| Budget Amount *help |
¥97,760,000 (Direct Cost: ¥75,200,000、Indirect Cost: ¥22,560,000)
Fiscal Year 2015: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2014: ¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2012: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Fiscal Year 2011: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
|
|---|
| Outline of Final Research Achievements |
For better understanding of the Matryoshka-type cell configuration by organelles evolved for the parasitism in malaria parasites, proteins located in the secretory organelles of the invasive stage of malaria parasites Plasmodium falciparum were comprehensively analyzed. To this end, 25 novel molecules were identified and characterized for their importance during the invasion and growth. Analysis of a parasite molecule SURFIN that is expressed on the parasite-infected erythrocyte identified essential regions for the trafficking to the erythrocyte cytosol and Maurer's clefts, nascent membranous structures generated by the parasite in the erythrocyte. The translocon responsible for this trafficking was also identified. In addition, regions required for the translocation from Maurer's clefts to the erythrocyte membrane and exposure on the erythrocyte surface was identified.
|
