| Budget Amount *help |
¥75,972,000 (Direct Cost: ¥58,440,000、Indirect Cost: ¥17,532,000)
Fiscal Year 2015: ¥12,376,000 (Direct Cost: ¥9,520,000、Indirect Cost: ¥2,856,000)
Fiscal Year 2014: ¥12,376,000 (Direct Cost: ¥9,520,000、Indirect Cost: ¥2,856,000)
Fiscal Year 2013: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2012: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2011: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
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| Outline of Final Research Achievements |
The principal investigator has established a quantitative system that combines adenovirus-mediated transduction of luciferase reporter gene into the liver with in vivo imaging system (IVIS) technique (in vivo Ad-luc analytical system) to create an intra-organ assay system for the analysis of energy metabolism and metabolic signals. Moreover, we have developed the Transcription Factor Expression Library (TFEL), which covers all known transcription factors encoded by the mouse genome, and created a method for the analysis of transcription complexes using this library (TFEL scan method). We employed these methods to identify the genomic regions acted upon by a range of signals related to energy metabolism and elucidated the mechanisms underlying the metabolic control of gene expression.
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