Roles of prostanoids in facilitation of lymphangiogenesis and lymph node metastasis

• Project Area: Machineries of bioactive lipids in homeostasis and diseases
• Project/Area Number: 23116102
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kitasato University
• Principal Investigator: MAJIMA Masataka 北里大学, 医学部, 教授 (70181641)
• Co-Investigator(Kenkyū-buntansha): FUJITA Tomoe 北里大学, 医学部, 講師 (20296510) ; 細野 加奈子 北里大学, 医学部, 助教 (80532556)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥70,200,000 (Direct Cost: ¥54,000,000、Indirect Cost: ¥16,200,000); Fiscal Year 2014: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000); Fiscal Year 2013: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000); Fiscal Year 2012: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
• Keywords: プロスタグランジン / サイクロオキシゲナーゼ / リンパ管新生 / がんリンパ節転移 / 慢性炎症 / 浮腫 / 前転移ニッテェ / 樹状細胞 / リンパ節転移 / がん / premetastatic niche / COX-2 / EP3 / SDF-1 / regulatory T cell / TPシグナリング / EP3シグナリング / VEGF / SDF1 / dendritic cell / VEGF-C / Prostaglandin / 受容体 / Cyclooxygenase / 炎症 / 腫瘍 / トロンボキサン / 血管新生 / 血小板 / セレクチン / 微小循環 / 虚血モデル / TP受容体 / IP受容体

Outline of Final Research Achievements

Lymphatic vasculature forms a network of vessels that drain interstitial fluid from tissues and return this fluid to the blood. Lymphangiogesis, the formation of lymphatic vessels from preexisting lymphatic vessels, plays an important role in homeostasis of interstitial fluids and immunity. We found that lymphangiogenesis in chronic inflammation and secondary lymphedema was regulated by COX-2. The lymphatic system is an important route for cancer dissemination, and lymph node metastasis (LNM) serves as a critical prognostic determinant in cancer patients. We clarified contribution of COX-2-derived PGE2 in formation of a premetastatic niche and LNM. Stromal cell-derived factor-1 (SDF-1) was elevated in DCs before LLC cell infiltration to lymph nodes, and was important to form premetastatic niche. Accumulation of Tregs and lymph node lymphangiogenesis was also COX-2/EP3-dependent. These results indicate that DCs induce a premetastatic niche via COX-2/EP3-dependent induction of SDF-1.

Research Products

• [Journal Article] Suppressed recruitment of alternatively activated macrophages reduces TGF-β1 and impairs wound healing in streptozotocin-induced diabetic mice. (2015)
  • Author(s): Okizaki S, Ito Y, Hosono K, Oba K, Ohkubo H, Amano H, Shichiri M, Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 70 Pages: 317-325
  • DOI: 10.1016/j.biopha.2014.10.020
  • Peer Reviewed / Open Access
• [Journal Article] Role of cyclooxygenase-2 in the development of interstitial fibrosis in kidneys following unilateral ureteral obstruction in mice (2015)
  • Author(s): Kamata M, Hosono K, Fujita T, Kamata K, Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 70 Pages: 174-180
  • DOI: 10.1016/j.biopha.2015.01.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] VEGFR1-positive macrophages facilitate liver repair and sinusoidal reconstruction after hepaticischemia/reperfusion injury. (2014)
  • Author(s): Ohkubo H, Ito Y, Minamino T, Eshima K, Kojo K, Okizaki S, Hirata M, Shibuya M, Watanabe M, Majima M.
  • Journal Title: PLoS One Volume: 9 Issue: 8 Pages: e105533-e105533
  • DOI: 10.1371/journal.pone.0105533
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of lung age on postoperative readmission in non-small cell. (2014)
  • Author(s): Ogawa F, Satoh Y, Iyoda A, Amano H, Kumagai Y, Majima M.
