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Luminal epithelium integrity and the EMT

Planned Research

Project AreaRegulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
Project/Area Number 23112008
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHokkaido University

Principal Investigator

Sabe Hisataka  北海道大学, 医学(系)研究科(研究院), 教授 (40187282)

Co-Investigator(Kenkyū-buntansha) ONEYAMA Chitose  愛知県がんセンター研究所, 感染腫瘍学部, 部長 (90373208)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥167,830,000 (Direct Cost: ¥129,100,000、Indirect Cost: ¥38,730,000)
Fiscal Year 2015: ¥31,070,000 (Direct Cost: ¥23,900,000、Indirect Cost: ¥7,170,000)
Fiscal Year 2014: ¥31,070,000 (Direct Cost: ¥23,900,000、Indirect Cost: ¥7,170,000)
Fiscal Year 2013: ¥32,890,000 (Direct Cost: ¥25,300,000、Indirect Cost: ¥7,590,000)
Fiscal Year 2012: ¥32,500,000 (Direct Cost: ¥25,000,000、Indirect Cost: ¥7,500,000)
Fiscal Year 2011: ¥40,300,000 (Direct Cost: ¥31,000,000、Indirect Cost: ¥9,300,000)
Keywords乳癌 / 腎名細胞がん / 癌間充識悪性 / 薬剤耐性 / p53変異 / メバロン酸合成経路 / Arf6 / LPA / 癌悪性度進展 / ゲノム変異 / エピゲノム変化 / 代謝 / miRNA / Src / 癌浸潤転移 / 微小環境因子 / 浸潤 / TGFβ1 / p53 / AMAP1 / GEP100 / microRNA / ILK
Outline of Final Research Achievements

Drug resistance and high motility of cancer are central to malignancies. These phenotypes often emerge coupled with the mesenchymal programs. Arf6 and its effector AMAP1 are often overexpressed in various cancers, and promote invasion and metastasis. We first found that AMAP1 binds to EPB41L5, which is normally expressed in mesenchymes to promote focal adhesion dynamics. Thus, the Arf6 pathway appears to be a cancer-specific mesenchymal pathway. Moreover, the mevalonate pathway (MVP) was essential to Arf6 activation, via geranylgeranyl transferase-II and its substrate Rab11b. Mutant-p53s promoted Arf6 activation, via enhancing MVP. Besides receptor tyrosine kinases, G-protein-coupled receptor for LPA also directly activated Arf6. We finally demonstrated that the overexpressed Arf6 pathway promotes drug resistance. Our results showed that the Arf6-based pathway is critical to cancer malignancies and drug resistance, and provide excellent therapeutic opportunities.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (139 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (32 results) (of which Peer Reviewed: 32 results,  Open Access: 9 results,  Acknowledgement Compliant: 3 results) Presentation (92 results) (of which Int'l Joint Research: 2 results,  Invited: 15 results) Book (5 results) Remarks (4 results) Patent(Industrial Property Rights) (5 results) Funded Workshop (1 results)

  • [Journal Article] P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.2016

    • Author(s)
      Hashimoto, A., Oikawa, T., Hashimoto, S., Sugino, H., Yoshikawa, A., Otsuka, Y., Handa, H., Onodera, Y., Nam, J.M., Oneyama, C., Okada, M., Fukuda M. and Sabe, H.
    • Journal Title

      J Cell Biol.

      Volume: 213 Issue: 1 Pages: 81-95

    • DOI

      10.1083/jcb.201510002

    • NAID

      120005763128

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.2016

    • Author(s)
      Hashimoto, S,. Mikami, S., Sugino, H., Yoshikawa, A., Hashimoto, A., Onodera, Y., Furukawa, S., Handa, H., Oikawa, T., Okada, Y., Oya, M. and Sabe, H.
    • Journal Title

      Nat. Commun.

      Volume: 7 Issue: 1 Pages: 10656-10656

    • DOI

      10.1038/ncomms10656

    • NAID

      120005743066

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] miR-27b suppresses tumor progression by regulating ARFGEF1 and the focal adhesion signaling.2016

    • Author(s)
      Matsuyama, R., Okuzaki, D., Okada, M., Oneyama, C.
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 1 Pages: 28-35

    • DOI

      10.1111/cas.12834

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fer tyrosine kinase oligomer mediates and amplifies Src-induced tumor progression2015

    • Author(s)
      Oneyama C, Yoshikawa Y, Ninomiya Y, Iino T, Tsukita S, Okada M
    • Journal Title

      Oncogene

      Volume: 35 Issue: 4 Pages: 501

    • DOI

      10.1038/onc.2015.110

    • URL

      https://pure.teikyo.jp/en/publications/5eab79ca-728b-4573-acd2-1630ccbeab92

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNAs as the fine-tuners of Src oncogenic signaling.2015

    • Author(s)
      Oneyama, C., Okada, M.
    • Journal Title

      J Biochem

      Volume: 157 Issue: 6 Pages: 431-438

    • DOI

      10.1093/jb/mvv036

    • NAID

      40020489200

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mLST8 promotes mTOR-mediated tumor progression.2015

    • Author(s)
      Kakumoto, K., Ikeda, J., Okada, M., Morii, E., Oneyama, C.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 4 Pages: e0119015-e0119015

    • DOI

      10.1371/journal.pone.0119015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions.2014

    • Author(s)
      Tien, D.N., Kishihata, M., Yoshikawa, A., Hashimoto, A., Sabe, H., Nishi, E., Kamei, K., Arai, H., Kita, T., Kimura, T., Yokode, M. and Ashida, N.
    • Journal Title

      Sci Rep.

