Planned Research
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
We have tried to understand the roles and mechanisms of senescent stromal cells in cancer microenvironment, and following findings are obtained : (1) In senescent cells, DNA damage response provokes degradation of G9a/GLP histone methyltransferases and thereby causing epigenetic de-repression of SASP factor genes. (2) Senescent hepatic stromal cells promote hepatocellular tumorigenesis through secreting SASP factors. (3) SASP primarily promotes tissue repair, contributing to maintenance of homeostasis. Excess amount and/or duration of SASP, however, provokes tumorigenesis.
All 2015 2014 2013 2012 2011 Other
All Journal Article (14 results) (of which Peer Reviewed: 14 results, Open Access: 5 results, Acknowledgement Compliant: 4 results) Presentation (25 results) (of which Invited: 22 results) Remarks (1 results)
Cell Cycle
Volume: 14 Issue: 8 Pages: 1164-1173
10.1080/15384101.2015.1010866
Cancer Sci
Volume: 106 Issue: 3 Pages: 244-52
10.1111/cas.12600
120005830611
Aging Cell
Volume: - Issue: 4 Pages: 1-9
10.1111/acel.12337
Nature Communications
Volume: 6:7035 Pages: 1-10
Cell Reports
Volume: 7 Issue: 1 Pages: 194-207
10.1016/j.celrep.2014.03.006
Mol.Cell
Volume: 55 Issue: 1 Pages: 73-84
10.1016/j.molcel.2014.05.003
Developmental Cell
Volume: 31 Issue: 6 Pages: 722-733
10.1016/j.devcel.2014.11.012
Cancer Research
Volume: 74 Issue: 7 Pages: 1885-11889
10.1158/0008-5472.can-13-3501
Nature
Volume: 499 Issue: 7456 Pages: 97-101
10.1038/nature12347
Cancer Science
Volume: 104 Issue: 5 Pages: 525-530
10.1111/cas.12118
Cell Stem Cell
Volume: 10 Issue: 6 Pages: 759-770
10.1016/j.stem.2012.02.022
Biochem. Biophys. Res. Commun
Volume: 427 Issue: 2 Pages: 285-292
10.1016/j.bbrc.2012.09.041
Molecular Cell
Volume: 45 Issue: 1 Pages: 123-131
10.1016/j.molcel.2011.10.018
International Journal of Oral Science
Volume: 4 Issue: 4 Pages: 200-208
10.4248/ijos11070
http://www.jfcr.or.jp/tci/canbio/index.html