  • Journal Title: J. Surg. Res. Volume: 193 Issue: 1 Pages: 442-448
  • DOI: 10.1016/j.jss.2014.08.028
  • Peer Reviewed / Open Access
• [Journal Article] Prostanoid induces premetastatic niche in regional lymph nodes. (2014)
  • Author(s): Ogawa F, Amano H, Eshima Y, Ito Y, Matsui Y, Hosono K, Kitasato H, Iyoda A, Iwabuchi K, Kumagai Y, Satoh Y, Narumiiya S, Majima M.
  • Journal Title: J. Clin. Invest. Volume: 124 Issue: 11 Pages: 4882-4894
  • DOI: 10.1172/jci73530
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Downregulation of the proangiogenic prostaglandin E receptor EP3 and reduced angiogenesis in a mouse model of diabetes mellitus. (2014)
  • Author(s): Oba K, Hosono K, Amano H, Okizaki S, Ito Y, Shichiri M, Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 68 Issue: 8 Pages: 1125-1133
  • DOI: 10.1016/j.biopha.2014.10.022
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. (2014)
  • Author(s): Takahashi R., Amano H., Satoh T., Tabata K., Ikeda M., Kitasato H., Akira S., Iwamura M., Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 68 Issue: 1 Pages: 71-77
  • DOI: 10.1016/j.biopha.2013.10.008
  • Peer Reviewed
• [Journal Article] Roles of microsomal prostaglandin E synthase-1 in lung metastasis formation in prostate cancer RM9 cells. (2014)
  • Author(s): Takahashi R., Amano H., Satoh T., Tabata K., Ikeda M., Kitasato H., Akira S., Iwamura M., Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 28 Issue: 3 Pages: 1237-1247
  • DOI: 10.1096/fj.13-238998
  • Peer Reviewed
• [Journal Article] Aspirin reduces lung cancer metastasis to regional lymph nodes. (2014)
  • Author(s): Ogawa F., Amano H., Ito H., Matsui Y., Hosono K., Kitasato H., Satoh Y., Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 68 Issue: 1 Pages: 79-86
  • DOI: 10.1016/j.biopha.2013.11.006
  • Peer Reviewed
• [Journal Article] Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment. (2013)
  • Author(s): Ohkubo H., Ito Y., Minamino T., Mishima T., Hirata M., Hosono K., Shibuya M., Yokomizo T., Shimizu T., Watanabe M., Majima M.
  • Journal Title: FASEB J. Volume: 27 Issue: 8 Pages: 3132-3143
  • DOI: 10.1096/fj.13-227421
  • Peer Reviewed
• [Journal Article] NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4+ VEGFR1+ cells to theulcer granulation tissues. (2013)
  • Author(s): Sato T., Amano H., Ito Y., Eshima K., Minamino .T, Ae T., Katada C., Ohno T., Hosono K., Suzuki T., Shibuya M., Koizumi W., Majima M.
  • Journal Title: Biomed Pharmacother Volume: 67 Issue: 7 Pages: 607-613
  • DOI: 10.1016/j.biopha.2013.01.009
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the up regulation of epidermal growth factor expression on VEGFR1+ CXCR4+ cells recruited from bone marrow. (2013)
  • Author(s): Sato T., Amano H., Ito Y., Eshima K., Minamino T., Ae T., Katada C., Ohno T., Hosono K., Suzuki T., Shibuya M., Koizumi W., Majima M.
  • Journal Title: J Gastroenterol. Volume: 49 Issue: 3 Pages: 455-469
  • DOI: 10.1007/s00535-013-0869-z
  • Peer Reviewed
• [Journal Article] A common polymorphism in the tissue kallikrein gene is associated with increased urinary excretions of calcium and sodium in Japanese volunteers. (2013)
  • Author(s): Fujita T., Yasuda S., Kamata T., Kamata K., Kumagai Y., Majima M.