      Volume: 4 Issue: 1 Pages: 5094-5094

    • DOI

      10.1038/srep05094

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients.2014

    • Author(s)
      Sato H, Hatanaka KC, Hatanaka Y, Hatakeyama H, Hashimoto A, Matsuno Y, Fukuda S, Sabe H.
    • Journal Title

      Cell Commun Signal.

      Volume: 12 Issue: 1 Pages: 17-17

    • DOI

      10.1186/1478-811x-12-17

    • NAID

      120005438264

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of Raft-Anchored Adaptor Cbp/PAG1 in Spatial Regulation of c-Src Kinase.2014

    • Author(s)
      Saitou T, Kajiwara K, Oneyama C, Suzuki T, Okada M.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 3 Pages: e93470-e93470

    • DOI

      10.1371/journal.pone.0093470

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-Src-induced activation of ceramide metabolism impairs membrane microdomains and promotes malignant progression by facilitating the translocation of c-Src to focal adhesions2014

    • Author(s)
      Kajiwara K, Yamada T, Bamba T, Fukusaki E, Imamoto F, Okada M, Oneyama C.
    • Journal Title

      Biochem J.

      Volume: 458(1) Issue: 1 Pages: 81-93

    • DOI

      10.1042/bj20130527

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy.2013

    • Author(s)
      Kinoshita R, Nam JM, Ito YM, Hatanaka KC, Hashimoto A, Handa H, Otsuka Y, Hashimoto S, Onodera Y, Hosoda M, Onodera S, Shimizu S, Tanaka S, Shirato H, Tanino M, Sabe H.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 10 Pages: e76791-e76791

    • DOI

      10.1371/journal.pone.0076791

    • NAID

      120005348196

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β1-integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer.2013

    • Author(s)
      Nam JM, Ahmed KM, Costes S, Zhang H, Onodera Y, Olshen AB, Hatanaka KC, Kinoshita R, Ishikawa M, Sabe H, Shirato H, Park CC.
    • Journal Title

      Breast Cancer Res.

      Volume: 15 Issue: 4

    • DOI

      10.1186/bcr3454

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracellular trafficking of integrins in cancer cells.2013

    • Author(s)
      Onodera Y, Nam JM, Sabe H.
    • Journal Title

      Pharmacol Ther.

      Volume: 140 Issue: 1 Pages: 1-9

    • DOI

      10.1016/j.pharmthera.2013.05.007

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase2013

    • Author(s)
      Miura, K.
    • Journal Title

      Oncogene

      Volume: 32 Issue: 45 Pages: 5292-5301

    • DOI

      10.1038/onc.2012.571

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MiR-424/503-mediated Rictor upregulation promotes tumor progression2013

    • Author(s)
      Oneyama C, Kito Y, Asai R, Ikeda J, Yoshida T, Okuzaki D, Kokuda R, Kakumoto K, Takayama K, Inoue S, Morii E, Okada M.
    • Journal Title

      PLos ONE 2013

      Volume: 8(11) Issue: 11 Pages: e80300-e80300

    • DOI

      10.1371/journal.pone.0080300

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains2013

    • Author(s)
      Tanaka H, Akagi K, Oneyama C, Tanaka M, Sasaki Y, Kanou T, Lee YH, Yokogawa D, Dobenecker MW, Nakagawa A, Okada M, Ikegami T
    • Journal Title

      J Biol Chem 2013

      Volume: 288(21) Issue: 21 Pages: 15240-54

    • DOI

      10.1074/jbc.m112.439075

    • NAID

      120006770869

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of a new interaction mode between the Src homology 2 (SH2) domain of C-terminal Src kinase (Csk) and Csk-binding protein (Cbp)/phosphoprotein associated with glycosphingolipid microdomains (PAG).2013

    • Author(s)
      Tanaka H, Akagi KI, Oneyama C, Tanaka M, Sasaki Y, Kanou T, Lee YH, Yokogawa D, Dobenecker MW, Nakagawa A, Okada M, Ikegami T.
    • Journal Title

      J Biol Chem.

      Volume: (in press)

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones2013

    • Author(s)
      Sekino-Suzuki N, Yuyama K, Yamamoto T. (10名)
    • Journal Title

      J Neurochem

      Volume: Vol.124 Issue: 4 Pages: 514-522

    • DOI

      10.1111/jnc.12040

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression2012

    • Author(s)
      Oneyama C, Morii E, Okuzaki D, Takahashi Y, Ikeda J, Wakabayashi N, Akamatsu H, Tsujimoto M, Nishida T, Aozasa K, Okada M
    • Journal Title

      Oncogene 2012

      Volume: 31(13) Issue: 13 Pages: 1623-35

    • DOI

      10.1038/onc.2011.367

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes2012

    • Author(s)
      Takahashi Y, Nada S, Mori S, Soma-Nagae T, Oneyama C, Okada M
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 417(4) Issue: 4 Pages: 1151-7

    • DOI

      10.1016/j.bbrc.2011.12.082

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase(MMP-13) expression2012

    • Author(s)
      Yamagata K, Li X, Ikegaki S, Oneyama C, Okada M, Nishita M, Minami Y
    • Journal Title

      J Biol Chem

      Volume: 287(2) Issue: 2 Pages: 1588-99

    • DOI

      10.1074/jbc.m111.315127

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab5c mediates AMAP1-PRKD2 complexto enhance β1 integrin recycling inEGF-induced cancer invasion2012

    • Author(s)
      Onodera Y., Nam JM., Hashimoto A., Norman JC., Shirato H., Hashimoto S. and Sabe H
    • Journal Title

      J.Cell Biol

      Volume: 197 Issue: 7 Pages: 983-996

    • DOI

      10.1083/jcb.201201065

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GBF1 bears a novel phosphatidylinositol-phosphate binding module, BP3K, to link PI3Kg activity with Arf1 activation involved in GPCR-mediated neutrophil chemotaxis and superoxide production.2012

    • Author(s)
      Mazaki Y, Nishimura Y, Sabe H.
    • Journal Title

      Mol Biol Cell.

