| Budget Amount *help |
¥187,824,000 (Direct Cost: ¥144,480,000、Indirect Cost: ¥43,344,000)
Fiscal Year 2015: ¥33,007,000 (Direct Cost: ¥25,390,000、Indirect Cost: ¥7,617,000)
Fiscal Year 2014: ¥33,007,000 (Direct Cost: ¥25,390,000、Indirect Cost: ¥7,617,000)
Fiscal Year 2013: ¥39,130,000 (Direct Cost: ¥30,100,000、Indirect Cost: ¥9,030,000)
Fiscal Year 2012: ¥38,740,000 (Direct Cost: ¥29,800,000、Indirect Cost: ¥8,940,000)
Fiscal Year 2011: ¥43,940,000 (Direct Cost: ¥33,800,000、Indirect Cost: ¥10,140,000)
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| Outline of Final Research Achievements |
The intercellular methyl group donor S-adenosyl-L-methionine (SAM) is produced in the methionine cycle. In this study, we investigated the crosstalk between methionine metabolism and methylation levels in the transcriptional environment. We first established the highly sensitive measurement system for detecting cellular methionine and SAM. In addition, by using C. elegans as a model organism, we revealed that food-derived methionine affects methylation levels of histones by being converted into SAM and one of phospholipid synthases that consumes a large amount of SAM is involved in lifespan regulation.
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