  • Journal Title: J Hum Genet. Volume: 58 Issue: 11 Pages: 758-761
  • DOI: 10.1038/jhg.2013.93
  • Peer Reviewed
• [Journal Article] Lymphangiogenesis (2013)
  • Author(s): 細野加奈子、馬嶋正隆
  • Journal Title: Folia Pharmacologica Japonica Volume: 141 Issue: 5 Pages: 290-291
  • DOI: 10.1254/fpj.141.290
  • NAID: 10031171132
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells (2013)
  • Author(s): Amano H, Ito Y, Ogawa F, Eshima K, Suzuki T, Oba K, Matsui Y, Kato S, Fukui T, Nakamura M, Kitasato H, Fukamizu A, Majima M
  • Journal Title: Am J Pathol Volume: 182(2) Issue: 2 Pages: 553-64
  • DOI: 10.1016/j.ajpath.2012.10.026
  • Peer Reviewed
• [Journal Article] NSAID, aspirin delays gastric ulcer healing with reduced accumulation of CXCR4+ VEGFR1+ cells to the ulcer granulation tissues (2013)
  • Author(s): Sato T, Amano H, Ito Y, Eshima K, Minamino T, Ae T, Katada C, Ohno T, Hosono K, Suzuki T, Shibuya M, Koizumi W, Majima M.
  • Journal Title: Biomed Pharmacother. Volume: 183
  • Peer Reviewed
• [Journal Article] VEGF/VEGFR signaling in the liver repair from acetaminophen hepatotoxicity. (2013)
  • Author(s): Kato T, Ito Y, Majima M.
  • Journal Title: Inflammation and Regeneration. Volume: 33
  • NAID: 130004943833
  • Peer Reviewed
• [Journal Article] Leukotriene B4 type-1 receptor signaling promotes liver repair after hepatic ischemia/reperfusion injury through the enhancement of macrophage recruitment (2013)
  • Author(s): Ohkubo H, Ito Y, Minamino T, Mishima T, Hirata M, Hosono K, Shibuya M, Yokomizo T, Shimizu T, Watanabe M, Majima M.
  • Journal Title: FASEB Journal Volume: 68
  • Peer Reviewed
• [Journal Article] リンパ管新生：病態時の制御機構 (2013)
  • Author(s): 細野加奈子、馬嶋正隆
  • Journal Title: 日本薬理学会雑誌 Volume: 141 Pages: 290-291
  • Peer Reviewed
• [Journal Article] Tumor apoptosis in prostate cancer by PGD(2) and its metabolite 15d-PGJ(2) in murine model (2012)
  • Author(s): Nakamura M, Tsumura H, Satoh T, Matsumoto K, Maruyama H, Majima M, Kitasato H
  • Journal Title: Biomed Pharmacother Volume: 67(1) Issue: 1 Pages: 66-71
  • DOI: 10.1016/j.biopha.2012.10.012
  • Peer Reviewed
• [Journal Article] Thromboxane A_2 receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells (2012)
  • Author(s): Matsui Y, Amano H, Ito Y, Eshima K, Suzuki T, Ogawa F, Iyoda A, Satoh Y, Kato S, Nakamura M, Kitasato H, Narumiya S, Majima M
  • Journal Title: Cancer Sci Volume: 103(4) Issue: 4 Pages: 700-7
  • DOI: 10.1111/j.1349-7006.2012.02200.x
  • Peer Reviewed
• [Journal Article] 病態時のリンパ管新生を制御するプロスタノイドの役割 (2012)
  • Author(s): 馬嶋正隆
  • Journal Title: 生体の科学 Volume: 63 Pages: 564-571
• [Journal Article] Thromboxane A2 receptor signaling promotes liver tissue repair after toxic injury through the enhancement of macrophage recruitment (2012)
  • Author(s): Minamino T., et.al.
  • Journal Title: Toxicol Appl Pharmacol Volume: 259(1) Pages: 104-114
  • Peer Reviewed
• [Journal Article] In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats (2011)
  • Author(s): Fujita T, Ishihara K, Yasuda S, Nakamura T, Maeda M, Kobayashi M, Sahashi K, Ikeda Y, Kumagai Y, Majima M
  • Journal Title: J Pharmacol Exp Ther Volume: 341(3) Issue: 3 Pages: 626-33
  • DOI: 10.1124/jpet.111.187732
  • Peer Reviewed
• [Journal Article] Application of a heatand steam-generating sheet increases peripheral blood flow and induces parasympathetic predominance (2011)
  • Author(s): Nagashima Y, Igaki M, Suzuki A, Tsuchiya S, Yamazaki Y, Hishinuma M,Oh-Ishi S, Majima M
  • Journal Title: Evid Based Complement Alternat Med Volume: 2011 Issue: 1 Pages: 965095-965095
  • DOI: 10.1155/2011/965095
  • Peer Reviewed
• [Journal Article] Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema (2011)
  • Author(s): Kashiwagi S, et.al.