      Volume: 23 Issue: 13 Pages: 2457-2467

    • DOI

      10.1091/mbc.e12-01-0062

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grp1 plays a key role in linking insulin signaling to glut4 recycling.2012

    • Author(s)
      Li J, Malaby AW, Famulok M, Sabe H, Lambright DG, Hsu VW.
    • Journal Title

      Dev Cell.

      Volume: 22 Issue: 6 Pages: 1286-1298

    • DOI

      10.1016/j.devcel.2012.03.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Grp1 plays a key role in linking insulin signaling to glut4 recycling2012

    • Author(s)
      Li J., Malaby AW., Famulok M., Sabe H., Lambright DG., Hsu VW.
    • Journal Title

      Dev Cell

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways2011

    • Author(s)
      Oneyama C, Ikeda J, Okuzaki D, Suzuki K, Kanou T, Shintani Y, Morii E, Okumura M, Aozasa K, Okada M
    • Journal Title

      Oncogene 2011

      Volume: 30(32) Issue: 32 Pages: 3489-501

    • DOI

      10.1038/onc.2011.63

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation2011

    • Author(s)
      Kuroiwa, Oneyama C, Nada S, Okada M
    • Journal Title

      J Cell Sci 2011

      Volume: 124(Pt 10) Issue: 10 Pages: 1726-38

    • DOI

      10.1242/jcs.080291

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Down-regulation of the tumor suppressor Cbp/PAG1 is mediated by epigenetic histone modifications via the MAPK/ PI3K pathway2011

    • Author(s)
      Suzuki K, Oneyama C, Kimura H, Tajima S, Okada M
    • Journal Title

      J Biol Chem 2011

      Volume: 286(18) Issue: 18 Pages: 15698-706

    • DOI

      10.1074/jbc.m110.195362

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating Ezrin through negative regulation of RhoA2011

    • Author(s)
      Wakayama Y., Miura K., Sabe H. and Mochizuki N.
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 51 Pages: 44243-44253

    • DOI

      10.1074/jbc.m111.267047

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma2011

    • Author(s)
      Menju T., Hashimoto S., Hashimoto A., Otsuka Y., Handa H., Ogawa E., Toda Y., Wada H., Date H. and Sabe H.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 9 Pages: e25301-e25301

    • DOI

      10.1371/journal.pone.0025301

    • NAID

      120003464637

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis2011

    • Author(s)
      Hashimoto A., Hashimoto S., Ando R., Noda K., Ogawa E., Kotani H., Hirose M., Menju T., Morishige M., Manabe T., Toda Y., Ishida S. and Sabe H.
    • Journal Title

      PLoS One

      Volume: 6 Issue: 8 Pages: e23359-e23359

    • DOI

      10.1371/journal.pone.0023359

    • NAID

      120003295085

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer early dissemination : cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor β signalling2011

    • Author(s)
      Sabe H.
    • Journal Title

      J Biochem

      Volume: 149 Issue: 6 Pages: 633-639

    • DOI

      10.1093/jb/mvr044

    • NAID

      10030585535

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Arf6-AMAP1 pathway drives mesenchymal metastasis and drug resistance of cancers under RTK and GPCR signaling2016

    • Author(s)
      Hisataka Sabe
    • Organizer
      OOTR第12回年次学会
    • Place of Presentation
      ウエスティン都ホテル京都(京都府・京都市)
    • Year and Date
      2016-03-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Srcシグナルの制御破綻を標的としたがん治療シーズの探索2016

    • Author(s)
      小根山千歳
    • Organizer
      平成27年度中部地区医療・バイオ系シーズ発表会
    • Place of Presentation
      吹上ホール(愛知県・名古屋市)
    • Year and Date
      2016-02-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] c-Srcがん化初期に発現減少するmicroRNAのがん抑制作用2015

    • Author(s)
      二宮悠一、小根山千歳
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] c-Srcがん化におけるエクソソームの制御2015

    • Author(s)
      桑原敦、小根山千歳
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] FerキナーゼによるSrcがんシグナルの増幅と伝搬2015

    • Author(s)
      小根山千歳、吉川由利子、二宮悠一
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] p53 warrants epithelial gene expressions through epigenetic regulation2015

    • Author(s)
      Tsukasa Oikawa, Yasuhito Onodera, Yutaro Otsuka, Haruka Handa, Ari Hashimoto, Shigeru Hashimoto, Yutaka Suzuki and Hisataka Sabe
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Arf6-AMAP1 pathway confers radioresistance via regulation of ROS in breast cancer2015

    • Author(s)
      Yasuhito Onodera, Jin-Min Nam, Tsukasa Oikawa, Hiroki Shirato, Hisataka Sabe
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] c-Srcがん形質発現初期におけるmicroRNAの発現減少とがん抑制における重要性2015

    • Author(s)
      二宮悠一、小根山千歳
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] c-Srcによりがん化した細胞から分泌されるエクソソームの制御とその機能2015

    • Author(s)
      桑原敦、小根山千歳
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] microRNAを介したc-Src発現亢進とがん形質2015

    • Author(s)
      小根山千歳、二宮悠一、穀田理恵
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-06
    • Related Report
      2015 Annual Research Report
  • [Presentation] Grb2 promotes cancer invasive activities via EGF-induced GEP100-Arf6 pathway2015

