Axon branch remodeling mechanisms in mesoscopic neuronal circuit formation
| Project Area | Mesoscopic neurocircuitry: towards understanding of the functional and structural basis of brain information processing |
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| Project/Area Number |
23115102
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤島 和人 京都大学, 物質－細胞統合システム拠点, 特定拠点助教 (20525852)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGO Noriyuki 大阪大学, 大学院生命機能研究科, 助教 (20372625)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2014: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2013: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2012: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
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| Keywords | 軸索分岐 / 大脳 / 視床 / 神経活動 / RhoA / Unc5B / netrin-4 / 樹状突起 / 視床由来分子 / 軸索誘導 / ネトリン / 受容体 |
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| Outline of Final Research Achievements |
The aim of this study is to reveal the role of neuronal activity in axon branching and the molecular mechanisms of branch formation, focusing on the thalamocortical projection system. We found that branching of thalamocortical axons is promoted by target-derived molecules which are expressed in an activity-dependent fashion and that an activity-independent mechanism also works on axon branching. We furhter found that branches mostly emerge from presynaptic sites of thalamic axons in normal conditions but appear from non-presynaptic sites with high neuronal activity. Evidence also suggests that a cytoskeleton-regulatory mechanism is involved in axon branching.
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] Single-molecule imaging reveals dynamics of CREB transcription factor bound to its target sequence2015
Author(s)
Sugo, N., Morimatsu, M., Arai, Y., Kousoku, Y., Ohkuni, A., Nomura, T., Yanagida, T. & Yamamoto, N.
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Journal Title
Scientific Report
Volume: 5
Issue: 1
Pages: 10662-10662
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Polβ deficiency increases DNA double-strand breaks in postnatal cortical2015
Author(s)
Uyeda, A., Onishi, K., Sugo, N., Toyoda S., Hiyayama, T., Yagi, T. & Yamamoto, N.
Organizer
第38回日本分子生物学会
Place of Presentation
神戸
Year and Date
2015-12-01
Related Report
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[Presentation] DNA polymerase β activity in neural progenitors is required for postmitotic neuronal survival in the developing cortex2015
Author(s)
Onishi, k., Sugo, N., Toyoda, S., Hirayama, T., Yagi, T. & Yamamoto, N.
Organizer
Society for Neuroscience
Place of Presentation
Chicago, USA
Year and Date
2015-10-17
Related Report
Int'l Joint Research
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