| Budget Amount *help |
¥108,316,000 (Direct Cost: ¥83,320,000、Indirect Cost: ¥24,996,000)
Fiscal Year 2015: ¥19,188,000 (Direct Cost: ¥14,760,000、Indirect Cost: ¥4,428,000)
Fiscal Year 2014: ¥19,188,000 (Direct Cost: ¥14,760,000、Indirect Cost: ¥4,428,000)
Fiscal Year 2013: ¥22,490,000 (Direct Cost: ¥17,300,000、Indirect Cost: ¥5,190,000)
Fiscal Year 2012: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2011: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
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| Outline of Final Research Achievements |
In this study, it is suggested that formation of heterochromatin-like structures is involved in regulation of intracellular localization of DNA damage recognition factors for nucleotide excision repair. We also elucidate novel roles of various post-translational modifications (ubiquitination, SUMOylation, acetylation, etc.) in functional regulation of the DDB2 protein, which is involved in crosstalks between DNA repair and transcription, thereby regulating cellular DNA damage responses. Furthermore, the molecular mechanism is uncovered for regulating stability of thymine DNA glycosylase (TDG), which is a key factor involved in both base excision repair suppressing spontaneous mutagenesis as well as active DNA demethylation. TDG is also shown to interact functionally with the nucleotide excision repair pathway by affecting functions of the xeroderma pigmentosum group C (XPC) protein.
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