    • Author(s)
      Toshi Menju, Naoto Imamura, Shinya Neri, Hiroyuki Cho, Takao Nakanishi, Kei Shikuma, Terumasa Sowa, Makoto Sonobe, Hisataka Sabe, Stephan M Feller, Hiroshi Date
    • Organizer
      第18回欧州癌学会、第40回欧州癌治療学会 共催
    • Place of Presentation
      Messe Wien Exhibition & Congress Center(ウィーン・オーストリア)
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] c-Srcがん化初期におけるmicroRNAの発現減少とがん抑制作用2015

    • Author(s)
      二宮悠一、小根山千歳
    • Organizer
      第7回日本RNAi研究会/第2回日本細胞外小胞学会
    • Place of Presentation
      グランドプリンスホテル広島(広島県広島市)
    • Year and Date
      2015-08-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] c-Srcによるエクソソームの制御とがん形質2015

    • Author(s)
      桑原敦、小根山千歳
    • Organizer
      第7回日本RNAi研究会/第2回日本細胞外小胞学会
    • Place of Presentation
      グランドプリンスホテル広島(広島県・広島市)
    • Year and Date
      2015-08-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] MicroRNAs as the fine-tuners of Src oncogenic signaling2015

    • Author(s)
      小根山千歳
    • Organizer
      第7回日本RNAi研究会/第2回日本細胞外小胞学会
    • Place of Presentation
      グランドプリンスホテル広島(広島県・広島市)
    • Year and Date
      2015-08-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ZEB1-EPB4.1L5 axis drives mesenchymal-type invasion and metastasis of primary breast cancers2015

    • Author(s)
      Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Haruka Handa, Yutaro Otsuka, Jin-Min Nam, Yasuhito Onodera, Tsukasa Oikawa and Hisataka Sabe
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀(東京都・江戸川区)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] microRNAによるSrcがんシグナル制御とその破綻2015

    • Author(s)
      小根山千歳
    • Organizer
      第67回日本細胞生物学会大会
    • Place of Presentation
      タワーホール船堀(東京都・江戸川区)
    • Year and Date
      2015-06-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脂質ラフトによるSrcの空間的制御とがん進展2015

    • Author(s)
      小根山千歳
    • Organizer
      日本がん分子標的治療学会第19回学術総会
    • Place of Presentation
      松山全日空ホテル(愛媛県・松山市)
    • Year and Date
      2015-06-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Different genome statuses in breast cancer and renal cancer generate the Arf6-based mesenchymal machinery critical for metastasis and poor survival2014

    • Author(s)
      Hisataka Sabe, Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Haruka Handa, Yutaro Otsuka, Tsukasa Oikawa, Shuji Mikami, Mototsugu Oya
    • Organizer
      The 4th Global Cancer Genomics Consortium Symposium
    • Place of Presentation
      芝蘭会館(京都市)
    • Year and Date
      2014-11-14 – 2014-11-15
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] p53 recalls epithelial memory in mammary cancer cells with mesenchymal phenotypes2014

    • Author(s)
      Tsukasa Oikawa, Yasuhito Onodera, Ari Hashimoto, Shigeru Hashimoto, and Hisataka Sabe
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Analysis of molecular mechanism involved in invasiveness of2014

    • Author(s)
      Jin-Min Nam, Yasuhito Onodera, Hisataka Sabe, Hiroki Shirato
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] EZH2 generates Arf6-based mesenchymal invasion machinery2014

    • Author(s)
      shigeru Hashimoto, Hirokazu Sugino, Ari Hashimoto, Ayumu
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] TP53 alterations generate Arf6-based mesenchymal invasion pathway that is activated by RTKs and TGFβ1 in breast cancer2014

    • Author(s)
      Ari Hashimoto, Shigeru Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Tsukasa Oikawa, Yasuhito Onodera, Haruka Handa, Yutaro Otsuka, Kosuke Iwami, Hiroki Sato, Chitose Oneyama, Masato Okada, Satoshi Fukuda, Mitsunori Fukuda, and Hisataka Sabe
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Robust redox homeostasis mediated by Arf6-AMAP1 pathway confers resistance to ionizing radiation in breast cancer2014

    • Author(s)
      Yasuhito Onodera, Jin-Min Nam, Tsukasa Oikawa, Hiroki Shirato and Hisataka Sabe
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] EZH2 overexpression generates Arf6-based mesenchymal invasion machinery that is activated by LPA and central to poor prognosis of renal cancer2014

    • Author(s)
      Shigeru Hashimoto, Hirokazu Sugino, Ari Hashimoto, Ayumu Yoshikawa, Tsukasa Oikawa, Haruka Handa, Mototsugu Oya, Shuji Mikami, and Hisataka Sabe
    • Organizer
      Mechanisms & Models of Cancer
    • Place of Presentation
      Cold Spring Harbor Laboratory(USA)
    • Year and Date
      2014-08-12 – 2014-08-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] RTKs-GEP100-Arf6-AMAP1 pathway mediates cancerous EMT in response to mutant p53 and TGFβ1 signaling2013

    • Author(s)
      佐邊壽孝
    • Organizer
      グローバルCOEシンポジウム
    • Place of Presentation
      艮陵会館記念ホール(宮城県)
    • Year and Date
      2013-02-01
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Roles of Arf6-AMAP1-PKD2 pathway in disorganization of epithelial architecture2012

    • Author(s)
      Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Mina Bissell, Shigeru Hashimoto, Hisataka Sabe
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-15
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regulation of c-Src-induecd oncogenic pathways via membrane microdomain2012

    • Author(s)
      吉川由利子、小根山千歳、飯野琢也、岡田雅人
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] EZH2 suppresses miR-203 expression to promote cancer invasion2012

