠藤 光晴、土井 亮助、西田 満、南 康博
  • Organizer: 2013年度包括脳ネットワーク夏のワークショップ
  • Place of Presentation: 名古屋
• [Presentation] 尿管芽形成におけるWnt5a-Ror2シグナルの役割と腎尿路奇形 (2013)
  • Author(s): 西田 満, 喬 森,宮本 真里, 沖中 由佳, 山田 真紀子, 飯島 一誠, 大谷 浩, Christine Hartmann, 西中村 隆一, 南 康博
  • Organizer: 第22回発達腎研究会
  • Place of Presentation: 大阪（高槻）
  • Invited
• [Presentation] Functional analysis of Wnt5a-Ror signaling in regulation of progenitor proliferation during neocortical neurogenesis (2013)
  • Author(s): Mtisuharu Endo, Yasuhiro Minami
  • Organizer: Neuroscience 2013
  • Place of Presentation: San Diego, U.S.A.
• [Presentation] 反応性アストロサイトにおけるRorファミリー受容体型チロシンキナーゼの役割 (2013)
  • Author(s): 遠藤 光晴、加藤 英、疋田 壮舞、南 康博
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸
• [Presentation] 骨格筋分化・再生モデルを用いたRorシグナルの機能解析 (2012)
  • Author(s): 土井亮介
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ
  • Year and Date: 2012-12-14
• [Presentation] マウス腎臓発生におけるWnt5a-Ror2シグナルの役割 (2012)
  • Author(s): 西田満
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: 福岡国際会議場・マリンメッセ
  • Year and Date: 2012-12-14
• [Presentation] Wnt5a-Ror signaling under physiological and pathological conditions (2012)
  • Author(s): 南康博
  • Organizer: 第3回GCOE国際シンポジウム
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2012-12-10
  • Invited
• [Presentation] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP)-13 expression (2011)
  • Author(s): Kaoru Yamagata, Shunkichi Ikegaki, Xin Li, Yasuhiro Minami
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-16
• [Presentation] Rorファミリー受容体型チロシンキナーゼは大脳皮質神経幹細胞の維持に働く (2011)
  • Author(s): 遠藤光晴、土井亮助、西田満、南康博
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-12-13
• [Presentation] Ror-family receptor tyrosine kinases regulate maintenance of neural progenitor cells in the developing neocortex (2011)
  • Author(s): 遠藤光晴、西田満、南康博
  • Organizer: 第63回日本細胞生物学会大会ワークショップ
  • Place of Presentation: 北海道大学クラーク会館
  • Year and Date: 2011-06-28
• [Book] Receptor Tyrosine Kinases: Family and Subfamilies (2015)
  • Author(s): Endo, M., Nishita, M., Doi, R., Hayashi, M., Minami, Y.
  • Total Pages: 878
  • Publisher: Springer Science
• [Book] ROR Receptor Tyrosine Kinase Family (Chapter 13) Receptor Tyrosine Kinases: Family and subfamilies (2015)
  • Author(s): Endo, M., Nishita, M., Doi, R., Hayashi, M., Minami, Y.
  • Publisher: Springer Science
• [Book] The Receptor Tyrosine Kinase Handbook (2014)
  • Author(s): Endo, M., Nishita, M., Doi, R., Minami, Y. (Wheeler, D. L., Yarden, Y. edited)
  • Publisher: Springer Science
• [Book] Progenitor Cells: Biology, Characterization and Potential Clinical Applications (2013)
  • Author(s): Endo, M., Minami, Y. (Horton, P. M., Lawrence, B. E. edited)
  • Total Pages: 16
  • Publisher: Nova Science Publishers, Inc.
• [Book] The Receptor Tyrosine Kinase Handbook (chapter: Ror receptor family) (2013)
  • Author(s): Endo, M
  • Publisher: Springer Science
• [Book] Progenitor Cells: Biology, Characterization, and Potential Clinical Applications (2013)
  • Author(s): Endo, M
  • Publisher: Nova Science Publishers, Inc.
• [Book] The Receptor Tyrosine Kinase Handbook (chapter : Ror receptor family) (2012)
  • Author(s): Endo, M., Nishita, M., Doi, R., Minami, Y.
  • Publisher: Springer Science(印刷中)
• [Remarks] 神戸大学大学院医学研究科ホームページ
  • URL: http://www.med.kobe-u.ac.jp/medzoo/
• [Remarks] 研究室ホームページ
  • URL: http://www.med.kobe-u.ac.jp/medzoo/
• [Remarks] 新学術領域ホームページ
  • URL: http://www.med.osaka-u.ac.jp/pub/molbiobc/tubulology/index.html
• [Remarks] 研究室ホームページ
  • URL: http://www.med.kobe-u.ac.jp/medzoo/
• [Remarks] 新学術領域ホームページ
  • URL: http://www.med.osaka-u.ac.jp/pub/molbiobc/tubulology/index.html
• [Remarks] 新学術領域研究 上皮管腔組織の形成・維持と破綻における極性シグナル制御の分子基盤の確立HP
  • URL: http://www.med.osaka-u.ac.jp/pub/molbiobc/tubulology
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  • URL: http://www.med.kobe-u.ac.jp/medzoo/
• [Remarks]
  • URL: http://www.med.osaka-u.ac.jp/pub/molbiobc/tubulology/
• [Remarks]
  • URL: http://www.med.kobe-u.ac.jp/medzoo/