| Budget Amount *help |
¥81,120,000 (Direct Cost: ¥62,400,000、Indirect Cost: ¥18,720,000)
Fiscal Year 2015: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2014: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2013: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2011: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
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| Outline of Final Research Achievements |
I investigated the mechanisms of novel functions and novel regulations of telomeres and subtelomeres at chromosome ends in eukaryotes. I found that Rap1, a telomere-binding protein, is phosphorylated by Cdc2 at M phase, which induces transient release of telomeres from the nuclear envelope, ensuring proper chromosome segregation. I also analyzed the mechanisms of formation of telomere protein complexes and their physiological importance. Furthermore, I investigated the functions of Sgo2, a shugoshin-family protein, at subtelomeres. Sgo2 is localized at subtelomeres only at interphase and plays various roles, such as replication timing control.
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