    • Author(s)
      Shigeru Hashimoto, Hirokazu Sugino, Ari Hashimoto, Ayumu Yoshikawa, Yutaro Otsuka, Masanao Yoshino, Haruka Handa, Hisataka Sabe
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mutant-p53 generates the GEP100-Arf6-AMAP1 pathway to be activated by TGFβ1 and receptor tyrosine kinases to promote cancer invasion2012

    • Author(s)
      Ari Hashimoto, et al.
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-12
    • Related Report
      2012 Annual Research Report
  • [Presentation] Src-induced ceramide overexpression promotes tumor progression by perturbing membrane microdomains2012

    • Author(s)
      梶原健太郎、小根山千歳、今本文男、岡田雅人
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2012-12-11
    • Related Report
      2012 Annual Research Report
  • [Presentation] 癌浸潤におけるインテグリン活性化機構の解明と医療への応用2012

    • Author(s)
      小野寺康仁
    • Organizer
      第7回北海道大学医学研究科 連携センターシンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-11-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] p53変異によるリガンド依存性癌浸潤転移シグナル経路の創出2012

    • Author(s)
      佐邊壽孝
    • Organizer
      第4回 Kansai Cardiovascular Metabolic Frontier
    • Place of Presentation
      ヒルトン大阪(大阪府)
    • Year and Date
      2012-10-06
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] mutant-p53 generates an Arf6 pathway to be activated by TGFβ1 and RTKs to promote invasion2012

    • Author(s)
      佐邊壽孝
    • Organizer
      第22回北九州がんセミナー
    • Place of Presentation
      リーガロイヤルホテル小倉(福岡市)
    • Year and Date
      2012-10-05
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] RAB5C PROMOTES AMAP1-PRKD2 COMPLEX FORMATION TO ENHANCE β1 INTEGRIN RECYCLING IN EGF-INDUCED CANCER INVASION2012

    • Author(s)
      Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Jim C. Norman, Hiroki Shirato
    • Organizer
      第10回未来創薬・医療イノベーション拠点形成国際シンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-10-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] INHIBITION OF INTEGRIN SUPPRESSES INVASIVE RECURRENCE IN A 3D MODEL OF RADIATION TREATED DCIS2012

    • Author(s)
      Jin-Min Nam, Kazi Mokim Ahmed, Sylvain Costes, Hui Zhang, Hisataka Sabe, Hiroki Shirato, Catherine C. Park
    • Organizer
      第10回未来創薬・医療イノベーション拠点形成国際シンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-10-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] AMAP1 promotes β1 integrin recycling via PRKD2 and Rab5c in EGF-induced invasion of breast cancer cells (104/120)2012

    • Author(s)
      Yasuhito Onodera, Jin-Min Nam, Shigeru Hashimoto, Ari Hashimoto, Hiroki Shirato, Hisataka Sabe
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-21
    • Related Report
      2012 Annual Research Report
  • [Presentation] Targeting integrin suppresses invasive recurrence in a 3D model of radiation treated ductal carcinoma in situ2012

    • Author(s)
      Jin-Min Nam, Kazi Mokim Ahmed, Sylvain Costes, Hui Zhang, Hisataka Sabe, Hiroki Shirato, Catherine C. Park
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mutant-p53 generates GEP100-Arf6-AMAP1 pathway to promote breast cancer cell invasiveness in response to TGF β12012

    • Author(s)
      Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Sizuka Mito, Hiroki Sato, Yutaro Otsuka, Hinako Yoshino, Jin-Min Nam, Yasuhito Onodera, Hisataka Sabe
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] RTKs-GEP100-Arf6-AMAP1 pathway mediates cancerous EMT in response to mutant p53 and TGFβ1 signaling2012

    • Author(s)
      佐邊壽孝
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] MicroRNA-mediated downregulation of ARFGEF1 controls Src-induced tumor progression2012

    • Author(s)
      浅井麗伊、奥崎大介、池田純一郎、森井英一、岡田雅人、小根山千歳
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] MicroRNA-mediated upregulation of mTORC2 promotes Src-induced tumorigenesis2012

    • Author(s)
      小根山千歳、鬼頭頼子、浅井麗伊、角元恭子、奥崎大介、池田純一郎、森井英一、岡田雅人
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] EZH2-mediated downregulation of miR-203 promotes invasiveness of breast cancer cells2012

    • Author(s)
      Hirokazu Sugino,Shigeru Hashimoto,Ari Hashimoto,Ayumu Yoshikawa,Haruka Handa,Hisataka Sabe
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] GAB1 links c-Met signaling with GEP100-Arf6-AMAP1 pathway to promote breast cancer invasiveness2012

    • Author(s)
      Ayumu Yoshikawa, Shigeru Hashimoto, Ari Hashimoto, Hirokazu Sugino, Yutaro Otsuka, Shizuka Mito, Haruka Handa, Hisataka Sabe
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞膜ミクロドメイン“脂質ラフト”を介したc-Srcがん形質発現シグナルの制御2012

    • Author(s)
      吉川由利子、小根山千歳、飯野琢也、岡田雅人
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      ロイトン札幌(北海道)
    • Year and Date
      2012-09-19
    • Related Report
      2012 Annual Research Report
  • [Presentation] 細胞接着・浸潤関連遺伝子群を標的とするマイクロRNAによるSrcがん悪性化の制御機構2012

    • Author(s)
      浅井麗伊、森井英一、奥崎大介、池田純一郎、岡田雅人、小根山千歳
    • Organizer
      第4回日本RNAi研究会
    • Place of Presentation
      グランドプリンスホテル広島(広島県)
    • Year and Date
      2012-08-31
    • Related Report
      2012 Annual Research Report
  • [Presentation] ガン研究における今後のバイオイメージングの課題2012

