| Budget Amount *help |
¥181,350,000 (Direct Cost: ¥139,500,000、Indirect Cost: ¥41,850,000)
Fiscal Year 2015: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Fiscal Year 2014: ¥34,320,000 (Direct Cost: ¥26,400,000、Indirect Cost: ¥7,920,000)
Fiscal Year 2013: ¥36,140,000 (Direct Cost: ¥27,800,000、Indirect Cost: ¥8,340,000)
Fiscal Year 2012: ¥35,880,000 (Direct Cost: ¥27,600,000、Indirect Cost: ¥8,280,000)
Fiscal Year 2011: ¥40,690,000 (Direct Cost: ¥31,300,000、Indirect Cost: ¥9,390,000)
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| Outline of Final Research Achievements |
Noncoding genome plays critical roles in genome evolution. We investigated how DNA recombination in noncoding genome is integratedly regulated by repetitive sequences, recombination hotspots, chromatin structure, epigenetics, and noncoding RNA transcription. In this study, we revealed specific histone marks govern the position of fission yeast meiotic recombination hotspots. In addition, we discovered a new factor called "liaisonin", which is involved in the construction of 3D chromosome architectures required for the meiotic recombination initiation. Moreover, we found that the noncoding transcription of 5' upstream segments of some stress genes provides an integrated positive feedback control system for gene activation and silencing. We also provide new high-throughput DNA sequencer-based methodology for the study of noncoding DNA.
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