  • Journal Title: Lab Invest Volume: 91(9) Issue: 9 Pages: 1314-1325
  • DOI: 10.1038/labinvest.2011.84
  • Peer Reviewed
• [Journal Article] EP3/EP4 signaling regulates tumor microenvironment formation by bone marrow-derived fibroblasts (2011)
  • Author(s): Katoh H., et.al.
  • Journal Title: Inflammation and Regeneration Volume: 31(3) Pages: 316-324
  • Peer Reviewed
• [Journal Article] Roles of calcitonin gene-related peptide in ehancement of angiogenesis (2011)
  • Author(s): Majima M., et.al.
  • Journal Title: Inflammation and Regeneration Volume: 31(3) Pages: 146-150
  • NAID: 130004943780
  • Peer Reviewed
• [Journal Article] Anti-tumor effects of prostaglandin D2 and its metabolites, 15-deoxy-Δ12,14-PGJ2, by peroxisome proliferator-activated receptor (PPAR) γ-dependent and -independent pathways (2011)
  • Author(s): Nakamura M., et.al.
  • Journal Title: Inflammation and Regeneration Volume: 31(2) Pages: 189-195
  • Peer Reviewed
• [Journal Article] Roles of prostaglandin E2-EP3/EP4 receptor signaling in the enhancement of lymphangiogenesis during fibroblast growth factor-2-induced granulation formation (2011)
  • Author(s): Hosono K, Suzuki T, Tamaki H, Sakagami H, Hayashi I, Narumiya S, Alitalo K, Majima M
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 31(5) Issue: 5 Pages: 1049-58
  • DOI: 10.1161/atvbaha.110.222356
  • Peer Reviewed
• [Journal Article] Microsomal prostaglandin E synthase-1enhances bone cancer growth and bone cancer-related pain behaviors in mice (2011)
  • Author(s): Isono M., et.al.
  • Journal Title: Life Sci Volume: 88(15-16) Pages: 693-700
  • Peer Reviewed
• [Presentation] Roles of prostaglandins in regulation of plasticity of lymphatics and lymph nodes (2015)
  • Author(s): Masataka Majima
  • Organizer: 6th International Conference on Phospholipase A2 and Lipid Mediators (Symposium)
  • Place of Presentation: Keio Plaza Hotel (Shinjuku, Tokyo)
  • Year and Date: 2015-02-10 – 2015-02-12
  • Invited
• [Presentation] Roles of Arachidonic Acid Metabolites in Angiogenesis (2014)
  • Author(s): Masataka Majima
  • Organizer: Gordon Research Conference; Endothelial Cell Phenotypes in Health & Disease
  • Place of Presentation: Girona, Spain
  • Year and Date: 2014-07-06 – 2014-07-11
  • Invited
• [Presentation] Roles of prostanoid receptor signaling in enhancement of tumor metastasis (2013)
  • Author(s): Ogawa F. Amano H. Majima M.