    • Author(s)
      佐邊壽孝
    • Organizer
      蛍光バイオイメージング・ミニシンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-08-08
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] RAB5C PROMOTES AMAP1-PRKD2 COMPLEX FORMATION TO ENHANCE β1 INTEGRIN RECYCLING IN EGF-INDUCED CANCER INVASION2012

    • Author(s)
      Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Jim C. Norman, Hiroki Shirato
    • Organizer
      第31回札幌国際シンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-07-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] EZH2-MEDIATED DOWNREGULATION OF MIR-203 GENERATES THE ARF6-AMAP1 PATHWAY PIVOTAL FOR BREAST CANCER INVASIVENESS2012

    • Author(s)
      Hirokazu Sugino,Shigeru Hashimoto,Ari Hashimoto,Ayumu Yoshikawa,Haruka Handa,Hisataka Sabe
    • Organizer
      第31回札幌国際シンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-07-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] MUTANT-p53 GENERATES GEP100-Arf6-AMAP1 PATHWAY TO PROMOTE BREAST CANCER CELL INVASIVENESS IN RESPONSE TO TGFβ12012

    • Author(s)
      Ari Hashimoto, Shigeru Hashimoto, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Sizuka Mito, Hiroki Sato, Yutaro Otsuka, Hinako Yoshino, Jin-Min Nam, Yasuhito Onodera, Hisataka Sabe
    • Organizer
      第31回札幌国際シンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-07-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] GAB1 links c-Met signaling with GEP100-Arf6-AMAP1 pathway to promote breast cancer invasiveness2012

    • Author(s)
      Ayumu Yoshikawa, Shigeru Hashimoto, Ari Hashimoto, Hirokazu Sugino, Yutaro Otsuka, Shizuka Mito, Haruka Handa, Hisataka Sabe
    • Organizer
      第31回札幌国際シンポジウム
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2012-07-23
    • Related Report
      2012 Annual Research Report
  • [Presentation] EZH2-MEDIATED DOWNREGULATION OF MIR-203 GENERATES THE ARF6-AMAP1 PATHWAY PIVOTAL FOR BREAST CANCER INVASIVENESS2012

    • Author(s)
      Hirokazu Sugino,Shigeru Hashimoto,Ari Hashimoto,Ayumu Yoshikawa,Haruka Handa,Hisataka Sabe
    • Organizer
      BEATSON INTERNATIONAL ANCER CONFERENCE
    • Place of Presentation
      University of Glasgow(イギリス)
    • Year and Date
      2012-07-03
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳癌における発癌初期段階からの全身播種の分子機構とその予測バイオマーカー2012

    • Author(s)
      佐邊壽孝
    • Organizer
      平成24年JMTO臨床試験ワークショップ
    • Place of Presentation
      第二豊田ビル(愛知県)
    • Year and Date
      2012-06-23
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways2012

    • Author(s)
      小根山千歳
    • Organizer
      第7回ネットワークシンポジウム
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2012-06-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] EZH2 regulates breast cancer invasiveness through GEP100-Arf6-AMAP1 signaling pathway2012

    • Author(s)
      Hirokazu Sugino,Shigeru Hashimoto,Ari Hashimoto,Ayumu Yoshikawa,Yutaro Otsuka,Haruka Handa,Hisataka Sabe
    • Organizer
      第64回日本細胞生物学会/発生生物学会合同年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2012-05-30
    • Related Report
      2012 Annual Research Report
  • [Presentation] miRNAによるがん化制御2012

    • Author(s)
      小根山千歳、岡田雅人
    • Organizer
      第4回シグナルネットワーク研究会
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Annual Research Report
  • [Presentation] RTKs-GEP100-Arf6-AMAP1 pathway mediates cancerous EMT in response to mutant p53 and TGFβ signaling2012

    • Author(s)
      Hisataka Sabe, Ari Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Shizuka Mito, Hiroki Sato, Jin-Min Nam, Yasuhito Onodera, Shigeru Hashimoto
    • Organizer
      第8回OOTR年次学会
    • Place of Presentation
      ウェスティン都ホテル京都(京都府)
    • Year and Date
      2012-04-20
    • Related Report
      2012 Annual Research Report
  • [Presentation] p53 mutation and TGFβ signaling culminate in cancer invasiveness via GEP100-Arf6-AMAP1 pathway2012

    • Author(s)
      佐邊壽孝
    • Organizer
      平成23年度ライフサイエンスイノベージョン推進機構セミナー第371回学内セミナー
    • Place of Presentation
      福井大学(福井県)(招待講演)
    • Year and Date
      2012-02-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] p53 mutation and TGFβ signaling culminate in cancer invasiveness via GEP100-Arf6-AMAP1 pathway2012

    • Author(s)
      佐邊壽孝
    • Organizer
      Cell Migration in Biology and Medicine
    • Place of Presentation
      九州大学(福岡県)(招待講演)
    • Year and Date
      2012-01-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cell invasion2011

    • Author(s)
      橋本あり
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] p53 mutation and TGFβ signaling culminate in cancer invasiveness via GEP100-Arf6-AMAP1 pathway2011

    • Author(s)
      佐邊壽孝
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)(招待講演)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] EZH2 regulates Arf6 activity necessary for invasiveness of some breast cancer cells under normoxia and hypoxia2011

    • Author(s)
      橋本茂
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-12-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] がん細胞正常化を目指して-細胞内シグナルのリチューニング2011

    • Author(s)
      小根山千歳
    • Organizer
      大分統計談話会・第44回大会
    • Place of Presentation
      富士通大分システムラボラトリ(大分県)(招待講演)
    • Year and Date
      2011-10-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] MicroRNA controls c-Src-induced tumor progression2011

