| Budget Amount *help |
¥88,400,000 (Direct Cost: ¥68,000,000、Indirect Cost: ¥20,400,000)
Fiscal Year 2015: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2014: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2013: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2012: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2011: ¥21,970,000 (Direct Cost: ¥16,900,000、Indirect Cost: ¥5,070,000)
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| Outline of Final Research Achievements |
We analyzed neural circuit mechanisms in reward and aversion, and decision-making, using reversible neurotransmission blocking technique, in which neurotransmission of the direct and indirect striatal pathways was selectively and reversibly blocked. We showed that the activation of dopamine D1 receptors in the nucleus accumbens direct pathway neurons and the inactivation of potsynaptic dopamine D2 receptors in the nucleus accumbens indirect pathway neurons control reward and aversive behavior, respectively. Furthermore, we have revealed that reward and aversive behavior is regulated by pathway-specific neural plasticity via selective transmitter receptors and intracellular signaling in the basal ganglia circuit.
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