  • Organizer: 86th Jap Pharmacological Society Annual Meeting
  • Place of Presentation: Fukuoka
  • Year and Date: 2013-03-21
  • Invited
• [Presentation] RAMP-1シグナルによる創傷治癒および血管新生の増強 (2013)
  • Author(s): 藏重千絵、細野加奈子、松田弘美、馬嶋正隆
  • Organizer: 86th Jap Pharmacological Society Annual Meeting
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] 肝虚血再還流後肝再生に果たすロイコトリエンB4とその受容体の働き (2013)
  • Author(s): 大久保博世、伊藤義也、細野加奈子、馬嶋正隆
  • Organizer: 86th Jap Pharmacological Society Annual Meeting
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] エンドトキシン誘発性腹膜炎時のCOX-2依存性のリンパ管新生 (2013)
  • Author(s): 松田弘美、藏重千絵、細野加奈子、馬嶋正隆
  • Organizer: 86th Jap Pharmacological Society Annual Meeting
  • Place of Presentation: 福岡
  • Year and Date: 2013-03-21
• [Presentation] Impaired blood flow recovery in streptozotocin induced Diabetes Mellitus mice by down regulation of VEGFR1TK signaling (2013)
  • Author(s): Oba K, Amano H, Sato H, Ogawa F, Eshima K, Okizaki S, Okubo H, Kurashige C, Kamata M, Shichiri M, Majima M
  • Organizer: 第38回日本微小循環学会総会
  • Place of Presentation: Tokyo
  • Year and Date: 2013-02-07
• [Presentation] Role of VEGFR1 signaling in liver injury and repair following hepatic ischemia/reperfusion injury in mice (2013)
  • Author(s): Ohkubo H, Ito Y, Minamino T, Hosono K, Watanabe M, Majima M
  • Organizer: 第38回日本微小循環学会総会
  • Place of Presentation: Tokyo
  • Year and Date: 2013-02-07
• [Presentation] Roles of prostaglandins in enhancement of angiogenesis and lymphangiogenesis in diseases. (2012)
  • Author(s): Majima M.
  • Organizer: 第33回日本炎症・再生学会(シンポジウム)
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06
  • Invited
• [Presentation] 胃潰瘍治癒過程におけるVEGF １型受容体シグナリングの役割 (2012)
  • Author(s): 佐東 丈仁、天野 英樹、馬嶋 正隆
  • Organizer: 第33回日本炎症・再生学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06
• [Presentation] プロスタグランジン遺伝子導入によるマウス前立腺癌in vivo モデルにおけるアポトーシスの誘導 (2012)
  • Author(s): 中村 正樹、松本和将、馬嶋 正隆、北里 英郎
  • Organizer: 第33回日本炎症・再生学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06
• [Presentation] 虚血筋組織におけるトロンボキサンA ２シグナルによる虚血改善メカニズムの解析 (2012)
  • Author(s): 天野 英樹、伊藤 義也、大庭 和人、江島 耕二、成宮 周、馬嶋 正隆
  • Organizer: 第33回日本炎症・再生学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06
• [Presentation] 肺再生におけるVEGFR1TK シグナルの役割 (2012)
  • Author(s): 天野 英樹、松井 啓夫、小川 史洋、渋谷 正史、馬嶋 正隆
  • Organizer: 第33回日本炎症・再生学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-07-06
• [Presentation] Roles of prostaglandins in enhancement of angiogenesis and lymphangiogenesis (2012)
  • Author(s): Majima M.
  • Organizer: 1st International Symposium on Lipid Mediators
  • Place of Presentation: Fukuoka
  • Year and Date: 2012-06-06
  • Invited
• [Presentation] Roles of thromboxane receptor signaling in enhancement of angiogenesis. (2012)
  • Author(s): Majima M.
  • Organizer: 17th International Vascular Biology Meeting (IVBM) 2012
  • Place of Presentation: Wiesbaden（ドイツ）
  • Year and Date: 2012-06-01
  • Invited
• [Presentation] Roles of prostaglandins in enhancement of angiogenesis and lymphangiogenesis during the developments of cancers and inflammation. (2012)
  • Author(s): Majima M.
  • Organizer: Keystone Symposium: Inflammation during Carcinogenesis
  • Place of Presentation: Dubin (アイルランド)
  • Year and Date: 2012-05-21
  • Invited
• [Presentation] ショック研究における基礎医学と臨床医学の連携 (2012)
  • Author(s): 馬嶋正隆
  • Organizer: 第２７回日本Shock学会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-11
  • Invited
• [Presentation] Calcitonin Gene-related Peptide; A neuronal cue for angiogenesis (2012)
  • Author(s): Majima M.