    • Author(s)
      小根山千歳
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] EZH2 is essential to Arf6 activation necessary for TGFβ1- and hypoxia-induced invasiveness of breast cancer cells2011

    • Author(s)
      橋本茂
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mutant p53 is essential for TGFβ1-induced breast cancer cell invasiveness2011

    • Author(s)
      橋本あり
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] AMAP1 promotes β1 integrin nccycling via PRKD2 and Rab5c in EGF-induced invasion of breast cancer cells (104/120)2011

    • Author(s)
      小野寺康仁
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] miRNAによるSrcがん悪性化の制御機構2011

    • Author(s)
      小根山千歳
    • Organizer
      第3回日本RNAi研究会
    • Place of Presentation
      グランドプリンスホテル広島(広島県)
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] HGFR/c-Met-mediated activation of GEP100-Arf6-AMAP1 pathway is an integral part for TGFβ-induced cancerous EMT and invasiveness2011

    • Author(s)
      橋本あり
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2011-06-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Glucose metabolism and intracellular trafficking in tumor malignancy2011

    • Author(s)
      小野寺康仁
    • Organizer
      第63回日本細胞生物学会大会
    • Place of Presentation
      北海道大学(北海道)
    • Year and Date
      2011-06-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Srcチロシンキナーゼの脂質ラフトによるがん化シグナル制御

    • Author(s)
      小根山千歳
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪大学(吹田市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Srcがんモデルを用いた治療標的microRNAの探求

    • Author(s)
      小根山千歳
    • Organizer
      がん分子標的治療学会第9回トランスレーショナルリサーチワークショップ
    • Place of Presentation
      都市センターホテル(東京)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] LST8の発現上昇はmTORを介したがん形質発現を促進する

    • Author(s)
      角元恭子、池田純一郎、森井英一、小根山千歳
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] MicroRNAを介したSrc発現制御機構とがん形質発現

    • Author(s)
      穀田理恵、岡田雅人、小根山千歳
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Ferを介したc-Srcによるがん形質発現

    • Author(s)
      小根山千歳、吉川由利子、飯野琢也、月田早智子、岡田雅人
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanisms by which p53 alterations generate GEP100-Arf6-AMAP1 pathway as a mesenchymal invasion machinery to be activated by RTK-ligands and TGBβ1

    • Author(s)
      Ari Hashimoto, Shigeru Hashimoto, Yasuhito Onodera, Tsukasa Oikawa, Chitose Oneyama, Rumiko Kinoshita, Jin-Min Nam, Mishie Tanino, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Masanao Yoshino, Hiroki Sato, Satoshi Fukuda, Shinya Tanaka, Hiroki Shirato, Yoichi Ito, Masato Okada, and Hisataka Sabe
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] C末端SrcキナーゼのSH2ドメインとCbp/PAGとの間の新しい相互作用様式の発見

    • Author(s)
      田中宏明、赤木謙一、小根山千歳、田中雅千、佐々木優一、狩野孝、Lee Young-Ho、横川大輔、Dobenecker Marc-Werner、中川敦史、岡田雅人、池上貴久
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 乳癌におけるArf6-AMAP1経路の阻害による放射線増感作用の解析

    • Author(s)
      小野寺康仁
    • Organizer
      第8回北海道大学医学研究科 連携研究センター研究成果発表会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Srcによるがん形質発現メカニズムの再考

    • Author(s)
      小根山千歳
    • Organizer
      奈良先端技術大学未来開拓コロキウム
    • Place of Presentation
      奈良先端技術大学(生駒市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Possible mechanisms of non-invasive to invasive phenotypic conversion of breast cancer cells upon radiation

    • Author(s)
      Jin-Min Nam, Yasuhito Onodera, Masayori Ishikawa, Hisataka Sabe, Hiroki Shirato
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] MicroRNA-mediated mTORC2 upregulation promotes tumor progression

    • Author(s)
      小根山千歳、鬼頭頼子、池田純一郎、吉田卓也、奥崎大介、森井英一、岡田雅人
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] MicroRNA-mediated c-Src upregulation promotes tumor progression

    • Author(s)
      穀田理恵、岡田雅人、小根山千歳
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] トリプルネガティブ乳癌における治療標的としてのRictor

    • Author(s)
      中山明子、岡田雅人、小根山千歳
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] LST8 promotes mTORC2-mediated tumor progression

    • Author(s)
      角元恭子、池田純一郎、森井英一、岡田雅人、小根山千歳
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mechanisms by which oncogenic mutant-p53 generates mesenchymal invasive pathway pivotal to a radiation resistance

    • Author(s)
      Hisataka Sabe, Ari Hashimoto, Shigeru Hashimoto, Yasuhito Onodera, Tsukasa Oikawa, Jin-Min Nam, Chitose Oneyama, Hirokazu Sugino, Ayumu Yoshikawa, Yutaro Otsuka, Haruka Handa, Masanao Yoshino, Masato Okada
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Roles and mechanisms of “glycolytic signaling” in breast cancer.

    • Author(s)
      Onodera Y, Nam JM, Bissell M
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mutant-p53 generates the GEP100-Arf6-AMAP1 pathway to promote breast cancer invasiveness

    • Author(s)
      Shigeru Hashimoto, Ari Hashimoto, Chitose Oneyama, Ayumu Yoshikawa, Hirokazu Sugino, Haruka Handa, Masanao Yoshino, Yutaro Otsuka, Yasuhito Onodera, Masato Okada, Hisataka Sabe
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Novel regulatory mechanisms of cellular and physiological/pathological functions by actin cytoskeleton

    • Author(s)
      Tsukasa Oikawa, Masaaki Oyama, Hiroko Kozuka-Hata, Atsuko Nakamura, Nobuyuki Onishi, Shunsuke Uehara, Nobuyuki Udagawa, Taketo Yamada, Hideyuki Saya, Koichi Matsuo
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ARFGEF1およびPaxillinを標的とするmiRNAによるSrcがん形質の制御機構

    • Author(s)
      浅井麗伊、奥崎大介、池田純一郎、岡田雅人、森井英一、小根山千歳
    • Organizer
      第5回日本RNAi研究会
    • Place of Presentation
      グランドプリンス広島(広島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] マイクロRNAを介するSrc発現制御とがん形質発現

    • Author(s)
      穀田理恵、岡田雅人、小根山千歳
    • Organizer
      第5回日本RNAi研究会
    • Place of Presentation
      グランドプリンス広島(広島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癌の再発予測と再発部治療

    • Author(s)
      佐邊壽孝
    • Organizer
      第8回神戸がん研究会
    • Place of Presentation
      神緑会館(神戸市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Srcによるがん形質発現メカニズムの再考−マイクロRNAを介したシグナル制御

    • Author(s)
      小根山千歳
    • Organizer
      広島大学大学院医歯薬総合研究科セミナー
    • Place of Presentation
      広島大学(広島市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] MicroRNA-mediated upregulation of mTORC2 promotes tumor progression

    • Author(s)
      Chitose Oneyama, Yoriko Kito, Rei Asai, Kyoko Kakumoto, Junichiro Ikeda, Eiichi Morii, Masato Okada
    • Organizer
      Epithelial Tubulology The First International Meeting
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2013 Annual Research Report
  • [Book] 「がんシグナルとmicroRNA」生体の科学 67巻1号2016

    • Author(s)
      小根山千歳
    • Total Pages
      92
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 脂質ラフトによるSrcの空間的制御とがん進展」実験医学増刊:知る・見る・活かす!シグナリング研究20152015

    • Author(s)
      小根山千歳、岡田雅人
    • Total Pages
      214
    • Publisher
      羊土社
    • Related Report
      2015 Annual Research Report
  • [Book] ArfGAPs: not only for the termination.2014

    • Author(s)
      Shigeru Hashimoto, Ari Hashimoto, Hirokazu Sugino, Ayumu Yoshikawa, Haruka Handa, Masanao Yoshino, Yutaro Otsuka, and Hisataka Sabe.
    • Total Pages
      22
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] 「EMT-基礎的観点から」乳癌レビュー20122012

    • Author(s)
      橋本あり、杉野弘和、橋本茂、佐邊壽孝
    • Total Pages
      7
    • Publisher
      メディカルレビュー社
    • Related Report
      2012 Annual Research Report
  • [Book] 局所浸潤モデル-がんの浸潤転移に関わる分子 「疾患モデルの作製と利用-がん」2012

    • Author(s)
      橋本あり、橋本茂、佐邊壽孝
    • Total Pages
      11
    • Publisher
      エル・アイ・シー(株)
    • Related Report
      2012 Annual Research Report
  • [Remarks] 北海道大学大学院医学研究科 生化学講座分子生物学分野ホームページ

    • URL

      http://www.hucc.hokudai.ac.jp/~g21001/

    • Related Report
      2015 Annual Research Report 2012 Annual Research Report
  • [Remarks] 北海道大学大学院医学研究科生化学講座分子生物学分野ホームページ

    • URL

      http://www.hucc.hokudai.ac.jp/~g21001/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.hucc.hokudai.ac.jp/~g21001/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://info.coop.hokudai.ac.jp/bunsei/index.html

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 腎癌の再発リスクの予測に用いるための診断薬及びキット、並びに予測方法2015

    • Inventor(s)
      佐邊壽孝、平野聡、古川聖太郎
    • Industrial Property Rights Holder
      佐邊壽孝、平野聡、古川聖太郎
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 腎癌の再発リスクの予測に用いるための診断薬及びキット、並びに予測方法2013

    • Inventor(s)
      佐邊壽孝、大家基嗣、三上修治
    • Industrial Property Rights Holder
      佐邊壽孝、大家基嗣、三上修治
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-148969
    • Filing Date
      2013-07-17
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 放射線治療増強薬及び放射線抵抗性癌の治療方法2013

    • Inventor(s)
      佐邊壽孝、小野寺康仁、Nan Jin Min、橋本茂、橋本あり
    • Industrial Property Rights Holder
      佐邊壽孝、小野寺康仁、Nan Jin Min、橋本茂、橋本あり
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-148970
    • Filing Date
      2013-07-17
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 乳癌乳房温存療法後の再発リスクの予測に用いるための診断薬並びに予測方法2013

    • Inventor(s)
      佐邊壽孝、橋本茂、橋本あり、小野寺康仁、白土博樹、木下留美子
    • Industrial Property Rights Holder
      佐邊壽孝、橋本茂、橋本あり、小野寺康仁、白土博樹、木下留美子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-03-04
    • Related Report
      2012 Annual Research Report
  • [Patent(Industrial Property Rights)] mTOR阻害剤の投与が有効ながん患者の選択方法2011

    • Inventor(s)
      小根山千歳、岡田雅人、田村研治
    • Industrial Property Rights Holder
      小根山千歳、岡田雅人、田村研治
    • Industrial Property Number
      2011-218271
    • Filing Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Funded Workshop] The Second International Meeting for Epithelial Tubulology2015

    • Place of Presentation
      北海道大学(北海道・札幌市)
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report

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Published: 2011-08-01   Modified: 2019-07-29  

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