  • Organizer: Pacific Symposium on Vascular Biology in KAIST
  • Place of Presentation: Daejeon（韓国）
  • Year and Date: 2012-04-25
  • Invited
• [Presentation] 病態時の脈管新生を制御する脂質メディエーターの役割 (2012)
  • Author(s): 馬嶋正隆
  • Organizer: 千里ライフサイエンスセミナー D5 脂質メディエーターと疾患
  • Place of Presentation: 大阪
  • Invited
• [Presentation] Heterogeniety of endothelial cells : Thromboxane-dependent platelet adhesion and angiogenesis (2011)
  • Author(s): Majima M
  • Organizer: Gordon Research Conference ; Angiogenesis
  • Place of Presentation: Newport, RI, USA
  • Year and Date: 2011-08-24
• [Presentation] 病態時のリンパ管新生とリンパ流を制御するプロスタグランジンの役割
  • Author(s): 馬嶋正隆
  • Organizer: 第３７回日本リンパ学会総会
  • Place of Presentation: 福岡
  • Invited
• [Presentation] Roles of Prostanoids in Pathological Lymphangiogenesis
  • Author(s): 馬嶋正隆
  • Organizer: 第3回リンパ学に関する松本カンファランス
  • Place of Presentation: 松本
  • Invited
• [Presentation] Roles of Prostanoids in Regulation of Angiogenesis and Lymphatic Tissue Remodeling
  • Author(s): Majima M.
  • Organizer: 第39回日本微小循環学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Prostanoids regulate tumor stromal profiles via specific G-protein coupled receptors
  • Author(s): Majima M., Hosono K., Suzuki T., Amano H., Kato H., Ogawa F., Park K.
  • Organizer: 4th International conference on tumor-host interaction and Angiogenesis
  • Place of Presentation: Ascona (Switzerland)
  • Invited
• [Presentation] Microsomal prostaglandin E synthase-1 as a regulator of angiogenesis
  • Author(s): Majima M., Hosono K., Suzuki T., Amano H.
  • Organizer: GRC Angiogenesis
  • Place of Presentation: New Port (United States)
  • Invited
• [Presentation] Roles of Prostanoids in Regulation of Angiogenesis and Lymphangiogenesis
  • Author(s): Majima M., Hosono K., Suzuki T., Amano H.
  • Organizer: The 16th GEM-10th GERLI meeting: from membranes to pathologies
  • Place of Presentation: Saint-Jean Cap Ferrat (France)
  • Invited
• [Presentation] Prostanoids as Regulators of Pathological Lymphangiogenesis
  • Author(s): Majima M., Hosono K., Amano H., Ogawa F., Park K.
  • Organizer: GRC Molecular Mechanisms in Lymphatic Function & Diseas
  • Place of Presentation: Lucca (Italy)
  • Invited
• [Book] 標準薬理学第７版 (2015)
  • Author(s): 馬嶋正隆、監修今井正、編集飯野正光
  • Total Pages: 674
  • Publisher: 医学書院
• [Book] 遺伝子医学MOOK 24号 最新生理活性脂質研究-実験手法、基礎的知識とその応用- (2013)
  • Author(s): 馬嶋正隆、青木淳賢、杉本幸彦、村上誠、横溝岳彦（監修） 他
  • Total Pages: 312
  • Publisher: メディカル ドゥ社
• [Book] 「最新生理活性脂質研究-実験手法、基礎的知識とその応用-」遺伝子医学MOOK 24号 (2013)
  • Author(s): 馬嶋正隆
  • Publisher: メディカル ドゥ社
• [Book] 標準薬理学 第７版 (2013)
  • Author(s): 馬嶋正隆
  • Publisher: 医学書院
• [Book] New薬理学(改訂第6版) (2011)
  • Author(s): 馬嶋正隆
  • Publisher: 南江堂
• [Remarks] 北里大学医学部薬理学単位ホームページ
  • URL: http://www.med.kitasato-u.ac.jp/pharm/
• [Remarks] 北里大学大学院医療系研究科分子薬理学 北里大学医学部薬理学単位ホームページ
  • URL: http://www.med.kitasato-u.ac.jp/pharm/index.html